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How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond.

Dillon S, Staines KA, Millán JL, Farquharson C.

JBMR Plus. 2019 Jul 7;3(7):e10202. doi: 10.1002/jbm4.10202. eCollection 2019 Jul. Review.


Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.

Staines KA, Ikpegbu E, Törnqvist AE, Dillon S, Javaheri B, Amin AK, Clements DN, Buttle DJ, Pitsillides AA, Farquharson C.

BMC Musculoskelet Disord. 2019 Jul 27;20(1):344. doi: 10.1186/s12891-019-2731-9.


Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.

Plaut JS, Strzelecka-Kiliszek A, Bozycki L, Pikula S, Buchet R, Mebarek S, Chadli M, Bolean M, Simao AMS, Ciancaglini P, Magrini A, Rosato N, Magne D, Girard-Egrot A, Farquharson C, Esener SC, Millan JL, Bottini M.

Arch Biochem Biophys. 2019 May 30;667:14-21. doi: 10.1016/ Epub 2019 Apr 16.


ENPP1 in the Regulation of Mineralization and Beyond.

Roberts F, Zhu D, Farquharson C, Macrae VE.

Trends Biochem Sci. 2019 Jul;44(7):616-628. doi: 10.1016/j.tibs.2019.01.010. Epub 2019 Feb 21. Review.


The Ex Vivo Organ Culture of Bone.

Staines KA, Brown G, Farquharson C.

Methods Mol Biol. 2019;1914:199-215. doi: 10.1007/978-1-4939-8997-3_10.


Correction to: Optimised isolation method for RNA extraction suitable for RNA sequencing from feline teeth collected in a clinical setting and at post mortem.

Lee S, Trivedi U, Johnson C, Farquharson C, Bergkvist GT.

Vet Res Commun. 2019 Feb;43(1):29. doi: 10.1007/s11259-018-9740-2.


Optimised isolation method for RNA extraction suitable for RNA sequencing from feline teeth collected in a clinical setting and at post mortem.

Lee S, Trivedi U, Johnson C, Farquharson C, Bergkvist GT.

Vet Res Commun. 2019 Feb;43(1):17-27. doi: 10.1007/s11259-018-9739-8. Epub 2018 Nov 6. Erratum in: Vet Res Commun. 2018 Nov 27;:.


PHOSPHO1 is essential for normal bone fracture healing: An Animal Study.

Morcos MW, Al-Jallad H, Li J, Farquharson C, Millán JL, Hamdy RC, Murshed M.

Bone Joint Res. 2018 Jul 7;7(6):397-405. doi: 10.1302/2046-3758.76.BJR-2017-0140.R2. eCollection 2018 Jun.


Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

Huang NJ, Lin YC, Lin CY, Pishesha N, Lewis CA, Freinkman E, Farquharson C, Millán JL, Lodish H.

Blood. 2018 Jun 28;131(26):2955-2966. doi: 10.1182/blood-2018-03-838516. Epub 2018 Apr 30.


Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.

Dobie R, MacRae VE, Pass C, Milne EM, Ahmed SF, Farquharson C.

Dis Model Mech. 2018 Jan 17;11(1). pii: dmm028456. doi: 10.1242/dmm.028456.


Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification.

Lin C, Zhu D, Markby G, Corcoran BM, Farquharson C, Macrae VE.

J Vis Exp. 2017 Nov 20;(129). doi: 10.3791/56126.


FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.

Ikpegbu E, Basta L, Clements DN, Fleming R, Vincent TL, Buttle DJ, Pitsillides AA, Staines KA, Farquharson C.

J Cell Physiol. 2018 Jul;233(7):5334-5347. doi: 10.1002/jcp.26345. Epub 2018 Jan 23.


Exploiting novel valve interstitial cell lines to study calcific aortic valve disease.

Tsang HG, Cui L, Farquharson C, Corcoran BM, Summers KM, Macrae VE.

Mol Med Rep. 2018 Feb;17(2):2100-2106. doi: 10.3892/mmr.2017.8163. Epub 2017 Nov 27.


Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation.

Pandya M, Rosene L, Farquharson C, Millán JL, Diekwisch TGH.

Front Physiol. 2017 Oct 17;8:805. doi: 10.3389/fphys.2017.00805. eCollection 2017.


Animal models to explore the effects of glucocorticoids on skeletal growth and structure.

Wood CL, Soucek O, Wong SC, Zaman F, Farquharson C, Savendahl L, Ahmed SF.

J Endocrinol. 2018 Jan;236(1):R69-R91. doi: 10.1530/JOE-17-0361. Epub 2017 Oct 19. Review.


PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization.

Stewart AJ, Leong DTK, Farquharson C.

FASEB J. 2018 Jan;32(1):20-25. doi: 10.1096/fj.201700521R. Epub 2017 Sep 1. Review.


A distinctive patchy osteomalacia characterises Phospho1-deficient mice.

Boyde A, Staines KA, Javaheri B, Millan JL, Pitsillides AA, Farquharson C.

J Anat. 2017 Aug;231(2):298-308. doi: 10.1111/joa.12628.


Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.

Staines KA, Javaheri B, Hohenstein P, Fleming R, Ikpegbu E, Unger E, Hopkinson M, Buttle DJ, Pitsillides AA, Farquharson C.

J Cell Physiol. 2017 Nov;232(11):3006-3019. doi: 10.1002/jcp.25999. Epub 2017 Jun 14.


Skeletal energy homeostasis: a paradigm of endocrine discovery.

Suchacki KJ, Roberts F, Lovdel A, Farquharson C, Morton NM, MacRae VE, Cawthorn WP.

J Endocrinol. 2017 Jul;234(1):R67-R79. doi: 10.1530/JOE-17-0147. Epub 2017 Apr 28. Review.


Kinesiology tape mediates soccer-simulated and local peroneal fatigue in soccer players.

Farquharson C, Greig M.

Res Sports Med. 2017 Jul-Sep;25(3):313-321. doi: 10.1080/15438627.2017.1314294. Epub 2017 Apr 12.


End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.

Cui L, Rashdan NA, Zhu D, Milne EM, Ajuh P, Milne G, Helfrich MH, Lim K, Prasad S, Lerman DA, Vesey AT, Dweck MR, Jenkins WS, Newby DE, Farquharson C, Macrae VE.

J Cell Physiol. 2017 Nov;232(11):2985-2995. doi: 10.1002/jcp.25935. Epub 2017 May 24.


Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification.

Houston DA, Staines KA, MacRae VE, Farquharson C.

J Vis Exp. 2016 Dec 3;(118). doi: 10.3791/54978.


Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.

Al-Jazzar A, Javaheri B, Prideaux M, Boyde A, Scudamore CL, Cherifi C, Hay E, Hopkinson M, Boyd M, Cohen-Solal M, Farquharson C, Pitsillides AA.

Int J Mol Sci. 2016 Dec 26;18(1). pii: E29. doi: 10.3390/ijms18010029.


Family Medicine at the University of the West Indies: a model for the developing world.

Maharaj RG, Standard-Goldson A, Hanna-Mahase C, Roache-Barker S, Cunningham-Myrie C, Motilal MS, Farquharson C, Morris E, Paul-Charles J, Williams-Green P, Adams OP.

Educ Prim Care. 2016 Sep;27(5):405-408. Epub 2016 Aug 22.


The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures.

Houston DA, Myers K, MacRae VE, Staines KA, Farquharson C.

Calcif Tissue Int. 2016 Nov;99(5):510-524. Epub 2016 Jul 21.


Characterisation of matrix vesicles in skeletal and soft tissue mineralisation.

Cui L, Houston DA, Farquharson C, MacRae VE.

Bone. 2016 Jun;87:147-58. doi: 10.1016/j.bone.2016.04.007. Epub 2016 Apr 9. Review.


Role of PHOSPHO1 in Periodontal Development and Function.

Zweifler LE, Ao M, Yadav M, Kuss P, Narisawa S, Kolli TN, Wimer HF, Farquharson C, Somerman MJ, Millán JL, Foster BL.

J Dent Res. 2016 Jul;95(7):742-51. doi: 10.1177/0022034516640246. Epub 2016 Mar 25.


Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.

Yadav MC, Bottini M, Cory E, Bhattacharya K, Kuss P, Narisawa S, Sah RL, Beck L, Fadeel B, Farquharson C, Millán JL.

J Bone Miner Res. 2016 Jun;31(6):1275-86. doi: 10.1002/jbmr.2790. Epub 2016 May 17.


Growth and the Growth Hormone-Insulin Like Growth Factor 1 Axis in Children With Chronic Inflammation: Current Evidence, Gaps in Knowledge, and Future Directions.

Wong SC, Dobie R, Altowati MA, Werther GA, Farquharson C, Ahmed SF.

Endocr Rev. 2016 Feb;37(1):62-110. doi: 10.1210/er.2015-1026. Epub 2015 Dec 31. Review.



Farquharson C, Greig M.

Int J Sports Phys Ther. 2015 Dec;10(7):984-91.


E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.

Staines KA, Prideaux M, Allen S, Buttle DJ, Pitsillides AA, Farquharson C.

J Cell Physiol. 2016 Jun;231(6):1392-404. doi: 10.1002/jcp.25282. Epub 2015 Dec 28.


Endochondral Growth Defect and Deployment of Transient Chondrocyte Behaviors Underlie Osteoarthritis Onset in a Natural Murine Model.

Staines KA, Madi K, Mirczuk SM, Parker S, Burleigh A, Poulet B, Hopkinson M, Bodey AJ, Fowkes RC, Farquharson C, Lee PD, Pitsillides AA.

Arthritis Rheumatol. 2016 Apr;68(4):880-91. doi: 10.1002/art.39508.


Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.

Zaman G, Staines KA, Farquharson C, Newton PT, Dudhia J, Chenu C, Pitsillides AA, Dhoot GK.

Histochem Cell Biol. 2016 Jan;145(1):67-79. doi: 10.1007/s00418-015-1365-8. Epub 2015 Oct 14.


The Functional co-operativity of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 during initiation of Skeletal Mineralization.

Huesa C, Houston D, Kiffer-Moreira T, Yadav MM, Millan JL, Farquharson C.

Biochem Biophys Rep. 2015 Dec 1;4:196-201.


Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Javaheri B, Carriero A, Staines KA, Chang YM, Houston DA, Oldknow KJ, Millan JL, Kazeruni BN, Salmon P, Shefelbine S, Farquharson C, Pitsillides AA.

Bone. 2015 Dec;81:277-291. doi: 10.1016/j.bone.2015.07.035. Epub 2015 Jul 29.


MMP and TIMP temporal gene expression during osteocytogenesis.

Prideaux M, Staines KA, Jones ER, Riley GP, Pitsillides AA, Farquharson C.

Gene Expr Patterns. 2015 May-Jul;18(1-2):29-36. doi: 10.1016/j.gep.2015.04.004. Epub 2015 May 14.


Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

Dobie R, Ahmed SF, Staines KA, Pass C, Jasim S, MacRae VE, Farquharson C.

J Cell Physiol. 2015 Nov;230(11):2796-806. doi: 10.1002/jcp.25006.


Endocrine role of bone: recent and emerging perspectives beyond osteocalcin.

Oldknow KJ, MacRae VE, Farquharson C.

J Endocrinol. 2015 Apr;225(1):R1-19. doi: 10.1530/JOE-14-0584. Epub 2015 Feb 5. Review.


Piroxicam treatment augments bone abnormalities in interleukin-10 knockout mice.

Holgersen K, Dobie R, Farquharson C, vanʼt Hof R, Ahmed SF, Hansen AK, Holm TL.

Inflamm Bowel Dis. 2015 Feb;21(2):257-66. doi: 10.1097/MIB.0000000000000269.


A guide to modern quantitative fluorescent western blotting with troubleshooting strategies.

Eaton SL, Hurtado ML, Oldknow KJ, Graham LC, Marchant TW, Gillingwater TH, Farquharson C, Wishart TM.

J Vis Exp. 2014 Nov 20;(93):e52099. doi: 10.3791/52099.


An investigation of the mineral in ductile and brittle cortical mouse bone.

Rodriguez-Florez N, Garcia-Tunon E, Mukadam Q, Saiz E, Oldknow KJ, Farquharson C, Millán JL, Boyde A, Shefelbine SJ.

J Bone Miner Res. 2015 May;30(5):786-95. doi: 10.1002/jbmr.2414.


Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.

Huesa C, Zhu D, Glover JD, Ferron M, Karsenty G, Milne EM, Millan JL, Ahmed SF, Farquharson C, Morton NM, MacRae VE.

Dis Model Mech. 2014 Dec;7(12):1341-50. doi: 10.1242/dmm.017905. Epub 2014 Oct 31.


BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway.

Zhu D, Mackenzie NC, Shanahan CM, Shroff RC, Farquharson C, MacRae VE.

J Cell Mol Med. 2015 Jan;19(1):165-74. doi: 10.1111/jcmm.12373. Epub 2014 Oct 9.


Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness.

Carriero A, Bruse JL, Oldknow KJ, Millán JL, Farquharson C, Shefelbine SJ.

Bone. 2014 Dec;69:174-9. doi: 10.1016/j.bone.2014.09.020. Epub 2014 Oct 1.


Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

Bravo Y, Teriete P, Dhanya RP, Dahl R, Lee PS, Kiffer-Moreira T, Ganji SR, Sergienko E, Smith LH, Farquharson C, Millán JL, Cosford ND.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4308-11. doi: 10.1016/j.bmcl.2014.07.013. Epub 2014 Jul 15.


Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice.

Dobie R, MacRae VE, Huesa C, van't Hof R, Ahmed SF, Farquharson C.

J Endocrinol. 2014 Oct;223(1):93-106. doi: 10.1530/JOE-14-0292. Epub 2014 Jul 29.


Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.

Yadav MC, Huesa C, Narisawa S, Hoylaerts MF, Moreau A, Farquharson C, Millán JL.

J Bone Miner Res. 2014 Nov;29(11):2369-81. doi: 10.1002/jbmr.2281.


Upregulation of IGF2 expression during vascular calcification.

Zhu D, Mackenzie NC, Millan JL, Farquharson C, Macrae VE.

J Mol Endocrinol. 2014 Jan 30;52(2):77-85. doi: 10.1530/JME-13-0136. Print 2014 Apr.


Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting.

Eaton SL, Roche SL, Llavero Hurtado M, Oldknow KJ, Farquharson C, Gillingwater TH, Wishart TM.

PLoS One. 2013 Aug 30;8(8):e72457. doi: 10.1371/journal.pone.0072457. eCollection 2013.

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