Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 27

1.

In vivo elongation of thin filaments results in heart failure.

Mi-Mi L, Farman GP, Mayfield RM, Strom J, Chu M, Pappas CT, Gregorio CC.

PLoS One. 2020 Jan 3;15(1):e0226138. doi: 10.1371/journal.pone.0226138. eCollection 2020.

2.

Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy.

Ahrens-Nicklas RC, Pappas CT, Farman GP, Mayfield RM, Larrinaga TM, Medne L, Ritter A, Krantz ID, Murali C, Lin KY, Berger JH, Yum SW, Carreon CK, Gregorio CC.

Sci Adv. 2019 Sep 4;5(9):eaax2066. doi: 10.1126/sciadv.aax2066. eCollection 2019 Sep.

3.

Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure.

Pappas CT, Farman GP, Mayfield RM, Konhilas JP, Gregorio CC.

J Mol Cell Cardiol. 2018 Sep;122:88-97. doi: 10.1016/j.yjmcc.2018.08.009. Epub 2018 Aug 11.

4.

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR.

Arch Biochem Biophys. 2018 Jun 1;647:84-92. doi: 10.1016/j.abb.2018.04.002. Epub 2018 Apr 5.

5.

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.

Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI.

J Mol Biol. 2016 Jun 5;428(11):2446-2461. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20.

6.

Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.

Ait-Mou Y, Hsu K, Farman GP, Kumar M, Greaser ML, Irving TC, de Tombe PP.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2306-11. doi: 10.1073/pnas.1516732113. Epub 2016 Feb 8.

7.

Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.

Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH.

Nat Commun. 2015 Jan 19;6:6018. doi: 10.1038/ncomms7018.

8.

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics.

Farman GP, Muthu P, Kazmierczak K, Szczesna-Cordary D, Moore JR.

J Appl Physiol (1985). 2014 Dec 15;117(12):1471-7. doi: 10.1152/japplphysiol.00798.2014. Epub 2014 Oct 16.

9.

Energy landscapes reveal the myopathic effects of tropomyosin mutations.

Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP.

Arch Biochem Biophys. 2014 Dec 15;564:89-99. doi: 10.1016/j.abb.2014.09.007. Epub 2014 Sep 18.

10.

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.

Huang W, Liang J, Kazmierczak K, Muthu P, Duggal D, Farman GP, Sorensen L, Pozios I, Abraham TP, Moore JR, Borejdo J, Szczesna-Cordary D.

J Mol Cell Cardiol. 2014 Sep;74:318-29. doi: 10.1016/j.yjmcc.2014.06.011. Epub 2014 Jun 30.

11.

Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle.

Tanner BC, Farman GP, Irving TC, Maughan DW, Palmer BM, Miller MS.

Biophys J. 2012 Sep 19;103(6):1275-84. doi: 10.1016/j.bpj.2012.08.014.

12.

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.

Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones P, Tian X, Wilson LS, Ahmad F, Chen SRW, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH.

Circ Res. 2011 Oct 14;109(9):1024-1030. doi: 10.1161/CIRCRESAHA.111.250464. Epub 2011 Sep 8.

13.

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.

Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13576-81. doi: 10.1073/pnas.1106911108. Epub 2011 Aug 8.

14.

Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacing.

Miller MS, Farman GP, Braddock JM, Soto-Adames FN, Irving TC, Vigoreaux JO, Maughan DW.

Biophys J. 2011 Apr 6;100(7):1737-46. doi: 10.1016/j.bpj.2011.02.028.

15.

Myosin head orientation: a structural determinant for the Frank-Starling relationship.

Farman GP, Gore D, Allen E, Schoenfelt K, Irving TC, de Tombe PP.

Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2155-60. doi: 10.1152/ajpheart.01221.2010. Epub 2011 Apr 1.

16.

Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension.

Irving T, Wu Y, Bekyarova T, Farman GP, Fukuda N, Granzier H.

Biophys J. 2011 Mar 16;100(6):1499-508. doi: 10.1016/j.bpj.2011.01.059.

17.

Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression.

Panama BK, Latour-Villamil D, Farman GP, Zhao D, Bolz SS, Kirshenbaum LA, Backx PH.

Circ Res. 2011 Mar 4;108(5):537-43. doi: 10.1161/CIRCRESAHA.110.229112. Epub 2011 Jan 20.

PMID:
21252158
18.

The role of thin filament cooperativity in cardiac length-dependent calcium activation.

Farman GP, Allen EJ, Schoenfelt KQ, Backx PH, de Tombe PP.

Biophys J. 2010 Nov 3;99(9):2978-86. doi: 10.1016/j.bpj.2010.09.003.

19.

Myofilament length dependent activation.

de Tombe PP, Mateja RD, Tachampa K, Ait Mou Y, Farman GP, Irving TC.

J Mol Cell Cardiol. 2010 May;48(5):851-8. doi: 10.1016/j.yjmcc.2009.12.017. Epub 2010 Jan 4. Review.

20.

Phosphorylation and the N-terminal extension of the regulatory light chain help orient and align the myosin heads in Drosophila flight muscle.

Farman GP, Miller MS, Reedy MC, Soto-Adames FN, Vigoreaux JO, Maughan DW, Irving TC.

J Struct Biol. 2009 Nov;168(2):240-9. doi: 10.1016/j.jsb.2009.07.020. Epub 2009 Jul 25.

21.

Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics.

Miller MS, Dambacher CM, Knowles AF, Braddock JM, Farman GP, Irving TC, Swank DM, Bernstein SI, Maughan DW.

Biophys J. 2009 May 20;96(10):4132-43. doi: 10.1016/j.bpj.2009.02.034.

22.

Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila.

Miller MS, Lekkas P, Braddock JM, Farman GP, Ballif BA, Irving TC, Maughan DW, Vigoreaux JO.

Biophys J. 2008 Sep;95(5):2391-401. doi: 10.1529/biophysj.108.130005. Epub 2008 May 30.

23.

Blebbistatin: use as inhibitor of muscle contraction.

Farman GP, Tachampa K, Mateja R, Cazorla O, Lacampagne A, de Tombe PP.

Pflugers Arch. 2008 Mar;455(6):995-1005. Epub 2007 Nov 10.

PMID:
17994251
24.

Cardiac troponin I threonine 144: role in myofilament length dependent activation.

Tachampa K, Wang H, Farman GP, de Tombe PP.

Circ Res. 2007 Nov 26;101(11):1081-3. Epub 2007 Nov 1.

PMID:
17975107
25.

Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae.

Farman GP, Allen EJ, Gore D, Irving TC, de Tombe PP.

Biophys J. 2007 May 1;92(9):L73-5. Epub 2007 Feb 9.

26.

Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium.

Farman GP, Walker JS, de Tombe PP, Irving TC.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1847-55. Epub 2006 Jun 2.

27.

The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle.

Miller MS, Palmer BM, Ruch S, Martin LA, Farman GP, Wang Y, Robbins J, Irving TC, Maughan DW.

J Biol Chem. 2005 Oct 14;280(41):34427-34. Epub 2005 Aug 6.

Supplemental Content

Loading ...
Support Center