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Items: 1 to 50 of 85

1.

Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders.

Ratner MH, Kumaresan V, Farb DH.

Front Endocrinol (Lausanne). 2019 Apr 9;10:169. doi: 10.3389/fendo.2019.00169. eCollection 2019. Review.

2.

Younger age at onset of sporadic Parkinson's disease among subjects occupationally exposed to metals and pesticides.

Ratner MH, Farb DH, Ozer J, Feldman RG, Durso R.

Interdiscip Toxicol. 2014 Sep;7(3):123-33. doi: 10.2478/intox-2014-0017. Epub 2014 Dec 30.

3.
4.

Targeting the modulation of neural circuitry for the treatment of anxiety disorders.

Farb DH, Ratner MH.

Pharmacol Rev. 2014 Oct;66(4):1002-32. doi: 10.1124/pr.114.009126. Review.

PMID:
25237115
5.

A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.

Smith CC, Martin SC, Sugunan K, Russek SJ, Gibbs TT, Farb DH.

Mol Pharmacol. 2014 Oct;86(4):390-8. doi: 10.1124/mol.114.094128. Epub 2014 Jul 23.

6.

Pregnenolone sulfate as a modulator of synaptic plasticity.

Smith CC, Gibbs TT, Farb DH.

Psychopharmacology (Berl). 2014 Sep;231(17):3537-56. doi: 10.1007/s00213-014-3643-x. Epub 2014 Jul 6. Review.

7.

GABA-induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor.

GutiƩrrez ML, Ferreri MC, Farb DH, Gravielle MC.

J Neurosci Res. 2014 Aug;92(8):1054-61. doi: 10.1002/jnr.23387. Epub 2014 Apr 10.

PMID:
24723313
8.

An interview with David H Farb, Section Editor for Basic Pharmacology.

Farb DH.

BMC Pharmacol Toxicol. 2013 Aug 30;14:42. doi: 10.1186/2050-6511-14-42. No abstract available.

9.

Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity.

Saha S, Hu Y, Martin SC, Bandyopadhyay S, Russek SJ, Farb DH.

BMC Pharmacol Toxicol. 2013 Jul 23;14:37. doi: 10.1186/2050-6511-14-37.

10.

The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.

Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH.

Mol Pharmacol. 2013 Aug;84(2):261-74. doi: 10.1124/mol.113.085696. Epub 2013 May 28.

11.

Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons.

Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ.

J Neurochem. 2012 Jan;120(2):210-9. doi: 10.1111/j.1471-4159.2011.07555.x. Epub 2011 Nov 28.

12.

A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.

Kostakis E, Jang MK, Russek SJ, Gibbs TT, Farb DH.

J Neurochem. 2011 Nov;119(3):486-96. doi: 10.1111/j.1471-4159.2011.07442.x. Epub 2011 Sep 28.

13.

Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes.

Eagleson KL, Gravielle MC, Schlueter McFadyen-Ketchum LJ, Russek SJ, Farb DH, Levitt P.

Neuroscience. 2010 Jul 14;168(3):797-810. doi: 10.1016/j.neuroscience.2010.03.066. Epub 2010 Apr 7.

14.

Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site.

Berezhnoy D, Gibbs TT, Farb DH.

Mol Pharmacol. 2009 Aug;76(2):440-50. doi: 10.1124/mol.109.054650. Epub 2009 May 29.

15.

Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo.

Sadri-Vakili G, Janis GC, Pierce RC, Gibbs TT, Farb DH.

J Pharmacol Exp Ther. 2008 Dec;327(3):840-5. doi: 10.1124/jpet.108.143958. Epub 2008 Sep 4.

16.

Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.

Whittaker MT, Gibbs TT, Farb DH.

J Neurochem. 2008 Oct;107(2):510-21. doi: 10.1111/j.1471-4159.2008.05627.x. Epub 2008 Aug 14.

17.

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH.

BMC Pharmacol. 2008 Jun 13;8:11. doi: 10.1186/1471-2210-8-11.

18.

Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor.

Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ.

J Biol Chem. 2008 Apr 4;283(14):9328-40. doi: 10.1074/jbc.M705110200. Epub 2008 Jan 7.

19.

Sulfated steroids as endogenous neuromodulators.

Gibbs TT, Russek SJ, Farb DH.

Pharmacol Biochem Behav. 2006 Aug;84(4):555-67. Epub 2006 Oct 4. Review.

PMID:
17023038
20.

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.

J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13.

PMID:
16971504
21.
22.

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. Epub 2005 May 3.

23.

GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons.

Gravielle MC, Faris R, Russek SJ, Farb DH.

J Biol Chem. 2005 Jun 3;280(22):20954-60. Epub 2005 Apr 1.

25.

A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity.

Jang MK, Mierke DF, Russek SJ, Farb DH.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8198-203. Epub 2004 May 18.

26.
27.

Effects of prenatal malnutrition on GABAA receptor alpha1, alpha3 and beta2 mRNA levels.

Steiger JL, Alexander MJ, Galler JR, Farb DH, Russek SJ.

Neuroreport. 2003 Sep 15;14(13):1731-5.

PMID:
14512847
28.
29.

Prenatal protein malnutrition reduces beta(2), beta(3) and gamma(2L) GABA(A) receptor subunit mRNAs in the adult septum.

Steiger JL, Galler JR, Farb DH, Russek SJ.

Eur J Pharmacol. 2002 Jun 20;446(1-3):201-2.

PMID:
12098603
31.

Dueling enigmas: neurosteroids and sigma receptors in the limelight.

Gibbs TT, Farb DH.

Sci STKE. 2000 Nov 28;2000(60):pe1. Review.

PMID:
11752623
32.

Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2.

Martin SC, Russek SJ, Farb DH.

Gene. 2001 Oct 31;278(1-2):63-79.

PMID:
11707323
34.
35.

Geometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death.

Weaver CE, Land MB, Purdy RH, Richards KG, Gibbs TT, Farb DH.

J Pharmacol Exp Ther. 2000 Jun;293(3):747-54.

PMID:
10869372
36.

A minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificity.

McLean PJ, Shpektor D, Bandyopadhyay S, Russek SJ, Farb DH.

J Neurochem. 2000 May;74(5):1858-69.

37.
38.

Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.

Park-Chung M, Malayev A, Purdy RH, Gibbs TT, Farb DH.

Brain Res. 1999 May 29;830(1):72-87.

PMID:
10350561
39.
40.

Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons.

Weaver CE Jr, Wu FS, Gibbs TT, Farb DH.

Brain Res. 1998 Aug 24;803(1-2):129-36.

PMID:
9729331
41.

Neurosteroid modulation of recombinant ionotropic glutamate receptors.

Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH.

Brain Res. 1998 Aug 24;803(1-2):153-60.

PMID:
9729352
42.

Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.

Park-Chung M, Wu FS, Purdy RH, Malayev AA, Gibbs TT, Farb DH.

Mol Pharmacol. 1997 Dec;52(6):1113-23.

PMID:
9396781
43.

Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor.

Weaver CE Jr, Marek P, Park-Chung M, Tam SW, Farb DH.

Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10450-4.

44.

17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors.

Weaver CE Jr, Park-Chung M, Gibbs TT, Farb DH.

Brain Res. 1997 Jul 4;761(2):338-41.

PMID:
9252035
46.

From ion currents to genomic analysis: recent advances in GABAA receptor research.

Rabow LE, Russek SJ, Farb DH.

Synapse. 1995 Nov;21(3):189-274. Review.

PMID:
8578436
48.
50.

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