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Items: 6

1.

Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H.

J Comput Chem. 2020 Mar 5;41(6):538-551. doi: 10.1002/jcc.26105. Epub 2019 Nov 21.

PMID:
31750558
2.

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16.

Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H.

Nat Commun. 2019 Oct 31;10(1):4972. doi: 10.1038/s41467-019-12865-4.

3.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP.

Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1.

4.

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.

Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A.

Elife. 2019 Jan 16;8. pii: e43229. doi: 10.7554/eLife.43229.

5.

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.

Malvezzi M, Andra KK, Pandey K, Lee BC, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7033-E7042. doi: 10.1073/pnas.1806721115. Epub 2018 Jun 20.

6.

Known structures and unknown mechanisms of TMEM16 scramblases and channels.

Falzone ME, Malvezzi M, Lee BC, Accardi A.

J Gen Physiol. 2018 Jul 2;150(7):933-947. doi: 10.1085/jgp.201711957. Epub 2018 Jun 18. Review.

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