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Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity.

Barrachina MN, Izquierdo I, Hermida-Nogueira L, Sueiro AM, Guitián E, Casanueva FF, Farndale RW, Moroi M, Jung SM, Pardo M, García Á.

Data Brief. 2019 Feb 28;23:103784. doi: 10.1016/j.dib.2019.103784. eCollection 2019 Apr.


Collagen-binding proteins: insights from the Collagen Toolkits.

Farndale RW.

Essays Biochem. 2019 Jul 2. pii: EBC20180070. doi: 10.1042/EBC20180070. [Epub ahead of print] Review.


Covalent Capture of a Heterotrimeric Collagen Helix.

Li IC, Hulgan SAH, Walker DR, Farndale RW, Hartgerink JD, Jalan AA.

Org Lett. 2019 Jul 19;21(14):5480-5484. doi: 10.1021/acs.orglett.9b01771. Epub 2019 Jun 27.


Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces.

Jooss NJ, De Simone I, Provenzale I, Fernández DI, Brouns SLN, Farndale RW, Henskens YMC, Kuijpers MJE, Ten Cate H, van der Meijden PEJ, Cavill R, Heemskerk JWM.

Int J Mol Sci. 2019 Jun 7;20(11). pii: E2788. doi: 10.3390/ijms20112788.


A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids.

Hinz C, Liggi S, Mocciaro G, Jung S, Induruwa I, Pereira M, Bryant CE, Meckelmann SW, O'Donnell VB, Farndale RW, Fjeldsted J, Griffin JL.

Anal Chem. 2019 Jul 2;91(13):8025-8035. doi: 10.1021/acs.analchem.8b04615. Epub 2019 Jun 18.


GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity.

Barrachina MN, Sueiro AM, Izquierdo I, Hermida-Nogueira L, Guitián E, Casanueva FF, Farndale RW, Moroi M, Jung SM, Pardo M, García Á.

Atherosclerosis. 2019 Feb;281:62-70. doi: 10.1016/j.atherosclerosis.2018.12.023. Epub 2018 Dec 25.


Cellular response to collagen-elastin composite materials.

Bax DV, Smalley HE, Farndale RW, Best SM, Cameron RE.

Acta Biomater. 2019 Mar 1;86:158-170. doi: 10.1016/j.actbio.2018.12.033. Epub 2018 Dec 23.


Corrigendum to 'Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro' [Biochem. Pharmacol. 148 (2018) 288-297].

Misra A, Prakash P, Aggarwal H, Dhankani P, Kumar S, Prakash Pandey C, Pugh N, Bihan D, Kumar Barthwal M, Farndale RW, Kumar Dikshit D, Dikshit M.

Biochem Pharmacol. 2018 Dec;158:229-231. doi: 10.1016/j.bcp.2018.10.025. Epub 2018 Nov 1. No abstract available.


Proline provides site-specific flexibility for in vivo collagen.

Chow WY, Forman CJ, Bihan D, Puszkarska AM, Rajan R, Reid DG, Slatter DA, Colwell LJ, Wales DJ, Farndale RW, Duer MJ.

Sci Rep. 2018 Sep 14;8(1):13809. doi: 10.1038/s41598-018-31937-x.


Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF.

Malcor JD, Juskaite V, Gavriilidou D, Hunter EJ, Davidenko N, Hamaia S, Sinha S, Cameron RE, Best SM, Leitinger B, Farndale RW.

Biomaterials. 2018 Nov;182:21-34. doi: 10.1016/j.biomaterials.2018.07.050. Epub 2018 Jul 31.


MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation.

Howes JM, Pugh N, Hamaia SW, Jung SM, Knäuper V, Malcor JD, Farndale RW.

Res Pract Thromb Haemost. 2018 Mar 25;2(2):370-379. doi: 10.1002/rth2.12088. eCollection 2018 Apr.


Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites.

Rosini S, Pugh N, Bonna AM, Hulmes DJS, Farndale RW, Adams JC.

Sci Signal. 2018 May 29;11(532). pii: eaar2566. doi: 10.1126/scisignal.aar2566.


Collagen Gly missense mutations: Effect of residue identity on collagen structure and integrin binding.

Qiu Y, Mekkat A, Yu H, Yigit S, Hamaia S, Farndale RW, Kaplan DL, Lin YS, Brodsky B.

J Struct Biol. 2018 Sep;203(3):255-262. doi: 10.1016/j.jsb.2018.05.003. Epub 2018 May 11.


Correction to: Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry.

Davidenko N, Schuster CF, Bax DV, Farndale RW, Hamaia S, Best SM, Cameron RE.

J Mater Sci Mater Med. 2018 Mar 21;29(4):39. doi: 10.1007/s10856-018-6047-3.


The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis.

Sasikumar P, AlOuda KS, Kaiser WJ, Holbrook LM, Kriek N, Unsworth AJ, Bye AP, Sage T, Ushioda R, Nagata K, Farndale RW, Gibbins JM.

J Thromb Haemost. 2018 May;16(5):946-959. doi: 10.1111/jth.13998. Epub 2018 Apr 15.


Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro.

Misra A, Prakash P, Aggarwal H, Dhankani P, Kumar S, Pandey CP, Pugh N, Bihan D, Barthwal MK, Farndale RW, Dikshit DK, Dikshit M.

Biochem Pharmacol. 2018 Feb;148:288-297. doi: 10.1016/j.bcp.2018.01.013. Epub 2018 Jan 5. Erratum in: Biochem Pharmacol. 2018 Dec;158:229-231.


Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation.

Induruwa I, Moroi M, Bonna A, Malcor JD, Howes JM, Warburton EA, Farndale RW, Jung SM.

J Thromb Haemost. 2018 Feb;16(2):389-404. doi: 10.1111/jth.13919. Epub 2018 Jan 15.


Selecting the correct cellular model for assessing of the biological response of collagen-based biomaterials.

Davidenko N, Hamaia S, Bax DV, Malcor JD, Schuster CF, Gullberg D, Farndale RW, Best SM, Cameron RE.

Acta Biomater. 2018 Jan;65:88-101. doi: 10.1016/j.actbio.2017.10.035. Epub 2017 Oct 26.


Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions.

Pugh N, Maddox BD, Bihan D, Taylor KA, Mahaut-Smith MP, Farndale RW.

Thromb Haemost. 2017 Jul 26;117(8):1588-1600. doi: 10.1160/TH16-12-0906. Epub 2017 May 24.


Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.

Paracuellos P, Kalamajski S, Bonna A, Bihan D, Farndale RW, Hohenester E.

Matrix Biol. 2017 Nov;63:106-116. doi: 10.1016/j.matbio.2017.02.002. Epub 2017 Feb 17.


Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM.

J Thromb Haemost. 2017 Mar;15(3):549-564. doi: 10.1111/jth.13613. Epub 2017 Feb 16.


Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds.

Bax DV, Davidenko N, Gullberg D, Hamaia SW, Farndale RW, Best SM, Cameron RE.

Acta Biomater. 2017 Feb;49:218-234. doi: 10.1016/j.actbio.2016.11.059. Epub 2016 Nov 30.


Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry.

Davidenko N, Schuster CF, Bax DV, Farndale RW, Hamaia S, Best SM, Cameron RE.

J Mater Sci Mater Med. 2016 Oct;27(10):148. doi: 10.1007/s10856-016-5763-9. Epub 2016 Aug 31. Erratum in: J Mater Sci Mater Med. 2018 Mar 21;29(4):39.


Unique charge-dependent constraint on collagen recognition by integrin α10β1.

Hamaia SW, Luff D, Hunter EJ, Malcor JD, Bihan D, Gullberg D, Farndale RW.

Matrix Biol. 2017 May;59:80-94. doi: 10.1016/j.matbio.2016.08.010. Epub 2016 Aug 25.


Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding.

Yigit S, Yu H, An B, Hamaia S, Farndale RW, Kaplan DL, Lin YS, Brodsky B.

J Biol Chem. 2016 Sep 2;291(36):19196-207. doi: 10.1074/jbc.M116.726182. Epub 2016 Jul 18.


Intrinsic local destabilization of the C-terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding.

Nunes AM, Zhu J, Jezioro J, Minetti CA, Remeta DP, Farndale RW, Hamaia SW, Baum J.

Protein Sci. 2016 Sep;25(9):1672-81. doi: 10.1002/pro.2972. Epub 2016 Aug 1.


The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding.

Parker DN, Tasneem S, Farndale RW, Bihan D, Sadler JE, Sebastian S, de Groot PG, Hayward CP.

Thromb Haemost. 2016 Jul 4;116(1):87-95. doi: 10.1160/TH15-09-0700. Epub 2016 Apr 7.


Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase.

Kalamajski S, Bihan D, Bonna A, Rubin K, Farndale RW.

J Biol Chem. 2016 Apr 8;291(15):7951-60. doi: 10.1074/jbc.M115.693408. Epub 2016 Feb 18.


The synthesis and coupling of photoreactive collagen-based peptides to restore integrin reactivity to an inert substrate, chemically-crosslinked collagen.

Malcor JD, Bax D, Hamaia SW, Davidenko N, Best SM, Cameron RE, Farndale RW, Bihan D.

Biomaterials. 2016 Apr;85:65-77. doi: 10.1016/j.biomaterials.2016.01.044. Epub 2016 Jan 23.


Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor.

An B, Abbonante V, Xu H, Gavriilidou D, Yoshizumi A, Bihan D, Farndale RW, Kaplan DL, Balduini A, Leitinger B, Brodsky B.

J Biol Chem. 2016 Feb 26;291(9):4343-55. doi: 10.1074/jbc.M115.674507. Epub 2015 Dec 23.


Optimisation of UV irradiation as a binding site conserving method for crosslinking collagen-based scaffolds.

Davidenko N, Bax DV, Schuster CF, Farndale RW, Hamaia SW, Best SM, Cameron RE.

J Mater Sci Mater Med. 2016 Jan;27(1):14. doi: 10.1007/s10856-015-5627-8. Epub 2015 Dec 16.


Structural basis for collagen recognition by the immune receptor OSCAR.

Zhou L, Hinerman JM, Blaszczyk M, Miller JL, Conrady DG, Barrow AD, Chirgadze DY, Bihan D, Farndale RW, Herr AB.

Blood. 2016 Feb 4;127(5):529-37. doi: 10.1182/blood-2015-08-667055. Epub 2015 Nov 9.


Modified platelet deposition on matrix metalloproteinase 13 digested collagen I.

Howes JM, Pugh N, Knäuper V, Farndale RW.

J Thromb Haemost. 2015 Dec;13(12):2253-9. doi: 10.1111/jth.13166. Epub 2015 Nov 30.


Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner.

Watson BR, White NA, Taylor KA, Howes JM, Malcor JD, Bihan D, Sage SO, Farndale RW, Pugh N.

Metallomics. 2016 Jan;8(1):91-100. doi: 10.1039/c5mt00064e.


Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix.

Chow WY, Bihan D, Forman CJ, Slatter DA, Reid DG, Wales DJ, Farndale RW, Duer MJ.

Sci Rep. 2015 Jul 29;5:12556. doi: 10.1038/srep12556.


Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics.

Davidenko N, Schuster CF, Bax DV, Raynal N, Farndale RW, Best SM, Cameron RE.

Acta Biomater. 2015 Oct;25:131-42. doi: 10.1016/j.actbio.2015.07.034. Epub 2015 Jul 26.


A fluorescent approach for identifying P2X1 ligands.

Ruepp MD, Brozik JA, de Esch IJ, Farndale RW, Murrell-Lagnado RD, Thompson AJ.

Neuropharmacology. 2015 Nov;98:13-21. doi: 10.1016/j.neuropharm.2015.05.016. Epub 2015 May 28.


Structural constraints on the evolution of the collagen fibril: convergence on a 1014-residue COL domain.

Slatter DA, Farndale RW.

Open Biol. 2015 May;5(5). pii: 140220. doi: 10.1098/rsob.140220.


Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation.

Boudreau LH, Duchez AC, Cloutier N, Soulet D, Martin N, Bollinger J, Paré A, Rousseau M, Naika GS, Lévesque T, Laflamme C, Marcoux G, Lambeau G, Farndale RW, Pouliot M, Hamzeh-Cognasse H, Cognasse F, Garraud O, Nigrovic PA, Guderley H, Lacroix S, Thibault L, Semple JW, Gelb MH, Boilard E.

Blood. 2014 Oct 2;124(14):2173-83. doi: 10.1182/blood-2014-05-573543. Epub 2014 Jul 31.


Identification of platelet function defects by multi-parameter assessment of thrombus formation.

de Witt SM, Swieringa F, Cavill R, Lamers MM, van Kruchten R, Mastenbroek T, Baaten C, Coort S, Pugh N, Schulz A, Scharrer I, Jurk K, Zieger B, Clemetson KJ, Farndale RW, Heemskerk JW, Cosemans JM.

Nat Commun. 2014 Jul 16;5:4257. doi: 10.1038/ncomms5257.


Integrin recognition motifs in the human collagens.

Hamaia S, Farndale RW.

Adv Exp Med Biol. 2014;819:127-42. doi: 10.1007/978-94-017-9153-3_9. Review.


The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage.

Howes JM, Bihan D, Slatter DA, Hamaia SW, Packman LC, Knauper V, Visse R, Farndale RW.

J Biol Chem. 2014 Aug 29;289(35):24091-101. doi: 10.1074/jbc.M114.583443. Epub 2014 Jul 9.


NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization.

Chow WY, Rajan R, Muller KH, Reid DG, Skepper JN, Wong WC, Brooks RA, Green M, Bihan D, Farndale RW, Slatter DA, Shanahan CM, Duer MJ.

Science. 2014 May 16;344(6185):742-6. doi: 10.1126/science.1248167.


New insights into the DT40 B cell receptor cluster using a proteomic proximity labeling assay.

Li XW, Rees JS, Xue P, Zhang H, Hamaia SW, Sanderson B, Funk PE, Farndale RW, Lilley KS, Perrett S, Jackson AP.

J Biol Chem. 2014 May 23;289(21):14434-47. doi: 10.1074/jbc.M113.529578. Epub 2014 Apr 4.


Dynamic analysis of platelet deposition to resolve platelet adhesion receptor activity in whole blood at arterial shear rate.

Pugh N, Bihan D, Perry DJ, Farndale RW.

Platelets. 2015;26(3):216-9. doi: 10.3109/09537104.2014.893289. Epub 2014 Mar 28.


FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils.

Tersteeg C, Heijnen HF, Eckly A, Pasterkamp G, Urbanus RT, Maas C, Hoefer IE, Nieuwland R, Farndale RW, Gachet C, de Groot PG, Roest M.

Circ Res. 2014 Feb 28;114(5):780-91. doi: 10.1161/CIRCRESAHA.114.302361. Epub 2014 Jan 9.


Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets.

Sage SO, Pugh N, Farndale RW, Harper AG.

Physiol Rep. 2013 Oct;1(5):e00085. doi: 10.1002/phy2.85. Epub 2013 Oct 11.


An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens.

Carafoli F, Hamaia SW, Bihan D, Hohenester E, Farndale RW.

PLoS One. 2013 Jul 29;8(7):e69833. doi: 10.1371/journal.pone.0069833. Print 2013.


Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation.

Bleijerveld OB, van Holten TC, Preisinger C, van der Smagt JJ, Farndale RW, Kleefstra T, Willemsen MH, Urbanus RT, de Groot PG, Heck AJ, Roest M, Scholten A.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1538-43. doi: 10.1161/ATVBAHA.112.300916. Epub 2013 Apr 25.


Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy.

Attwood SJ, Simpson AM, Hamaia SW, Bihan D, Roy D, Farndale RW, Welland ME.

Int J Mol Sci. 2013 Jan 29;14(2):2832-45. doi: 10.3390/ijms14022832.

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