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Obesity, sleep apnea, and cancer.

Almendros I, Martinez-Garcia MA, Farré R, Gozal D.

Int J Obes (Lond). 2020 Feb 18. doi: 10.1038/s41366-020-0549-z. [Epub ahead of print]


Obstructive sleep apnea intensifies stroke severity following middle cerebral artery occlusion.

Cananzi SG, White LA, Barzegar M, Boyer CJ, Chernyshev OY, Yun JW, Kelley RE, Almendros I, Minagar A, Farré R, Alexander JS.

Sleep Med. 2020 Jan 29. pii: S1389-9457(20)30045-9. doi: 10.1016/j.sleep.2020.01.014. [Epub ahead of print]


Mobile health application to support CPAP therapy in obstructive sleep apnoea: design, feasibility and perspectives.

Suarez-Giron M, Garmendia O, Lugo V, Ruiz C, Salord N, Alsina X, Farré R, Montserrat JM, Torres M.

ERJ Open Res. 2020 Feb 10;6(1). pii: 00220-2019. doi: 10.1183/23120541.00220-2019. eCollection 2020 Jan.


Chronic Sleep Fragmentation Mimicking Sleep Apnea Does Not Worsen Left-Ventricular Function in Healthy and Heart Failure Mice.

Cabrera-Aguilera I, Benito B, Tajes M, Farré R, Gozal D, Almendros I, Farré N.

Front Neurol. 2020 Jan 9;10:1364. doi: 10.3389/fneur.2019.01364. eCollection 2019.


Relationship between bile salts, bacterial translocation, and duodenal mucosal integrity in functional dyspepsia.

Beeckmans D, Farré R, Riethorst D, Keita ÅV, Augustijns P, Söderholm JD, Vanuytsel T, Vanheel H, Tack J.

Neurogastroenterol Motil. 2020 Jan 8:e13788. doi: 10.1111/nmo.13788. [Epub ahead of print]


Prevalence of obstructive sleep apnea in Alzheimer's disease patients.

Gaeta AM, Benítez ID, Jorge C, Torres G, Dakterzada F, Minguez O, Huerto R, Pujol M, Carnes A, Dalmases M, Gibert A, Farré R, de la Torres MS, Barbé F, Piñol-Ripoll G.

J Neurol. 2019 Dec 12. doi: 10.1007/s00415-019-09668-4. [Epub ahead of print]


Differential effect of intermittent hypoxia and sleep fragmentation on PD-1/PD-L1 upregulation.

Cubillos-Zapata C, Almendros I, Díaz-García E, Toledano V, Casitas R, Galera R, López-Collazo E, Farre R, Gozal D, García-Rio F.

Sleep. 2019 Nov 29. pii: zsz285. doi: 10.1093/sleep/zsz285. [Epub ahead of print]


Technical Standards for Respiratory Oscillometry.

King GG, Bates J, Berger KI, Calverley P, de Melo PL, Dellacà RL, Farré R, Hall GL, Ioan I, Irvin CG, Kaczka DW, Kaminsky DA, Kurosawa H, Lombardi E, Maksym GN, Marchal F, Oppenheimer BW, Simpson SJ, Thamrin C, van den Berge M, Oostveen E.

Eur Respir J. 2019 Nov 26. pii: 1900753. doi: 10.1183/13993003.00753-2019. [Epub ahead of print] No abstract available.


Quality Assessment of Real-Life Performance of Home Mechanical Ventilators.

Garmendia O, Farré R, González M, Alonso-Alvarez ML, Perez N, Martí S, Montserrat JM.

Arch Bronconeumol. 2019 Nov 19. pii: S0300-2896(19)30376-X. doi: 10.1016/j.arbres.2019.08.017. [Epub ahead of print] English, Spanish. No abstract available.


Biophysically Preconditioning Mesenchymal Stem Cells Improves Treatment of Ventilator-Induced Lung Injury.

Nonaka PN, Falcones B, Farre R, Artigas A, Almendros I, Navajas D.

Arch Bronconeumol. 2019 Nov 17. pii: S0300-2896(19)30370-9. doi: 10.1016/j.arbres.2019.08.014. [Epub ahead of print] English, Spanish. No abstract available.


Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial.

Lugo VM, Garmendia O, Suarez-Girón M, Torres M, Vázquez-Polo FJ, Negrín MA, Moraleda A, Roman M, Puig M, Ruiz C, Egea C, Masa JF, Farré R, Montserrat JM.

PLoS One. 2019 Oct 24;14(10):e0224069. doi: 10.1371/journal.pone.0224069. eCollection 2019.


Accuracy of one-night actigraphy for estimating sleep in patients with sleep apnea.

Villanueva JA, Garmendia O, Farré R, Montserrat JM.

Sleep Med. 2019 Nov;63:3-4. doi: 10.1016/j.sleep.2019.05.007. Epub 2019 May 25. No abstract available.


Effects of Sustained and Intermittent Hypoxia on Human Lung Cancer Cells.

Marhuenda E, Campillo N, Gabasa M, Martínez-García MA, Campos-Rodríguez F, Gozal D, Navajas D, Alcaraz J, Farré R, Almendros I.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):540-544. doi: 10.1165/rcmb.2018-0412LE. No abstract available.


Biomechanical Response of Lung Epithelial Cells to Iron Oxide and Titanium Dioxide Nanoparticles.

Oliveira VR, Uriarte JJ, Falcones B, Jorba I, Zin WA, Farré R, Navajas D, Almendros I.

Front Physiol. 2019 Aug 16;10:1047. doi: 10.3389/fphys.2019.01047. eCollection 2019.


Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion.

Rubies C, Dantas AP, Batlle M, Torres M, Farre R, Sangüesa G, Montserrat JM, Mont L, Almendros I, Guasch E.

Sci Rep. 2019 Aug 7;9(1):11443. doi: 10.1038/s41598-019-47813-1.


Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea.

Almendros I, Martínez-Ros P, Farré N, Rubio-Zaragoza M, Torres M, Gutiérrez-Bautista ÁJ, Carrillo-Poveda JM, Sopena-Juncosa JJ, Gozal D, Gonzalez-Bulnes A, Farré R.

J Appl Physiol (1985). 2019 Sep 1;127(3):745-752. doi: 10.1152/japplphysiol.00303.2019. Epub 2019 Aug 1.


Cancer and Sleep Apnea: Cutaneous Melanoma as a Case Study.

Martinez-Garcia MA, Campos-Rodriguez F, Almendros I, Garcia-Rio F, Sanchez-de-la-Torre M, Farre R, Gozal D.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1345-1353. doi: 10.1164/rccm.201903-0577PP. No abstract available.


Effect of age on the cardiovascular remodelling induced by chronic intermittent hypoxia as a murine model of sleep apnoea.

Castro-Grattoni AL, Suarez-Giron M, Benitez I, Torres M, Almendros I, Farre R, Montserrat JM, Dalmases M, Gozal D, Sánchez-de-la-Torre M; Spanish Sleep Network.

Respirology. 2020 Mar;25(3):312-320. doi: 10.1111/resp.13610. Epub 2019 Jun 18.


Telematic Multi-physician Decision-making for Improving CPAP Prescription in Sleep Apnoea.

Farré R, Navajas D, Gozal D, Montserrat JM.

Arch Bronconeumol. 2019 Nov;55(11):604-606. doi: 10.1016/j.arbres.2019.03.017. Epub 2019 May 18. English, Spanish. No abstract available.


Nonlinear elasticity of the lung extracellular microenvironment is regulated by macroscale tissue strain.

Jorba I, Beltrán G, Falcones B, Suki B, Farré R, García-Aznar JM, Navajas D.

Acta Biomater. 2019 Jul 1;92:265-276. doi: 10.1016/j.actbio.2019.05.023. Epub 2019 May 11.


Colonic hypersensitivity and low-grade inflammation in a spontaneous animal model for functional gastrointestinal disorders.

Meleine M, Accarie A, Wauters L, Toth J, Gourcerol G, Tack J, Farré R, Vanuytsel T.

Neurogastroenterol Motil. 2019 Jul;31(7):e13614. doi: 10.1111/nmo.13614. Epub 2019 May 8.


Intra- and Inter-Physician Agreement in Therapeutic Decision for Sleep Apnea Syndrome.

Lugo VM, Torres M, Garmendia O, Suarez-Giron M, Ruiz C, Carmona C, Chiner E, Tarraubella N, Dalmases M, Pedro AM, Egea CJ, Abellana M, Mayos M, Monasterio C, Masa JF, Farré R, Montserrat JM.

Arch Bronconeumol. 2020 Jan;56(1):18-22. doi: 10.1016/j.arbres.2019.02.014. Epub 2019 Apr 5. English, Spanish.


Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis.

Vancamelbeke M, Laeremans T, Vanhove W, Arnauts K, Ramalho AS, Farré R, Cleynen I, Ferrante M, Vermeire S.

J Crohns Colitis. 2019 Sep 27;13(10):1351-1361. doi: 10.1093/ecco-jcc/jjz064.


An in-vitro study to evaluate high-volume low-pressure endotracheal tube cuff deflation dynamics.

Marti JD, Li Bassi G, Isetta V, Lazaro MR, Aguilera-Xiol E, Comaru T, Battaglini D, Meli A, Ferrer M, Navajas D, Pelosi P, Chiumello D, Torres A, Farre R.

Minerva Anestesiol. 2019 Aug;85(8):846-853. doi: 10.23736/S0375-9393.19.13133-1. Epub 2019 Mar 12.


Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept.

Campillo N, Falcones B, Otero J, Colina R, Gozal D, Navajas D, Farré R, Almendros I.

Front Oncol. 2019 Feb 6;9:43. doi: 10.3389/fonc.2019.00043. eCollection 2019.


Easy-to-build and affordable continuous positive airway pressure CPAP device for adult patients in low-income countries.

Farré R, Montserrat JM, Solana G, Gozal D, Navajas D.

Eur Respir J. 2019 May 2;53(5). pii: 1802290. doi: 10.1183/13993003.02290-2018. Print 2019 May. No abstract available.


Age-dependent hypoxia-induced PD-L1 upregulation in patients with obstructive sleep apnoea.

Cubillos-Zapata C, Balbás-García C, Avendaño-Ortiz J, Toledano V, Torres M, Almendros I, Casitas R, Zamarrón E, García-Sánchez A, Feliu J, Aguirre LA, Farre R, López-Collazo E, García-Rio F.

Respirology. 2019 Jul;24(7):684-692. doi: 10.1111/resp.13470. Epub 2019 Jan 17.


Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut.

Wang Q, Liszt KI, Deloose E, Canovai E, Thijs T, Farré R, Ceulemans LJ, Lannoo M, Tack J, Depoortere I.

FASEB J. 2019 Apr;33(4):4907-4920. doi: 10.1096/fj.201801661RR. Epub 2019 Jan 10.


Gas Partial Pressure in Cultured Cells: Patho-Physiological Importance and Methodological Approaches.

Farré R, Almendros I, Montserrat JM, Gozal D, Navajas D.

Front Physiol. 2018 Dec 13;9:1803. doi: 10.3389/fphys.2018.01803. eCollection 2018. Review.


Escherichia coli lipopolysaccharide induces alveolar epithelial cell stiffening.

Oliveira VR, Uriarte JJ, Falcones B, Zin WA, Navajas D, Farré R, Almendros I.

J Biomech. 2019 Jan 23;83:315-318. doi: 10.1016/j.jbiomech.2018.11.034. Epub 2018 Nov 29.


Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients.

Cubillos-Zapata C, Martínez-García MÁ, Campos-Rodríguez F, Sánchez de la Torre M, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Chiner Vives E, Abad-Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Diaz-Cambriles T, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros I, Farré R, López-Collazo E, Gozal D, García-Río F; Spanish Sleep Network.

Eur Respir J. 2019 Jan 31;53(2). pii: 1801298. doi: 10.1183/13993003.01298-2018. Print 2019 Feb.


Maintaining Intestinal Mucosal Integrity by Plugging Leaks with Homoectoine.

Farré R, Vicario M.

Dig Dis Sci. 2019 Feb;64(2):292-293. doi: 10.1007/s10620-018-5383-y. No abstract available.


Intermittent Hypoxia Severity in Animal Models of Sleep Apnea.

Farré R, Montserrat JM, Gozal D, Almendros I, Navajas D.

Front Physiol. 2018 Nov 6;9:1556. doi: 10.3389/fphys.2018.01556. eCollection 2018. No abstract available.


Passive Stiffness of Left Ventricular Myocardial Tissue Is Reduced by Ovariectomy in a Post-menopause Mouse Model.

Farré N, Jorba I, Torres M, Falcones B, Martí-Almor J, Farré R, Almendros I, Navajas D.

Front Physiol. 2018 Nov 5;9:1545. doi: 10.3389/fphys.2018.01545. eCollection 2018.


Equine lung decellularization: a potential approach for in vitro modeling the role of the extracellular matrix in asthma.

da Palma RK, Fratini P, Schiavo Matias GS, Cereta AD, Guimarães LL, Anunciação ARA, de Oliveira LVF, Farre R, Miglino MA.

J Tissue Eng. 2018 Nov 12;9:2041731418810164. doi: 10.1177/2041731418810164. eCollection 2018 Jan-Dec.


Altered duodenal bile salt concentration and receptor expression in functional dyspepsia.

Beeckmans D, Riethorst D, Augustijns P, Vanuytsel T, Farré R, Tack J, Vanheel H.

United European Gastroenterol J. 2018 Nov;6(9):1347-1355. doi: 10.1177/2050640618799120. Epub 2018 Sep 4.


Novel Approach for Providing Pediatric Continuous Positive Airway Pressure Devices in Low-Income, Underresourced Regions.

Farré R, Trias G, Solana G, Ginovart G, Gozal D, Navajas D.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):118-120. doi: 10.1164/rccm.201808-1452LE. No abstract available.


Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study.

Farré N, Otero J, Falcones B, Torres M, Jorba I, Gozal D, Almendros I, Farré R, Navajas D.

Front Physiol. 2018 Aug 15;9:1143. doi: 10.3389/fphys.2018.01143. eCollection 2018.


Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.

Martinez-Garcia MA, Campos-Rodriguez F, Nagore E, Martorell A, Rodriguez-Peralto JL, Riveiro-Falkenbach E, Hernandez L, Bañuls J, Arias E, Ortiz P, Cabriada V, Gardeazabal J, Montserrat JM, Carrera C, Corral J, Masa JF, de Terreros JG, Abad J, Boada A, Mediano O, de Eusebio E, Chiner E, Landete P, Mayos M, Fortuño A, Barbé F, Sánchez de la Torre M, Sanchez de la Torre A, Cano I, Gonzalez C, Pérez-Gil A, Gómez-García T, Cullen D, Somoza M, Formigón M, Aizpuru F, Navarro C, Selma-Ferrer MJ, Garcia-Ortega A, de Unamuno B, Almendros I, Farré R, Gozal D; Spanish Sleep Network.

Chest. 2018 Dec;154(6):1348-1358. doi: 10.1016/j.chest.2018.07.015. Epub 2018 Jul 27.


Intestinal Barrier Function in Chronic Kidney Disease.

Meijers B, Farré R, Dejongh S, Vicario M, Evenepoel P.

Toxins (Basel). 2018 Jul 19;10(7). pii: E298. doi: 10.3390/toxins10070298. Review.


Aging Reduces Intermittent Hypoxia-induced Lung Carcinoma Growth in a Mouse Model of Sleep Apnea.

Torres M, Campillo N, Nonaka PN, Montserrat JM, Gozal D, Martínez-García MA, Campos-Rodriguez F, Navajas D, Farré R, Almendros I.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1234-1236. doi: 10.1164/rccm.201805-0892LE. No abstract available.


A Portable Continuous Positive Airway Pressure Device That Can Perform Optimally under Strenuous Conditions.

Villanueva JA, Isetta V, Montserrat JM, Navajas D, Farré R.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):956-958. doi: 10.1164/rccm.201803-0584LE. Review. No abstract available.


A reduced esophageal epithelial integrity in a subgroup of healthy individuals increases with proton pump inhibitor therapy.

Pauwels A, Broers C, Vanuytsel T, Pardon N, Cocca S, Roman S, Zerbib F, Tack J, Farré R.

United European Gastroenterol J. 2018 May;6(4):511-518. doi: 10.1177/2050640617749115. Epub 2017 Dec 17.


Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea.

Suarez-Giron MC, Castro-Grattoni A, Torres M, Farré R, Barbé F, Sánchez-de-la-Torre M, Gozal D, Picado C, Montserrat JM, Almendros I.

Front Physiol. 2018 May 24;9:600. doi: 10.3389/fphys.2018.00600. eCollection 2018.


Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society.

Randerath W, Bassetti CL, Bonsignore MR, Farre R, Ferini-Strambi L, Grote L, Hedner J, Kohler M, Martinez-Garcia MA, Mihaicuta S, Montserrat J, Pepin JL, Pevernagie D, Pizza F, Polo O, Riha R, Ryan S, Verbraecken J, McNicholas WT.

Eur Respir J. 2018 Sep 16;52(3). pii: 1702616. doi: 10.1183/13993003.02616-2017. Print 2018 Sep. Review.


Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients.

Almendros I, Martínez-García MÁ, Campos-Rodríguez F, Riveiro-Falkenbach E, Rodríguez-Peralto JL, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Bañuls Roca J, Chiner Vives E, Sánchez-de-la-Torre A, Abad-Capa J, Montserrat JM, Pérez-Gil A, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Diaz-Cambriles T, Mediano O, Dalmau-Arias J, Farré R, Gozal D; Spanish Sleep Network.

Front Neurol. 2018 Apr 26;9:272. doi: 10.3389/fneur.2018.00272. eCollection 2018.


Basic and translational research in the European Respiratory Journal.

Farré R, Hiemstra PS, Dinh-Xuan AT.

Eur Respir J. 2018 May 3;51(5). pii: 1800377. doi: 10.1183/13993003.00377-2018. Print 2018 May. No abstract available.


Head-to-head comparison of two engineered cardiac grafts for myocardial repair: From scaffold characterization to pre-clinical testing.

Perea-Gil I, Gálvez-Montón C, Prat-Vidal C, Jorba I, Segú-Vergés C, Roura S, Soler-Botija C, Iborra-Egea O, Revuelta-López E, Fernández MA, Farré R, Navajas D, Bayes-Genis A.

Sci Rep. 2018 Apr 30;8(1):6708. doi: 10.1038/s41598-018-25115-2.


Design of Amperometric Biosensors for the Detection of Glucose Prepared by Immobilization of Glucose Oxidase on Conducting (Poly)Thiophene Films.

Pilo M, Farre R, Lachowicz JI, Masolo E, Panzanelli A, Sanna G, Senes N, Sobral A, Spano N.

J Anal Methods Chem. 2018 Mar 1;2018:1849439. doi: 10.1155/2018/1849439. eCollection 2018.


Mimicking a flow-limited human upper airway using a collapsible tube: relationships between flow patterns and pressures in a respiratory model.

Zhu K, Farré R, Katz I, Hardy S, Escourrou P.

J Appl Physiol (1985). 2018 Aug 1;125(2):605-614. doi: 10.1152/japplphysiol.00877.2017. Epub 2018 Apr 19.

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