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Contributions of Aging to Cerebral Small Vessel Disease.

De Silva TM, Faraci FM.

Annu Rev Physiol. 2019 Oct 16. doi: 10.1146/annurev-physiol-021119-034338. [Epub ahead of print]


Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.

Faraci FM, Taugher RJ, Lynch C, Fan R, Gupta S, Wemmie JA.

Circ Res. 2019 Oct 25;125(10):907-920. doi: 10.1161/CIRCRESAHA.119.315024. Epub 2019 Aug 27.


Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging.

De Silva TM, Li Y, Kinzenbaw DA, Sigmund CD, Faraci FM.

Hypertension. 2018 Jul;72(1):227-234. doi: 10.1161/HYPERTENSIONAHA.117.10799. Epub 2018 May 7.


Watching Small Vessel Disease Grow.

Faraci FM.

Circ Res. 2018 Mar 16;122(6):810-812. doi: 10.1161/CIRCRESAHA.118.312762. Review. No abstract available.


Changes in Cerebral Arteries and Parenchymal Arterioles With Aging: Role of Rho Kinase 2 and Impact of Genetic Background.

De Silva TM, Modrick ML, Dabertrand F, Faraci FM.

Hypertension. 2018 May;71(5):921-927. doi: 10.1161/HYPERTENSIONAHA.118.10865. Epub 2018 Mar 12.


Disease Highlights the Cellular Diversity of Neurovascular Units: Sign in Stranger.

Faraci FM.

Circ Res. 2017 Jul 21;121(3):203-205. doi: 10.1161/CIRCRESAHA.117.311386. No abstract available.


Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.

De Silva TM, Hu C, Kinzenbaw DA, Modrick ML, Sigmund CD, Faraci FM.

Hypertension. 2017 Sep;70(3):559-565. doi: 10.1161/HYPERTENSIONAHA.117.09358. Epub 2017 Jul 3.


ASIC1A in neurons is critical for fear-related behaviors.

Taugher RJ, Lu Y, Fan R, Ghobbeh A, Kreple CJ, Faraci FM, Wemmie JA.

Genes Brain Behav. 2017 Nov;16(8):745-755. doi: 10.1111/gbb.12398. Epub 2017 Jul 21.


Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia.

Dayal S, Baumbach GL, Arning E, Bottiglieri T, Faraci FM, Lentz SR.

PLoS One. 2017 Apr 17;12(4):e0175732. doi: 10.1371/journal.pone.0175732. eCollection 2017.


Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke.

Hu X, De Silva TM, Chen J, Faraci FM.

Circ Res. 2017 Feb 3;120(3):449-471. doi: 10.1161/CIRCRESAHA.116.308427. Review.


Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.

Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, Gulati M, Kamel H, Knopman DS, Launer LJ, Saczynski JS, Seshadri S, Zeki Al Hazzouri A; American Heart Association Council on Hypertension; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council.

Hypertension. 2016 Dec;68(6):e67-e94. Epub 2016 Oct 10. Review.


Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries.

Baron-Menguy C, Domenga-Denier V, Ghezali L, Faraci FM, Joutel A.

Hypertension. 2017 Jan;69(1):60-70. Epub 2016 Nov 7.


Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function.

De Silva TM, Kinzenbaw DA, Modrick ML, Reinhardt LD, Faraci FM.

Hypertension. 2016 Sep;68(3):809-17. doi: 10.1161/HYPERTENSIONAHA.116.07430. Epub 2016 Jul 18.


Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells.

Li Y, Kinzenbaw DA, Modrick ML, Pewe LL, Faraci FM.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H146-56. doi: 10.1152/ajpheart.00204.2016. Epub 2016 Apr 22.


Microvascular Dysfunction and Cognitive Impairment.

De Silva TM, Faraci FM.

Cell Mol Neurobiol. 2016 Mar;36(2):241-58. doi: 10.1007/s10571-015-0308-1. Epub 2016 Mar 17. Review.


Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.

Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD.

Hypertension. 2016 Jan;67(1):214-22. doi: 10.1161/HYPERTENSIONAHA.115.06391. Epub 2015 Nov 23.


Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction.

Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD.

Physiol Genomics. 2016 Feb;48(2):124-34. doi: 10.1152/physiolgenomics.00087.2015. Epub 2015 Nov 3.


Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.

Peña Silva RA, Mitchell IJ, Kung DK, Pewe LL, Granja MF, Harty JT, Faraci FM, Heistad DD, Hasan DM.

Neurosurgery. 2015 Oct;77(4):613-20. doi: 10.1227/NEU.0000000000000883.


Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.

Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD.

Hypertension. 2015 Jul;66(1):211-20. doi: 10.1161/HYPERTENSIONAHA.115.05332. Epub 2015 Apr 27.


Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism.

De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM.

Hypertension. 2015 Feb;65(2):345-51. doi: 10.1161/HYPERTENSIONAHA.114.04541. Epub 2014 Nov 10.


Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.

Dayal S, Blokhin IO, Erger RA, Jensen M, Arning E, Stevens JW, Bottiglieri T, Faraci FM, Lentz SR.

PLoS One. 2014 Sep 16;9(9):e107734. doi: 10.1371/journal.pone.0107734. eCollection 2014.


Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation.

De Silva TM, Modrick ML, Ketsawatsomkron P, Lynch C, Chu Y, Pelham CJ, Sigmund CD, Faraci FM.

Hypertension. 2014 Nov;64(5):1088-93. doi: 10.1161/HYPERTENSIONAHA.114.03935. Epub 2014 Sep 2.


Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation.

Chrissobolis S, Drummond GR, Faraci FM, Sobey CG.

J Hypertens. 2014 Sep;32(9):1815-21. doi: 10.1097/HJH.0000000000000259.


Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.

Peña Silva RA, Kung DK, Mitchell IJ, Alenina N, Bader M, Santos RA, Faraci FM, Heistad DD, Hasan DM.

Hypertension. 2014 Aug;64(2):362-8. doi: 10.1161/HYPERTENSIONAHA.114.03415. Epub 2014 May 5.


Interleukin-10 protects against aging-induced endothelial dysfunction.

Kinzenbaw DA, Chu Y, Peña Silva RA, Didion SP, Faraci FM.

Physiol Rep. 2013 Nov;1(6):e00149. doi: 10.1002/phy2.149. Epub 2013 Nov 11.


Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity.

Lynch CM, Kinzenbaw DA, Chen X, Zhan S, Mezzetti E, Filosa J, Ergul A, Faulkner JL, Faraci FM, Didion SP.

Stroke. 2013 Nov;44(11):3195-201. doi: 10.1161/STROKEAHA.113.001366. Epub 2013 Sep 26.


Response to letter regarding article, "Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging".

Pena-Silva RA, Faraci FM, Heistad DD.

Stroke. 2013 Apr;44(4):e35. No abstract available.


Effects of angiotensin II on the cerebral circulation: role of oxidative stress.

De Silva TM, Faraci FM.

Front Physiol. 2013 Jan 3;3:484. doi: 10.3389/fphys.2012.00484. eCollection 2012.


Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension.

Johnson AW, Kinzenbaw DA, Modrick ML, Faraci FM.

Hypertension. 2013 Feb;61(2):437-42. doi: 10.1161/HYPERTENSIONAHA.111.00299. Epub 2012 Dec 24.


Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.

Peña Silva RA, Chu Y, Miller JD, Mitchell IJ, Penninger JM, Faraci FM, Heistad DD.

Stroke. 2012 Dec;43(12):3358-63. doi: 10.1161/STROKEAHA.112.667063. Epub 2012 Nov 15.


Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.

Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD.

Cell Metab. 2012 Oct 3;16(4):462-72. doi: 10.1016/j.cmet.2012.08.011.


PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity.

Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD.

Circ Res. 2012 Nov 9;111(11):1446-58. doi: 10.1161/CIRCRESAHA.112.271577. Epub 2012 Sep 7.


Breathe, breathe in the air: the ins and outs of hypoxia take their toll.

Faraci FM.

Hypertension. 2012 Jul;60(1):22-4. doi: 10.1161/HYPERTENSIONAHA.112.195628. Epub 2012 Jun 11. No abstract available.


Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain.

Chrissobolis S, Banfi B, Sobey CG, Faraci FM.

J Appl Physiol (1985). 2012 Jul;113(2):184-91. doi: 10.1152/japplphysiol.00455.2012. Epub 2012 May 24.


Peroxisome proliferator-activated receptor-γ protects against vascular aging.

Modrick ML, Kinzenbaw DA, Chu Y, Sigmund CD, Faraci FM.

Am J Physiol Regul Integr Comp Physiol. 2012 May 15;302(10):R1184-90. doi: 10.1152/ajpregu.00557.2011. Epub 2012 Mar 28.


Free radical biology of the cardiovascular system.

Chen AF, Chen DD, Daiber A, Faraci FM, Li H, Rembold CM, Laher I.

Clin Sci (Lond). 2012 Jul;123(2):73-91. doi: 10.1042/CS20110562. Review.


Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia.

Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci FM, Kruger WD, Lentz SR.

Blood. 2012 Mar 29;119(13):3176-83. doi: 10.1182/blood-2011-09-380568. Epub 2011 Dec 20.


Trans-forming endothelial nitric oxide synthase in hypertension: more than meets the eye.

Johnson AW, Faraci FM.

Hypertension. 2011 Sep;58(3):359-60. doi: 10.1161/HYPERTENSIONAHA.111.177139. Epub 2011 Aug 1. No abstract available.


Protecting against vascular disease in brain.

Faraci FM.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1566-82. doi: 10.1152/ajpheart.01310.2010. Epub 2011 Feb 18. Review.


Leaky vessels: how the brain deals with pregnancy under pressure.

Faraci FM.

J Appl Physiol (1985). 2011 Feb;110(2):305-6. doi: 10.1152/japplphysiol.01356.2010. Epub 2010 Nov 25. No abstract available.


Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction.

Chrissobolis S, Zhang Z, Kinzenbaw DA, Lynch CM, Russo AF, Faraci FM.

Stroke. 2010 Oct;41(10):2329-34. doi: 10.1161/STROKEAHA.110.589648. Epub 2010 Sep 2.


Sex differences in protection against angiotensin II-induced endothelial dysfunction by manganese superoxide dismutase in the cerebral circulation.

Chrissobolis S, Faraci FM.

Hypertension. 2010 Apr;55(4):905-10. doi: 10.1161/HYPERTENSIONAHA.109.147041. Epub 2010 Mar 1.


Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?

Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD.

J Biol Chem. 2010 Mar 26;285(13):9311-6. doi: 10.1074/jbc.R109.025031. Epub 2010 Feb 3. Review.


Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.

Rodionov RN, Dayoub H, Lynch CM, Wilson KM, Stevens JW, Murry DJ, Kimoto M, Arning E, Bottiglieri T, Cooke JP, Baumbach GL, Faraci FM, Lentz SR.

Circ Res. 2010 Feb 19;106(3):551-8. doi: 10.1161/CIRCRESAHA.109.200360. Epub 2009 Dec 17.


Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta.

Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):518-25. doi: 10.1161/ATVBAHA.109.200733. Epub 2009 Dec 17.


The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM, Lynch CM, Faraci FM, Howard MA 3rd, Welsh MJ, Wemmie JA.

Cell. 2009 Nov 25;139(5):1012-21. doi: 10.1016/j.cell.2009.10.029.


Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction.

Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM.

Hypertension. 2009 Sep;54(3):619-24. doi: 10.1161/HYPERTENSIONAHA.109.137158. Epub 2009 Jul 20.


Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging.

Modrick ML, Didion SP, Sigmund CD, Faraci FM.

Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1914-9. doi: 10.1152/ajpheart.00300.2009. Epub 2009 Apr 24.


Role of hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone.

Modrick ML, Didion SP, Lynch CM, Dayal S, Lentz SR, Faraci FM.

J Cereb Blood Flow Metab. 2009 Jun;29(6):1130-7. doi: 10.1038/jcbfm.2009.37. Epub 2009 Apr 8.

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