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Items: 1 to 50 of 413

1.

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.

Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr, Walther TC.

J Cell Biol. 2018 Oct 16. pii: jcb.201809067. doi: 10.1083/jcb.201809067. [Epub ahead of print]

PMID:
30327422
2.

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV Jr.

Atherosclerosis. 2018 Oct;277:145-154. doi: 10.1016/j.atherosclerosis.2018.08.042. Epub 2018 Aug 30.

PMID:
30212683
3.

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV Jr, Walther TC.

Mol Biol Cell. 2018 Aug 15;29(17):2045-2054. doi: 10.1091/mbc.E18-05-0282. Epub 2018 Jun 27.

PMID:
29949452
4.

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2849-E2858. doi: 10.1073/pnas.1722344115. Epub 2018 Mar 6.

5.

Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.

Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV Jr.

Mol Cell Proteomics. 2018 May;17(5):836-849. doi: 10.1074/mcp.RA117.000560. Epub 2018 Feb 5.

PMID:
29414761
6.

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.

Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV Jr, Walther TC.

Dev Cell. 2018 Jan 8;44(1):73-86.e4. doi: 10.1016/j.devcel.2017.12.011. Epub 2018 Jan 8.

PMID:
29316443
7.

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV Jr, Cravatt BF.

Biochemistry. 2018 Feb 6;57(5):827-838. doi: 10.1021/acs.biochem.7b01028. Epub 2017 Dec 26.

PMID:
29278326
8.

Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.

Sajan MP, Lee MC, Foufelle F, Sajan J, Cleland C, Farese RV.

Cell Signal. 2018 Mar;43:62-70. doi: 10.1016/j.cellsig.2017.12.005. Epub 2017 Dec 18.

PMID:
29269047
9.

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.

Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV Jr, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL.

Alzheimers Dement (N Y). 2017 Sep 12;3(4):507-512. doi: 10.1016/j.trci.2017.08.002. eCollection 2017 Nov.

10.

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.

Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV.

Neurobiol Aging. 2018 Jan;61:225-237. doi: 10.1016/j.neurobiolaging.2017.09.001. Epub 2017 Sep 15.

PMID:
29032894
11.

Lipid Droplet Biogenesis.

Walther TC, Chung J, Farese RV Jr.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:491-510. doi: 10.1146/annurev-cellbio-100616-060608. Epub 2017 Aug 9. Review.

PMID:
28793795
12.

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV Jr.

Cell Metab. 2017 Aug 1;26(2):407-418.e3. doi: 10.1016/j.cmet.2017.07.012.

13.

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):5029-5034. doi: 10.1073/pnas.1700477114. Epub 2017 Apr 24.

14.

Lipid droplets and liver disease: from basic biology to clinical implications.

Gluchowski NL, Becuwe M, Walther TC, Farese RV Jr.

Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):343-355. doi: 10.1038/nrgastro.2017.32. Epub 2017 Apr 21. Review.

PMID:
28428634
15.

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.

Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV Jr.

J Lipid Res. 2017 Jun;58(6):1230-1237. doi: 10.1194/jlr.P075119. Epub 2017 Apr 3.

16.

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP.

Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10.

17.

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV Jr, Walther TC.

J Lipid Res. 2017 Jan;58(1):226-235. doi: 10.1194/jlr.M072538. Epub 2016 Nov 11.

18.

Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.

Fröhlich F, Olson DK, Christiano R, Farese RV Jr, Walther TC.

Proteomics. 2016 Nov;16(21):2759-2763. doi: 10.1002/pmic.201600269.

19.

Seipin is required for converting nascent to mature lipid droplets.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.

Elife. 2016 Aug 26;5. pii: e16582. doi: 10.7554/eLife.16582.

20.

Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice.

Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hernández AI, Cottrell JE, Shouval HZ, Fenton AA, Sacktor TC.

Elife. 2016 May 17;5. pii: e14846. doi: 10.7554/eLife.14846.

21.

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.

Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV Jr, Paz JT, Barres BA, Huang EJ.

Cell. 2016 May 5;165(4):921-35. doi: 10.1016/j.cell.2016.04.001. Epub 2016 Apr 21.

22.

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.

Kory N, Farese RV Jr, Walther TC.

Trends Cell Biol. 2016 Jul;26(7):535-546. doi: 10.1016/j.tcb.2016.02.007. Epub 2016 Mar 16. Review.

23.

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.

Sajan M, Hansen B, Ivey R 3rd, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV.

Diabetes. 2016 Jul;65(7):1892-903. doi: 10.2337/db15-1428. Epub 2016 Feb 19.

24.

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.

Agarwal AK, Tunison K, Dalal JS, Yen CL, Farese RV Jr, Horton JD, Garg A.

J Lipid Res. 2016 Apr;57(4):616-30. doi: 10.1194/jlr.M065896. Epub 2016 Feb 15.

25.

Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.

Olson DK, Fröhlich F, Farese RV Jr, Walther TC.

Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):784-792. doi: 10.1016/j.bbalip.2015.12.021. Epub 2015 Dec 30. Review.

26.

Lipid droplets go nuclear.

Farese RV Jr, Walther TC.

J Cell Biol. 2016 Jan 4;212(1):7-8. doi: 10.1083/jcb.201512056.

27.

Contraction stimulates muscle glucose uptake independent of atypical PKC.

Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ.

Physiol Rep. 2015 Nov;3(11). pii: e12565. doi: 10.14814/phy2.12565.

28.

BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.

Sajan MP, Ivey RA 3rd, Farese RV.

Metabolism. 2015 Nov;64(11):1454-65. doi: 10.1016/j.metabol.2015.08.011. Epub 2015 Aug 24.

29.

The GARP complex is required for cellular sphingolipid homeostasis.

Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC.

Elife. 2015 Sep 10;4. doi: 10.7554/eLife.08712.

30.

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.

Kory N, Thiam AR, Farese RV Jr, Walther TC.

Dev Cell. 2015 Aug 10;34(3):351-63. doi: 10.1016/j.devcel.2015.06.007. Epub 2015 Jul 23.

31.

Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats.

Zhang N, Liang H, Farese RV, Li J, Musi N, Hussey SE.

PLoS One. 2015 Jul 21;10(7):e0132575. doi: 10.1371/journal.pone.0132575. eCollection 2015.

32.

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.

Sajan MP, Ivey RA, Lee MC, Farese RV.

J Lipid Res. 2015 Jan;56(1):70-80. doi: 10.1194/jlr.M052977. Epub 2014 Nov 13.

33.

The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV Jr, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M.

J Biol Chem. 2014 Dec 26;289(52):35770-80. doi: 10.1074/jbc.M114.587816. Epub 2014 Nov 7.

34.

MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.

Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV Jr, Seeley RJ, Sandoval DA.

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1065-72. doi: 10.1152/ajpendo.00376.2014. Epub 2014 Oct 14.

35.

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.

Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV Jr, Gan L.

Nat Med. 2014 Oct;20(10):1157-64. doi: 10.1038/nm.3672. Epub 2014 Sep 28.

36.

Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus.

Farese RV, Lee MC, Sajan MP.

Expert Opin Ther Targets. 2014 Oct;18(10):1163-75. Review.

PMID:
25213731
37.

Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV Jr, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ.

J Biol Chem. 2014 Oct 24;289(43):29881-91. doi: 10.1074/jbc.M114.601864. Epub 2014 Aug 25.

38.

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L.

J Exp Med. 2014 Sep 22;211(10):1937-45. doi: 10.1084/jem.20140214. Epub 2014 Aug 25.

39.

Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.

Ivey RA, Sajan MP, Farese RV.

J Biol Chem. 2014 Sep 5;289(36):25021-30. doi: 10.1074/jbc.M114.565671. Epub 2014 Jul 17.

40.

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

Sajan MP, Ivey RA 3rd, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV.

Mol Endocrinol. 2014 Jul;28(7):1097-107. doi: 10.1210/me.2014-1025. Epub 2014 May 30.

41.

In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy.

Fu D, Yu Y, Folick A, Currie E, Farese RV Jr, Tsai TH, Xie XS, Wang MC.

J Am Chem Soc. 2014 Jun 18;136(24):8820-8. doi: 10.1021/ja504199s. Epub 2014 Jun 9.

42.

High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.

Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV Jr.

J Lipid Res. 2014 Jul;55(7):1465-77. doi: 10.1194/jlr.M050229. Epub 2014 May 27.

43.

Lipid droplet biogenesis.

Wilfling F, Haas JT, Walther TC, Farese RV Jr.

Curr Opin Cell Biol. 2014 Aug;29:39-45. doi: 10.1016/j.ceb.2014.03.008. Epub 2014 Apr 14. Review.

44.

Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.

Sajan MP, Acevedo-Duncan ME, Standaert ML, Ivey RA, Lee M, Farese RV.

Diabetes. 2014 Aug;63(8):2690-701. doi: 10.2337/db13-1863. Epub 2014 Apr 4.

45.
46.

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.

Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV Jr, Walther TC.

Elife. 2014;3:e01607. doi: 10.7554/eLife.01607. Epub 2014 Feb 4.

48.

The biophysics and cell biology of lipid droplets.

Thiam AR, Farese RV Jr, Walther TC.

Nat Rev Mol Cell Biol. 2013 Dec;14(12):775-86. doi: 10.1038/nrm3699. Epub 2013 Nov 13. Review.

49.

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV Jr, Moore MJ, Shaw CE, Gao FB.

PLoS One. 2013 Oct 15;8(10):e76055. doi: 10.1371/journal.pone.0076055. eCollection 2013.

50.

Progranulin: at the interface of neurodegenerative and metabolic diseases.

Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV Jr.

Trends Endocrinol Metab. 2013 Dec;24(12):597-606. doi: 10.1016/j.tem.2013.08.003. Epub 2013 Sep 10. Review.

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