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Delineating the role of cooperativity in the design of potent PROTACs for BTK.

Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, Zhu H, Farley KA, Ding W, Schiemer J, Feng X, Chang JS, Uccello DP, Young JA, Garcia-Irrizary CN, Czabaniuk L, Schuff B, Oliver R, Montgomery J, Hayward MM, Coe J, Chen J, Niosi M, Luthra S, Shah JC, El-Kattan A, Qiu X, West GM, Noe MC, Shanmugasundaram V, Gilbert AM, Brown MF, Calabrese MF.

Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201803662. doi: 10.1073/pnas.1803662115. [Epub ahead of print]


Rapid recovery of life at ground zero of the end-Cretaceous mass extinction.

Lowery CM, Bralower TJ, Owens JD, Rodríguez-Tovar FJ, Jones H, Smit J, Whalen MT, Claeys P, Farley K, Gulick SPS, Morgan JV, Green S, Chenot E, Christeson GL, Cockell CS, Coolen MJL, Ferrière L, Gebhardt C, Goto K, Kring DA, Lofi J, Ocampo-Torres R, Perez-Cruz L, Pickersgill AE, Poelchau MH, Rae ASP, Rasmussen C, Rebolledo-Vieyra M, Riller U, Sato H, Tikoo SM, Tomioka N, Urrutia-Fucugauchi J, Vellekoop J, Wittmann A, Xiao L, Yamaguchi KE, Zylberman W.

Nature. 2018 Jun;558(7709):288-291. doi: 10.1038/s41586-018-0163-6. Epub 2018 May 30.


Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.


Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye.

Sarkar A, Gogia N, Farley K, Payton L, Singh A.

PLoS One. 2018 Apr 27;13(4):e0196365. doi: 10.1371/journal.pone.0196365. eCollection 2018.


Non-Uniform Sampling for All: More NMR Spectral Quality, Less Measurement Time.

Delaglio F, Walker GS, Farley KA, Sharma R, Hoch JC, Arbogast LW, Brinson RG, Marino JP.

Am Pharm Rev. 2017 May/Jun;20(4). pii: 339681. Epub 2017 Jun 30. No abstract available.


Social prescribing: less rhetoric and more reality. A systematic review of the evidence.

Bickerdike L, Booth A, Wilson PM, Farley K, Wright K.

BMJ Open. 2017 Apr 7;7(4):e013384. doi: 10.1136/bmjopen-2016-013384. Review.


Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue.

Price DA, Eng H, Farley KA, Goetz GH, Huang Y, Jiao Z, Kalgutkar AS, Kablaoui NM, Khunte B, Liras S, Limberakis C, Mathiowetz AM, Ruggeri RB, Quan JM, Yang Z.

Org Biomol Chem. 2017 Mar 28;15(12):2501-2506. doi: 10.1039/c7ob00096k. Epub 2017 Mar 7.


Does access to a demand-led evidence briefing service improve uptake and use of research evidence by health service commissioners? A controlled before and after study.

Wilson PM, Farley K, Bickerdike L, Booth A, Chambers D, Lambert M, Thompson C, Turner R, Watt IS.

Implement Sci. 2017 Feb 14;12(1):20. doi: 10.1186/s13012-017-0545-4.


Effects of a demand-led evidence briefing service on the uptake and use of research evidence by commissioners of health services: a controlled before-and-after study.

Wilson PM, Farley K, Bickerdike L, Booth A, Chambers D, Lambert M, Thompson C, Turner R, Watt IS.

Southampton (UK): NIHR Journals Library; 2017 Feb.


Epidemiology of long-stay patients in a university teaching hospital.

O'Sullivan K, Martensson J, Robbins R, Farley KJ, Johnson D, Jones D.

Intern Med J. 2017 May;47(5):513-521. doi: 10.1111/imj.13379.


Probing the mechanisms underlying human diseases in making ribosomes.

Farley KI, Baserga SJ.

Biochem Soc Trans. 2016 Aug 15;44(4):1035-44. doi: 10.1042/BST20160064. Review.


Molecular and morphological evidence for Penstemon luculentus (Plantaginaceae): a replacement name for Penstemon fremontii var. glabrescens.

Johnson RL, Stevens MR, Johnson LA, Robbins MD, Anderson CD, Ricks NJ, Farley KM.

PhytoKeys. 2016 May 20;(63):47-62. doi: 10.3897/phytokeys.63.7952. eCollection 2016.


Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis.

Farley KA, Reilly U, Anderson DP, Boscoe BP, Bundesmann MW, Foley DA, Lall MS, Li C, Reese MR, Yan J.

Magn Reson Chem. 2017 Apr;55(4):348-354. doi: 10.1002/mrc.4494. Epub 2016 Aug 11.


Micromotion at the tibial plateau in primary and revision total knee arthroplasty: fixed versus rotating platform designs.

Small SR, Rogge RD, Malinzak RA, Reyes EM, Cook PL, Farley KA, Ritter MA.

Bone Joint Res. 2016 Apr;5(4):122-9. doi: 10.1302/2046-3758.54.2000481.


Identification and characterization of microsatellite markers in Penstemon scariosus (Plantaginaceae).

Anderson CD, Ricks NJ, Farley KM, Maughan PJ, Stevens MR.

Appl Plant Sci. 2016 Mar 3;4(3). pii: apps.1500105. doi: 10.3732/apps.1500105. eCollection 2016 Mar.


How to improve communication quality with patients and relatives in the ICU.

Warrillow S, Farley KJ, Jones D.

Minerva Anestesiol. 2016 Jul;82(7):797-803. Epub 2016 Feb 17.


Enhanced East Pacific Rise hydrothermal activity during the last two glacial terminations.

Lund DC, Asimow PD, Farley KA, Rooney TO, Seeley E, Jackson EW, Durham ZM.

Science. 2016 Jan 29;351(6272):478-82. doi: 10.1126/science.aad4296.


An Unexpected Route to an Essential Cofactor: Escherichia coli Relies on Threonine for Thiamine Biosynthesis.

Bazurto JV, Farley KR, Downs DM.

MBio. 2016 Jan 5;7(1):e01840-15. doi: 10.1128/mBio.01840-15.


Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.

Martinod K, Witsch T, Farley K, Gallant M, Remold-O'Donnell E, Wagner DD.

J Thromb Haemost. 2016 Mar;14(3):551-8. doi: 10.1111/jth.13239. Epub 2016 Feb 5.


A practical approach to end-of-life care rapid response team calls.

Farley KJ, Mitchell I, Jones D.

Crit Care Resusc. 2015 Sep;17(3):208-10.


Assessment of fidelity in an educational workshop designed to increase the uptake of a primary care alcohol screening recommendation.

Hanbury A, Farley K, Thompson C, Wilson PM.

J Eval Clin Pract. 2015 Oct;21(5):873-8. doi: 10.1111/jep.12393. Epub 2015 Jul 17.


Charge density waves in individual nanoribbons of orthorhombic-TaS₃.

Farley KE, Shi Z, Sambandamurthy G, Banerjee S.

Phys Chem Chem Phys. 2015 Jul 28;17(28):18374-9. doi: 10.1039/c5cp03351a.


Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.

Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M.

Virology. 2015 Sep;483:185-202. doi: 10.1016/j.virol.2015.03.036. Epub 2015 May 15.


Ten practical strategies for effective communication with relatives of ICU patients.

Warrillow S, Farley KJ, Jones D.

Intensive Care Med. 2015 Dec;41(12):2173-6. doi: 10.1007/s00134-015-3815-0. Epub 2015 Apr 23. No abstract available.


Design and experimental demonstration of a large pedestal thulium-doped fibre.

Simakov N, Hemming AV, Carter A, Farley K, Davidson A, Carmody N, Hughes M, Daniel JM, Corena L, Stepanov D, Haub J.

Opt Express. 2015 Feb 9;23(3):3126-33. doi: 10.1364/OE.23.003126.


Emptying and filling a tunnel bronze.

Marley PM, Abtew TA, Farley KE, Horrocks GA, Dennis RV, Zhang P, Banerjee S.

Chem Sci. 2015 Mar 1;6(3):1712-1718. doi: 10.1039/c4sc03748k. Epub 2015 Jan 13.


Determinants of mammalian nucleolar architecture.

Farley KI, Surovtseva Y, Merkel J, Baserga SJ.

Chromosoma. 2015 Sep;124(3):323-31. doi: 10.1007/s00412-015-0507-z. Epub 2015 Feb 12. Review.


Effects of a demand-led evidence briefing service on the uptake and use of research evidence by commissioners of health services: protocol for a controlled before and after study.

Wilson PM, Farley K, Thompson C, Chambers D, Bickerdike L, Watt IS, Lambert M, Turner R.

Implement Sci. 2015 Jan 9;10:7. doi: 10.1186/s13012-014-0199-4.


Mars atmosphere. Mars methane detection and variability at Gale crater.

Webster CR, Mahaffy PR, Atreya SK, Flesch GJ, Mischna MA, Meslin PY, Farley KA, Conrad PG, Christensen LE, Pavlov AA, Martín-Torres J, Zorzano MP, McConnochie TH, Owen T, Eigenbrode JL, Glavin DP, Steele A, Malespin CA, Archer PD Jr, Sutter B, Coll P, Freissinet C, McKay CP, Moores JE, Schwenzer SP, Bridges JC, Navarro-Gonzalez R, Gellert R, Lemmon MT; MSL Science Team.

Science. 2015 Jan 23;347(6220):415-7. doi: 10.1126/science.1261713. Epub 2014 Dec 16.


Metal mixture modeling evaluation project: 3. Lessons learned and steps forward.

Farley KJ, Meyer JS.

Environ Toxicol Chem. 2015 Apr;34(4):821-32. doi: 10.1002/etc.2837.


Managing water services in tropical regions: From land cover proxies to hydrologic fluxes.

Ponette-González AG, Brauman KA, Marín-Spiotta E, Farley KA, Weathers KC, Young KR, Curran LM.

Ambio. 2015 Sep;44(5):367-75. doi: 10.1007/s13280-014-0578-8. Epub 2014 Nov 29.


Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ.

J Med Chem. 2014 Dec 26;57(24):10527-43. doi: 10.1021/jm501649k. Epub 2014 Dec 9.


Metal mixture modeling evaluation project: 2. Comparison of four modeling approaches.

Farley KJ, Meyer JS, Balistrieri LS, De Schamphelaere KA, Iwasaki Y, Janssen CR, Kamo M, Lofts S, Mebane CA, Naito W, Ryan AC, Santore RC, Tipping E.

Environ Toxicol Chem. 2015 Apr;34(4):741-53. doi: 10.1002/etc.2820. Epub 2015 Feb 20.


Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides.

Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS.

Org Lett. 2014 Dec 5;16(23):6088-91. doi: 10.1021/ol503170b. Epub 2014 Nov 20.


Metal mixtures modeling evaluation project: 1. Background.

Meyer JS, Farley KJ, Garman ER.

Environ Toxicol Chem. 2015 Apr;34(4):726-40. doi: 10.1002/etc.2792.


Helium and lead isotopes reveal the geochemical geometry of the Samoan plume.

Jackson MG, Hart SR, Konter JG, Kurz MD, Blusztajn J, Farley KA.

Nature. 2014 Oct 16;514(7522):355-8. doi: 10.1038/nature13794.


Mortality related to after-hours discharge from intensive care in Australia and New Zealand, 2005-2012.

Gantner D, Farley K, Bailey M, Huckson S, Hicks P, Pilcher D.

Intensive Care Med. 2014 Oct;40(10):1528-35. doi: 10.1007/s00134-014-3438-x. Epub 2014 Aug 15.


Ferroelastic domain organization and precursor control of size in solution-grown hafnium dioxide nanorods.

Depner SW, Cultrara ND, Farley KE, Qin Y, Banerjee S.

ACS Nano. 2014 May 27;8(5):4678-88. doi: 10.1021/nn501632d. Epub 2014 Apr 21.


Gathering opinion leader data for a tailored implementation intervention in secondary healthcare: a randomised trial.

Farley K, Hanbury A, Thompson C.

BMC Med Res Methodol. 2014 Mar 10;14:38. doi: 10.1186/1471-2288-14-38.


The association between contraceptive use at the time of conception and hypertensive disorders during pregnancy: a retrospective cohort study of prams participants.

Farley KE, Huber LR, Warren-Findlow J, Ersek JL.

Matern Child Health J. 2014 Oct;18(8):1779-85. doi: 10.1007/s10995-014-1447-6.


Amphitheater-headed canyons formed by megaflooding at Malad Gorge, Idaho.

Lamb MP, Mackey BH, Farley KA.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):57-62. doi: 10.1073/pnas.1312251111. Epub 2013 Dec 16.


Volatile and organic compositions of sedimentary rocks in Yellowknife Bay, Gale crater, Mars.

Ming DW, Archer PD Jr, Glavin DP, Eigenbrode JL, Franz HB, Sutter B, Brunner AE, Stern JC, Freissinet C, McAdam AC, Mahaffy PR, Cabane M, Coll P, Campbell JL, Atreya SK, Niles PB, Bell JF 3rd, Bish DL, Brinckerhoff WB, Buch A, Conrad PG, Des Marais DJ, Ehlmann BL, Fairén AG, Farley K, Flesch GJ, Francois P, Gellert R, Grant JA, Grotzinger JP, Gupta S, Herkenhoff KE, Hurowitz JA, Leshin LA, Lewis KW, McLennan SM, Miller KE, Moersch J, Morris RV, Navarro-González R, Pavlov AA, Perrett GM, Pradler I, Squyres SW, Summons RE, Steele A, Stolper EM, Sumner DY, Szopa C, Teinturier S, Trainer MG, Treiman AH, Vaniman DT, Vasavada AR, Webster CR, Wray JJ, Yingst RA; MSL Science Team.

Science. 2014 Jan 24;343(6169):1245267. doi: 10.1126/science.1245267. Epub 2013 Dec 9.


In situ radiometric and exposure age dating of the martian surface.

Farley KA, Malespin C, Mahaffy P, Grotzinger JP, Vasconcelos PM, Milliken RE, Malin M, Edgett KS, Pavlov AA, Hurowitz JA, Grant JA, Miller HB, Arvidson R, Beegle L, Calef F, Conrad PG, Dietrich WE, Eigenbrode J, Gellert R, Gupta S, Hamilton V, Hassler DM, Lewis KW, McLennan SM, Ming D, Navarro-González R, Schwenzer SP, Steele A, Stolper EM, Sumner DY, Vaniman D, Vasavada A, Williford K, Wimmer-Schweingruber RF; MSL Science Team.

Science. 2014 Jan 24;343(6169):1247166. doi: 10.1126/science.1247166. Epub 2013 Dec 9.


SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells.

Zhao P, Hou L, Farley K, Sundrud MS, Remold-O'Donnell E.

J Leukoc Biol. 2014 Mar;95(3):521-30. doi: 10.1189/jlb.0613331. Epub 2013 Nov 18.


Reply: To PMID 23790348.

Brunner Huber LR, Lyerly JE, Farley KE, Alkhazraji T.

Ann Epidemiol. 2014 Jan;24(1):80-1. doi: 10.1016/j.annepidem.2013.10.010. Epub 2013 Oct 18. No abstract available.


Immediate versus sustained effects: interrupted time series analysis of a tailored intervention.

Hanbury A, Farley K, Thompson C, Wilson PM, Chambers D, Holmes H.

Implement Sci. 2013 Nov 5;8:130. doi: 10.1186/1748-5908-8-130.


Low upper limit to methane abundance on Mars.

Webster CR, Mahaffy PR, Atreya SK, Flesch GJ, Farley KA; MSL Science Team.

Science. 2013 Oct 18;342(6156):355-7. doi: 10.1126/science.1242902. Epub 2013 Sep 19.


Inappropriate continuation of stress ulcer prophylaxis beyond the intensive care setting.

Farley KJ, Barned KL, Crozier TM.

Crit Care Resusc. 2013 Jun;15(2):147-51.


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