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Items: 1 to 50 of 261

1.

AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.

Aznar N, Patel A, Rohena CC, Dunkel Y, Joosen LP, Taupin V, Kufareva I, Farquhar MG, Ghosh P.

Elife. 2016 Nov 4;5. pii: e20795. doi: 10.7554/eLife.20795.

2.

GIV/Girdin activates Gαi and inhibits Gαs via the same motif.

Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12.

3.

Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.

Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18.

4.

Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling.

Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P.

Dev Cell. 2015 Apr 20;33(2):189-203. doi: 10.1016/j.devcel.2015.02.009. Epub 2015 Apr 9.

5.

GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation.

Garcia-Marcos M, Ghosh P, Farquhar MG.

J Biol Chem. 2015 Mar 13;290(11):6697-704. doi: 10.1074/jbc.R114.613414. Epub 2015 Jan 20. Review.

6.

GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.

Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar MG.

J Am Soc Nephrol. 2015 Feb;26(2):314-27. doi: 10.1681/ASN.2013090985. Epub 2014 Jul 10.

7.

Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury.

Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K.

Kidney Int. 2014 Mar;85(3):611-23. doi: 10.1038/ki.2013.462. Epub 2013 Dec 4. Erratum in: Kidney Int. 2014 Jun;85(6):1474. Kidney Int. 2017 Sep;92(3):769.

8.

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.

Shah M, Baterina OY Jr, Taupin V, Farquhar MG.

J Cell Biol. 2013 Jul 8;202(1):113-27. doi: 10.1083/jcb.201211110.

9.

Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.

López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5510-5. doi: 10.1073/pnas.1303392110. Epub 2013 Mar 18.

10.

The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.

Varsano T, Taupin V, Guo L, Baterina OY Jr, Farquhar MG.

PLoS One. 2012;7(11):e49227. doi: 10.1371/journal.pone.0049227. Epub 2012 Nov 8.

11.

Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin).

Beas AO, Taupin V, Teodorof C, Nguyen LT, Garcia-Marcos M, Farquhar MG.

Mol Biol Cell. 2012 Dec;23(23):4623-34. doi: 10.1091/mbc.E12-02-0133. Epub 2012 Oct 10.

12.

A man for all seasons: reflections on the life and legacy of George Palade.

Farquhar MG.

Annu Rev Cell Dev Biol. 2012;28:1-28. doi: 10.1146/annurev-cellbio-101011-155813. Epub 2012 Jul 20.

PMID:
22831641
13.

Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.

Wasik AA, Polianskyte-Prause Z, Dong MQ, Shaw AS, Yates JR 3rd, Farquhar MG, Lehtonen S.

Mol Biol Cell. 2012 Sep;23(17):3370-9. doi: 10.1091/mbc.E11-12-1010. Epub 2012 Jul 18.

14.

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.

Dvir H, Shah M, Girardi E, Guo L, Farquhar MG, Zajonc DM.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6916-21. doi: 10.1073/pnas.1114128109. Epub 2012 Apr 16.

15.

Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling.

Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1961-6. doi: 10.1073/pnas.1120538109. Epub 2012 Jan 25.

16.

A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development.

Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush KT, Willert K, Farquhar MG, Nigam SK.

Dev Biol. 2012 Apr 1;364(1):11-21. doi: 10.1016/j.ydbio.2012.01.014. Epub 2012 Jan 24.

17.

Phosphorylation of podocalyxin (Ser415) Prevents RhoA and ezrin activation and disrupts its interaction with the actin cytoskeleton.

Fukasawa H, Obayashi H, Schmieder S, Lee J, Ghosh P, Farquhar MG.

Am J Pathol. 2011 Nov;179(5):2254-65. doi: 10.1016/j.ajpath.2011.07.046. Epub 2011 Sep 25.

18.

G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.

Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG.

J Biol Chem. 2011 Aug 12;286(32):28138-49. doi: 10.1074/jbc.M110.204099. Epub 2011 Jun 8.

19.

GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression.

Ghosh P, Garcia-Marcos M, Farquhar MG.

Cell Adh Migr. 2011 May-Jun;5(3):237-48. Epub 2011 May 1.

20.

Molecular basis of a novel oncogenic mutation in GNAO1.

Garcia-Marcos M, Ghosh P, Farquhar MG.

Oncogene. 2011 Jun 9;30(23):2691-6. doi: 10.1038/onc.2010.645. Epub 2011 Feb 14.

21.

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.

Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P.

Mol Biol Cell. 2011 Mar 1;22(5):673-86. doi: 10.1091/mbc.E10-08-0738. Epub 2011 Jan 5.

22.

The Palade symposium: celebrating cell biology at its best.

Schmid SL, Farquhar MG.

Mol Biol Cell. 2010 Jul 15;21(14):2367-70. doi: 10.1091/mbc.E10-03-0179. Epub 2010 May 26.

23.

A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.

Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG.

Mol Biol Cell. 2010 Jul 1;21(13):2338-54. doi: 10.1091/mbc.E10-01-0028. Epub 2010 May 12.

24.

A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.

Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG.

J Biol Chem. 2010 Apr 23;285(17):12765-77. doi: 10.1074/jbc.M109.045161. Epub 2010 Feb 15.

25.

GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding.

Dippold HC, Ng MM, Farber-Katz SE, Lee SK, Kerr ML, Peterman MC, Sim R, Wiharto PA, Galbraith KA, Madhavarapu S, Fuchs GJ, Meerloo T, Farquhar MG, Zhou H, Field SJ.

Cell. 2009 Oct 16;139(2):337-51. doi: 10.1016/j.cell.2009.07.052.

26.

Slit diaphragms contain tight junction proteins.

Fukasawa H, Bornheimer S, Kudlicka K, Farquhar MG.

J Am Soc Nephrol. 2009 Jul;20(7):1491-503. doi: 10.1681/ASN.2008101117. Epub 2009 May 28.

27.

Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells.

Lin P, Fischer T, Lavoie C, Huang H, Farquhar MG.

Mol Neurodegener. 2009 Mar 25;4:15. doi: 10.1186/1750-1326-4-15.

28.

GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.

Garcia-Marcos M, Ghosh P, Farquhar MG.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3178-83. doi: 10.1073/pnas.0900294106. Epub 2009 Feb 11.

29.

hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis.

Tang T, Zheng B, Chen SH, Murphy AN, Kudlicka K, Zhou H, Farquhar MG.

J Biol Chem. 2009 Feb 20;284(8):5414-24. doi: 10.1074/jbc.M807797200. Epub 2008 Dec 22.

30.

Activation of Galphai3 triggers cell migration via regulation of GIV.

Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG.

J Cell Biol. 2008 Jul 28;182(2):381-93. doi: 10.1083/jcb.200712066.

31.

The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.

Lehtonen S, Shah M, Nielsen R, Iino N, Ryan JJ, Zhou H, Farquhar MG.

Mol Biol Cell. 2008 Jul;19(7):2949-61. doi: 10.1091/mbc.E07-05-0521. Epub 2008 Apr 16.

32.

Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.

Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD.

Immunity. 2007 Aug;27(2):308-20. Epub 2007 Aug 2.

33.

Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.

Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA.

FASEB J. 2007 Sep;21(11):2970-9. Epub 2007 Apr 30.

PMID:
17470567
34.

Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection.

Chen Y, Lin P, Qiu S, Peng XX, Looi K, Farquhar MG, Zhang JY.

Int J Oncol. 2007 May;30(5):1137-44.

35.

Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis.

Lin P, Li F, Zhang YW, Huang H, Tong G, Farquhar MG, Xu H.

J Neurochem. 2007 Mar;100(6):1505-14.

36.

Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics.

Zheng B, Tang T, Tang N, Kudlicka K, Ohtsubo K, Ma P, Marth JD, Farquhar MG, Lehtonen E.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81. Epub 2006 Oct 31.

37.

GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling.

Varsano T, Dong MQ, Niesman I, Gacula H, Lou X, Ma T, Testa JR, Yates JR 3rd, Farquhar MG.

Mol Cell Biol. 2006 Dec;26(23):8942-52. Epub 2006 Oct 2.

38.

The glomerular basement membrane: not gone, just forgotten.

Farquhar MG.

J Clin Invest. 2006 Aug;116(8):2090-3.

39.

Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components.

Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA.

J Biol Chem. 2006 Sep 8;281(36):26391-9. Epub 2006 Jul 3.

40.

Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex.

Lehtonen S, Ryan JJ, Kudlicka K, Iino N, Zhou H, Farquhar MG.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9814-9. Epub 2005 Jul 1.

41.

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes.

Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA.

J Biol Chem. 2005 Sep 2;280(35):31036-44. Epub 2005 Jun 16.

42.

Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.

Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG.

J Biol Chem. 2005 Jun 10;280(23):22012-20. Epub 2005 Mar 4.

43.

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H.

J Biol Chem. 2005 Apr 29;280(17):17020-6. Epub 2005 Feb 11.

44.

Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction.

Bornheimer SJ, Maurya MR, Farquhar MG, Subramaniam S.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15899-904. Epub 2004 Nov 1.

45.

Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein.

Zheng B, Lavoie C, Tang TD, Ma P, Meerloo T, Beas A, Farquhar MG.

Mol Biol Cell. 2004 Dec;15(12):5538-50. Epub 2004 Oct 6.

46.

Podocalyxin activates RhoA and induces actin reorganization through NHERF1 and Ezrin in MDCK cells.

Schmieder S, Nagai M, Orlando RA, Takeda T, Farquhar MG.

J Am Soc Nephrol. 2004 Sep;15(9):2289-98.

47.

Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin.

Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG.

Am J Pathol. 2004 Sep;165(3):923-36.

48.

The adaptor protein ARH escorts megalin to and through endosomes.

Nagai M, Meerloo T, Takeda T, Farquhar MG.

Mol Biol Cell. 2003 Dec;14(12):4984-96. Epub 2003 Oct 3.

49.

Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.

Fischer T, De Vries L, Meerloo T, Farquhar MG.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8270-5. Epub 2003 Jun 25.

50.

Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP.

Elenko E, Fischer T, Niesman I, Harding T, McQuistan T, Von Zastrow M, Farquhar MG.

Mol Pharmacol. 2003 Jul;64(1):11-20.

PMID:
12815156

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