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Global Analysis of Osteosarcoma Lipidomes Reveal Altered Lipid Profiles in Metastatic vs. Non-Metastatic Cells.

Roy J, Dibaeinia P, Fan TM, Sinha S, Das A.

J Lipid Res. 2018 Nov 30. pii: jlr.M088559. doi: 10.1194/jlr.M088559. [Epub ahead of print]


Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research.

Overgaard NH, Fan TM, Schachtschneider KM, Principe DR, Schook LB, Jungersen G.

ILAR J. 2018 Nov 22. doi: 10.1093/ilar/ily014. [Epub ahead of print]


Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma.

Svec RL, Furiassi L, Skibinski CG, Fan TM, Riggins GJ, Hergenrother PJ.

ACS Chem Biol. 2018 Nov 16;13(11):3206-3216. doi: 10.1021/acschembio.8b00864. Epub 2018 Nov 8.


Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury.

Wang D, Gladysheva IP, Sullivan RD, Fan TM, Mehta RM, Tripathi R, Sun Y, Reed GL.

PLoS One. 2018 Sep 7;13(9):e0202571. doi: 10.1371/journal.pone.0202571. eCollection 2018.


Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1.

Anorma C, Hedhli J, Bearrood TE, Pino NW, Gardner SH, Inaba H, Zhang P, Li Y, Feng D, Dibrell SE, Kilian KA, Dobrucki LW, Fan TM, Chan J.

ACS Cent Sci. 2018 Aug 22;4(8):1045-1055. doi: 10.1021/acscentsci.8b00313. Epub 2018 Jul 25.


Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom.

Phillips H, Maxwell EA, Schaeffer DJ, Fan TM.

Am J Vet Res. 2018 Jun;79(6):592-599. doi: 10.2460/ajvr.79.6.592.


Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides.

Roy J, Watson JE, Hong IS, Fan TM, Das A.

J Med Chem. 2018 Jul 12;61(13):5569-5579. doi: 10.1021/acs.jmedchem.8b00243. Epub 2018 Jun 26.


Albumin as a "Trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting.

Yin Q, Tang L, Cai K, Yang X, Yin L, Zhang Y, Dobrucki LW, Helferich WG, Fan TM, Cheng J.

Biomater Sci. 2018 May 1;6(5):1189-1200. doi: 10.1039/c8bm00149a.


Device Closure Versus Medical Therapy Alone for Patent Foramen Ovale in Patients With Cryptogenic Stroke: A Systematic Review and Meta-analysis.

Shah R, Nayyar M, Jovin IS, Rashid A, Bondy BR, Fan TM, Flaherty MP, Rao SV.

Ann Intern Med. 2018 Mar 6;168(5):335-342. doi: 10.7326/M17-2679. Epub 2018 Jan 9.


Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy.

Tripathi R, Sullivan R, Fan TM, Wang D, Sun Y, Reed GL, Gladysheva IP.

PLoS One. 2017 Dec 14;12(12):e0189315. doi: 10.1371/journal.pone.0189315. eCollection 2017.


In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin.

Maxwell EA, Phillips H, Schaeffer DJ, Fan TM.

Vet Surg. 2018 Feb;47(2):219-226. doi: 10.1111/vsu.12709. Epub 2017 Nov 9.


Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients.

Joshi AD, Botham RC, Schlein LJ, Roth HS, Mangraviti A, Borodovsky A, Tyler B, Joslyn S, Looper JS, Podell M, Fan TM, Hergenrother PJ, Riggins GJ.

Oncotarget. 2017 Jul 7;8(46):80124-80138. doi: 10.18632/oncotarget.19085. eCollection 2017 Oct 6.


Melanoma topology reveals a stem-like phenotype that promotes angiogenesis.

Lee J, Abdeen AA, Hedhli J, Wycislo KL, Dobrucka IT, Fan TM, Dobrucki LW, Kilian KA.

Sci Adv. 2017 Oct 25;3(10):e1701350. doi: 10.1126/sciadv.1701350. eCollection 2017 Oct.


Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin.

Roy J, Wycislo KL, Pondenis H, Fan TM, Das A.

PLoS One. 2017 Sep 14;12(9):e0183930. doi: 10.1371/journal.pone.0183930. eCollection 2017.


Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses.

Saba CF, Vickery KR, Clifford CA, Burgess KE, Phillips B, Vail DM, Wright ZM, Morges MA, Fan TM, Thamm DH.

Vet Comp Oncol. 2018 Mar;16(1):E76-E82. doi: 10.1111/vco.12337. Epub 2017 Sep 11.


Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation.

Glover J, Man TK, Barkauskas DA, Hall D, Tello T, Sullivan MB, Gorlick R, Janeway K, Grier H, Lau C, Toretsky JA, Borinstein SC, Khanna C, Fan TM; COG Osteosarcoma Biology Group.

PLoS One. 2017 Jul 21;12(7):e0181204. doi: 10.1371/journal.pone.0181204. eCollection 2017.


Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma.

Zhang D, Lee J, Sun MB, Pei Y, Chu J, Gillette MU, Fan TM, Kilian KA.

ACS Cent Sci. 2017 May 24;3(5):381-393. doi: 10.1021/acscentsci.6b00329. Epub 2017 Apr 26.


Meta-Analysis of the Relative Efficacy and Safety of Oral P2Y12 Inhibitors in Patients With Acute Coronary Syndrome.

Shah R, Rashid A, Hwang I, Fan TM, Khouzam RN, Reed GL.

Am J Cardiol. 2017 Jun 1;119(11):1723-1728. doi: 10.1016/j.amjcard.2017.03.011. Epub 2017 Mar 16. Review.


Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma.

Thamm DH, Vail DM, Post GS, Fan TM, Phillips BS, Axiak-Bechtel S, Elmslie RS, Klein MK, Ruslander DA.

J Vet Intern Med. 2017 May;31(3):872-878. doi: 10.1111/jvim.14700. Epub 2017 Apr 3.


Selective in vivo metabolic cell-labeling-mediated cancer targeting.

Wang H, Wang R, Cai K, He H, Liu Y, Yen J, Wang Z, Xu M, Sun Y, Zhou X, Yin Q, Tang L, Dobrucki IT, Dobrucki LW, Chaney EJ, Boppart SA, Fan TM, Lezmi S, Chen X, Yin L, Cheng J.

Nat Chem Biol. 2017 Apr;13(4):415-424. doi: 10.1038/nchembio.2297. Epub 2017 Feb 13.


Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.

Lundberg AP, Francis JM, Pajak M, Parkinson EI, Wycislo KL, Rosol TJ, Brown ME, London CA, Dirikolu L, Hergenrother PJ, Fan TM.

Invest New Drugs. 2017 Apr;35(2):134-144. doi: 10.1007/s10637-016-0414-z. Epub 2016 Dec 14.


Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics.

Botham RC, Roth HS, Book AP, Roady PJ, Fan TM, Hergenrother PJ.

ACS Cent Sci. 2016 Aug 24;2(8):545-59. doi: 10.1021/acscentsci.6b00165. Epub 2016 Jul 25.


Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis.

Yin Q, Tang L, Cai K, Tong R, Sternberg R, Yang X, Dobrucki LW, Borst LB, Kamstock D, Song Z, Helferich WG, Cheng J, Fan TM.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4601-9. doi: 10.1073/pnas.1603316113. Epub 2016 Jul 25.


mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo.

Morrow JJ, Mendoza A, Koyen A, Lizardo MM, Ren L, Waybright TJ, Hansen RJ, Gustafson DL, Zhou M, Fan TM, Scacheri PC, Khanna C.

Clin Cancer Res. 2016 Dec 15;22(24):6129-6141. Epub 2016 Jun 24.


The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas.

Peh J, Fan TM, Wycislo KL, Roth HS, Hergenrother PJ.

Mol Cancer Ther. 2016 Aug;15(8):1859-69. doi: 10.1158/1535-7163.MCT-16-0025. Epub 2016 Jun 13.


Zoledronate-Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma.

Lundberg AP, Roady PJ, Somrak AJ, Howes ME, Fan TM.

J Vet Intern Med. 2016 Jul;30(4):1235-40. doi: 10.1111/jvim.13980. Epub 2016 Jun 14. No abstract available.


Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma.

Byrum ML, Pondenis HC, Fredrickson RL, Wycislo KL, Fan TM.

J Vet Intern Med. 2016 Jul;30(4):1187-96. doi: 10.1111/jvim.14257. Epub 2016 Jun 2.


Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.

LeBlanc AK, Mazcko C, Brown DE, Koehler JW, Miller AD, Miller CR, Bentley RT, Packer RA, Breen M, Boudreau CE, Levine JM, Simpson RM, Halsey C, Kisseberth W, Rossmeisl JH Jr, Dickinson PJ, Fan TM, Corps K, Aldape K, Puduvalli V, Pluhar GE, Gilbert MR.

Neuro Oncol. 2016 Sep;18(9):1209-18. doi: 10.1093/neuonc/now051. Epub 2016 May 14. Review.


Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013).

Cesario L, Garrett LD, Barger AM, O'Brien RT, Fan TM.

Aust Vet J. 2016 May;94(5):160-5. doi: 10.1111/avj.12435.


Interfacial geometry dictates cancer cell tumorigenicity.

Lee J, Abdeen AA, Wycislo KL, Fan TM, Kilian KA.

Nat Mater. 2016 Aug;15(8):856-62. doi: 10.1038/nmat4610. Epub 2016 Apr 4.


Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology.

LeBlanc AK, Breen M, Choyke P, Dewhirst M, Fan TM, Gustafson DL, Helman LJ, Kastan MB, Knapp DW, Levin WJ, London C, Mason N, Mazcko C, Olson PN, Page R, Teicher BA, Thamm DH, Trent JM, Vail DM, Khanna C.

Sci Transl Med. 2016 Feb 3;8(324):324ps5. doi: 10.1126/scitranslmed.aaf0746. Review. No abstract available.


Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs.

Larson JC, Allstadt SD, Fan TM, Khanna C, Lunghofer PJ, Hansen RJ, Gustafson DL, Legendre AM, Galyon GD, LeBlanc AK, Martin-Jimenez T.

Am J Vet Res. 2016 Jan;77(1):65-71. doi: 10.2460/ajvr.77.1.65.


A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.

Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ.

Cell Rep. 2015 Dec 1;13(9):2027-36. doi: 10.1016/j.celrep.2015.10.042. Epub 2015 Nov 19.


The Association of Endothelin-1 Signaling with Bone Alkaline Phosphatase Expression and Protumorigenic Activities in Canine Osteosarcoma.

Neumann ZL, Pondenis HC, Masyr A, Byrum ML, Wycislo KL, Fan TM.

J Vet Intern Med. 2015 Nov-Dec;29(6):1584-94. doi: 10.1111/jvim.13635. Epub 2015 Oct 1.


Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs.

Roy J, Pondenis H, Fan TM, Das A.

Biochemistry. 2015 Oct 20;54(41):6299-302. doi: 10.1021/acs.biochem.5b00954. Epub 2015 Oct 6.


Comparative Aspects of Osteosarcoma Pathogenesis in Humans and Dogs.

Fan TM, Khanna C.

Vet Sci. 2015 Aug 17;2(3):210-230. doi: 10.3390/vetsci2030210. Review.


Targeting tumor vasculature with aptamer-functionalized doxorubicin-polylactide nanoconjugates for enhanced cancer therapy.

Tang L, Tong R, Coyle VJ, Yin Q, Pondenis H, Borst LB, Cheng J, Fan TM.

ACS Nano. 2015 May 26;9(5):5072-81. doi: 10.1021/acsnano.5b00166. Epub 2015 May 4.


The immunotherapy of canine osteosarcoma: a historical and systematic review.

Wycislo KL, Fan TM.

J Vet Intern Med. 2015 May-Jun;29(3):759-69. doi: 10.1111/jvim.12603. Epub 2015 Apr 30. Review.


Alkylation and Carbamylation Effects of Lomustine and Its Major Metabolites and MGMT Expression in Canine Cells.

Chakkath T, Lavergne S, Fan TM, Bunick D, Dirikolu L.

Vet Sci. 2015 Apr 24;2(2):52-68. doi: 10.3390/vetsci2020052.


Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics.

Roth HS, Botham RC, Schmid SC, Fan TM, Dirikolu L, Hergenrother PJ.

J Med Chem. 2015 May 14;58(9):4046-65. doi: 10.1021/acs.jmedchem.5b00413. Epub 2015 Apr 20.


An 81-year-old man with an abnormal right-sided heart shadow on chest radiograph.

Shah R, Khan MR, Fan TM, Ruff G, Ramanathan KB.

Chest. 2015 Feb;147(2):e52-e55. doi: 10.1378/chest.14-1393.


A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation.

Glover J, Krailo M, Tello T, Marina N, Janeway K, Barkauskas D, Fan TM, Gorlick R, Khanna C; COG Osteosarcoma Biology Group.

Pediatr Blood Cancer. 2015 Mar;62(3):450-5. doi: 10.1002/pbc.25346. Epub 2014 Dec 8.


Expression of nociceptive ligands in canine osteosarcoma.

Shor S, Fadl-Alla BA, Pondenis HC, Zhang X, Wycislo KL, Lezmi S, Fan TM.

J Vet Intern Med. 2015 Jan;29(1):268-75. doi: 10.1111/jvim.12511. Epub 2015 Jan 8.


Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus).

Watson MK, Stern AW, Labelle AL, Joslyn S, Fan TM, Leister K, Kohles M, Marshall K, Mitchell MA.

PLoS One. 2014 Dec 17;9(12):e114413. doi: 10.1371/journal.pone.0114413. eCollection 2014.


Investigating the optimal size of anticancer nanomedicine.

Tang L, Yang X, Yin Q, Cai K, Wang H, Chaudhury I, Yao C, Zhou Q, Kwon M, Hartman JA, Dobrucki IT, Dobrucki LW, Borst LB, Lezmi S, Helferich WG, Ferguson AL, Fan TM, Cheng J.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15344-9. doi: 10.1073/pnas.1411499111. Epub 2014 Oct 14.


Pain management in veterinary patients with cancer.

Fan TM.

Vet Clin North Am Small Anim Pract. 2014 Sep;44(5):989-1001. doi: 10.1016/j.cvsm.2014.05.005. Epub 2014 Jun 11. Review.


Toward a drug development path that targets metastatic progression in osteosarcoma.

Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton PJ, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Meltzer P, Kirsch DG, Janeway KA, Weigel B, Randall L, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Smith M, Uren A, Patel SR, Trent J, Savage SA, Mirabello L, Reinke D, Barkaukas DA, Krailo M, Bernstein M.

Clin Cancer Res. 2014 Aug 15;20(16):4200-9. doi: 10.1158/1078-0432.CCR-13-2574. Epub 2014 May 6.


Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma.

Portela RF, Fadl-Alla BA, Pondenis HC, Byrum ML, Garrett LD, Wycislo KL, Borst LB, Fan TM.

J Vet Intern Med. 2014 May-Jun;28(3):894-904. doi: 10.1111/jvim.12348. Epub 2014 Mar 31.


Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity.

Botham RC, Fan TM, Im I, Borst LB, Dirikolu L, Hergenrother PJ.

J Am Chem Soc. 2014 Jan 29;136(4):1312-9. doi: 10.1021/ja4124303. Epub 2014 Jan 16.


Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker.

Yin Q, Tong R, Yin L, Fan TM, Cheng J.

Polym Chem. 2014;5(5):1581-1585.

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