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Items: 17

1.

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.

Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR.

Blood. 2019 Nov 7;134(19):1670-1682. doi: 10.1182/blood.2019001950.

PMID:
31533918
2.

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P.

EMBO J. 2019 May 15;38(10). pii: e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22.

PMID:
30902848
3.

Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase-1 knockout.

Laux H, Romand S, Nuciforo S, Farady CJ, Tapparel J, Buechmann-Moeller S, Sommer B, Oakeley EJ, Bodendorf U.

Biotechnol Bioeng. 2018 Oct;115(10):2530-2540. doi: 10.1002/bit.26731. Epub 2018 Jun 29.

PMID:
29777593
4.

Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.

Namoto K, Sirockin F, Sellner H, Wiesmann C, Villard F, Moreau RJ, Valeur E, Paulding SC, Schleeger S, Schipp K, Loup J, Andrews L, Swale R, Robinson M, Farady CJ.

Bioorg Med Chem Lett. 2018 Mar 1;28(5):906-909. doi: 10.1016/j.bmcl.2018.01.064. Epub 2018 Feb 1.

PMID:
29433930
5.

Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells.

Unterreiner A, Stoehr N, Huppertz C, Calzascia T, Farady CJ, Bornancin F.

Immunol Lett. 2017 Dec;192:48-51. doi: 10.1016/j.imlet.2017.10.009. Epub 2017 Oct 24. No abstract available.

PMID:
29079202
6.

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.

Feuerbach D, Schindler P, Barske C, Joller S, Beng-Louka E, Worringer KA, Kommineni S, Kaykas A, Ho DJ, Ye C, Welzenbach K, Elain G, Klein L, Brzak I, Mir AK, Farady CJ, Aichholz R, Popp S, George N, Neumann U.

Neurosci Lett. 2017 Nov 1;660:109-114. doi: 10.1016/j.neulet.2017.09.034. Epub 2017 Sep 18.

PMID:
28923481
7.

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.

Sborgi L, Rühl S, Mulvihill E, Pipercevic J, Heilig R, Stahlberg H, Farady CJ, Müller DJ, Broz P, Hiller S.

EMBO J. 2016 Aug 15;35(16):1766-78. doi: 10.15252/embj.201694696. Epub 2016 Jul 14.

8.

Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.

Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS.

ChemMedChem. 2016 Apr 19;11(8):862-9. doi: 10.1002/cmdc.201500526. Epub 2016 Jan 28.

9.

Phosphorylation meets proteolysis.

Renatus M, Farady CJ.

Structure. 2012 Apr 4;20(4):570-1. doi: 10.1016/j.str.2012.03.006. Epub 2012 Apr 3.

10.

A reverse binding motif that contributes to specific protease inhibition by antibodies.

Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS.

J Mol Biol. 2012 Jan 27;415(4):699-715. doi: 10.1016/j.jmb.2011.11.036. Epub 2011 Nov 27.

11.

Mechanisms of macromolecular protease inhibitors.

Farady CJ, Craik CS.

Chembiochem. 2010 Nov 22;11(17):2341-6. doi: 10.1002/cbic.201000442. Review. No abstract available.

12.

Tumor detection by imaging proteolytic activity.

Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS.

Cancer Res. 2010 Feb 15;70(4):1505-12. doi: 10.1158/0008-5472.CAN-09-1640. Epub 2010 Feb 9.

13.

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS.

J Biol Chem. 2009 Sep 18;284(38):25697-703. doi: 10.1074/jbc.M109.014340. Epub 2009 Jul 20.

14.

Improving the species cross-reactivity of an antibody using computational design.

Farady CJ, Sellers BD, Jacobson MP, Craik CS.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3744-7. doi: 10.1016/j.bmcl.2009.05.005. Epub 2009 May 7.

15.

Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.

Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS.

J Mol Biol. 2008 Jul 4;380(2):351-60. doi: 10.1016/j.jmb.2008.05.009. Epub 2008 May 11.

16.

The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).

Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS.

J Mol Biol. 2007 Jun 15;369(4):1041-51. Epub 2007 Apr 4.

17.

Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.

Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5771-6. Epub 2007 Mar 27.

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