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Comparative Immunogenicity of Several Enhanced Influenza Vaccine Options for Older Adults: A Randomized, Controlled Trial.

Cowling BJ, Perera RAPM, Valkenburg SA, Leung NHL, Iuliano AD, Tam YH, Wong JHF, Fang VJ, Li APY, So HC, Ip DKM, Azziz-Baumgartner E, Fry AM, Levine MZ, Gangappa S, Sambhara S, Barr IG, Skowronski DM, Peiris JSM, Thompson MG.

Clin Infect Dis. 2019 Dec 12. pii: ciz1034. doi: 10.1093/cid/ciz1034. [Epub ahead of print]


Cross-reactive antibody-dependent cellular cytotoxicity antibodies are increased by recent infection in a household study of influenza transmission.

Valkenburg SA, Fang VJ, Leung NH, Chu DK, Ip DK, Perera RA, Wang Y, Li AP, Peiris JM, Cowling BJ, Poon LL.

Clin Transl Immunology. 2019 Nov 20;8(11):e1092. doi: 10.1002/cti2.1092. eCollection 2019.


Maternal antibodies against influenza in cord blood and protection against laboratory-confirmed influenza in infants.

Cowling BJ, Perera RAPM, Fang VJ, Chu DKW, Hui APW, Yeung APC, Peiris JSM, Wong WHS, Chan ELY, Chiu SS.

Clin Infect Dis. 2019 Oct 29. pii: ciz1058. doi: 10.1093/cid/ciz1058. [Epub ahead of print]


Influenza-associated excess respiratory mortality in China, 2010-15: a population-based study.

Li L, Liu Y, Wu P, Peng Z, Wang X, Chen T, Wong JYT, Yang J, Bond HS, Wang L, Lau YC, Zheng J, Feng S, Qin Y, Fang VJ, Jiang H, Lau EHY, Liu S, Qi J, Zhang J, Yang J, He Y, Zhou M, Cowling BJ, Feng L, Yu H.

Lancet Public Health. 2019 Sep;4(9):e473-e481. doi: 10.1016/S2468-2667(19)30163-X.


Real-time estimation of the influenza-associated excess mortality in Hong Kong.

Wong JY, Goldstein E, Fang VJ, Cowling BJ, Wu P.

Epidemiol Infect. 2019 Jan;147:e217. doi: 10.1017/S0950268819001067.


The Effect of Influenza Vaccination History on Changes in Hemagglutination Inhibition Titers After Receipt of the 2015-2016 Influenza Vaccine in Older Adults in Hong Kong.

Ng TWY, Perera RAPM, Fang VJ, Yau EM, Peiris JSM, Tam YH, Cowling BJ.

J Infect Dis. 2020 Jan 1;221(1):33-41. doi: 10.1093/infdis/jiz327.


Age-specific differences in the dynamics of protective immunity to influenza.

Ranjeva S, Subramanian R, Fang VJ, Leung GM, Ip DKM, Perera RAPM, Peiris JSM, Cowling BJ, Cobey S.

Nat Commun. 2019 Apr 10;10(1):1660. doi: 10.1038/s41467-019-09652-6.


Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections.

Karunarathna HMTK, Perera RAPM, Fang VJ, Yen HL, Cowling BJ, Peiris M.

Emerg Microbes Infect. 2019;8(1):404-412. doi: 10.1080/22221751.2019.1572433.


Indirect protection from vaccinating children against influenza in households.

Tsang TK, Fang VJ, Ip DKM, Perera RAPM, So HC, Leung GM, Peiris JSM, Cowling BJ, Cauchemez S.

Nat Commun. 2019 Jan 10;10(1):106. doi: 10.1038/s41467-018-08036-6.


Mitigation of Influenza B Epidemic with School Closures, Hong Kong, 2018.

Ali ST, Cowling BJ, Lau EHY, Fang VJ, Leung GM.

Emerg Infect Dis. 2018 Nov;24(11):2071-2073. doi: 10.3201/eid2411.180612.


Influenza Hemagglutination-inhibition Antibody Titer as a Mediator of Vaccine-induced Protection for Influenza B.

Cowling BJ, Lim WW, Perera RAPM, Fang VJ, Leung GM, Peiris JSM, Tchetgen Tchetgen EJ.

Clin Infect Dis. 2019 May 2;68(10):1713-1717. doi: 10.1093/cid/ciy759.


The effectiveness of influenza vaccination against medically-attended illnesses in Hong Kong across three years with different degrees of vaccine match, 2014-17.

Tam YH, Ng TWY, Chu DKW, Fang VJ, Cowling BJ, Malik Peiris JS, Ip DKM.

Vaccine. 2018 Oct 1;36(41):6117-6123. doi: 10.1016/j.vaccine.2018.08.075. Epub 2018 Sep 3.


Variation in Influenza B Virus Epidemiology by Lineage, China.

Yang J, Lau YC, Wu P, Feng L, Wang X, Chen T, Ali ST, Peng Z, Fang VJ, Zhang J, He Y, Lau EHY, Qin Y, Yang J, Zheng J, Jiang H, Yu H, Cowling BJ.

Emerg Infect Dis. 2018 Aug;24(8):1536-1540. doi: 10.3201/eid2408.180063.


Incidence of influenza A(H3N2) virus infections in Hong Kong in a longitudinal sero-epidemiological study, 2009-2015.

Wei VWI, Wong JYT, Perera RAPM, Kwok KO, Fang VJ, Barr IG, Peiris JSM, Riley S, Cowling BJ.

PLoS One. 2018 May 24;13(5):e0197504. doi: 10.1371/journal.pone.0197504. eCollection 2018.


Ambient ozone and influenza transmissibility in Hong Kong.

Ali ST, Wu P, Cauchemez S, He D, Fang VJ, Cowling BJ, Tian L.

Eur Respir J. 2018 May 10;51(5). pii: 1800369. doi: 10.1183/13993003.00369-2018. Print 2018 May. No abstract available.


Evaluation of animal-to-human and human-to-human transmission of influenza A (H7N9) virus in China, 2013-15.

Virlogeux V, Feng L, Tsang TK, Jiang H, Fang VJ, Qin Y, Wu P, Wang X, Zheng J, Lau EHY, Peng Z, Yang J, Cowling BJ, Yu H.

Sci Rep. 2018 Jan 11;8(1):552. doi: 10.1038/s41598-017-17335-9.


Immune Responses to Twice-Annual Influenza Vaccination in Older Adults in Hong Kong.

Tam YH, Valkenburg SA, Perera RAPM, Wong JHF, Fang VJ, Ng TWY, Kwong ASK, Tsui WWS, Ip DKM, Poon LLM, Chau CKV, Barr IG, Peiris JSM, Cowling BJ.

Clin Infect Dis. 2018 Mar 5;66(6):904-912. doi: 10.1093/cid/cix900.


A Smart Card-Based Electronic School Absenteeism System for Influenza-Like Illness Surveillance in Hong Kong: Design, Implementation, and Feasibility Assessment.

Ip DK, Lau EH, So HC, Xiao J, Lam CK, Fang VJ, Tam YH, Leung GM, Cowling BJ.

JMIR Public Health Surveill. 2017 Oct 6;3(4):e67. doi: 10.2196/publichealth.6810.


Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series.

Wang X, Jiang H, Wu P, Uyeki TM, Feng L, Lai S, Wang L, Huo X, Xu K, Chen E, Wang X, He J, Kang M, Zhang R, Zhang J, Wu J, Hu S, Zhang H, Liu X, Fu W, Ou J, Wu S, Qin Y, Zhang Z, Shi Y, Zhang J, Artois J, Fang VJ, Zhu H, Guan Y, Gilbert M, Horby PW, Leung GM, Gao GF, Cowling BJ, Yu H.

Lancet Infect Dis. 2017 Aug;17(8):822-832. doi: 10.1016/S1473-3099(17)30323-7. Epub 2017 Jun 2.


A joint analysis of influenza-associated hospitalizations and mortality in Hong Kong, 1998-2013.

Wu P, Presanis AM, Bond HS, Lau EHY, Fang VJ, Cowling BJ.

Sci Rep. 2017 Apr 20;7(1):929. doi: 10.1038/s41598-017-01021-x.


Preliminary Epidemiologic Assessment of Human Infections With Highly Pathogenic Avian Influenza A(H5N6) Virus, China.

Jiang H, Wu P, Uyeki TM, He J, Deng Z, Xu W, Lv Q, Zhang J, Wu Y, Tsang TK, Kang M, Zheng J, Wang L, Yang B, Qin Y, Feng L, Fang VJ, Gao GF, Leung GM, Yu H, Cowling BJ.

Clin Infect Dis. 2017 Aug 1;65(3):383-388. doi: 10.1093/cid/cix334.


Population-Based Pediatric Hospitalization Burden of Lineage-Specific Influenza B in Hong Kong, 2004-2014.

Cowling BJ, Wu P, Lo JYC, Chan KH, Chan ELY, Fang VJ, So LY, Peiris JSM, Chiu SS.

Clin Infect Dis. 2017 Jul 15;65(2):300-307. doi: 10.1093/cid/cix312.


Viral Shedding and Transmission Potential of Asymptomatic and Paucisymptomatic Influenza Virus Infections in the Community.

Ip DK, Lau LL, Leung NH, Fang VJ, Chan KH, Chu DK, Leung GM, Peiris JS, Uyeki TM, Cowling BJ.

Clin Infect Dis. 2017 Mar 15;64(6):736-742. doi: 10.1093/cid/ciw841.


A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes.

Garbati MA, Fagbo SF, Fang VJ, Skakni L, Joseph M, Wani TA, Cowling BJ, Peiris M, Hakawi A.

PLoS One. 2016 Nov 3;11(11):e0165978. doi: 10.1371/journal.pone.0165978. eCollection 2016.


Serum 25-Hydroxyvitamin D Was Not Associated with Influenza Virus Infection in Children and Adults in Hong Kong, 2009-2010.

Xu C, Fang VJ, Perera RA, Kam AM, Ng S, Chan YH, Chan KH, Ip DK, Peiris JM, Cowling BJ.

J Nutr. 2016 Dec;146(12):2506-2512. Epub 2016 Oct 26.


Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia.

Virlogeux V, Fang VJ, Park M, Wu JT, Cowling BJ.

Sci Rep. 2016 Oct 24;6:35839. doi: 10.1038/srep35839.


Human Infection with Influenza A(H7N9) Virus during 3 Major Epidemic Waves, China, 2013-2015.

Wu P, Peng Z, Fang VJ, Feng L, Tsang TK, Jiang H, Lau EH, Yang J, Zheng J, Qin Y, Li Z, Leung GM, Yu H, Cowling BJ.

Emerg Infect Dis. 2016 Jun;22(6):964-72. doi: 10.3201/eid2206.151752.


Individual Correlates of Infectivity of Influenza A Virus Infections in Households.

Tsang TK, Fang VJ, Chan KH, Ip DK, Leung GM, Peiris JS, Cowling BJ, Cauchemez S.

PLoS One. 2016 May 6;11(5):e0154418. doi: 10.1371/journal.pone.0154418. eCollection 2016.


Real-time estimation of the hospitalization fatality risk of influenza A(H1N1)pdm09 in Hong Kong.

Wong JY, Wu P, Lau EH, Tsang TK, Fang VJ, Ho LM, Cowling BJ.

Epidemiol Infect. 2016 Jun;144(8):1579-83. doi: 10.1017/S0950268815003179.


Quantifying homologous and heterologous antibody titre rises after influenza virus infection.

Freeman G, Perera RA, Ngan E, Fang VJ, Cauchemez S, Ip DK, Peiris JS, Cowling BJ.

Epidemiol Infect. 2016 Aug;144(11):2306-16. doi: 10.1017/S0950268816000583. Epub 2016 Mar 28.


Association between the Severity of Influenza A(H7N9) Virus Infections and Length of the Incubation Period.

Virlogeux V, Yang J, Fang VJ, Feng L, Tsang TK, Jiang H, Wu P, Zheng J, Lau EH, Qin Y, Peng Z, Peiris JS, Yu H, Cowling BJ.

PLoS One. 2016 Feb 17;11(2):e0148506. doi: 10.1371/journal.pone.0148506. eCollection 2016.


The Dynamic Relationship Between Clinical Symptomatology and Viral Shedding in Naturally Acquired Seasonal and Pandemic Influenza Virus Infections.

Ip DKM, Lau LLH, Chan KH, Fang VJ, Leung GM, Peiris MJS, Cowling BJ.

Clin Infect Dis. 2016 Feb 15;62(4):431-437. doi: 10.1093/cid/civ909. Epub 2015 Oct 30.


Interpreting Seroepidemiologic Studies of Influenza in a Context of Nonbracketing Sera.

Tsang TK, Fang VJ, Perera RA, Ip DK, Leung GM, Peiris JS, Cauchemez S, Cowling BJ.

Epidemiology. 2016 Jan;27(1):152-8. doi: 10.1097/EDE.0000000000000408.


Quantifying Protection Against Influenza Virus Infection Measured by Hemagglutination-inhibition Assays in Vaccine Trials.

Zhao X, Fang VJ, Ohmit SE, Monto AS, Cook AR, Cowling BJ.

Epidemiology. 2016 Jan;27(1):143-51. doi: 10.1097/EDE.0000000000000402.


Estimating the Distribution of the Incubation Periods of Human Avian Influenza A(H7N9) Virus Infections.

Virlogeux V, Li M, Tsang TK, Feng L, Fang VJ, Jiang H, Wu P, Zheng J, Lau EH, Cao Y, Qin Y, Liao Q, Yu H, Cowling BJ.

Am J Epidemiol. 2015 Oct 15;182(8):723-9. doi: 10.1093/aje/kwv115. Epub 2015 Sep 26.


Comparative Epidemiology of Influenza B Yamagata- and Victoria-Lineage Viruses in Households.

Xu C, Chan KH, Tsang TK, Fang VJ, Fung RO, Ip DK, Cauchemez S, Leung GM, Peiris JS, Cowling BJ.

Am J Epidemiol. 2015 Oct 15;182(8):705-13. doi: 10.1093/aje/kwv110. Epub 2015 Sep 22.


Live Poultry Exposure and Public Response to Influenza A(H7N9) in Urban and Rural China during Two Epidemic Waves in 2013-2014.

Wu P, Wang L, Cowling BJ, Yu J, Fang VJ, Li F, Zeng L, Wu JT, Li Z, Leung GM, Yu H.

PLoS One. 2015 Sep 14;10(9):e0137831. doi: 10.1371/journal.pone.0137831. eCollection 2015.


Brief Report: Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection.

Virlogeux V, Fang VJ, Wu JT, Ho LM, Peiris JS, Leung GM, Cowling BJ.

Epidemiology. 2015 Sep;26(5):666-9. doi: 10.1097/EDE.0000000000000339.


Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015.

Cowling BJ, Park M, Fang VJ, Wu P, Leung GM, Wu JT.

Euro Surveill. 2015 Jun 25;20(25):7-13. Erratum in: Euro Surveill. 2015;20(26). pii: 21175.


Determinants of serum 25-hydroxyvitamin D in Hong Kong.

Xu C, Perera RA, Chan YH, Fang VJ, Ng S, Ip DK, Kam AM, Leung GM, Peiris JS, Cowling BJ.

Br J Nutr. 2015 Jul 14;114(1):144-51. doi: 10.1017/S0007114515001683. Epub 2015 Jun 8.


Burden, seasonal pattern and symptomatology of acute respiratory illnesses with different viral aetiologies in children presenting at outpatient clinics in Hong Kong.

Wei L, Chan KH, Ip DK, Fang VJ, Fung RO, Leung GM, Peiris MJ, Cowling BJ.

Clin Microbiol Infect. 2015 Sep;21(9):861-6. doi: 10.1016/j.cmi.2015.05.027. Epub 2015 May 30.


Influenza A Virus Shedding and Infectivity in Households.

Tsang TK, Cowling BJ, Fang VJ, Chan KH, Ip DK, Leung GM, Peiris JS, Cauchemez S.

J Infect Dis. 2015 Nov 1;212(9):1420-8. doi: 10.1093/infdis/jiv225. Epub 2015 Apr 15.


Public risk perception and attitudes towards live poultry markets before and after their closure due to influenza A(H7N9), Hong Kong, January-February 2014.

Liao Q, Wu P, Lam WW, Fang VJ, Wu JT, Leung GM, Fielding R, Cowling BJ.

J Public Health (Oxf). 2016 Mar;38(1):34-43. doi: 10.1093/pubmed/fdv020. Epub 2015 Feb 25.


Association of Oseltamivir Treatment With Virus Shedding, Illness, and Household Transmission of Influenza Viruses.

Cheung DH, Tsang TK, Fang VJ, Xu J, Chan KH, Ip DK, Peiris JS, Leung GM, Cowling BJ.

J Infect Dis. 2015 Aug 1;212(3):391-6. doi: 10.1093/infdis/jiv058. Epub 2015 Feb 2.


Clinical severity of human infections with avian influenza A(H7N9) virus, China, 2013/14.

Feng L, Wu JT, Liu X, Yang P, Tsang TK, Jiang H, Wu P, Yang J, Fang VJ, Qin Y, Lau EH, Li M, Zheng J, Peng Z, Xie Y, Wang Q, Li Z, Leung GM, Gao GF, Yu H, Cowling BJ.

Euro Surveill. 2014 Dec 11;19(49). pii: 20984.


Poultry market closures and human infection with influenza A(H7N9) virus, China, 2013-14.

Wu P, Jiang H, Wu JT, Chen E, He J, Zhou H, Wei L, Yang J, Yang B, Qin Y, Fang VJ, Li M, Tsang TK, Zheng J, Lau EH, Cao Y, Chai C, Zhong H, Li Z, Leung GM, Feng L, Gao GF, Cowling BJ, Yu H.

Emerg Infect Dis. 2014 Nov;20(11):1891-4. doi: 10.3201/eid2011.140556.


Modes of transmission of influenza B virus in households.

Cowling BJ, Ip DK, Fang VJ, Suntarattiwong P, Olsen SJ, Levy J, Uyeki TM, Leung GM, Peiris JS, Chotpitayasunondh T, Nishiura H, Simmerman JM.

PLoS One. 2014 Sep 30;9(9):e108850. doi: 10.1371/journal.pone.0108850. eCollection 2014.


The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets.

Yen HL, Zhou J, Choy KT, Sia SF, Teng O, Ng IH, Fang VJ, Hu Y, Wang W, Cowling BJ, Nicholls JM, Guan Y, Peiris JS.

J Infect Dis. 2014 Dec 15;210(12):1900-8. doi: 10.1093/infdis/jiu353. Epub 2014 Jun 20.


Incidence of influenza virus infections in children in Hong Kong in a 3-year randomized placebo-controlled vaccine study, 2009-2012.

Cowling BJ, Perera RA, Fang VJ, Chan KH, Wai W, So HC, Chu DK, Wong JY, Shiu EY, Ng S, Ip DK, Peiris JS, Leung GM.

Clin Infect Dis. 2014 Aug 15;59(4):517-24. doi: 10.1093/cid/ciu356. Epub 2014 May 13.


Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children.

Freeman G, Ng S, Perera RA, Fang VJ, Ip DK, Leung GM, Peiris JS, Cowling BJ.

Epidemiol Infect. 2015 Feb;143(3):540-9. doi: 10.1017/S0950268814000855. Epub 2014 May 1.

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