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Items: 1 to 50 of 62

1.

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease.

Lautrup S, Lou G, Aman Y, Nilsen H, Tao J, Fang EF.

Neurochem Int. 2019 May 15;129:104469. doi: 10.1016/j.neuint.2019.104469. [Epub ahead of print]

2.

Mitophagy and NAD+ inhibit Alzheimer disease.

Fang EF.

Autophagy. 2019 Jun;15(6):1112-1114. doi: 10.1080/15548627.2019.1596497. Epub 2019 Mar 28.

3.

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA.

Nat Neurosci. 2019 Mar;22(3):401-412. doi: 10.1038/s41593-018-0332-9. Epub 2019 Feb 11.

PMID:
30742114
4.

Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases.

Lautrup S, Caponio D, Cheung HH, Piccoli C, Stevnsner T, Chan WY, Fang EF.

Biogerontology. 2019 Jun;20(3):255-269. doi: 10.1007/s10522-019-09798-2. Epub 2019 Jan 21. Review.

PMID:
30666569
5.

Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.

Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T, Gong W, Wu WKK, Cho CH.

Autophagy. 2019 Apr;15(4):707-725. doi: 10.1080/15548627.2018.1557835. Epub 2019 Jan 6.

6.

Emerging Antitumor Activities of the Bitter Melon (Momordica charantia).

Fang EF, Froetscher L, Scheibye-Knudsen M, Bohr VA, Wong JH, Ng TB.

Curr Protein Pept Sci. 2019;20(3):296-301. doi: 10.2174/1389203719666180622095800.

7.

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R.

Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001.

8.

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice.

Fang EF, Palikaras K, Sun N, Fivenson EM, Spangler RD, Kerr JS, Cordonnier SA, Hou Y, Dombi E, Kassahun H, Tavernarakis N, Poulton J, Nilsen H, Bohr VA.

J Vis Exp. 2017 Nov 22;(129). doi: 10.3791/56301.

9.

NAD+ in Aging: Molecular Mechanisms and Translational Implications.

Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, Bohr VA.

Trends Mol Med. 2017 Oct;23(10):899-916. doi: 10.1016/j.molmed.2017.08.001. Epub 2017 Sep 9. Review.

PMID:
28899755
10.

Sarcopenia, Aging and Prospective Interventional Strategies.

Waltz TB, Fivenson EM, Morevati M, Li C, Becker KG, Bohr VA, Fang EF.

Curr Med Chem. 2018;25(40):5588-5596. doi: 10.2174/0929867324666170801095850. Review.

11.

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG.

Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208.

12.

Mitophagy in neurodegeneration and aging.

Fivenson EM, Lautrup S, Sun N, Scheibye-Knudsen M, Stevnsner T, Nilsen H, Bohr VA, Fang EF.

Neurochem Int. 2017 Oct;109:202-209. doi: 10.1016/j.neuint.2017.02.007. Epub 2017 Feb 21. Review.

13.

Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, Fang EF.

Trends Neurosci. 2017 Mar;40(3):151-166. doi: 10.1016/j.tins.2017.01.002. Epub 2017 Feb 9. Review.

14.

NAD+ in DNA repair and mitochondrial maintenance.

Croteau DL, Fang EF, Nilsen H, Bohr VA.

Cell Cycle. 2017 Mar 19;16(6):491-492. doi: 10.1080/15384101.2017.1285631. Epub 2017 Feb 1. No abstract available.

15.

NAD+: The convergence of DNA repair and mitophagy.

Fang EF, Bohr VA.

Autophagy. 2017 Feb;13(2):442-443. doi: 10.1080/15548627.2016.1257467. Epub 2016 Dec 8.

16.

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

Scheibye-Knudsen M, Tseng A, Borch Jensen M, Scheibye-Alsing K, Fang EF, Iyama T, Bharti SK, Marosi K, Froetscher L, Kassahun H, Eckley DM, Maul RW, Bastian P, De S, Ghosh S, Nilsen H, Goldberg IG, Mattson MP, Wilson DM 3rd, Brosh RM Jr, Gorospe M, Bohr VA.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. Epub 2016 Oct 18.

17.

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA.

Cell Metab. 2016 Oct 11;24(4):566-581. doi: 10.1016/j.cmet.2016.09.004.

18.

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.

Misiak M, Vergara Greeno R, Baptiste BA, Sykora P, Liu D, Cordonnier S, Fang EF, Croteau DL, Mattson MP, Bohr VA.

Aging Cell. 2017 Feb;16(1):162-172. doi: 10.1111/acel.12541. Epub 2016 Sep 30.

19.

Nuclear DNA damage signalling to mitochondria in ageing.

Fang EF, Scheibye-Knudsen M, Chua KF, Mattson MP, Croteau DL, Bohr VA.

Nat Rev Mol Cell Biol. 2016 May;17(5):308-21. doi: 10.1038/nrm.2016.14. Epub 2016 Mar 9. Review.

20.

Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection.

Zhang L, Wu WK, Gallo RL, Fang EF, Hu W, Ling TK, Shen J, Chan RL, Lu L, Luo XM, Li MX, Chan KM, Yu J, Wong VW, Ng SC, Wong SH, Chan FK, Sung JJ, Chan MT, Cho CH.

J Immunol. 2016 Feb 15;196(4):1799-809. doi: 10.4049/jimmunol.1500021. Epub 2016 Jan 22.

21.

DNA Damage, DNA Repair, Aging, and Neurodegeneration.

Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA.

Cold Spring Harb Perspect Med. 2015 Sep 18;5(10). pii: a025130. doi: 10.1101/cshperspect.a025130. Review.

22.

A research agenda for aging in China in the 21st century.

Fang EF, Scheibye-Knudsen M, Jahn HJ, Li J, Ling L, Guo H, Zhu X, Preedy V, Lu H, Bohr VA, Chan WY, Liu Y, Ng TB.

Ageing Res Rev. 2015 Nov;24(Pt B):197-205. doi: 10.1016/j.arr.2015.08.003. Epub 2015 Aug 22. Review.

23.

A review of fish lectins.

Ng TB, Fai Cheung RC, Wing Ng CC, Fang EF, Wong JH.

Curr Protein Pept Sci. 2015;16(4):337-51. Review.

PMID:
25929869
24.

A trypsin inhibitor from rambutan seeds with antitumor, anti-HIV-1 reverse transcriptase, and nitric oxide-inducing properties.

Fang EF, Ng TB.

Appl Biochem Biotechnol. 2015 Apr;175(8):3828-39. doi: 10.1007/s12010-015-1550-1. Epub 2015 Feb 18.

PMID:
25820360
25.

Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans.

Dan X, Wong JH, Fang EF, Chan FC, Ng TB.

J Agric Food Chem. 2015 Apr 22;63(15):3903-14. doi: 10.1021/acs.jafc.5b00106. Epub 2015 Apr 9.

PMID:
25816710
26.

Protecting the mitochondrial powerhouse.

Scheibye-Knudsen M, Fang EF, Croteau DL, Wilson DM 3rd, Bohr VA.

Trends Cell Biol. 2015 Mar;25(3):158-70. doi: 10.1016/j.tcb.2014.11.002. Epub 2014 Dec 11. Review.

27.

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.

Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM 3rd, Croteau DL, de Cabo R, Bohr VA.

Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005. Epub 2014 Nov 4.

28.

Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis.

Li X, Fang EF, Scheibye-Knudsen M, Cui H, Qiu L, Li J, He Y, Huang J, Bohr VA, Ng TB, Guo H.

Sci Rep. 2014 Sep 22;4:6434. doi: 10.1038/srep06434.

29.

Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma.

Zhang CZ, Fang EF, Zhang HT, Liu LL, Yun JP.

Invest New Drugs. 2015 Feb;33(1):1-11. doi: 10.1007/s10637-014-0156-8. Epub 2014 Sep 9.

PMID:
25200916
30.

Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders.

Scheibye-Knudsen M, Fang EF, Croteau DL, Bohr VA.

Autophagy. 2014 Aug;10(8):1468-9. doi: 10.4161/auto.29321. Epub 2014 Jun 12.

31.

Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.

Lu H, Fang EF, Sykora P, Kulikowicz T, Zhang Y, Becker KG, Croteau DL, Bohr VA.

Cell Death Dis. 2014 May 15;5:e1226. doi: 10.1038/cddis.2014.168.

32.

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA.

Cell. 2014 May 8;157(4):882-896. doi: 10.1016/j.cell.2014.03.026.

33.

Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.

Pan WL, Wong JH, Fang EF, Chan YS, Ng TB, Cheung RC.

Biochem Pharmacol. 2014 Jun 1;89(3):329-39. doi: 10.1016/j.bcp.2014.03.004. Epub 2014 Mar 14.

34.

Antifungal and antiviral products of marine organisms.

Cheung RC, Wong JH, Pan WL, Chan YS, Yin CM, Dan XL, Wang HX, Fang EF, Lam SK, Ngai PH, Xia LX, Liu F, Ye XY, Zhang GQ, Liu QH, Sha O, Lin P, Ki C, Bekhit AA, Bekhit Ael-D, Wan DC, Ye XJ, Xia J, Ng TB.

Appl Microbiol Biotechnol. 2014 Apr;98(8):3475-94. doi: 10.1007/s00253-014-5575-0. Epub 2014 Feb 23. Review.

35.

Chronic unpredictable mild stress impairs erythrocyte immune function and changes T-lymphocyte subsets in a rat model of stress-induced depression.

Guan SZ, Liu JW, Fang EF, Ng TB, Lian YL, Ge H.

Environ Toxicol Pharmacol. 2014 Jan;37(1):414-22. doi: 10.1016/j.etap.2013.12.013. Epub 2014 Jan 1.

PMID:
24448466
36.
37.

Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on estrogen receptor (ER)-positive and ER-negative breast cancer cells.

Pan WL, Wong JH, Fang EF, Chan YS, Ye XJ, Ng TB.

Biochim Biophys Acta. 2013 May;1833(5):987-96. doi: 10.1016/j.bbamcr.2012.12.013. Epub 2012 Dec 26.

38.

Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis.

Fang EF, Zhang CZ, Zhang L, Wong JH, Chan YS, Pan WL, Dan XL, Yin CM, Cho CH, Ng TB.

PLoS One. 2012;7(9):e41592. doi: 10.1371/journal.pone.0041592. Epub 2012 Sep 5.

39.

Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells.

Chan YS, Wong JH, Fang EF, Pan W, Ng TB.

PLoS One. 2012;7(6):e38961. doi: 10.1371/journal.pone.0038961. Epub 2012 Jun 14.

40.

Pharmacotherapy approaches to antifungal prophylaxis.

Ng TB, Cheung RC, Ye Xj, Fang EF, Chan YS, Pan WL, Dan XL, Yin CM, Lam SK, Lin P, Ngai PH, Xia LX, Liu F, Ye XY, Wang HX, Wong JH.

Expert Opin Pharmacother. 2012 Aug;13(12):1695-705. doi: 10.1517/14656566.2012.698263. Epub 2012 Jun 20. Review.

PMID:
22716311
41.

The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo.

Fang EF, Zhang CZ, Wong JH, Shen JY, Li CH, Ng TB.

Cancer Lett. 2012 Nov 1;324(1):66-74. doi: 10.1016/j.canlet.2012.05.005. Epub 2012 May 9.

PMID:
22579806
42.

In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells.

Fang EF, Zhang CZ, Zhang L, Fong WP, Ng TB.

Int J Biochem Cell Biol. 2012 Aug;44(8):1351-60. doi: 10.1016/j.biocel.2012.04.013. Epub 2012 Apr 24.

PMID:
22554586
43.

An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean.

Chan YS, Wong JH, Fang EF, Pan WL, Ng TB.

Acta Biochim Biophys Sin (Shanghai). 2012 Apr;44(4):307-15. doi: 10.1093/abbs/gms003. Epub 2012 Feb 9.

PMID:
22321825
44.

Defensins and other biocidal proteins from bean seeds with medicinal activities.

Ng TB, Wong JH, Fang EF.

Curr Med Chem. 2011;18(36):5644-54. Review.

PMID:
22172069
45.
46.

A potential human hepatocellular carcinoma inhibitor from Bauhinia purpurea L. seeds: from purification to mechanism exploration.

Fang EF, Bah CS, Wong JH, Pan WL, Chan YS, Ye XJ, Ng TB.

Arch Toxicol. 2012 Feb;86(2):293-304. doi: 10.1007/s00204-011-0751-9. Epub 2011 Oct 4.

PMID:
21969071
47.

Momordica Charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo.

Fang EF, Zhang CZ, Ng TB, Wong JH, Pan WL, Ye XJ, Chan YS, Fong WP.

Cancer Prev Res (Phila). 2012 Jan;5(1):109-21. doi: 10.1158/1940-6207.CAPR-11-0203. Epub 2011 Sep 20.

48.
49.

Protein from red cabbage (Brassica oleracea) seeds with antifungal, antibacterial, and anticancer activities.

Ye XJ, Ng TB, Wu ZJ, Xie LH, Fang EF, Wong JH, Pan WL, Wing SS, Zhang YB.

J Agric Food Chem. 2011 Sep 28;59(18):10232-8. doi: 10.1021/jf201874j. Epub 2011 Aug 24.

PMID:
21830763

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