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Items: 26

1.

Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection.

Kim HK, Falugi F, Missiakas DM, Schneewind O.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5718-23. doi: 10.1073/pnas.1524267113. Epub 2016 May 2.

2.

Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin.

Fiaschi L, Di Palo B, Scarselli M, Pozzi C, Tomaszewski K, Galletti B, Nardi-Dei V, Arcidiacono L, Mishra RP, Mori E, Pallaoro M, Falugi F, Torre A, Fontana MR, Soriani M, Bubeck Wardenburg J, Grandi G, Rappuoli R, Ferlenghi I, Bagnoli F.

Clin Vaccine Immunol. 2016 Jun 6;23(6):442-50. doi: 10.1128/CVI.00091-16. Print 2016 Jun.

3.

Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs.

Kim HK, Falugi F, Thomer L, Missiakas DM, Schneewind O.

MBio. 2015 Jan 6;6(1). pii: e02369-14. doi: 10.1128/mBio.02369-14.

4.

Staphylococcus aureus infection induces protein A-mediated immune evasion in humans.

Pauli NT, Kim HK, Falugi F, Huang M, Dulac J, Henry Dunand C, Zheng NY, Kaur K, Andrews SF, Huang Y, DeDent A, Frank KM, Charnot-Katsikas A, Schneewind O, Wilson PC.

J Exp Med. 2014 Nov 17;211(12):2331-9. doi: 10.1084/jem.20141404. Epub 2014 Oct 27.

5.

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of SpyCEP, a candidate antigen for a vaccine against Streptococcus pyogenes.

Abate F, Malito E, Falugi F, Margarit Y Ros I, Bottomley MJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1103-6. doi: 10.1107/S1744309113024871. Epub 2013 Sep 28.

6.

Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus.

Falugi F, Kim HK, Missiakas DM, Schneewind O.

MBio. 2013 Aug 27;4(5):e00575-13. doi: 10.1128/mBio.00575-13.

7.

Mining the bacterial unknown proteome: identification and characterization of a novel family of highly conserved protective antigens in Staphylococcus aureus.

Schluepen C, Malito E, Marongiu A, Schirle M, McWhinnie E, Lo Surdo P, Biancucci M, Falugi F, Nardi-Dei V, Marchi S, Fontana MR, Lombardi B, De Falco MG, Rinaudo CD, Spraggon G, Nissum M, Bagnoli F, Grandi G, Bottomley MJ, Liberatori S.

Biochem J. 2013 Nov 1;455(3):273-84. doi: 10.1042/BJ20130540.

PMID:
23895222
8.

Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence.

Chiarot E, Faralla C, Chiappini N, Tuscano G, Falugi F, Gambellini G, Taddei A, Capo S, Cartocci E, Veggi D, Corrado A, Mangiavacchi S, Tavarini S, Scarselli M, Janulczyk R, Grandi G, Margarit I, Bensi G.

MBio. 2013 Jan 8;4(1):e00387-12. doi: 10.1128/mBio.00387-12.

9.

Staphylococcus aureus FhuD2 is involved in the early phase of staphylococcal dissemination and generates protective immunity in mice.

Mishra RP, Mariotti P, Fiaschi L, Nosari S, Maccari S, Liberatori S, Fontana MR, Pezzicoli A, De Falco MG, Falugi F, Altindis E, Serruto D, Grandi G, Bagnoli F.

J Infect Dis. 2012 Oct 1;206(7):1041-9. doi: 10.1093/infdis/jis463. Epub 2012 Jul 24.

PMID:
22829645
10.

Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice.

Kim HK, Emolo C, DeDent AC, Falugi F, Missiakas DM, Schneewind O.

Infect Immun. 2012 Oct;80(10):3460-70. doi: 10.1128/IAI.00230-12. Epub 2012 Jul 23.

11.

Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case.

Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G.

Mol Cell Proteomics. 2012 Jun;11(6):M111.015693. doi: 10.1074/mcp.M111.015693. Epub 2012 Jan 27.

12.

Surface interactome in Streptococcus pyogenes.

Galeotti CL, Bove E, Pezzicoli A, Nogarotto R, Norais N, Pileri S, Lelli B, Falugi F, Balloni S, Tedde V, Chiarot E, Bombaci M, Soriani M, Bracci L, Grandi G, Grifantini R.

Mol Cell Proteomics. 2012 Apr;11(4):M111.015206. doi: 10.1074/mcp.M111.015206. Epub 2011 Dec 22.

13.

Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features.

Zingaretti C, Falugi F, Nardi-Dei V, Pietrocola G, Mariani M, Liberatori S, Gallotta M, Tontini M, Tani C, Speziale P, Grandi G, Margarit I.

FASEB J. 2010 Aug;24(8):2839-48. doi: 10.1096/fj.09-145631. Epub 2010 Mar 25.

PMID:
20339024
14.

Protein array profiling of tic patient sera reveals a broad range and enhanced immune response against Group A Streptococcus antigens.

Bombaci M, Grifantini R, Mora M, Reguzzi V, Petracca R, Meoni E, Balloni S, Zingaretti C, Falugi F, Manetti AG, Margarit I, Musser JM, Cardona F, Orefici G, Grandi G, Bensi G.

PLoS One. 2009 Jul 22;4(7):e6332. doi: 10.1371/journal.pone.0006332.

15.

Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes.

Falugi F, Zingaretti C, Pinto V, Mariani M, Amodeo L, Manetti AG, Capo S, Musser JM, Orefici G, Margarit I, Telford JL, Grandi G, Mora M.

J Infect Dis. 2008 Dec 15;198(12):1834-41. doi: 10.1086/593176.

PMID:
18928376
16.

Scavenger receptor gp340 aggregates group A streptococci by binding pili.

Edwards AM, Manetti AG, Falugi F, Zingaretti C, Capo S, Buccato S, Bensi G, Telford JL, Margarit I, Grandi G.

Mol Microbiol. 2008 Jun;68(6):1378-94. doi: 10.1111/j.1365-2958.2008.06220.x. Epub 2008 Apr 29.

17.

A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response.

Sumby P, Zhang S, Whitney AR, Falugi F, Grandi G, Graviss EA, Deleo FR, Musser JM.

Infect Immun. 2008 Mar;76(3):978-85. doi: 10.1128/IAI.01354-07. Epub 2008 Jan 3.

18.

Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation.

Manetti AG, Zingaretti C, Falugi F, Capo S, Bombaci M, Bagnoli F, Gambellini G, Bensi G, Mora M, Edwards AM, Musser JM, Graviss EA, Telford JL, Grandi G, Margarit I.

Mol Microbiol. 2007 May;64(4):968-83.

19.

Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens.

Mora M, Bensi G, Capo S, Falugi F, Zingaretti C, Manetti AG, Maggi T, Taddei AR, Grandi G, Telford JL.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15641-6. Epub 2005 Oct 13.

20.

Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop.

Kitadokoro K, Ponassi M, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M.

Biol Chem. 2002 Sep;383(9):1447-52.

PMID:
12437138
21.

Genomic approach for analysis of surface proteins in Chlamydia pneumoniae.

Montigiani S, Falugi F, Scarselli M, Finco O, Petracca R, Galli G, Mariani M, Manetti R, Agnusdei M, Cevenini R, Donati M, Nogarotto R, Norais N, Garaguso I, Nuti S, Saletti G, Rosa D, Ratti G, Grandi G.

Infect Immun. 2002 Jan;70(1):368-79.

22.

Rationally designed strings of promiscuous CD4(+) T cell epitopes provide help to Haemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines.

Falugi F, Petracca R, Mariani M, Luzzi E, Mancianti S, Carinci V, Melli ML, Finco O, Wack A, Di Tommaso A, De Magistris MT, Costantino P, Del Giudice G, Abrignani S, Rappuoli R, Grandi G.

Eur J Immunol. 2001 Dec;31(12):3816-24.

23.

CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

Kitadokoro K, Bordo D, Galli G, Petracca R, Falugi F, Abrignani S, Grandi G, Bolognesi M.

EMBO J. 2001 Jan 15;20(1-2):12-8.

24.

Crystallization and preliminary crystallographic studies on the large extracellular domain of human CD81, a tetraspanin receptor for hepatitis C virus.

Kitadokoro K, Galli G, Petracca R, Falugi F, Grandi G, Bolognesi M.

Acta Crystallogr D Biol Crystallogr. 2001 Jan;57(Pt 1):156-8.

PMID:
11134943
25.

Structure-function analysis of hepatitis C virus envelope-CD81 binding.

Petracca R, Falugi F, Galli G, Norais N, Rosa D, Campagnoli S, Burgio V, Di Stasio E, Giardina B, Houghton M, Abrignani S, Grandi G.

J Virol. 2000 May;74(10):4824-30.

26.

Binding of hepatitis C virus to CD81.

Pileri P, Uematsu Y, Campagnoli S, Galli G, Falugi F, Petracca R, Weiner AJ, Houghton M, Rosa D, Grandi G, Abrignani S.

Science. 1998 Oct 30;282(5390):938-41.

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