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Items: 1 to 50 of 120

1.

A Young Male with Parafibromin-Deficient Parathyroid Carcinoma Due to a Rare Germline HRPT2/CDC73 Mutation.

Kapur A, Singh N, Mete O, Hegele RA, Fantus IG.

Endocr Pathol. 2018 Dec;29(4):374-379. doi: 10.1007/s12022-018-9552-5.

PMID:
30361844
2.

Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats.

Mori Y, Ko E, Furrer R, Qu LC, Wiber SC, Fantus IG, Thevis M, Medline A, Giacca A.

Endocr Connect. 2018 May;7(5):739-748. doi: 10.1530/EC-17-0358. Epub 2018 Apr 24.

3.

Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ.

Lu H, Bogdanovic E, Yu Z, Cho C, Liu L, Ho K, Guo J, Yeung LSN, Lehmann R, Hundal HS, Giacca A, Fantus IG.

Endocrinology. 2018 Apr 1;159(4):1658-1677. doi: 10.1210/en.2017-00312.

4.

Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity.

Jin T, Song Z, Weng J, Fantus IG.

Am J Physiol Endocrinol Metab. 2018 Mar 1;314(3):E201-E205. doi: 10.1152/ajpendo.00285.2017. Epub 2017 Oct 31. Review.

5.

The bradykinin-cGMP-PKG pathway augments insulin sensitivity via upregulation of MAPK phosphatase-5 and inhibition of JNK.

Frigolet ME, Thomas G, Beard K, Lu H, Liu L, Fantus IG.

Am J Physiol Endocrinol Metab. 2017 Sep 1;313(3):E321-E334. doi: 10.1152/ajpendo.00298.2016. Epub 2017 Jul 5.

6.

Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial.

Feig DS, Murphy K, Asztalos E, Tomlinson G, Sanchez J, Zinman B, Ohlsson A, Ryan EA, Fantus IG, Armson AB, Lipscombe LL, Barrett JF; MiTy Collaborative Group.

BMC Pregnancy Childbirth. 2016 Jul 19;16(1):173. doi: 10.1186/s12884-016-0954-4.

7.

Effects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats.

Midaoui AE, Talbot S, Lahjouji K, Dias JP, Fantus IG, Couture R.

J Diabetes Metab. 2015 Jun 1;6(6):1-7.

8.

Short-Term Curcumin Gavage Sensitizes Insulin Signaling in Dexamethasone-Treated C57BL/6 Mice.

Tian L, Zeng K, Shao W, Yang BB, Fantus IG, Weng J, Jin T.

J Nutr. 2015 Oct;145(10):2300-7. doi: 10.3945/jn.115.216853. Epub 2015 Sep 2.

PMID:
26338887
9.

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

Guo J, Breen DM, Pereira TJ, Dalvi PS, Zhang H, Mori Y, Ghanim H, Tumiati L, Fantus IG, Bendeck MP, Dandona P, Rao V, Dolinsky VW, Heximer SP, Giacca A.

Atherosclerosis. 2015 Jul;241(1):111-20. doi: 10.1016/j.atherosclerosis.2015.04.799. Epub 2015 Apr 25.

PMID:
25974101
10.

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy.

Shah A, Xia L, Masson EA, Gui C, Momen A, Shikatani EA, Husain M, Quaggin S, John R, Fantus IG.

J Am Soc Nephrol. 2015 Dec;26(12):2963-77. doi: 10.1681/ASN.2014050528. Epub 2015 Apr 8.

11.

Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes.

Chen ZL, Shao WJ, Xu F, Liu L, Lin BS, Wei XH, Song ZL, Lu HG, Fantus IG, Weng JP, Jin TR.

Cell Signal. 2015 Mar;27(3):587-97. doi: 10.1016/j.cellsig.2014.12.012. Epub 2014 Dec 27.

PMID:
25550093
12.

In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity.

Pereira S, Breen DM, Naassan AE, Wang PY, Uchino H, Fantus IG, Carpentier AC, Gutierrez-Juarez R, Brindley DN, Lam TK, Giacca A.

Metabolism. 2015 Feb;64(2):315-22. doi: 10.1016/j.metabol.2014.10.019. Epub 2014 Oct 25.

PMID:
25467844
13.

Is metformin ready for prime time in pregnancy? Probably not yet.

Fantus IG.

Diabetes Metab Res Rev. 2015 Jan;31(1):36-8. doi: 10.1002/dmrr.2587. Epub 2014 Sep 11.

PMID:
25132618
14.

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.

Pereira S, Park E, Mori Y, Haber CA, Han P, Uchida T, Stavar L, Oprescu AI, Koulajian K, Ivovic A, Yu Z, Li D, Bowman TA, Dewald J, El-Benna J, Brindley DN, Gutierrez-Juarez R, Lam TK, Najjar SM, McKay RA, Bhanot S, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E34-46. doi: 10.1152/ajpendo.00436.2013. Epub 2014 May 13.

15.

The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.

Prentice KJ, Luu L, Allister EM, Liu Y, Jun LS, Sloop KW, Hardy AB, Wei L, Jia W, Fantus IG, Sweet DH, Sweeney G, Retnakaran R, Dai FF, Wheeler MB.

Cell Metab. 2014 Apr 1;19(4):653-66. doi: 10.1016/j.cmet.2014.03.008.

16.

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].

17.

Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice.

Taniguchi K, Xia L, Goldberg HJ, Lee KW, Shah A, Stavar L, Masson EA, Momen A, Shikatani EA, John R, Husain M, Fantus IG.

Diabetes. 2013 Nov;62(11):3874-86. doi: 10.2337/db12-1010. Epub 2013 Aug 13.

18.

Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo.

Koulajian K, Ivovic A, Ye K, Desai T, Shah A, Fantus IG, Ran Q, Giacca A.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E254-62. doi: 10.1152/ajpendo.00481.2012. Epub 2013 May 21.

19.

Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells.

Shah A, Xia L, Goldberg H, Lee KW, Quaggin SE, Fantus IG.

J Biol Chem. 2013 Mar 8;288(10):6835-48. doi: 10.1074/jbc.M112.419101. Epub 2013 Jan 17.

20.

Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity.

Pereira S, Yu WQ, Frigolet ME, Beaudry JL, Shpilberg Y, Park E, Dirlea C, Nyomba BL, Riddell MC, Fantus IG, Giacca A.

J Endocrinol. 2013 Mar 15;217(1):31-43. doi: 10.1530/JOE-12-0214. Print 2013 Apr.

21.

A 24-week dietary and physical activity lifestyle intervention reduces hepatic insulin resistance in the obese with chronic hepatitis C.

Pattullo V, Duarte-Rojo A, Soliman W, Vargas-Vorackova F, Sockalingam S, Fantus IG, Allard J, Heathcote J.

Liver Int. 2013 Mar;33(3):410-9. doi: 10.1111/liv.12041. Epub 2012 Dec 26.

PMID:
23278982
22.

Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function.

Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M, Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE.

Cell. 2012 Oct 12;151(2):384-99. doi: 10.1016/j.cell.2012.08.037.

23.

Insulin's discovery: new insights on its ninetieth birthday.

Roth J, Qureshi S, Whitford I, Vranic M, Kahn CR, Fantus IG, Dirks JH.

Diabetes Metab Res Rev. 2012 May;28(4):293-304. doi: 10.1002/dmrr.2300. Review.

PMID:
22576778
24.

Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes.

Shao W, Yu Z, Chiang Y, Yang Y, Chai T, Foltz W, Lu H, Fantus IG, Jin T.

PLoS One. 2012;7(1):e28784. doi: 10.1371/journal.pone.0028784. Epub 2012 Jan 9.

25.

Effect of rosiglitazone on bone quality in a rat model of insulin resistance and osteoporosis.

Sardone LD, Renlund R, Willett TL, Fantus IG, Grynpas MD.

Diabetes. 2011 Dec;60(12):3271-8. doi: 10.2337/db10-1672. Epub 2011 Oct 12.

26.

O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells.

Goldberg H, Whiteside C, Fantus IG.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26. doi: 10.1152/ajpendo.00108.2011. Epub 2011 Jun 28.

27.

Molecular target characterization and antimyeloma activity of the novel, insulin-like growth factor 1 receptor inhibitor, GTx-134.

Liang SB, Yang XZ, Trieu Y, Li Z, Zive J, Leung-Hagesteijn C, Wei E, Zozulya S, Coss CC, Dalton JT, Fantus IG, Trudel S.

Clin Cancer Res. 2011 Jul 15;17(14):4693-704. doi: 10.1158/1078-0432.CCR-10-3097. Epub 2011 Jun 1.

28.

Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways.

Li L, Hossain MA, Sadat S, Hager L, Liu L, Tam L, Schroer S, Huogen L, Fantus IG, Connelly PW, Woo M, Ng DS.

J Biol Chem. 2011 May 20;286(20):17809-20. doi: 10.1074/jbc.M110.180893. Epub 2011 Mar 16.

29.

Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.

Yu Z, Shao W, Chiang Y, Foltz W, Zhang Z, Ling W, Fantus IG, Jin T.

Diabetologia. 2011 Apr;54(4):922-34. doi: 10.1007/s00125-010-2001-8. Epub 2010 Dec 16. Erratum in: Diabetologia. 2011 Apr;54(4):989.

PMID:
21161163
30.

Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling.

Sison K, Eremina V, Baelde H, Min W, Hirashima M, Fantus IG, Quaggin SE.

J Am Soc Nephrol. 2010 Oct;21(10):1691-701. doi: 10.1681/ASN.2010030295. Epub 2010 Aug 5. Erratum in: J Am Soc Nephrol. 2011 Jul;22(7):1390.

31.

Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cells.

Shao W, Yu Z, Fantus IG, Jin T.

Cell Signal. 2010 Aug;22(8):1240-6. doi: 10.1016/j.cellsig.2010.04.001. Epub 2010 Apr 10.

PMID:
20385228
32.

Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis.

Khalid S, Hwang D, Babichev Y, Kolli R, Altamentova S, Koren S, Goodwin PJ, Ennis M, Pollak M, Sonenberg N, Fantus IG.

Breast Cancer Res Treat. 2010 Aug;122(3):647-59. doi: 10.1007/s10549-009-0586-8. Epub 2009 Oct 23.

PMID:
19851863
33.

Triple X syndrome in a patient with partial lipodystrophy discovered using a high-density oligonucleotide microarray: a case report.

Lanktree MB, Fantus IG, Hegele RA.

J Med Case Rep. 2009 Aug 12;3:8867. doi: 10.4076/1752-1947-3-8867.

34.

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways.

Ragheb R, Shanab GM, Medhat AM, Seoudi DM, Adeli K, Fantus IG.

Biochem Biophys Res Commun. 2009 Nov 13;389(2):211-6. doi: 10.1016/j.bbrc.2009.08.106. Epub 2009 Aug 23.

35.

Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.

Whiteside C, Wang H, Xia L, Munk S, Goldberg HJ, Fantus IG.

Exp Diabetes Res. 2009;2009:910783. doi: 10.1155/2009/910783. Epub 2009 Jul 7.

36.

P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.

Sun J, Khalid S, Rozakis-Adcock M, Fantus IG, Jin T.

Oncogene. 2009 Sep 3;28(35):3132-44. doi: 10.1038/onc.2009.167. Epub 2009 Jul 6.

PMID:
19581924
37.

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1251-61. doi: 10.1152/ajpendo.90619.2008. Epub 2009 Feb 17.

38.

Insulin-lowering effects of metformin in women with early breast cancer.

Goodwin PJ, Pritchard KI, Ennis M, Clemons M, Graham M, Fantus IG.

Clin Breast Cancer. 2008 Dec;8(6):501-5. doi: 10.3816/CBC.2008.n.060.

PMID:
19073504
39.

Comparative effects of N-acetyl-L-cysteine and ramipril on arterial hypertension, insulin resistance, and oxidative stress in chronically glucose-fed rats.

El Midaoui A, Ismael MA, Lu H, Fantus IG, de Champlain J, Couture R.

Can J Physiol Pharmacol. 2008 Nov;86(11):752-60. doi: 10.1139/Y08-090.

PMID:
19011670
40.

High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF-beta1 signaling in mesangial cells.

Xia L, Wang H, Munk S, Kwan J, Goldberg HJ, Fantus IG, Whiteside CI.

Am J Physiol Renal Physiol. 2008 Dec;295(6):F1705-14. doi: 10.1152/ajprenal.00043.2008. Epub 2008 Sep 24.

41.

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

Stambolic V, Woodgett JR, Fantus IG, Pritchard KI, Goodwin PJ.

Breast Cancer Res Treat. 2009 Mar;114(2):387-9. doi: 10.1007/s10549-008-0015-4. Epub 2008 Apr 26. Review. No abstract available.

PMID:
18438706
42.

High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome.

Goodwin PJ, Ennis M, Bahl M, Fantus IG, Pritchard KI, Trudeau ME, Koo J, Hood N.

Breast Cancer Res Treat. 2009 Apr;114(3):517-25. doi: 10.1007/s10549-008-0019-0. Epub 2008 Apr 25.

PMID:
18437560
43.

Links between enhanced fatty acid flux, protein kinase C and NFkappaB activation, and apoB-lipoprotein production in the fructose-fed hamster model of insulin resistance.

Ragheb R, Medhat AM, Shanab GM, Seoudi DM, Fantus IG.

Biochem Biophys Res Commun. 2008 May 23;370(1):134-9. doi: 10.1016/j.bbrc.2008.03.044. Epub 2008 Mar 19.

PMID:
18358236
44.

Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells.

Yi F, Sun J, Lim GE, Fantus IG, Brubaker PL, Jin T.

Endocrinology. 2008 May;149(5):2341-51. doi: 10.1210/en.2007-1142. Epub 2008 Feb 7.

PMID:
18258680
45.

Chlamydophila pneumoniae inhibits differentiation of progenitor adipose cells and impairs insulin signaling.

Shi Y, Liu Y, Murdin A, Raudonikiene-Mancevski A, Ayach BB, Yu Z, Fantus IG, Liu PP.

J Infect Dis. 2008 Feb 1;197(3):439-48. doi: 10.1086/525045.

PMID:
18199028
46.

Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus.

Koren S, Fantus IG.

Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):621-40. Review.

PMID:
18054739
47.

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N.

Cancer Res. 2007 Nov 15;67(22):10804-12.

48.

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.

49.

Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells.

Xia L, Wang H, Munk S, Frecker H, Goldberg HJ, Fantus IG, Whiteside CI.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1280-8. Epub 2007 Aug 21.

50.

Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer.

Mulligan AM, O'Malley FP, Ennis M, Fantus IG, Goodwin PJ.

Breast Cancer Res Treat. 2007 Nov;106(1):39-47. Epub 2007 Jan 13.

PMID:
17221153

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