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Items: 49


Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards.

Farfel JM, Yu L, Boyle PA, Leurgans S, Shah RC, Schneider JA, Bennett DA.

Acta Neuropathol Commun. 2019 Jul 3;7(1):104. doi: 10.1186/s40478-019-0752-0.


Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis.

Lisboa BCG, Oliveira KC, Tahira AC, Barbosa AR, Feltrin AS, Gouveia G, Lima L, Feio Dos Santos AC, Martins DC Jr, Puga RD, Moretto AC, De Bragança Pereira CA, Lafer B, Leite REP, Ferretti-Rebustini REL, Farfel JM, Grinberg LT, Jacob-Filho W, Miguel EC, Hoexter MQ, Brentani H.

Sci Rep. 2019 Feb 28;9(1):3086. doi: 10.1038/s41598-019-38965-1.


Is Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease?

Godoy MDCL, Fornazieri MA, Doty RL, Pinna FR, Farfel JM, Santos GBD, Molina M, Ferretti-Rebustini REL, Leite REP, Suemoto CK, Grinberg LT, Pasqualucci CAG, Voegels RL, Nitrini R, Jacob Filho W.

Ann Otol Rhinol Laryngol. 2018 Dec 2:3489418814865. doi: 10.1177/0003489418814865. [Epub ahead of print]


Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects.

Soltys DT, Pereira CPM, Rowies FT, Farfel JM, Grinberg LT, Suemoto CK, Leite REP, Rodriguez RD, Ericson NG, Bielas JH, Souza-Pinto NC.

Neurobiol Aging. 2019 Jan;73:161-170. doi: 10.1016/j.neurobiolaging.2018.09.015. Epub 2018 Sep 22.


Sex differences in Alzheimer's disease and common neuropathologies of aging.

Oveisgharan S, Arvanitakis Z, Yu L, Farfel J, Schneider JA, Bennett DA.

Acta Neuropathol. 2018 Dec;136(6):887-900. doi: 10.1007/s00401-018-1920-1. Epub 2018 Oct 17.


APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults.

Lamar M, Yu L, Rubin LH, James BD, Barnes LL, Farfel JM, Gaiteri C, Buchman AS, Bennett DA, Schneider JA.

Alzheimers Dement. 2019 Feb;15(2):258-266. doi: 10.1016/j.jalz.2018.08.007. Epub 2018 Oct 12.


Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive-compulsive disorder.

de Oliveira KC, Grinberg LT, Hoexter MQ, Brentani H, Suemoto CK, Nery FG, Lima LC, Alho ATDL, Farfel JM, Ferretti-Rebustini REL, Leite REP, Moretto AC, da Silva AV, Lafer B, Miguel EC, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci CA.

Brain Struct Funct. 2019 Jan;224(1):191-203. doi: 10.1007/s00429-018-1752-8. Epub 2018 Oct 8.


APOE ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.

Oveisgharan S, Buchman AS, Yu L, Farfel J, Hachinski V, Gaiteri C, De Jager PL, Schneider JA, Bennett DA.

Neurology. 2018 Jun 12;90(24):e2127-e2134. doi: 10.1212/WNL.0000000000005677. Epub 2018 May 11.


Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study.

Nishizawa A, Suemoto CK, Farias-Itao DS, Campos FM, Silva KCS, Bittencourt MS, Grinberg LT, Leite REP, Ferretti-Rebustini REL, Farfel JM, Jacob-Filho W, Pasqualucci CA.

PLoS One. 2017 Oct 16;12(10):e0186630. doi: 10.1371/journal.pone.0186630. eCollection 2017.


Diabetes is Not Associated with Alzheimer's Disease Neuropathology.

Dos Santos Matioli MNP, Suemoto CK, Rodriguez RD, Farias DS, da Silva MM, Leite REP, Ferretti-Rebustini REL, Farfel JM, Pasqualucci CA, Jacob Filho W, Arvanitakis Z, Naslavsky MS, Zatz M, Grinberg LT, Nitrini R.

J Alzheimers Dis. 2017;60(3):1035-1043. doi: 10.3233/JAD-170179.


Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.

Yu L, Lutz MW, Farfel JM, Wilson RS, Burns DK, Saunders AM, De Jager PL, Barnes LL, Schneider JA, Bennett DA.

Alzheimers Dement. 2017 Dec;13(12):1380-1388. doi: 10.1016/j.jalz.2017.05.002. Epub 2017 Jun 15.


Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study.

Suemoto CK, Ferretti-Rebustini RE, Rodriguez RD, Leite RE, Soterio L, Brucki SM, Spera RR, Cippiciani TM, Farfel JM, Chiavegatto Filho A, Naslavsky MS, Zatz M, Pasqualucci CA, Jacob-Filho W, Nitrini R, Grinberg LT.

PLoS Med. 2017 Mar 28;14(3):e1002267. doi: 10.1371/journal.pmed.1002267. eCollection 2017 Mar.


Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.

Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):393-408. doi: 10.1111/nan.12387. Epub 2017 Mar 31.


Applicability of the Spoken Knowledge in Low Literacy Patients with Diabetes in Brazilian elderly.

Souza JG, Apolinario D, Farfel JM, Jaluul O, Magaldi RM, Busse AL, Campora F, Jacob-Filho W.

Einstein (Sao Paulo). 2016 Oct-Dec;14(4):513-519. doi: 10.1590/S1679-45082016AO3747. English, Portuguese.


Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study.

Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Farfel JM, de Oliveira KC, Grinberg LT, da Costa NR, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob-Filho W, Lafer B.

Int J Geriatr Psychiatry. 2018 Jan;33(1):14-20. doi: 10.1002/gps.4649. Epub 2017 Jan 5.


Association between adiposity and systemic atherosclerosis: a protocol of a cross-sectional autopsy study.

Nishizawa A, Suemoto CK, Farias DS, Campos FM, da Silva KC, Cuelho A, Leite RE, Ferretti-Rebustini RE, Grinberg LT, Farfel JM, Jacob-Filho W, Pasqualucci CA.

Open Heart. 2016 Aug 23;3(2):e000433. doi: 10.1136/openhrt-2016-000433. eCollection 2016.


Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies.

Ferretti-Rebustini RE, Balbinotti MA, Jacob-Filho W, Rebustini F, Suemoto CK, Pasqualucci CA, Farfel JM, Leite RE, Grinberg LT, Nitrini R.

Rev Esc Enferm USP. 2015 Dec;49(6):946-52. doi: 10.1590/S0080-623420150000600010.


Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.

Farfel JM, Yu L, Buchman AS, Schneider JA, De Jager PL, Bennett DA.

Neurology. 2016 Aug 2;87(5):489-96. doi: 10.1212/WNL.0000000000002909. Epub 2016 Jul 1.


Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study.

Rodriguez RD, Suemoto CK, Molina M, Nascimento CF, Leite RE, de Lucena Ferretti-Rebustini RE, Farfel JM, Heinsen H, Nitrini R, Ueda K, Pasqualucci CA, Jacob-Filho W, Yaffe K, Grinberg LT.

J Neuropathol Exp Neurol. 2016 Jul;75(7):628-35. doi: 10.1093/jnen/nlw034. Epub 2016 Jun 9.


Association of APOE with tau-tangle pathology with and without β-amyloid.

Farfel JM, Yu L, De Jager PL, Schneider JA, Bennett DA.

Neurobiol Aging. 2016 Jan;37:19-25. doi: 10.1016/j.neurobiolaging.2015.09.011. Epub 2015 Sep 28.


APOE and cerebral amyloid angiopathy in community-dwelling older persons.

Yu L, Boyle PA, Nag S, Leurgans S, Buchman AS, Wilson RS, Arvanitakis Z, Farfel JM, De Jager PL, Bennett DA, Schneider JA.

Neurobiol Aging. 2015 Nov;36(11):2946-2953. doi: 10.1016/j.neurobiolaging.2015.08.008. Epub 2015 Aug 15.


Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample.

Nascimento C, Suemoto CK, Rodriguez RD, Alho AT, Leite RP, Farfel JM, Pasqualucci CA, Jacob-Filho W, Grinberg LT.

Brain Pathol. 2016 Mar;26(2):177-85. doi: 10.1111/bpa.12296. Epub 2015 Sep 17.


Olfaction in neurologic and neurodegenerative diseases: a literature review.

Godoy MD, Voegels RL, Pinna Fde R, Imamura R, Farfel JM.

Int Arch Otorhinolaryngol. 2015 Apr;19(2):176-9. doi: 10.1055/s-0034-1390136. Epub 2014 Nov 14.


Factors associated with morphometric brain changes in cognitively normal aging.

Ferretti-Rebustini REL, Jacob-Filho W, Suemoto CK, Farfel JM, Leite REP, Grinberg LT, Pasqualucci CA, Nitrini R.

Dement Neuropsychol. 2015 Apr-Jun;9(2):103-109. doi: 10.1590/1980-57642015DN92000004.


Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.

Corradini BR, Iamashita P, Tampellini E, Farfel JM, Grinberg LT, Moreira-Filho CA.

Biomed Res Int. 2014;2014:543673. doi: 10.1155/2014/543673. Epub 2014 Nov 26.


Vascular risk as a predictor of cognitive decline in a cohort of elderly patients with mild to moderate dementia.

Curiati PK, Magaldi RM, Suemoto CK, Bottino CM, Nitrini R, Farfel JM, Jacob-Filho W.

Dement Geriatr Cogn Dis Extra. 2014 Oct 29;4(3):402-9. doi: 10.1159/000368190. eCollection 2014 Sep.


Comprehensive geriatric assessment predicts mortality and adverse outcomes in hospitalized older adults.

Avelino-Silva TJ, Farfel JM, Curiati JA, Amaral JR, Campora F, Jacob-Filho W.

BMC Geriatr. 2014 Dec 3;14:129. doi: 10.1186/1471-2318-14-129.


Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males.

Oliveira-Pinto AV, Santos RM, Coutinho RA, Oliveira LM, Santos GB, Alho AT, Leite RE, Farfel JM, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R.

PLoS One. 2014 Nov 5;9(11):e111733. doi: 10.1371/journal.pone.0111733. eCollection 2014.


Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Silva AR, Santos AC, Farfel JM, Grinberg LT, Ferretti RE, Campos AH, Cunha IW, Begnami MD, Rocha RM, Carraro DM, de Bragança Pereira CA, Jacob-Filho W, Brentani H.

PLoS One. 2014 Jun 17;9(6):e99897. doi: 10.1371/journal.pone.0099897. eCollection 2014.


Prevalence of dementia subtypes in a developing country: a clinicopathological study.

Grinberg LT, Nitrini R, Suemoto CK, Lucena Ferretti-Rebustini RE, Leite RE, Farfel JM, Santos E, Andrade MP, Alho AT, Lima Mdo C, Oliveira KC, Tampellini E, Polichiso L, Santos GB, Rodriguez RD, Ueda K, Pasqualucci CA, Jacob-Filho W.

Clinics (Sao Paulo). 2013;68(8):1140-5. doi: 10.6061/clinics/2013(08)13.


The human cerebral cortex is neither one nor many: neuronal distribution reveals two quantitatively different zones in the gray matter, three in the white matter, and explains local variations in cortical folding.

Ribeiro PF, Ventura-Antunes L, Gabi M, Mota B, Grinberg LT, Farfel JM, Ferretti-Rebustini RE, Leite RE, Filho WJ, Herculano-Houzel S.

Front Neuroanat. 2013 Sep 2;7:28. doi: 10.3389/fnana.2013.00028. eCollection 2013.


Very low levels of education and cognitive reserve: a clinicopathologic study.

Farfel JM, Nitrini R, Suemoto CK, Grinberg LT, Ferretti RE, Leite RE, Tampellini E, Lima L, Farias DS, Neves RC, Rodriguez RD, Menezes PR, Fregni F, Bennett DA, Pasqualucci CA, Jacob Filho W; Brazilian Aging Brain Study Group.

Neurology. 2013 Aug 13;81(7):650-7. doi: 10.1212/WNL.0b013e3182a08f1b. Epub 2013 Jul 19.


Estimating premorbid cognitive abilities in low-educated populations.

Apolinario D, Brucki SM, Ferretti RE, Farfel JM, Magaldi RM, Busse AL, Jacob-Filho W.

PLoS One. 2013;8(3):e60084. doi: 10.1371/journal.pone.0060084. Epub 2013 Mar 21.


Medical adverse events in elderly hospitalized patients: a prospective study.

Szlejf C, Farfel JM, Curiati JA, Couto Ede B Jr, Jacob-Filho W, Azevedo RS.

Clinics (Sao Paulo). 2012 Nov;67(11):1247-52.


Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease.

Silva AR, Grinberg LT, Farfel JM, Diniz BS, Lima LA, Silva PJ, Ferretti RE, Rocha RM, Filho WJ, Carraro DM, Brentani H.

PLoS One. 2012;7(11):e48751. doi: 10.1371/journal.pone.0048751. Epub 2012 Nov 7.


Depression and cardiovascular risk factors: evidence from a large postmortem sample.

Suemoto CK, Damico MV, Ferretti RE, Grinberg LT, Farfel JM, Leite RE, Nitrini R, Lafer B, Jacob-Filho W, Pasqualucci CA; Brazilian Aging Brain Study Group.

Int J Geriatr Psychiatry. 2013 May;28(5):487-93. doi: 10.1002/gps.3850. Epub 2012 Jun 29.


African ancestry protects against Alzheimer's disease-related neuropathology.

Schlesinger D, Grinberg LT, Alba JG, Naslavsky MS, Licinio L, Farfel JM, Suemoto CK, de Lucena Ferretti RE, Leite RE, de Andrade MP, dos Santos AC, Brentani H, Pasqualucci CA, Nitrini R, Jacob-Filho W, Zatz M; Brazilian Aging Brain Study Group.

Mol Psychiatry. 2013 Jan;18(1):79-85. doi: 10.1038/mp.2011.136. Epub 2011 Nov 8.


Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries.

Suemoto CK, Nitrini R, Grinberg LT, Ferretti RE, Farfel JM, Leite RE, Menezes PR, Fregni F, Jacob-Filho W, Pasqualucci CA; Brazilian Aging Brain Study Group.

Stroke. 2011 Dec;42(12):3614-5. doi: 10.1161/STROKEAHA.111.628156. Epub 2011 Sep 22.


Morphometric brain changes during aging: Results from a Brazilian necropsy sample.

Ferretti REL, Jacob-Filho W, Grinberg LT, Leite REP, Farfel JM, Suemoto CK, Saldiva PHN, Rosemberg S, Pasqualucci CA, Nitrini R.

Dement Neuropsychol. 2010 Oct-Dec;4(4):332-337. doi: 10.1590/S1980-57642010DN40400013.


Adverse drug events leading to emergency department visits in elderly: the role of inappropriate prescription.

Farfel JM, Accorsi TA, Franken M, Doudement SP, Moran M, Iervolino M, Bastos Neto AS.

Einstein (Sao Paulo). 2010 Jun;8(2):175-9. doi: 10.1590/S1679-45082010AO1473. English, Portuguese.


Delirium in hospitalized elderly patients and post-discharge mortality.

Lima DP, Ochiai ME, Lima AB, Curiati JA, Farfel JM, Filho WJ.

Clinics (Sao Paulo). 2010 Mar;65(3):251-5. doi: 10.1590/S1807-59322010000300003.


Post-Mortem diagnosis of dementia by informant interview.

Ferretti REL, Damin AE, Brucki SMD, Morillo LS, Perroco TR, Campora F, Moreira EG, Balbino ÉS, Lima MDCA, Battela C, Ruiz L, Grinberg LT, Farfel JM, Leite REP, Suemoto CK, Pasqualucci CA, Rosemberg S, Saldiva PHN, Jacob-Filho W, Nitrini R.

Dement Neuropsychol. 2010 Apr-Jun;4(2):138-144. doi: 10.1590/S1980-57642010DN40200011.


Association between cardiovascular disease and dementia.

Suemoto CK, Ferretti RE, Grinberg LT, de Oliveira KC, Farfel JM, Leite REP, Nitrini R, Jacob Filho W, Pasqualucci CA; Brazilian Aging Brain Study Group.

Dement Neuropsychol. 2009 Oct-Dec;3(4):308-314. doi: 10.1590/S1980-57642009DN30400008.


Predictors of in-hospital mortality among older patients.

Silva TJ, Jerussalmy CS, Farfel JM, Curiati JA, Jacob-Filho W.

Clinics (Sao Paulo). 2009;64(7):613-8. doi: 10.1590/S1807-59322009000700002.


Age, invasive ventilatory support and outcomes in elderly patients admitted to intensive care units.

Farfel JM, Franca SA, Sitta Mdo C, Filho WJ, Carvalho CR.

Age Ageing. 2009 Sep;38(5):515-20. doi: 10.1093/ageing/afp119. Epub 2009 Jul 15.


The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?

Grinberg LT, Rüb U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H; Brazilian Brain Bank Study Group.

Neuropathol Appl Neurobiol. 2009 Aug;35(4):406-16. doi: 10.1111/j.1365-2990.2009.00997.x.


Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain.

Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S.

J Comp Neurol. 2009 Apr 10;513(5):532-41. doi: 10.1002/cne.21974.


Clinicopathological correlates of Alzheimer's disease in a general autopsy series from Brazil.

Grinberg LT, Ferretti REL, Leite REP, Farfel JM, Pacheco SP, Alho ATDL, Grisoli RP, Matos HTM, Moreira EG, Balbino ES, Oliveira KC, Rosemberg S, Carvalho HB, Pasquallucci CAG, Saldiva PHN, Jacob-Filho W, Nitrini R.

Dement Neuropsychol. 2007 Oct-Dec;1(4):356-360. doi: 10.1590/S1980-57642008DN10400005.


Brain bank of the Brazilian aging brain study group - a milestone reached and more than 1,600 collected brains.

Grinberg LT, Ferretti RE, Farfel JM, Leite R, Pasqualucci CA, Rosemberg S, Nitrini R, Saldiva PH, Filho WJ; Brazilian Aging Brain Study Group.

Cell Tissue Bank. 2007;8(2):151-62. Epub 2006 Oct 31.


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