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Items: 30

1.

Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B.

Biochemistry. 2014 Dec 16;53(49):7854-65. doi: 10.1021/bi501396v. Epub 2014 Dec 1.

2.

iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B.

J Biol Chem. 2009 Oct 23;284(43):29746-56. doi: 10.1074/jbc.M109.046805. Epub 2009 Sep 2.

3.

TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).

Banskota AH, Aouidate M, Sørensen D, Ibrahim A, Piraee M, Zazopoulos E, Alarco AM, Gourdeau H, Mellon C, Farnet CM, Falardeau P, McAlpine JB.

J Antibiot (Tokyo). 2009 Oct;62(10):565-70. doi: 10.1038/ja.2009.77. Epub 2009 Aug 14.

PMID:
19680283
4.

Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system.

McAlpine JB, Banskota AH, Charan RD, Schlingmann G, Zazopoulos E, Piraee M, Janso J, Bernan VS, Aouidate M, Farnet CM, Feng X, Zhao Z, Carter GT.

J Nat Prod. 2008 Sep;71(9):1585-90. doi: 10.1021/np800376n. Epub 2008 Aug 23.

PMID:
18722414
5.

Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes.

Hu Y, Phelan VV, Farnet CM, Zazopoulos E, Bachmann BO.

Chembiochem. 2008 Jul 2;9(10):1603-8. doi: 10.1002/cbic.200800029.

PMID:
18512205
6.

Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.

Gourdeau H, McAlpine JB, Ranger M, Simard B, Berger F, Beaudry F, Farnet CM, Falardeau P.

Cancer Chemother Pharmacol. 2008 May;61(6):911-21. Epub 2007 Jul 11. Erratum in: Cancer Chemother Pharmacol. 2008 Oct 22. doi: 10.1007/s00280-008-0848-x. Farnet, Chris M [added]. Cancer Chemother Pharmacol. 2009 Feb;63(3):569.

PMID:
17622531
7.

Benzodiazepine biosynthesis in Streptomyces refuineus.

Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO.

Chem Biol. 2007 Jun;14(6):691-701. Erratum in: Chem Biol. 2007 Jul;14(7):870.

8.

Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.

Banskota AH, Mcalpine JB, Sørensen D, Ibrahim A, Aouidate M, Piraee M, Alarco AM, Farnet CM, Zazopoulos E.

J Antibiot (Tokyo). 2006 Sep;59(9):533-42.

PMID:
17136886
9.

Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two streptomyces species using a genomic screening approach.

Banskota AH, Mcalpine JB, Sørensen D, Aouidate M, Piraee M, Alarco AM, Omura S, Shiomi K, Farnet CM, Zazopoulos E.

J Antibiot (Tokyo). 2006 Mar;59(3):168-76.

PMID:
16724457
10.

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

McAlpine JB, Bachmann BO, Piraee M, Tremblay S, Alarco AM, Zazopoulos E, Farnet CM.

J Nat Prod. 2005 Apr;68(4):493-6.

PMID:
15844935
11.

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B.

Chem Biol. 2005 Mar;12(3):293-302.

12.

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM.

Nat Biotechnol. 2003 Feb;21(2):187-90. Epub 2003 Jan 21.

PMID:
12536216
13.

The calicheamicin gene cluster and its iterative type I enediyne PKS.

Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS.

Science. 2002 Aug 16;297(5584):1173-6.

14.

Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.

Farnet CM, Wang B, Hansen M, Lipford JR, Zalkow L, Robinson WE Jr, Siegel J, Bushman F.

Antimicrob Agents Chemother. 1998 Sep;42(9):2245-53.

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18.

Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules.

Farnet CM, Wang B, Lipford JR, Bushman FD.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9742-7.

19.

HIV cDNA integration: molecular biology and inhibitor development.

Farnet CM, Bushman FD.

AIDS. 1996;10 Suppl A:S3-11. Review. No abstract available.

PMID:
8883604
20.

DNA end-joining in extracts from human cells.

Bøe SO, Sodroski J, Helland DE, Farnet CM.

Biochem Biophys Res Commun. 1995 Oct 24;215(3):987-93.

PMID:
7488071
21.
22.

Nucleotide binding by the HIV-1 integrase protein in vitro.

Lipford JR, Worland ST, Farnet CM.

J Acquir Immune Defic Syndr. 1994 Dec;7(12):1215-23.

PMID:
7965631
23.

Genetic analysis of the human immunodeficiency virus type 1 integrase protein.

Shin CG, Taddeo B, Haseltine WA, Farnet CM.

J Virol. 1994 Mar;68(3):1633-42.

24.

Circularization of human immunodeficiency virus type 1 DNA in vitro.

Farnet CM, Haseltine WA.

J Virol. 1991 Dec;65(12):6942-52.

25.
26.

Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS.

Amerongen HM, Weltzin R, Farnet CM, Michetti P, Haseltine WA, Neutra MR.

J Acquir Immune Defic Syndr. 1991;4(8):760-5.

PMID:
1856788
27.

Integration of human immunodeficiency virus type 1 DNA in vitro.

Farnet CM, Haseltine WA.

Proc Natl Acad Sci U S A. 1990 Jun;87(11):4164-8.

28.

Molecular analysis of X-ray-induced alcohol dehydrogenase (ADH) null mutations in Drosophila melanogaster.

Kelley MR, Mims IP, Farnet CM, Dicharry SA, Lee WR.

Genetics. 1985 Feb;109(2):365-77.

29.

Ligation of highly modified bacteriophage DNA.

Cao XM, Huang LH, Farnet CM, Ehrlich M.

Biochim Biophys Acta. 1983 Nov 17;741(2):237-43.

PMID:
6652091
30.

Digestion of highly modified bacteriophage DNA by restriction endonucleases.

Huang LH, Farnet CM, Ehrlich KC, Ehrlich M.

Nucleic Acids Res. 1982 Mar 11;10(5):1579-91.

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