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Items: 1 to 50 of 171

1.

Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity.

Chedik L, Bruyere A, Bacle A, Potin S, Le Vée M, Fardel O.

Expert Opin Drug Metab Toxicol. 2018 Jul;14(7):739-752. doi: 10.1080/17425255.2018.1487398. Epub 2018 Jun 20. Review.

PMID:
29886753
2.

New insights in the in vitro characterisation and molecular modelling of the P-glycoprotein inhibitory promiscuity.

Bocci G, Moreau A, Vayer P, Denizot C, Fardel O, Parmentier Y.

Eur J Pharm Sci. 2018 Apr 28;121:85-94. doi: 10.1016/j.ejps.2018.04.039. [Epub ahead of print]

PMID:
29709579
3.

Distinct Properties of Human M-CSF and GM-CSF Monocyte-Derived Macrophages to Simulate Pathological Lung Conditions In Vitro: Application to Systemic and Inflammatory Disorders with Pulmonary Involvement.

Lescoat A, Ballerie A, Augagneur Y, Morzadec C, Vernhet L, Fardel O, Jégo P, Jouneau S, Lecureur V.

Int J Mol Sci. 2018 Mar 17;19(3). pii: E894. doi: 10.3390/ijms19030894.

4.

Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters.

Chedik L, Bruyere A, Fardel O.

Xenobiotica. 2018 Mar 6:1-12. doi: 10.1080/00498254.2018.1442030. [Epub ahead of print]

PMID:
29448871
5.

Carrier-mediated uptake of clonidine in cultured human lung cells.

Le Vée M, Jouan E, Fardel O.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Apr;391(4):361-369. doi: 10.1007/s00210-018-1467-7. Epub 2018 Jan 19.

PMID:
29352450
6.

Comparative study of diesel and biodiesel exhausts on lung oxidative stress and genotoxicity in rats.

Douki T, Corbière C, Preterre D, Martin PJ, Lecureur V, André V, Landkocz Y, Pottier I, Keravec V, Fardel O, Moreira-Rebelo S, Pottier D, Vendeville C, Dionnet F, Gosset P, Billet S, Monteil C, Sichel F.

Environ Pollut. 2018 Apr;235:514-524. doi: 10.1016/j.envpol.2017.12.077. Epub 2018 Jan 8.

PMID:
29324381
7.

Repression of interferon β-regulated cytokines by the JAK1/2 inhibitor ruxolitinib in inflammatory human macrophages.

Febvre-James M, Lecureur V, Augagneur Y, Mayati A, Fardel O.

Int Immunopharmacol. 2018 Jan;54:354-365. doi: 10.1016/j.intimp.2017.11.032. Epub 2017 Dec 1.

PMID:
29202299
8.

The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes.

Febvre-James M, Bruyère A, Le Vée M, Fardel O.

Drug Metab Dispos. 2018 Feb;46(2):131-140. doi: 10.1124/dmd.117.078048. Epub 2017 Nov 21.

PMID:
29162613
9.

In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans.

Chedik L, Mias-Lucquin D, Bruyere A, Fardel O.

Int J Environ Res Public Health. 2017 Jun 30;14(7). pii: E708. doi: 10.3390/ijerph14070708.

10.

Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate.

Sayyed K, Le Vee M, Abdel-Razzak Z, Fardel O.

Toxicol In Vitro. 2017 Oct;44:27-35. doi: 10.1016/j.tiv.2017.06.014. Epub 2017 Jun 17.

11.

Benzo(a)pyrene triggers desensitization of β2-adrenergic pathway.

Mayati A, Podechard N, Rineau M, Sparfel L, Lagadic-Gossmann D, Fardel O, Le Ferrec E.

Sci Rep. 2017 Jun 12;7(1):3262. doi: 10.1038/s41598-017-03646-4.

12.

β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine.

Mayati A, Moreau A, Denizot C, Stieger B, Parmentier Y, Fardel O.

Eur J Pharm Sci. 2017 Aug 30;106:302-312. doi: 10.1016/j.ejps.2017.06.010. Epub 2017 Jun 8.

PMID:
28603032
13.

Relationship between pharmacy residency examination rank and specialty choice for French pharmacy residency-admitted students.

Fardel O.

Pharm Pract (Granada). 2017 Jan-Mar;15(1):912. doi: 10.18549/PharmPract.2017.01.912. Epub 2017 Mar 15.

14.

Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression.

Mayati A, Moreau A, Le Vée M, Stieger B, Denizot C, Parmentier Y, Fardel O.

Int J Mol Sci. 2017 Apr 4;18(4). pii: E764. doi: 10.3390/ijms18040764. Review.

15.

CD16-positive circulating monocytes and fibrotic manifestations of systemic sclerosis.

Lescoat A, Lecureur V, Roussel M, Sunnaram BL, Ballerie A, Coiffier G, Jouneau S, Fardel O, Fest T, Jégo P.

Clin Rheumatol. 2017 Jul;36(7):1649-1654. doi: 10.1007/s10067-017-3597-6. Epub 2017 Mar 14.

PMID:
28293753
16.

Effect of Gevokizumab on Interleukin-1β-Mediated Cytochrome P450 3A4 and Drug Transporter Repression in Cultured Human Hepatocytes.

Moreau A, Le Vée M, Jouan E, Denizot C, Parmentier Y, Fardel O.

Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):871-878. doi: 10.1007/s13318-017-0406-1.

PMID:
28260174
17.

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin.

Chedik L, Bruyere A, Le Vee M, Stieger B, Denizot C, Parmentier Y, Potin S, Fardel O.

PLoS One. 2017 Jan 18;12(1):e0169480. doi: 10.1371/journal.pone.0169480. eCollection 2017.

18.

Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells.

Jouan E, Le Vée M, Denizot C, Parmentier Y, Fardel O.

Pharmaceutics. 2016 Dec 28;9(1). pii: E3. doi: 10.3390/pharmaceutics9010003.

19.

Inhibition of SLC drug transporter activities by environmental bisphenols.

Bruyere A, Hubert C, Le Vee M, Chedik L, Sayyed K, Stieger B, Denizot C, Parmentier Y, Fardel O.

Toxicol In Vitro. 2017 Apr;40:34-44. doi: 10.1016/j.tiv.2016.12.009. Epub 2016 Dec 15.

PMID:
27989701
20.

Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate.

Sayyed K, Vee ML, Abdel-Razzak Z, Jouan E, Stieger B, Denizot C, Parmentier Y, Fardel O.

Toxicology. 2016 Jul 1;363-364:58-71. doi: 10.1016/j.tox.2016.07.011. Epub 2016 Jul 19.

21.

Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation Assay.

Jouan E, Le Vée M, Mayati A, Denizot C, Parmentier Y, Fardel O.

Pharmaceutics. 2016 Apr 12;8(2). pii: E12. doi: 10.3390/pharmaceutics8020012.

22.

Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220.

Mayati A, Bruyere A, Moreau A, Jouan E, Denizot C, Parmentier Y, Fardel O.

PLoS One. 2015 Dec 10;10(12):e0144667. doi: 10.1371/journal.pone.0144667. eCollection 2015.

23.

Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.

Le Vee M, Jouan E, Lecureur V, Fardel O.

Toxicol Appl Pharmacol. 2016 Jan 1;290:74-85. doi: 10.1016/j.taap.2015.11.014. Epub 2015 Nov 24.

24.

Protein kinase C-dependent regulation of human hepatic drug transporter expression.

Mayati A, Le Vee M, Moreau A, Jouan E, Bucher S, Stieger B, Denizot C, Parmentier Y, Fardel O.

Biochem Pharmacol. 2015 Dec 15;98(4):703-17. doi: 10.1016/j.bcp.2015.10.007. Epub 2015 Oct 14.

25.

Analysis of Sinusoidal Drug Uptake Transporter Activities in Primary Human Hepatocytes.

Le Vée M, Jouan E, Denizot C, Parmentier Y, Fardel O.

Methods Mol Biol. 2015;1250:287-302. doi: 10.1007/978-1-4939-2074-7_21.

PMID:
26272151
26.

Nature and uses of fluorescent dyes for drug transporter studies.

Fardel O, Le Vee M, Jouan E, Denizot C, Parmentier Y.

Expert Opin Drug Metab Toxicol. 2015;11(8):1233-51. doi: 10.1517/17425255.2015.1053462. Epub 2015 Jun 7. Review.

PMID:
26050735
27.

AhR-dependent secretion of PDGF-BB by human classically activated macrophages exposed to DEP extracts stimulates lung fibroblast proliferation.

Jaguin M, Fardel O, Lecureur V.

Toxicol Appl Pharmacol. 2015 Jun 15;285(3):170-8. doi: 10.1016/j.taap.2015.04.007. Epub 2015 Apr 17.

PMID:
25896968
28.

Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes.

Le Vee M, Jouan E, Noel G, Stieger B, Fardel O.

Toxicol In Vitro. 2015 Aug;29(5):938-46. doi: 10.1016/j.tiv.2015.03.019. Epub 2015 Apr 7.

29.

Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract.

Le Vee M, Jouan E, Stieger B, Lecureur V, Fardel O.

PLoS One. 2015 Mar 24;10(3):e0121232. doi: 10.1371/journal.pone.0121232. eCollection 2015.

30.

Interleukin 6 inhibits HBV entry through NTCP down regulation.

Bouezzedine F, Fardel O, Gripon P.

Virology. 2015 Jul;481:34-42. doi: 10.1016/j.virol.2015.02.026. Epub 2015 Mar 9.

31.

Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2.

Jaguin M, Fardel O, Lecureur V.

PLoS One. 2015 Feb 24;10(2):e0116560. doi: 10.1371/journal.pone.0116560. eCollection 2015.

32.

Nrf2-dependent repression of interleukin-12 expression in human dendritic cells exposed to inorganic arsenic.

Macoch M, Morzadec C, Génard R, Pallardy M, Kerdine-Römer S, Fardel O, Vernhet L.

Free Radic Biol Med. 2015 Nov;88(Pt B):381-390. doi: 10.1016/j.freeradbiomed.2015.02.003. Epub 2015 Feb 11.

PMID:
25680285
33.

Calcium signaling and β2-adrenergic receptors regulate 1-nitropyrene induced CXCL8 responses in BEAS-2B cells.

Mayati A, Le Ferrec E, Holme JA, Fardel O, Lagadic-Gossmann D, Ovrevik J.

Toxicol In Vitro. 2014 Sep;28(6):1153-7. doi: 10.1016/j.tiv.2014.05.012. Epub 2014 Jun 4.

34.

Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone.

Morzadec C, Macoch M, Sparfel L, Kerdine-Römer S, Fardel O, Vernhet L.

Free Radic Biol Med. 2014 Jun;71:133-45. doi: 10.1016/j.freeradbiomed.2014.03.006. Epub 2014 Mar 13.

35.

The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation.

Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L.

Eur J Immunol. 2014 May;44(5):1330-40. doi: 10.1002/eji.201343920. Epub 2014 Feb 18.

36.

Regulation of hepatic drug transporter activity and expression by organochlorine pesticides.

Bucher S, Le Vee M, Jouan E, Fardel O.

J Biochem Mol Toxicol. 2014 Mar;28(3):119-28. doi: 10.1002/jbt.21543. Epub 2013 Nov 27.

PMID:
24464585
37.

Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene.

Le Vee M, Kolasa E, Jouan E, Collet N, Fardel O.

Chem Biol Interact. 2014 Mar 5;210:1-11. doi: 10.1016/j.cbi.2013.12.004. Epub 2013 Dec 17.

PMID:
24361490
38.

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells.

Le Vee M, Noel G, Jouan E, Stieger B, Fardel O.

Toxicol In Vitro. 2013 Sep;27(6):1979-86. doi: 10.1016/j.tiv.2013.07.003. Epub 2013 Jul 12.

39.

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin.

Jaguin M, Houlbert N, Fardel O, Lecureur V.

Cell Immunol. 2013 Jan;281(1):51-61. doi: 10.1016/j.cellimm.2013.01.010. Epub 2013 Feb 4.

PMID:
23454681
40.

AhR- and NF-κB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-α in human mammary MCF-7 cells.

Kolasa E, Houlbert N, Balaguer P, Fardel O.

Chem Biol Interact. 2013 Apr 25;203(2):391-400. doi: 10.1016/j.cbi.2013.01.005. Epub 2013 Feb 8.

PMID:
23396138
41.

Functional expression and regulation of drug transporters in monolayer- and sandwich-cultured mouse hepatocytes.

Noel G, Le Vee M, Moreau A, Stieger B, Parmentier Y, Fardel O.

Eur J Pharm Sci. 2013 Apr 11;49(1):39-50. doi: 10.1016/j.ejps.2013.01.013. Epub 2013 Feb 6.

42.

Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.

Le Vee M, Jouan E, Stieger B, Fardel O.

Eur J Pharm Sci. 2013 Mar 12;48(4-5):767-74. doi: 10.1016/j.ejps.2013.01.005. Epub 2013 Jan 23.

43.

Cytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification.

Fardel O.

Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):141-52. doi: 10.1517/17425255.2013.738194. Epub 2012 Dec 12. Review.

PMID:
23230817
44.

Inorganic arsenic impairs differentiation and functions of human dendritic cells.

Macoch M, Morzadec C, Fardel O, Vernhet L.

Toxicol Appl Pharmacol. 2013 Jan 15;266(2):204-13. doi: 10.1016/j.taap.2012.11.008. Epub 2012 Nov 16.

PMID:
23164666
45.

The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2.

Jouan E, Le Vee M, Denizot C, Da Violante G, Fardel O.

Fundam Clin Pharmacol. 2014 Feb;28(1):65-77. doi: 10.1111/j.1472-8206.2012.01071.x. Epub 2012 Aug 23.

PMID:
22913740
46.

Inorganic arsenic impairs proliferation and cytokine expression in human primary T lymphocytes.

Morzadec C, Bouezzedine F, Macoch M, Fardel O, Vernhet L.

Toxicology. 2012 Oct 9;300(1-2):46-56. doi: 10.1016/j.tox.2012.05.025. Epub 2012 Jun 6.

PMID:
22683347
47.

Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.

Kolasa E, Balaguer P, Houlbert N, Fardel O.

Toxicol In Vitro. 2012 Sep;26(6):807-16. doi: 10.1016/j.tiv.2012.05.006. Epub 2012 May 27.

PMID:
22643241
48.

Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes.

Morzadec C, Macoch M, Robineau M, Sparfel L, Fardel O, Vernhet L.

Toxicol Appl Pharmacol. 2012 Aug 1;262(3):217-22. doi: 10.1016/j.taap.2012.05.004. Epub 2012 May 19.

PMID:
22617429
49.

Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.

Fardel O, Kolasa E, Le Vee M.

Expert Opin Drug Metab Toxicol. 2012 Jan;8(1):29-46. doi: 10.1517/17425255.2012.637918. Epub 2011 Dec 19. Review.

PMID:
22176607
50.

Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.

Mayati A, Levoin N, Paris H, N'Diaye M, Courtois A, Uriac P, Lagadic-Gossmann D, Fardel O, Le Ferrec E.

J Biol Chem. 2012 Feb 3;287(6):4041-52. doi: 10.1074/jbc.M111.319970. Epub 2011 Dec 13.

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