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Items: 25


Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis.

Ferrero Restelli F, Fontanet PA, De Vincenti AP, Falzone TL, Ledda F, Paratcha G.

Cell Mol Life Sci. 2019 Aug 22. doi: 10.1007/s00018-019-03282-3. [Epub ahead of print]


Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.

Cromberg LE, Saez TMM, Otero MG, Tomasella E, Alloatti M, Damianich A, Pozo Devoto V, Ferrario J, Gelman D, Rubinstein M, Falzone TL.

J Neurochem. 2019 May;149(3):362-380. doi: 10.1111/jnc.14665. Epub 2019 Feb 14.


SOX-11 regulates LINE-1 retrotransposon activity during neuronal differentiation.

Orqueda AJ, Gatti CR, Ogara MF, Falzone TL.

FEBS Lett. 2018 Nov;592(22):3708-3719. doi: 10.1002/1873-3468.13260. Epub 2018 Oct 23.


Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes.

Otero MG, Fernandez Bessone I, Hallberg AE, Cromberg LE, De Rossi MC, Saez TM, Levi V, Almenar-Queralt A, Falzone TL.

J Cell Sci. 2018 Jun 11;131(11). pii: jcs214536. doi: 10.1242/jcs.214536.


Methods for Quantitative Analysis of Axonal Cargo Transport.

Alloatti M, Bruno L, Falzone TL.

Methods Mol Biol. 2018;1727:217-226. doi: 10.1007/978-1-4939-7571-6_16.


Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?

Pozo Devoto VM, Falzone TL.

Dis Model Mech. 2017 Sep 1;10(9):1075-1087. doi: 10.1242/dmm.026294. Review.


αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.

Pozo Devoto VM, Dimopoulos N, Alloatti M, Pardi MB, Saez TM, Otero MG, Cromberg LE, Marín-Burgin A, Scassa ME, Stokin GB, Schinder AF, Sevlever G, Falzone TL.

Sci Rep. 2017 Jul 11;7(1):5042. doi: 10.1038/s41598-017-05334-9.


Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons.

Lacovich V, Espindola SL, Alloatti M, Pozo Devoto V, Cromberg LE, Čarná ME, Forte G, Gallo JM, Bruno L, Stokin GB, Avale ME, Falzone TL.

J Neurosci. 2017 Jan 4;37(1):58-69. doi: 10.1523/JNEUROSCI.2305-16.2016.


Hippocampal to basal forebrain transport of Mn2+ is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule-based motor.

Medina CS, Biris O, Falzone TL, Zhang X, Zimmerman AJ, Bearer EL.

Neuroimage. 2017 Jan 15;145(Pt A):44-57. doi: 10.1016/j.neuroimage.2016.09.035. Epub 2016 Oct 14.


Mouse sperm begin to undergo acrosomal exocytosis in the upper isthmus of the oviduct.

La Spina FA, Puga Molina LC, Romarowski A, Vitale AM, Falzone TL, Krapf D, Hirohashi N, Buffone MG.

Dev Biol. 2016 Mar 15;411(2):172-182. doi: 10.1016/j.ydbio.2016.02.006. Epub 2016 Feb 10.


UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.

Almenar-Queralt A, Falzone TL, Shen Z, Lillo C, Killian RL, Arreola AS, Niederst ED, Ng KS, Kim SN, Briggs SP, Williams DS, Goldstein LS.

J Neurosci. 2014 Feb 26;34(9):3320-39. doi: 10.1523/JNEUROSCI.1503-13.2014.


Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function.

Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Bruno L, Goldstein LS, Falzone TL.

J Cell Sci. 2014 Apr 1;127(Pt 7):1537-49. doi: 10.1242/jcs.140780. Epub 2014 Feb 12.


Imaging amyloid precursor protein in vivo: an axonal transport assay.

Falzone TL, Stokin GB.

Methods Mol Biol. 2012;846:295-303. doi: 10.1007/978-1-61779-536-7_25.


Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.

Falzone TL, Gunawardena S, McCleary D, Reis GF, Goldstein LS.

Hum Mol Genet. 2010 Nov 15;19(22):4399-408. doi: 10.1093/hmg/ddq363. Epub 2010 Sep 3.


Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS.

J Neurosci. 2009 May 6;29(18):5758-67. doi: 10.1523/JNEUROSCI.0780-09.2009.


Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI).

Bearer EL, Falzone TL, Zhang X, Biris O, Rasin A, Jacobs RE.

Neuroimage. 2007;37 Suppl 1:S37-46. Epub 2007 May 13.


Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.

Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS.

Science. 2005 Feb 25;307(5713):1282-8.


Enhanced expression of dopamine D(1) and glutamate NMDA receptors in dopamine D(4) receptor knockout mice.

Gan L, Falzone TL, Zhang K, Rubinstein M, Baldessarini RJ, Tarazi FI.

J Mol Neurosci. 2004;22(3):167-78.


The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder.

Avale ME, Falzone TL, Gelman DM, Low MJ, Grandy DK, Rubinstein M.

Mol Psychiatry. 2004 Jul;9(7):718-26.


Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear.

Falzone TL, Gelman DM, Young JI, Grandy DK, Low MJ, Rubinstein M.

Eur J Neurosci. 2002 Jan;15(1):158-64.


Dopamine D4 receptor-deficient mice display cortical hyperexcitability.

Rubinstein M, Cepeda C, Hurst RS, Flores-Hernandez J, Ariano MA, Falzone TL, Kozell LB, Meshul CK, Bunzow JR, Low MJ, Levine MS, Grandy DK.

J Neurosci. 2001 Jun 1;21(11):3756-63.


Quantitative analysis of the dopamine D4 receptor in the mouse brain.

Defagot MC, Falzone TL, Low MJ, Grandy DK, Rubinstein M, Antonelli MC.

J Neurosci Res. 2000 Jan 15;59(2):202-8.


Accurate spatial and temporal transgene expression driven by a 3.8-kilobase promoter of the bovine beta-casein gene in the lactating mouse mammary gland.

Cerdán MG, Young JI, Zino E, Falzone TL, Otero V, Torres HN, Rubinstein M.

Mol Reprod Dev. 1998 Mar;49(3):236-45.


Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine.

Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougall JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, Grandy DK.

Cell. 1997 Sep 19;90(6):991-1001.

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