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Items: 34

1.

Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites.

Yu ZJ, Roesner JM, Lutz R, Liang Y, Baker J, Smith DM, Fan PW.

Drug Metab Pharmacokinet. 2019 Oct;34(5):308-316. doi: 10.1016/j.dmpk.2019.05.004. Epub 2019 May 31.

PMID:
31235362
2.

Estimation of Fraction Dissolved After Intratracheal Delivery of a Potent Janus Kinase Inhibitor, iJAK-001, with Low Solubility in Rat and Sheep: Impact of Preclinical PKPD on Inhaled Human Dose Projection.

Caniga M, Yu H, Lee HH, Wang M, Witter D, Salmon M, Fan PW.

J Aerosol Med Pulm Drug Deliv. 2019 Oct;32(5):251-265. doi: 10.1089/jamp.2018.1492. Epub 2019 May 14.

PMID:
31084462
3.

Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations.

Chiang PC, Nagapudi K, Fan PW, Liu J.

J Pharm Sci. 2019 Jan;108(1):109-119. doi: 10.1016/j.xphs.2018.06.003. Epub 2018 Jun 14.

PMID:
29909029
4.

Human Leukocyte Antigen-A Allele Distribution in Nasopharyngeal Carcinoma Patients Showing Anti-Melanoma-Associated Antigen A or Synovial Sarcoma X-2 T Cell Response in Blood.

Fan PW, Huang L, Chang XM, Feng YN, Yao X, Peng YC, Dong T, Wang RZ.

Chin Med J (Engl). 2018 Jun 5;131(11):1289-1295. doi: 10.4103/0366-6999.232791.

5.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.

Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, Lesch J, Bents K, Everett C, Kohli PB, Linge S, Christian L, Barrett K, Jaochico A, Berezhkovskiy LM, Fan PW, Modrusan Z, Veliz K, Townsend MJ, DeVoss J, Johnson AR, Godemann R, Lee WP, Austin CD, McKenzie BS, Hackney JA, Crawford JJ, Staben ST, Alaoui Ismaili MH, Wu LC, Ghilardi N.

Nat Commun. 2018 Jan 12;9(1):179. doi: 10.1038/s41467-017-02672-0.

6.

The aqueous extract of Brucea javanica suppresses cell growth and alleviates tumorigenesis of human lung cancer cells by targeting mutated epidermal growth factor receptor.

Kim SH, Liu CY, Fan PW, Hsieh CH, Lin HY, Lee MC, Fang K.

Drug Des Devel Ther. 2016 Nov 3;10:3599-3609. eCollection 2016.

7.

The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis.

Chen JH, Kim SH, Fan PW, Liu CY, Hsieh CH, Fang K.

Drug Des Devel Ther. 2016 Jun 17;10:2003-13. doi: 10.2147/DDDT.S107909. eCollection 2016.

8.

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC.

Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Review.

PMID:
27117704
9.

Elucidating the Mechanism of Tofacitinib Oxidative Decyanation.

Le H, Fan PW, Wong S, Ma S, Driscoll JP, Hop CE, Cyrus Khojasteh S.

Drug Metab Lett. 2016;10(2):136-43.

PMID:
27117606
10.

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.

Fan PW, Chen JZ, Allan Jaochico M, La H, Liu N, Mulder T, Cass RT, Durk M, Messick K, Valle N, Liu S, Lee W, Crawford JJ, Rudolf J, Murray LJ, Cyrus Khojasteh S, Wright M.

Drug Metab Lett. 2016;10(2):91-100.

11.

An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions.

Liu CY, Wu PT, Wang JP, Fan PW, Hsieh CH, Su CL, Chiu CC, Yao CF, Fang K.

Apoptosis. 2015 Nov;20(11):1471-82. doi: 10.1007/s10495-015-1165-6.

PMID:
26349782
12.

Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System.

Wang X, Sun M, New C, Nam S, Blackaby WP, Hodges AJ, Nash D, Matteucci M, Lyssikatos JP, Fan PW, Tay S, Chang JH.

ACS Med Chem Lett. 2015 Jul 12;6(8):925-9. doi: 10.1021/acsmedchemlett.5b00191. eCollection 2015 Aug 13.

13.

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

Crawford JJ, Lee W, Aliagas I, Mathieu S, Hoeflich KP, Zhou W, Wang W, Rouge L, Murray L, La H, Liu N, Fan PW, Cheong J, Heise CE, Ramaswamy S, Mintzer R, Liu Y, Chao Q, Rudolph J.

J Med Chem. 2015 Jun 25;58(12):5121-36. doi: 10.1021/acs.jmedchem.5b00572. Epub 2015 Jun 12.

PMID:
26030457
14.

Body Mass Changes Across a Variety of Running Race Distances in the Tropics.

Tan DW, Yap SH, Wang M, Fan PW, Teo YS, Krishnasamy P, Krishna L, Hew-Butler T, Lee JK.

Sports Med Open. 2016 Jul 19;2(1):26. eCollection 2015 Jun.

15.

Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery.

Fan PW, Song Y, Berezhkovskiy LM, Cheong J, Plise EG, Khojasteh SC.

Future Med Chem. 2014;6(18):1995-2012. doi: 10.4155/fmc.14.141.

PMID:
25531965
16.

Effects of a carbohydrate-electrolyte solution on cognitive performance following exercise-induced hyperthermia in humans.

Lee JK, Ang WH, Ng JW, Fan PW, Teo YS, Nolte HW, Yeo YY.

J Int Soc Sports Nutr. 2014 Nov 4;11(1):51. doi: 10.1186/s12970-014-0051-x. eCollection 2014.

17.

Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.

Johnson MG, Liu JJ, Li AR, van Lengerich B, Wang S, Medina JC, Collins TL, Danao J, Seitz L, Willee A, D'Souza W, Budelsky AL, Fan PW, Wong SG.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2877-80. doi: 10.1016/j.bmcl.2014.04.092. Epub 2014 May 4.

PMID:
24825301
18.

Neck cooling and cognitive performance following exercise-induced hyperthermia.

Lee JK, Koh AC, Koh SX, Liu GJ, Nio AQ, Fan PW.

Eur J Appl Physiol. 2014 Feb;114(2):375-84. doi: 10.1007/s00421-013-2774-9. Epub 2013 Dec 7.

PMID:
24318656
19.

Effect of thermal annealing on the surface properties of electrospun polymer fibers.

Chen JT, Chen WL, Fan PW, Yao IC.

Macromol Rapid Commun. 2014 Feb;35(3):360-6. doi: 10.1002/marc.201300290. Epub 2013 May 31.

PMID:
23723054
20.

Transformation of polymer nanofibers to nanospheres driven by the Rayleigh instability.

Huang YC, Fan PW, Lee CW, Chu CW, Tsai CC, Chen JT.

ACS Appl Mater Interfaces. 2013 Apr 24;5(8):3134-42. doi: 10.1021/am400029j. Epub 2013 Apr 3.

PMID:
23514621
21.

Elucidation of the mechanism of ribose conjugation in a pyrazole-containing compound in rodent liver.

Le H, Ford KA, Khojasteh SC, Fan PW.

Xenobiotica. 2013 Mar;43(3):236-45. doi: 10.3109/00498254.2012.715211. Epub 2012 Aug 30.

PMID:
22931212
22.

Ice slurry on outdoor running performance in heat.

Yeo ZW, Fan PW, Nio AQ, Byrne C, Lee JK.

Int J Sports Med. 2012 Nov;33(11):859-66. doi: 10.1055/s-0032-1304643. Epub 2012 Jun 22.

PMID:
22730052
23.

Quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors.

Li WY, Xiong XQ, Zhao DM, Shi YF, Yang ZH, Yu C, Fan PW, Cheng MS, Shen JK.

Molecules. 2012 May 9;17(5):5497-507. doi: 10.3390/molecules17055497.

24.

Annealing effect on electrospun polymer fibers and their transformation into polymer microspheres.

Fan PW, Chen WL, Lee TH, Chen JT.

Macromol Rapid Commun. 2012 Feb 27;33(4):343-9. doi: 10.1002/marc.201100734. Epub 2012 Jan 23.

PMID:
22271584
25.

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.

Zhang C, Kenny JR, Le H, Deese A, Ford KA, Lightning LK, Fan PW, Driscoll JP, Halladay JS, Hop CE, Khojasteh SC.

Chem Res Toxicol. 2011 Oct 17;24(10):1668-77. doi: 10.1021/tx2002228. Epub 2011 Sep 25.

PMID:
21905702
26.
27.

Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor.

Fan PW, Gu C, Marsh SA, Stevens JC.

Drug Metab Dispos. 2003 Jan;31(1):28-36.

PMID:
12485950
28.
29.

1,4-Naphthoquinone Disulfides and Methyl Sulfides: Self-Assembled Monolayers on Gold Substrates.

Panetta CA, Fan PW, Fattah R, Greever JC, He Z, Hussey CL, Sha D, Wescott LD Jr.

J Org Chem. 1999 Apr 16;64(8):2919-2923. No abstract available.

PMID:
11674367
30.

Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA.

Fan PW, Bolton JL.

Drug Metab Dispos. 2001 Jun;29(6):891-6.

PMID:
11353759
31.

Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.

Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL.

Chem Res Toxicol. 2000 Jan;13(1):53-62.

PMID:
10649967
32.
33.

Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry.

Nikolic D, Fan PW, Bolton JL, van Breemen RB.

Comb Chem High Throughput Screen. 1999 Jun;2(3):165-75.

PMID:
10420970
34.

Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen.

Ramakrishna KV, Fan PW, Boyer CS, Dalvie D, Bolton JL.

Chem Res Toxicol. 1997 Aug;10(8):887-94.

PMID:
9282838

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