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Synthesis of Ultrathin Biotite Nanosheets as an Intelligent Theranostic Platform for Combination Cancer Therapy.

Ji X, Kang Y, Ouyang J, Chen Y, Artzi D, Zeng X, Xiao Y, Feng C, Qi B, Kim NY, Saw PE, Kong N, Farokhzad OC, Tao W.

Adv Sci (Weinh). 2019 Aug 20;6(19):1901211. doi: 10.1002/advs.201901211. eCollection 2019 Oct 2.


Stimuli-Responsive Polymer-Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy.

Saw PE, Yao H, Lin C, Tao W, Farokhzad OC, Xu X.

Nano Lett. 2019 Sep 11;19(9):5967-5974. doi: 10.1021/acs.nanolett.9b01660. Epub 2019 Aug 7.


2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine.

Ouyang J, Feng C, Ji X, Li L, Gutti HK, Kim NY, Artzi D, Xie A, Kong N, Liu YN, Tearney GJ, Sui X, Tao W, Farokhzad OC.

Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13405-13410. doi: 10.1002/anie.201908377. Epub 2019 Aug 13.


Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications.

Tao W, Kong N, Ji X, Zhang Y, Sharma A, Ouyang J, Qi B, Wang J, Xie N, Kang C, Zhang H, Farokhzad OC, Kim JS.

Chem Soc Rev. 2019 Jun 4;48(11):2891-2912. doi: 10.1039/c8cs00823j. Review.


Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.

Islam MA, Xu Y, Tao W, Ubellacker JM, Lim M, Aum D, Lee GY, Zhou K, Zope H, Yu M, Cao W, Oswald JT, Dinarvand M, Mahmoudi M, Langer R, Kantoff PW, Farokhzad OC, Zetter BR, Shi J.

Nat Biomed Eng. 2018 Dec;2(12):968. doi: 10.1038/s41551-018-0331-x.


Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA.

Islam MA, Xu Y, Tao W, Ubellacker JM, Lim M, Aum D, Lee GY, Zhou K, Zope H, Yu M, Cao W, Oswald JT, Dinarvand M, Mahmoudi M, Langer R, Kantoff PW, Farokhzad OC, Zetter BR, Shi J.

Nat Biomed Eng. 2018 Nov;2(11):850-864. doi: 10.1038/s41551-018-0284-0. Epub 2018 Sep 17. Erratum in: Nat Biomed Eng. 2018 Dec;2(12):968.


Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications.

Tao W, Wang J, Parak WJ, Farokhzad OC, Shi J.

ACS Nano. 2019 May 28;13(5):4876-4882. doi: 10.1021/acsnano.9b01696. Epub 2019 Apr 15.


Drug Delivery Strategies for the Treatment of Metabolic Diseases.

Shi S, Kong N, Feng C, Shajii A, Bejgrowicz C, Tao W, Farokhzad OC.

Adv Healthc Mater. 2019 Jun;8(12):e1801655. doi: 10.1002/adhm.201801655. Epub 2019 Apr 8. Review.


Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery.

Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao RFC, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner MMB, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC.

Theranostics. 2018 Nov 15;8(21):6008-6024. doi: 10.7150/thno.24365. eCollection 2018.


Drug loading augmentation in polymeric nanoparticles using a coaxial turbulent jet mixer: Yong investigator perspective.

Lim JM, Cai T, Mandaric S, Chopra S, Han H, Jang S, Il Choi W, Langer R, Farokhzad OC, Karnik R.

J Colloid Interface Sci. 2019 Mar 7;538:45-50. doi: 10.1016/j.jcis.2018.11.029. Epub 2018 Nov 10.


Glutathione-Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy.

Ling X, Tu J, Wang J, Shajii A, Kong N, Feng C, Zhang Y, Yu M, Xie T, Bharwani Z, Aljaeid BM, Shi B, Tao W, Farokhzad OC.

ACS Nano. 2019 Jan 22;13(1):357-370. doi: 10.1021/acsnano.8b06400. Epub 2018 Dec 4.


Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy.

Xu X, Wu J, Liu S, Saw PE, Tao W, Li Y, Krygsman L, Yegnasubramanian S, De Marzo AM, Shi J, Bieberich CJ, Farokhzad OC.

Small. 2018 Oct;14(41):e1802565. doi: 10.1002/smll.201802565. Epub 2018 Sep 17.


Two-Dimensional Antimonene-Based Photonic Nanomedicine for Cancer Theranostics.

Tao W, Ji X, Zhu X, Li L, Wang J, Zhang Y, Saw PE, Li W, Kong N, Islam MA, Gan T, Zeng X, Zhang H, Mahmoudi M, Tearney GJ, Farokhzad OC.

Adv Mater. 2018 Sep;30(38):e1802061. doi: 10.1002/adma.201802061. Epub 2018 Jul 24.


Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance.

Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J.

Nano Lett. 2018 Jul 11;18(7):4618-4625. doi: 10.1021/acs.nanolett.8b01924. Epub 2018 Jun 19.


Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy.

Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B.

Trends Biotechnol. 2018 May;36(5):562-575. doi: 10.1016/j.tibtech.2018.01.006. Epub 2018 Feb 6. Review.


Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy.

Zhu X, Ji X, Kong N, Chen Y, Mahmoudi M, Xu X, Ding L, Tao W, Cai T, Li Y, Gan T, Barrett A, Bharwani Z, Chen H, Farokhzad OC.

ACS Nano. 2018 Mar 27;12(3):2922-2938. doi: 10.1021/acsnano.8b00516. Epub 2018 Mar 12.


Emerging Advances in Nanotheranostics with Intelligent Bioresponsive Systems.

Wang J, Tao W, Chen X, Farokhzad OC, Liu G.

Theranostics. 2017 Sep 5;7(16):3915-3919. doi: 10.7150/thno.21317. eCollection 2017.


Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics.

Bertrand N, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim JM, Karnik R, Langer R, Farokhzad OC.

Nat Commun. 2017 Oct 3;8(1):777. doi: 10.1038/s41467-017-00600-w.


Nanomedicine for safe healing of bone trauma: Opportunities and challenges.

Behzadi S, Luther GA, Harris MB, Farokhzad OC, Mahmoudi M.

Biomaterials. 2017 Nov;146:168-182. doi: 10.1016/j.biomaterials.2017.09.005. Epub 2017 Sep 4. Review.


Multiscale technologies for treatment of ischemic cardiomyopathy.

Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC.

Nat Nanotechnol. 2017 Sep 6;12(9):845-855. doi: 10.1038/nnano.2017.167. Review.


Evolution of macromolecular complexity in drug delivery systems.

Kakkar A, Traverso G, Farokhzad OC, Weissleder R, Langer R.

Nat Rev Chem. 2017 Aug;1(8). pii: 63. doi: 10.1038/s41570-017-0063. Epub 2017 Aug 9.


Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice.

Yu M, Amengual J, Menon A, Kamaly N, Zhou F, Xu X, Saw PE, Lee SJ, Si K, Ortega CA, Choi WI, Lee IH, Bdour Y, Shi J, Mahmoudi M, Jon S, Fisher EA, Farokhzad OC.

Adv Healthc Mater. 2017 Oct;6(20). doi: 10.1002/adhm.201700313. Epub 2017 Jul 21.


ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy.

Xu X, Saw PE, Tao W, Li Y, Ji X, Bhasin S, Liu Y, Ayyash D, Rasmussen J, Huo M, Shi J, Farokhzad OC.

Adv Mater. 2017 Sep;29(33). doi: 10.1002/adma.201700141. Epub 2017 Jul 6.


Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems.

Shi B, Zheng M, Tao W, Chung R, Jin D, Ghaffari D, Farokhzad OC.

Biomacromolecules. 2017 Aug 14;18(8):2231-2246. doi: 10.1021/acs.biomac.7b00803. Epub 2017 Jul 14. Review.


Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy.

Tao W, Ji X, Xu X, Islam MA, Li Z, Chen S, Saw PE, Zhang H, Bharwani Z, Guo Z, Shi J, Farokhzad OC.

Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11896-11900. doi: 10.1002/anie.201703657. Epub 2017 Jul 17.


Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo.

Zhu X, Tao W, Liu D, Wu J, Guo Z, Ji X, Bharwani Z, Zhao L, Zhao X, Farokhzad OC, Shi J.

Theranostics. 2017 May 12;7(7):1990-2002. doi: 10.7150/thno.18136. eCollection 2017.


Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy.

Xu X, Saw PE, Tao W, Li Y, Ji X, Yu M, Mahmoudi M, Rasmussen J, Ayyash D, Zhou Y, Farokhzad OC, Shi J.

Nano Lett. 2017 Jul 12;17(7):4427-4435. doi: 10.1021/acs.nanolett.7b01571. Epub 2017 Jun 26.


Cellular uptake of nanoparticles: journey inside the cell.

Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M.

Chem Soc Rev. 2017 Jul 17;46(14):4218-4244. doi: 10.1039/c6cs00636a. Review.


Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation.

Chopra S, Bertrand N, Lim JM, Wang A, Farokhzad OC, Karnik R.

ACS Appl Mater Interfaces. 2017 Apr 5;9(13):11440-11450. doi: 10.1021/acsami.6b16854. Epub 2017 Mar 21.


Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy.

Xu X, Wu J, Liu Y, Saw PE, Tao W, Yu M, Zope H, Si M, Victorious A, Rasmussen J, Ayyash D, Farokhzad OC, Shi J.

ACS Nano. 2017 Mar 28;11(3):2618-2627. doi: 10.1021/acsnano.6b07195. Epub 2017 Mar 3.


Hyper-cell-permeable micelles as a drug delivery carrier for effective cancer therapy.

Saw PE, Yu M, Choi M, Lee E, Jon S, Farokhzad OC.

Biomaterials. 2017 Apr;123:118-126. doi: 10.1016/j.biomaterials.2017.01.040. Epub 2017 Jan 31.


Personalized protein corona on nanoparticles and its clinical implications.

Corbo C, Molinaro R, Tabatabaei M, Farokhzad OC, Mahmoudi M.

Biomater Sci. 2017 Feb 28;5(3):378-387. doi: 10.1039/c6bm00921b. Review.


Cancer nanomedicine: progress, challenges and opportunities.

Shi J, Kantoff PW, Wooster R, Farokhzad OC.

Nat Rev Cancer. 2017 Jan;17(1):20-37. doi: 10.1038/nrc.2016.108. Epub 2016 Nov 11. Review.


A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin.

Saw PE, Park J, Jon S, Farokhzad OC.

Nanomedicine. 2017 Feb;13(2):713-722. doi: 10.1016/j.nano.2016.10.005. Epub 2016 Oct 19.


Nanomedicines for renal disease: current status and future applications.

Kamaly N, He JC, Ausiello DA, Farokhzad OC.

Nat Rev Nephrol. 2016 Dec;12(12):738-753. doi: 10.1038/nrneph.2016.156. Epub 2016 Oct 31. Review.


Biological Identity of Nanoparticles In Vivo: Clinical Implications of the Protein Corona.

Caracciolo G, Farokhzad OC, Mahmoudi M.

Trends Biotechnol. 2017 Mar;35(3):257-264. doi: 10.1016/j.tibtech.2016.08.011. Epub 2016 Sep 20. Review.


Targeted nanoparticles for colorectal cancer.

Cisterna BA, Kamaly N, Choi WI, Tavakkoli A, Farokhzad OC, Vilos C.

Nanomedicine (Lond). 2016 Sep;11(18):2443-56. doi: 10.2217/nnm-2016-0194. Epub 2016 Aug 16. Review.


Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer.

Liu Y, Gunda V, Zhu X, Xu X, Wu J, Askhatova D, Farokhzad OC, Parangi S, Shi J.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7750-5. doi: 10.1073/pnas.1605841113. Epub 2016 Jun 24.


Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.

Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5552-7. doi: 10.1073/pnas.1603840113. Epub 2016 May 2.


Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy.

Xu X, Wu J, Liu Y, Yu M, Zhao L, Zhu X, Bhasin S, Li Q, Ha E, Shi J, Farokhzad OC.

Angew Chem Int Ed Engl. 2016 Jun 13;55(25):7091-7094. doi: 10.1002/anie.201601273. Epub 2016 May 3.


Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis.

Kamaly N, Fredman G, Fojas JJ, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M, Gadde S, Wu J, Milton J, Carvalho Leitao R, Rosa Fernandes L, Hasan M, Gao H, Nguyen V, Harris J, Tabas I, Farokhzad OC.

ACS Nano. 2016 May 24;10(5):5280-92. doi: 10.1021/acsnano.6b01114. Epub 2016 Apr 28.


Nanomedicines for Endothelial Disorders.

Chung BL, Toth MJ, Kamaly N, Sei YJ, Becraft J, Mulder WJ, Fayad ZA, Farokhzad OC, Kim Y, Langer R.

Nano Today. 2015 Dec 1;10(6):759-776.


Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.

Kamaly N, Yameen B, Wu J, Farokhzad OC.

Chem Rev. 2016 Feb 24;116(4):2602-63. doi: 10.1021/acs.chemrev.5b00346. Epub 2016 Feb 8. Review. No abstract available.


Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins.

Zhu X, Wu J, Shan W, Tao W, Zhao L, Lim JM, D'Ortenzio M, Karnik R, Huang Y, Shi J, Farokhzad OC.

Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3309-12. doi: 10.1002/anie.201509183. Epub 2016 Feb 5.


Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.

Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R.

Sci Transl Med. 2015 Nov 18;7(314):314ra183. doi: 10.1126/scitranslmed.aac6522.


Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.

Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R.

Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692.


Nanotechnology for protein delivery: Overview and perspectives.

Yu M, Wu J, Shi J, Farokhzad OC.

J Control Release. 2016 Oct 28;240:24-37. doi: 10.1016/j.jconrel.2015.10.012. Epub 2015 Oct 13. Review.


Nanotechnology: Platelet mimicry.

Farokhzad OC.

Nature. 2015 Oct 1;526(7571):47-8. doi: 10.1038/nature15218. Epub 2015 Sep 16. No abstract available.


Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone.

Yameen B, Vilos C, Choi WI, Whyte A, Huang J, Pollit L, Farokhzad OC.

Chemistry. 2015 Aug 3;21(32):11325-9. doi: 10.1002/chem.201502233. Epub 2015 Jul 14.


Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics.

Wu J, Zhao L, Xu X, Bertrand N, Choi WI, Yameen B, Shi J, Shah V, Mulvale M, MacLean JL, Farokhzad OC.

Angew Chem Int Ed Engl. 2015 Aug 3;54(32):9218-23. doi: 10.1002/anie.201503863. Epub 2015 Jun 26.


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