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Items: 21

1.

Integrin CD11b activation drives anti-tumor innate immunity.

Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA.

Nat Commun. 2018 Dec 19;9(1):5379. doi: 10.1038/s41467-018-07387-4.

2.

Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases.

Shahid M, Hermes EL, Chandra D, Tauseef M, Siddiqui MR, Faridi MH, Wu MX.

J Am Heart Assoc. 2018 Nov 6;7(21):e009261. doi: 10.1161/JAHA.118.009261. No abstract available.

3.

Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients.

Dickinson CM, LeBlanc BW, Edhi MM, Heffernan DS, Faridi MH, Gupta V, Cioffi WG, O'Brien X, Reichner JS.

J Intensive Care. 2018 Mar 15;6:19. doi: 10.1186/s40560-018-0289-5. eCollection 2018.

4.

CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.

Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ, Gupta V.

J Clin Invest. 2017 Apr 3;127(4):1271-1283. doi: 10.1172/JCI88442. Epub 2017 Mar 6.

5.

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1.

Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V.

J Biol Chem. 2017 Jan 13;292(2):732-747. doi: 10.1074/jbc.M116.753822. Epub 2016 Dec 2.

6.

Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response.

Johnson CM, O'Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi MH, LeFort CT, Gupta V, Kim M, Reichner JS.

J Immunol. 2017 Jan 1;198(1):318-334. doi: 10.4049/jimmunol.1502381. Epub 2016 Nov 16.

7.

Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria.

Yu H, Kistler A, Faridi MH, Meyer JO, Tryniszewska B, Mehta D, Yue L, Dryer S, Reiser J.

J Am Soc Nephrol. 2016 Nov;27(11):3308-3319. Epub 2016 Mar 28.

8.

Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats.

Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S, Faridi MH, Gupta V, Wu S.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):793-801. doi: 10.1165/rcmb.2014-0422OC.

9.

A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.

Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V.

J Am Soc Nephrol. 2015 Nov;26(11):2741-52. doi: 10.1681/ASN.2014090859. Epub 2015 Apr 9.

10.

A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy.

Khan SQ, Guo L, Cimbaluk DJ, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A, Gupta V.

Front Med (Lausanne). 2014 Nov 12;1:45. doi: 10.3389/fmed.2014.00045. eCollection 2014.

11.

Reduction of proteinuria through podocyte alkalinization.

Altintas MM, Moriwaki K, Wei C, Möller CC, Flesche J, Li J, Yaddanapudi S, Faridi MH, Gödel M, Huber TB, Preston RA, Jiang JX, Kerjaschki D, Sever S, Reiser J.

J Biol Chem. 2014 Jun 20;289(25):17454-67. doi: 10.1074/jbc.M114.568998. Epub 2014 May 9.

12.

Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflammatory signatures of vascular remodeling.

Rodriguez-Menocal L, Faridi MH, Martinez L, Shehadeh LA, Duque JC, Wei Y, Mesa A, Pena A, Gupta V, Pham SM, Vazquez-Padron RI.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H641-53. doi: 10.1152/ajpheart.00641.2013. Epub 2014 Jan 10.

13.

Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers.

Celik E, Faridi MH, Kumar V, Deep S, Moy VT, Gupta V.

Biophys J. 2013 Dec 3;105(11):2517-27. doi: 10.1016/j.bpj.2013.10.020.

14.

Abatacept in B7-1-positive proteinuric kidney disease.

Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P.

N Engl J Med. 2013 Dec 19;369(25):2416-23. doi: 10.1056/NEJMoa1304572. Epub 2013 Nov 8.

15.

Heat-induced fibrillation of BclXL apoptotic repressor.

Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, Deegan BJ, McDonald CB, Seldeen KL, Kurouski D, Faridi MH, Shareef MM, Gupta V, Lednev IK, Farooq A.

Biophys Chem. 2013 Sep;179:12-25. doi: 10.1016/j.bpc.2013.04.002. Epub 2013 May 7.

16.

Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Faridi MH, Altintas MM, Gomez C, Duque JC, Vazquez-Padron RI, Gupta V.

Biochim Biophys Acta. 2013 Jun;1830(6):3696-710. doi: 10.1016/j.bbagen.2013.02.018. Epub 2013 Feb 26.

17.

Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins.

Reed JH, Jain M, Lee K, Kandimalla ER, Faridi MH, Buyon JP, Gupta V, Clancy RM.

J Biol Chem. 2013 Mar 29;288(13):9077-83. doi: 10.1074/jbc.M112.403303. Epub 2013 Feb 5.

18.

Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.

Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Schürer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V.

Sci Signal. 2011 Sep 6;4(189):ra57. doi: 10.1126/scisignal.2001811.

19.

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.

Faridi MH, Maiguel D, Brown BT, Suyama E, Barth CJ, Hedrick M, Vasile S, Sergienko E, Schürer S, Gupta V.

Biochem Biophys Res Commun. 2010 Mar 26;394(1):194-9. doi: 10.1016/j.bbrc.2010.02.151. Epub 2010 Feb 25.

20.

Identification of novel agonists of the integrin CD11b/CD18.

Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Schürer S, Gupta V.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6902-6. doi: 10.1016/j.bmcl.2009.10.077. Epub 2009 Oct 22.

21.

Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.

Qureshi AH, Chaoji V, Maiguel D, Faridi MH, Barth CJ, Salem SM, Singhal M, Stoub D, Krastins B, Ogihara M, Zaki MJ, Gupta V.

PLoS One. 2009 Oct 27;4(10):e7627. doi: 10.1371/journal.pone.0007627.

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