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Items: 34


Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.

Niu J, Tsai HH, Hoi KK, Huang N, Yu G, Kim K, Baranzini SE, Xiao L, Chan JR, Fancy SPJ.

Nat Neurosci. 2019 May;22(5):709-718. doi: 10.1038/s41593-019-0369-4. Epub 2019 Apr 15.


Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors.

Baror R, Neumann B, Segel M, Chalut KJ, Fancy SPJ, Schafer DP, Franklin RJM.

Glia. 2019 Jul;67(7):1374-1384. doi: 10.1002/glia.23612. Epub 2019 Mar 12.


Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis.

Daynac M, Chouchane M, Collins HY, Murphy NE, Andor N, Niu J, Fancy SPJ, Stallcup WB, Petritsch CK.

Nat Commun. 2018 Aug 21;9(1):2862. doi: 10.1038/s41467-018-05099-3.


Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia.

Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F.

Neuron. 2018 Aug 22;99(4):689-701.e5. doi: 10.1016/j.neuron.2018.07.017. Epub 2018 Aug 2.


Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury.

Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ.

Brain. 2018 Jan 1;141(1):85-98. doi: 10.1093/brain/awx312.


Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K.

Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2.


Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone.

Dawes WJ, Zhang X, Fancy SPJ, Rowitch D, Marino S.

Dev Neurosci. 2016;38(6):430-444. doi: 10.1159/000455839. Epub 2017 Mar 25.


Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von B├╝dingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR.

Elife. 2016 Sep 27;5. pii: e18246. doi: 10.7554/eLife.18246.


Oligodendrocyte precursors migrate along vasculature in the developing nervous system.

Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP.

Science. 2016 Jan 22;351(6271):379-84. doi: 10.1126/science.aad3839.


Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination.

Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ.

J Neurosci. 2015 Aug 19;35(33):11482-99. doi: 10.1523/JNEUROSCI.3655-14.2015.


Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.

Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B.

Glia. 2015 Oct;63(10):1840-9. doi: 10.1002/glia.22848. Epub 2015 May 6.


Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.

Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B.

Neuron. 2015 Mar 18;85(6):1227-43. doi: 10.1016/j.neuron.2015.02.024. Epub 2015 Mar 5.


Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.

Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH.

Cell. 2014 Jul 17;158(2):383-396. doi: 10.1016/j.cell.2014.04.052. Epub 2014 Jul 10.


Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR.

Nat Med. 2014 Aug;20(8):954-960. doi: 10.1038/nm.3618. Epub 2014 Jul 6.


Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.

Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH.

Nat Neurosci. 2014 Apr;17(4):506-12. doi: 10.1038/nn.3676. Epub 2014 Mar 9. Erratum in: Nat Neurosci. 2014 Dec;17(12):1841.


Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.

Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC.

Glia. 2013 Sep;61(9):1518-32. doi: 10.1002/glia.22538. Epub 2013 Jul 10.


Evidence that nuclear factor IA inhibits repair after white matter injury.

Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B.

Ann Neurol. 2012 Aug;72(2):224-33. doi: 10.1002/ana.23590. Epub 2012 Jul 17.


Regional astrocyte allocation regulates CNS synaptogenesis and repair.

Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH.

Science. 2012 Jul 20;337(6092):358-62. doi: 10.1126/science.1222381. Epub 2012 Jun 28.


Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.

Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1299-304. doi: 10.1073/pnas.1113540109. Epub 2011 Dec 12.


Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.

Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ.

Neurotherapeutics. 2011 Oct;8(4):650-8. doi: 10.1007/s13311-011-0065-x. Review.


Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.

Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH.

Nat Neurosci. 2011 Jun 26;14(8):1009-16. doi: 10.1038/nn.2855.


Myelin regeneration: a recapitulation of development?

Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH.

Annu Rev Neurosci. 2011;34:21-43. doi: 10.1146/annurev-neuro-061010-113629. Review.


Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.

Harrington EP, Zhao C, Fancy SP, Kaing S, Franklin RJ, Rowitch DH.

Ann Neurol. 2010 Nov;68(5):703-16. doi: 10.1002/ana.22090.


CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.

Zawadzka M, Rivers LE, Fancy SP, Zhao C, Tripathi R, Jamen F, Young K, Goncharevich A, Pohl H, Rizzi M, Rowitch DH, Kessaris N, Suter U, Richardson WD, Franklin RJ.

Cell Stem Cell. 2010 Jun 4;6(6):578-90. doi: 10.1016/j.stem.2010.04.002.


Overcoming remyelination failure in multiple sclerosis and other myelin disorders.

Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ.

Exp Neurol. 2010 Sep;225(1):18-23. doi: 10.1016/j.expneurol.2009.12.020. Epub 2010 Jan 4. Review.


Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.

Zhao C, Fancy SP, Franklin RJ, ffrench-Constant C.

J Neurosci Res. 2009 Nov 15;87(15):3447-55. doi: 10.1002/jnr.22231.


Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.

Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH.

Genes Dev. 2009 Jul 1;23(13):1571-85. doi: 10.1101/gad.1806309. Epub 2009 Jun 10.


Comparison of sevoflurane and isoflurane in dogs anaesthetised for clinical surgical or diagnostic procedures.

Bennett RC, Fancy SP, Walsh CM, Brown AJ, Taylor PM.

J Small Anim Pract. 2008 Aug;49(8):392-7. doi: 10.1111/j.1748-5827.2008.00586.x. Epub 2008 Jul 9.


Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.

Zhao C, Fancy SP, ffrench-Constant C, Franklin RJ.

Neurobiol Dis. 2008 Aug;31(2):209-17. doi: 10.1016/j.nbd.2008.04.007. Epub 2008 May 4.


Olig gene function in CNS development and disease.

Ligon KL, Fancy SP, Franklin RJ, Rowitch DH.

Glia. 2006 Jul;54(1):1-10. Review.


Stem cells, progenitors and myelin repair.

Zhao C, Fancy SP, Magy L, Urwin JE, Franklin RJ.

J Anat. 2005 Sep;207(3):251-8. Review.


Mechanisms of CNS remyelination--the key to therapeutic advances.

Zhao C, Fancy SP, Kotter MR, Li WW, Franklin RJ.

J Neurol Sci. 2005 Jun 15;233(1-2):87-91. Review.


bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.

Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD.

Science. 2004 Dec 17;306(5704):2111-5.


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