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Items: 33

1.

3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids.

Schnalzger TE, de Groot MH, Zhang C, Mosa MH, Michels BE, Röder J, Darvishi T, Wels WS, Farin HF.

EMBO J. 2019 Jun 17;38(12). pii: e100928. doi: 10.15252/embj.2018100928. Epub 2019 Apr 29.

PMID:
31036555
2.

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase.

Schwiebs A, Herrero San Juan M, Schmidt KG, Wiercinska E, Anlauf M, Ottenlinger F, Thomas D, Elwakeel E, Weigert A, Farin HF, Bonig H, Scholich K, Geisslinger G, Pfeilschifter JM, Radeke HH.

Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x. Epub 2019 Feb 28.

PMID:
30816345
3.

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.

Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF.

J Exp Med. 2019 Mar 4;216(3):704-720. doi: 10.1084/jem.20180823. Epub 2019 Feb 21.

4.

The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.

Hoang VT, Verma D, Godavarthy PS, Llavona P, Steiner M, Gerlach K, Michels BE, Bohnenberger H, Wachter A, Oellerich T, Müller-Kuller U, Weissenberger E, Voutsinas JM, Oehler VG, Farin HF, Zörnig M, Krause DS.

Leukemia. 2019 Jul;33(7):1700-1712. doi: 10.1038/s41375-018-0358-8. Epub 2019 Jan 11.

PMID:
30635626
5.

Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2-Deficient Intestinal Organoids.

Mosa MH, Nicolle O, Maschalidi S, Sepulveda FE, Bidaud-Meynard A, Menche C, Michels BE, Michaux G, de Saint Basile G, Farin HF.

Cell Mol Gastroenterol Hepatol. 2018 Aug 14;6(4):477-493.e1. doi: 10.1016/j.jcmgh.2018.08.001. eCollection 2018.

6.

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.

Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz D.

Gastroenterology. 2019 Jan;156(1):275-278. doi: 10.1053/j.gastro.2018.09.041. Epub 2018 Sep 26. No abstract available.

PMID:
30267714
7.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27.

8.

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

Lüdtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A.

Dev Cell. 2016 Oct 24;39(2):239-253. doi: 10.1016/j.devcel.2016.08.007. Epub 2016 Oct 6.

9.

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.

Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A.

PLoS One. 2016 Jun 2;11(6):e0156787. doi: 10.1371/journal.pone.0156787. eCollection 2016.

10.

Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.

Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A.

J Mol Cell Cardiol. 2016 Aug;97:140-9. doi: 10.1016/j.yjmcc.2016.05.004. Epub 2016 May 11.

PMID:
27180262
11.

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.

Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H.

Nature. 2016 Feb 18;530(7590):340-3. doi: 10.1038/nature16937. Epub 2016 Feb 10.

PMID:
26863187
12.

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.

Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2016 Feb 4;18(2):203-13. doi: 10.1016/j.stem.2016.01.001. Epub 2016 Jan 28.

13.

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development.

Weren RD, Venkatachalam R, Cazier JB, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ET, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KK, Carvajal-Carmona L, Nagtegaal ID, Schackert HK, Clevers H, van de Wetering M, Tomlinson IP, Ligtenberg MJ, Hoogerbrugge N, Geurts van Kessel A, Kuiper RP.

J Pathol. 2015 Jun;236(2):155-64. doi: 10.1002/path.4520. Epub 2015 Mar 26.

14.

Plasticity within stem cell hierarchies in mammalian epithelia.

Tetteh PW, Farin HF, Clevers H.

Trends Cell Biol. 2015 Feb;25(2):100-8. doi: 10.1016/j.tcb.2014.09.003. Epub 2014 Oct 9. Review.

PMID:
25308311
15.

Immune deficiency-related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency.

Lemoine R, Pachlopnik-Schmid J, Farin HF, Bigorgne A, Debré M, Sepulveda F, Héritier S, Lemale J, Talbotec C, Rieux-Laucat F, Ruemmele F, Morali A, Cathebras P, Nitschke P, Bole-Feysot C, Blanche S, Brousse N, Picard C, Clevers H, Fischer A, de Saint Basile G.

J Allergy Clin Immunol. 2014 Dec;134(6):1354-1364.e6. doi: 10.1016/j.jaci.2014.07.019. Epub 2014 Aug 28.

PMID:
25174867
16.

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.

Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H.

J Exp Med. 2014 Jun 30;211(7):1393-405. doi: 10.1084/jem.20130753.

17.

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells.

Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, Jaenisch R, Hockemeyer D.

Stem Cell Reports. 2014 Jun 3;2(6):838-52. doi: 10.1016/j.stemcr.2014.05.001. eCollection 2014 Jun 3. Erratum in: Stem Cell Reports. 2014 Jul 8;3(1):215.

18.

TTC7A mutations disrupt intestinal epithelial apicobasal polarity.

Bigorgne AE, Farin HF, Lemoine R, Mahlaoui N, Lambert N, Gil M, Schulz A, Philippet P, Schlesser P, Abrahamsen TG, Oymar K, Davies EG, Ellingsen CL, Leteurtre E, Moreau-Massart B, Berrebi D, Bole-Feysot C, Nischke P, Brousse N, Fischer A, Clevers H, de Saint Basile G.

J Clin Invest. 2014 Jan;124(1):328-37.

19.

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.

Yin X, Farin HF, van Es JH, Clevers H, Langer R, Karp JM.

Nat Methods. 2014 Jan;11(1):106-12. doi: 10.1038/nmeth.2737. Epub 2013 Dec 1.

20.

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.

de Groot RE, Farin HF, Macůrková M, van Es JH, Clevers HC, Korswagen HC.

PLoS One. 2013 Oct 9;8(10):e76971. doi: 10.1371/journal.pone.0076971. eCollection 2013.

21.

Generation of L cells in mouse and human small intestine organoids.

Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ.

Diabetes. 2014 Feb;63(2):410-20. doi: 10.2337/db13-0991. Epub 2013 Oct 15.

22.

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.

Farin HF, Lüdtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM, Kispert A.

PLoS Genet. 2013;9(4):e1003467. doi: 10.1371/journal.pgen.1003467. Epub 2013 Apr 25.

23.

Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.

Lüdtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A.

PLoS Genet. 2013;9(1):e1003189. doi: 10.1371/journal.pgen.1003189. Epub 2013 Jan 17.

24.

Tbx18 function in epicardial development.

Greulich F, Farin HF, Schuster-Gossler K, Kispert A.

Cardiovasc Res. 2012 Dec 1;96(3):476-83. doi: 10.1093/cvr/cvs277. Epub 2012 Aug 27.

PMID:
22926762
25.

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.

Farin HF, Van Es JH, Clevers H.

Gastroenterology. 2012 Dec;143(6):1518-1529.e7. doi: 10.1053/j.gastro.2012.08.031. Epub 2012 Aug 23.

PMID:
22922422
26.

Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.

Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A.

Development. 2012 Sep;139(17):3099-108. doi: 10.1242/dev.077388. Epub 2012 Jul 25.

27.

Controlled gene expression in primary Lgr5 organoid cultures.

Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H.

Nat Methods. 2011 Dec 4;9(1):81-3. doi: 10.1038/nmeth.1802.

PMID:
22138822
28.

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.

Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, 't Hoen PA, Kispert A, Christoffels VM.

Cell Mol Life Sci. 2012 Apr;69(8):1377-89. doi: 10.1007/s00018-011-0884-2. Epub 2011 Dec 1.

29.

Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme.

Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A.

Hum Mol Genet. 2010 Dec 15;19(24):4918-29. doi: 10.1093/hmg/ddq426. Epub 2010 Sep 29.

PMID:
20881014
30.

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.

Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A.

Circ Res. 2009 Aug 28;105(5):442-52. doi: 10.1161/CIRCRESAHA.109.196063. Epub 2009 Aug 6.

PMID:
19661464
31.

TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome.

Lausch E, Hermanns P, Farin HF, Alanay Y, Unger S, Nikkel S, Steinwender C, Scherer G, Spranger J, Zabel B, Kispert A, Superti-Furga A.

Am J Hum Genet. 2008 Nov;83(5):649-55. doi: 10.1016/j.ajhg.2008.10.011.

32.

T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm.

Farin HF, Mansouri A, Petry M, Kispert A.

J Biol Chem. 2008 Sep 12;283(37):25372-80. doi: 10.1074/jbc.M802723200. Epub 2008 Jul 21.

33.

Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.

Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A.

J Biol Chem. 2007 Aug 31;282(35):25748-59. Epub 2007 Jun 21.

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