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Items: 40

1.

An extraterrestrial trigger for the mid-Ordovician ice age: Dust from the breakup of the L-chondrite parent body.

Schmitz B, Farley KA, Goderis S, Heck PR, Bergström SM, Boschi S, Claeys P, Debaille V, Dronov A, van Ginneken M, Harper DAT, Iqbal F, Friberg J, Liao S, Martin E, Meier MMM, Peucker-Ehrenbrink B, Soens B, Wieler R, Terfelt F.

Sci Adv. 2019 Sep 18;5(9):eaax4184. doi: 10.1126/sciadv.aax4184. eCollection 2019 Sep.

2.

In Situ Geochronology on Mars and the Development of Future Instrumentation.

Cohen BA, Malespin CA, Farley KA, Martin PE, Cho Y, Mahaffy PR.

Astrobiology. 2019 Jul 30. doi: 10.1089/ast.2018.1871. [Epub ahead of print]

PMID:
31361510
3.

Cyclic Peptide Design Guided by Residual Dipolar Couplings, J-Couplings, and Intramolecular Hydrogen Bond Analysis.

Farley KA, Che Y, Navarro-Vázquez A, Limberakis C, Anderson D, Yan J, Shapiro M, Shanmugasundaram V, Gil RR.

J Org Chem. 2019 Apr 19;84(8):4803-4813. doi: 10.1021/acs.joc.8b02811. Epub 2019 Jan 15.

PMID:
30605335
4.

Delineating the role of cooperativity in the design of potent PROTACs for BTK.

Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, Zhu H, Farley KA, Ding W, Schiemer J, Feng X, Chang JS, Uccello DP, Young JA, Garcia-Irrizary CN, Czabaniuk L, Schuff B, Oliver R, Montgomery J, Hayward MM, Coe J, Chen J, Niosi M, Luthra S, Shah JC, El-Kattan A, Qiu X, West GM, Noe MC, Shanmugasundaram V, Gilbert AM, Brown MF, Calabrese MF.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292. doi: 10.1073/pnas.1803662115. Epub 2018 Jul 16.

5.

Non-Uniform Sampling for All: More NMR Spectral Quality, Less Measurement Time.

Delaglio F, Walker GS, Farley KA, Sharma R, Hoch JC, Arbogast LW, Brinson RG, Marino JP.

Am Pharm Rev. 2017 May/Jun;20(4). pii: 339681. Epub 2017 Jun 30. No abstract available.

6.

Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue.

Price DA, Eng H, Farley KA, Goetz GH, Huang Y, Jiao Z, Kalgutkar AS, Kablaoui NM, Khunte B, Liras S, Limberakis C, Mathiowetz AM, Ruggeri RB, Quan JM, Yang Z.

Org Biomol Chem. 2017 Mar 28;15(12):2501-2506. doi: 10.1039/c7ob00096k. Epub 2017 Mar 7.

PMID:
28266673
7.

Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis.

Farley KA, Reilly U, Anderson DP, Boscoe BP, Bundesmann MW, Foley DA, Lall MS, Li C, Reese MR, Yan J.

Magn Reson Chem. 2017 Apr;55(4):348-354. doi: 10.1002/mrc.4494. Epub 2016 Aug 11.

PMID:
27469271
8.

Micromotion at the tibial plateau in primary and revision total knee arthroplasty: fixed versus rotating platform designs.

Small SR, Rogge RD, Malinzak RA, Reyes EM, Cook PL, Farley KA, Ritter MA.

Bone Joint Res. 2016 Apr;5(4):122-9. doi: 10.1302/2046-3758.54.2000481.

9.

Enhanced East Pacific Rise hydrothermal activity during the last two glacial terminations.

Lund DC, Asimow PD, Farley KA, Rooney TO, Seeley E, Jackson EW, Durham ZM.

Science. 2016 Jan 29;351(6272):478-82. doi: 10.1126/science.aad4296.

10.

Mars atmosphere. Mars methane detection and variability at Gale crater.

Webster CR, Mahaffy PR, Atreya SK, Flesch GJ, Mischna MA, Meslin PY, Farley KA, Conrad PG, Christensen LE, Pavlov AA, Martín-Torres J, Zorzano MP, McConnochie TH, Owen T, Eigenbrode JL, Glavin DP, Steele A, Malespin CA, Archer PD Jr, Sutter B, Coll P, Freissinet C, McKay CP, Moores JE, Schwenzer SP, Bridges JC, Navarro-Gonzalez R, Gellert R, Lemmon MT; MSL Science Team.

Science. 2015 Jan 23;347(6220):415-7. doi: 10.1126/science.1261713. Epub 2014 Dec 16.

11.

Managing water services in tropical regions: From land cover proxies to hydrologic fluxes.

Ponette-González AG, Brauman KA, Marín-Spiotta E, Farley KA, Weathers KC, Young KR, Curran LM.

Ambio. 2015 Sep;44(5):367-75. doi: 10.1007/s13280-014-0578-8. Epub 2014 Nov 29.

12.

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ.

J Med Chem. 2014 Dec 26;57(24):10527-43. doi: 10.1021/jm501649k. Epub 2014 Dec 9.

PMID:
25431858
13.

Helium and lead isotopes reveal the geochemical geometry of the Samoan plume.

Jackson MG, Hart SR, Konter JG, Kurz MD, Blusztajn J, Farley KA.

Nature. 2014 Oct 16;514(7522):355-8. doi: 10.1038/nature13794.

PMID:
25318524
14.

Amphitheater-headed canyons formed by megaflooding at Malad Gorge, Idaho.

Lamb MP, Mackey BH, Farley KA.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):57-62. doi: 10.1073/pnas.1312251111. Epub 2013 Dec 16.

15.

In situ radiometric and exposure age dating of the martian surface.

Farley KA, Malespin C, Mahaffy P, Grotzinger JP, Vasconcelos PM, Milliken RE, Malin M, Edgett KS, Pavlov AA, Hurowitz JA, Grant JA, Miller HB, Arvidson R, Beegle L, Calef F, Conrad PG, Dietrich WE, Eigenbrode J, Gellert R, Gupta S, Hamilton V, Hassler DM, Lewis KW, McLennan SM, Ming D, Navarro-González R, Schwenzer SP, Steele A, Stolper EM, Sumner DY, Vaniman D, Vasavada A, Williford K, Wimmer-Schweingruber RF; MSL Science Team.

Science. 2014 Jan 24;343(6169):1247166. doi: 10.1126/science.1247166. Epub 2013 Dec 9.

PMID:
24324273
16.

Low upper limit to methane abundance on Mars.

Webster CR, Mahaffy PR, Atreya SK, Flesch GJ, Farley KA; MSL Science Team.

Science. 2013 Oct 18;342(6156):355-7. doi: 10.1126/science.1242902. Epub 2013 Sep 19.

17.

Regioselective hydroarylations and parallel kinetic resolution of Vince lactam.

Kamlet AS, Préville C, Farley KA, Piotrowski DW.

Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10607-10. doi: 10.1002/anie.201304818. Epub 2013 Aug 16.

PMID:
23956102
18.

Integrating intramolecular hydrogen bonding (IMHB) considerations in drug discovery using ΔlogP as a tool.

Shalaeva M, Caron G, Abramov YA, O'Connell TN, Plummer MS, Yalamanchi G, Farley KA, Goetz GH, Philippe L, Shapiro MJ.

J Med Chem. 2013 Jun 27;56(12):4870-9. doi: 10.1021/jm301850m. Epub 2013 Jun 12.

PMID:
23710574
19.

Response to Comments on "Apatite 4He/3He and (U-Th)/He Evidence for an Ancient Grand Canyon".

Flowers RM, Farley KA.

Science. 2013 Apr 12;340(6129):143. doi: 10.1126/science.1234203.

PMID:
23580513
20.

Apatite 4He/3He and (U-Th)/He evidence for an ancient Grand Canyon.

Flowers RM, Farley KA.

Science. 2012 Dec 21;338(6114):1616-9. doi: 10.1126/science.1229390. Epub 2012 Nov 29.

21.

Macrocyclizations for medicinal chemistry: synthesis of druglike macrocycles by high-concentration Ullmann coupling.

Collins JC, Farley KA, Limberakis C, Liras S, Price D, James K.

J Org Chem. 2012 Dec 21;77(24):11079-90. doi: 10.1021/jo302089f. Epub 2012 Dec 6.

PMID:
23167628
22.

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance().

Rand AC, Leung SS, Eng H, Rotter CJ, Sharma R, Kalgutkar AS, Zhang Y, Varma MV, Farley KA, Khunte B, Limberakis C, Price DA, Liras S, Mathiowetz AM, Jacobson MP, Lokey RS.

Medchemcomm. 2012 Oct;3(10):1282-1289.

23.

A new and useful method for the macrocyclization of linear peptides.

Londregan AT, Farley KA, Limberakis C, Mullins PB, Piotrowski DW.

Org Lett. 2012 Jun 1;14(11):2890-3. doi: 10.1021/ol301173m. Epub 2012 May 21.

PMID:
22612479
24.

Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.

Mascitti V, Stevens BD, Choi C, McClure KF, Guimarães CR, Farley KA, Munchhof MJ, Robinson RP, Futatsugi K, Lavergne SY, Lefker BA, Cornelius P, Bonin PD, Kalgutkar AS, Sharma R, Chen Y.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1306-9. doi: 10.1016/j.bmcl.2011.01.088. Epub 2011 Jan 25.

PMID:
21310611
25.

An asymmetric synthesis of (2S,5S)-5-substituted azepane-2-carboxylate derivatives.

Wishka DG, Bédard M, Brighty KE, Buzon RA, Farley KA, Fichtner MW, Kauffman GS, Kooistra J, Lewis JG, O'Dowd H, Samardjiev IJ, Samas B, Yalamanchi G, Noe MC.

J Org Chem. 2011 Mar 18;76(6):1937-40. doi: 10.1021/jo102475s. Epub 2011 Jan 28.

PMID:
21275376
26.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Magee TV, Ripp SL, Li B, Buzon RA, Chupak L, Dougherty TJ, Finegan SM, Girard D, Hagen AE, Falcone MJ, Farley KA, Granskog K, Hardink JR, Huband MD, Kamicker BJ, Kaneko T, Knickerbocker MJ, Liras JL, Marra A, Medina I, Nguyen TT, Noe MC, Obach RS, O'Donnell JP, Penzien JB, Reilly UD, Schafer JR, Shen Y, Stone GG, Strelevitz TJ, Sun J, Tait-Kamradt A, Vaz AD, Whipple DA, Widlicka DW, Wishka DG, Wolkowski JP, Flanagan ME.

J Med Chem. 2009 Dec 10;52(23):7446-57. doi: 10.1021/jm900729s.

PMID:
19775168
27.

Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine.

Bazin MJ, Shi H, Delaney J, Kline B, Zhu Z, Kuhn C, Berlioz F, Farley KA, Fate G, Lam W, Walker GS, Yu L, Pollastri MP.

Chem Biol Drug Des. 2007 Oct;70(4):354-9.

PMID:
17937780
28.

A late Miocene dust shower from the break-up of an asteroid in the main belt.

Farley KA, Vokrouhlický D, Bottke WF, Nesvorný D.

Nature. 2006 Jan 19;439(7074):295-7.

PMID:
16421563
29.

Trading water for carbon with biological carbon sequestration.

Jackson RB, Jobbágy EG, Avissar R, Roy SB, Barrett DJ, Cook CW, Farley KA, le Maitre DC, McCarl BA, Murray BC.

Science. 2005 Dec 23;310(5756):1944-7.

30.

Rapid glacial erosion at 1.8 Ma revealed by 4He/3He thermochronometry.

Shuster DL, Ehlers TA, Rusmoren ME, Farley KA.

Science. 2005 Dec 9;310(5754):1668-70.

31.

Is Bedout an impact crater? Take 2.

Renne PR, Melosh HJ, Farley KA, Reimold WU, Koeberl C, Rampino MR, Kelly SP, Ivanov BA.

Science. 2004 Oct 22;306(5696):610-2; author reply 610-2. No abstract available.

PMID:
15498994
32.

An extraterrestrial impact at the Permian-Triassic boundary?

Farley KA, Mukhopadhyay S.

Science. 2001 Sep 28;293(5539):2343. No abstract available.

33.

Preservation of extraterrestrial 3He in 480-Ma-old marine limestones.

Patterson DB, Farley KA, Schmitz B.

Earth Planet Sci Lett. 1998 Nov;163(1-4):315-25.

PMID:
11542873
34.

Screening of compound libraries for protein binding using flow-injection nuclear magnetic resonance spectroscopy.

Stockman BJ, Farley KA, Angwin DT.

Methods Enzymol. 2001;338:230-46. Review. No abstract available.

PMID:
11460550
35.

A short duration of the Cretaceous-Tertiary boundary event: evidence from extraterrestrial helium-3.

Mukhopadhyay S, Farley KA, Montanari A.

Science. 2001 Mar 9;291(5510):1952-5.

36.

A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.

Bozdogan B, Berrezouga L, Kuo MS, Yurek DA, Farley KA, Stockman BJ, Leclercq R.

Antimicrob Agents Chemother. 1999 Apr;43(4):925-9.

37.

Geochemical evidence for a comet shower in the late Eocene.

Farley KA, Montanari A, Shoemaker EM, Shoemaker CS.

Science. 1998 May 22;280(5367):1250-3.

38.
39.

Is "primordial" helium really extraterrestrial?

Farley KA.

Science. 1993 Jul 9;261(5118):166-7. No abstract available.

PMID:
17829268
40.

Mantle plumes and mantle sources.

Farley KA, Craig H.

Science. 1992 Oct 30;258(5083):821. No abstract available.

PMID:
17777037

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