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Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants.

Caserta MT, Yang H, Bandyopadhyay S, Qiu X, Gill SR, Java J, McDavid A, Falsey AR, Topham DJ, Holden-Wiltse J, Scheible K, Pryhuber G.

J Pediatr. 2019 Jul 31. pii: S0022-3476(19)30825-X. doi: 10.1016/j.jpeds.2019.06.061. [Epub ahead of print]


Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study.

Walsh EE, Mariani TJ, Chu C, Grier A, Gill SR, Qiu X, Wang L, Holden-Wiltse J, Corbett A, Thakar J, Benoodt L, McCall MN, Topham DJ, Falsey AR, Caserta MT.

JMIR Res Protoc. 2019 Jun 6;8(6):e12907. doi: 10.2196/12907.


What is the role of rapid molecular testing for seniors and other at-risk adults with respiratory syncytial virus infections?

Drews SJ, Branche AR, Falsey AR, Lee N.

J Clin Virol. 2019 Aug;117:27-32. doi: 10.1016/j.jcv.2019.05.010. Epub 2019 May 25. Review.


Highly efficient hypothesis testing methods for regression-type tests with correlated observations and heterogeneous variance structure.

Zhang Y, Bandyopadhyay G, Topham DJ, Falsey AR, Qiu X.

BMC Bioinformatics. 2019 Apr 15;20(1):185. doi: 10.1186/s12859-019-2783-8.


Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis.

Shi T, Denouel A, Tietjen AK, Campbell I, Moran E, Li X, Campbell H, Demont C, Nyawanda BO, Chu HY, Stoszek SK, Krishnan A, Openshaw P, Falsey AR, Nair H; RESCEU Investigators .

J Infect Dis. 2019 Mar 18. pii: jiz059. doi: 10.1093/infdis/jiz059. [Epub ahead of print]


The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis.

Shi T, Arnott A, Semogas I, Falsey AR, Openshaw P, Wedzicha JA, Campbell H, Nair H; RESCEU Investigators .

J Infect Dis. 2019 Mar 8. pii: jiy662. doi: 10.1093/infdis/jiy662. [Epub ahead of print]


Global and Regional Burden of Hospital Admissions for Pneumonia in Older Adults: A Systematic Review and Meta-Analysis.

Shi T, Denouel A, Tietjen AK, Lee JW, Falsey AR, Demont C, Nyawanda BO, Cai B, Fuentes R, Stoszek SK, Openshaw P, Campbell H, Nair H; RESCEU Investigators .

J Infect Dis. 2019 Mar 8. pii: jiz053. doi: 10.1093/infdis/jiz053. [Epub ahead of print]


Viral pathogens associated with acute respiratory illness in hospitalized adults and elderly from Zagreb, Croatia, 2016 to 2018.

Civljak R, Tot T, Falsey AR, Huljev E, Vranes J, Ljubin-Sternak S.

J Med Virol. 2019 Jul;91(7):1202-1209. doi: 10.1002/jmv.25437. Epub 2019 Mar 4.


Neonatal gut and respiratory microbiota: coordinated development through time and space.

Grier A, McDavid A, Wang B, Qiu X, Java J, Bandyopadhyay S, Yang H, Holden-Wiltse J, Kessler HA, Gill AL, Huyck H, Falsey AR, Topham DJ, Scheible KM, Caserta MT, Pryhuber GS, Gill SR.

Microbiome. 2018 Oct 26;6(1):193. doi: 10.1186/s40168-018-0566-5.


Host Gene Expression in Nose and Blood for the Diagnosis of Viral Respiratory Infection.

Yu J, Peterson DR, Baran AM, Bhattacharya S, Wylie TN, Falsey AR, Mariani TJ, Storch GA.

J Infect Dis. 2019 Apr 1;219(7):1151-1161. doi: 10.1093/infdis/jiy608.


Respiratory syncytial virus-associated illness in adults with advanced chronic obstructive pulmonary disease and/or congestive heart failure.

Falsey AR, Walsh EE, Esser MT, Shoemaker K, Yu L, Griffin MP.

J Med Virol. 2019 Jan;91(1):65-71. doi: 10.1002/jmv.25285. Epub 2018 Sep 24.


Procalcitonin in patients with fever: one approach does not fit all.

Schuetz P, Falsey AR.

Clin Microbiol Infect. 2018 Dec;24(12):1229-1230. doi: 10.1016/j.cmi.2018.07.022. Epub 2018 Aug 1. No abstract available.


Improving ability of RSV microneutralization assay to detect G-specific and cross-reactive neutralizing antibodies through immortalized cell line selection.

Boukhvalova MS, Mbaye A, Kovtun S, Yim KC, Konstantinova T, Getachew T, Khurana S, Falsey AR, Blanco JCG.

Vaccine. 2018 Jul 25;36(31):4657-4662. doi: 10.1016/j.vaccine.2018.06.045. Epub 2018 Jun 28.


T-Cell Responses in Adults During Natural Respiratory Syncytial Virus Infection.

Roumanes D, Falsey AR, Quataert S, Secor-Socha S, Lee FE, Yang H, Bandyopadhyay S, Holden-Wiltse J, Topham DJ, Walsh EE.

J Infect Dis. 2018 Jul 2;218(3):418-428. doi: 10.1093/infdis/jiy016.


The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates.

Mazur NI, Higgins D, Nunes MC, Melero JA, Langedijk AC, Horsley N, Buchholz UJ, Openshaw PJ, McLellan JS, Englund JA, Mejias A, Karron RA, Simões EA, Knezevic I, Ramilo O, Piedra PA, Chu HY, Falsey AR, Nair H, Kragten-Tabatabaie L, Greenough A, Baraldi E, Papadopoulos NG, Vekemans J, Polack FP, Powell M, Satav A, Walsh EE, Stein RT, Graham BS, Bont LJ; Respiratory Syncytial Virus Network (ReSViNET) Foundation.

Lancet Infect Dis. 2018 Oct;18(10):e295-e311. doi: 10.1016/S1473-3099(18)30292-5. Epub 2018 Jun 18. Review. Erratum in: Lancet Infect Dis. 2018 Jul 25;:.


Effect of prior vaccination on carriage rates of Streptococcus pneumoniae in older adults: A longitudinal surveillance study.

Branche AR, Yang H, Java J, Holden-Wiltse J, Topham DJ, Peasley M, Frost MR, Nahm MH, Falsey AR.

Vaccine. 2018 Jul 5;36(29):4304-4310. doi: 10.1016/j.vaccine.2018.05.107. Epub 2018 Jun 2.


Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection.

Walsh EE, Wang L, Falsey AR, Qiu X, Corbett A, Holden-Wiltse J, Mariani TJ, Topham DJ, Caserta MT.

J Infect Dis. 2018 Jun 20;218(2):208-217. doi: 10.1093/infdis/jiy106.


Influenza burden in frail elderly.

Falsey AR, McElhaney JE.

Lancet Respir Med. 2018 Jan;6(1):e2. doi: 10.1016/S2213-2600(17)30442-3. No abstract available. Erratum in: Lancet Respir Med. 2018 Jan 17;:.


Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions.

Wirz Y, Branche A, Wolff M, Welte T, Nobre V, Reinhart K, Falsey AR, Damas P, Beishuizen A, Deliberato RO, Shehabi Y, Jensen JS, Mueller B, Schuetz P.

ACS Infect Dis. 2017 Dec 8;3(12):875-879. doi: 10.1021/acsinfecdis.7b00199. Epub 2017 Nov 9.


Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.

Schuetz P, Wirz Y, Sager R, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, Nobre V, Wei L, Bucher HC, Annane D, Reinhart K, Falsey AR, Branche A, Damas P, Nijsten M, de Lange DW, Deliberato RO, Oliveira CF, Maravić-Stojković V, Verduri A, Beghé B, Cao B, Shehabi Y, Jensen JS, Corti C, van Oers JAH, Beishuizen A, Girbes ARJ, de Jong E, Briel M, Mueller B.

Lancet Infect Dis. 2018 Jan;18(1):95-107. doi: 10.1016/S1473-3099(17)30592-3. Epub 2017 Oct 13.


An Adjuvanted, Postfusion F Protein-Based Vaccine Did Not Prevent Respiratory Syncytial Virus Illness in Older Adults.

Falloon J, Yu J, Esser MT, Villafana T, Yu L, Dubovsky F, Takas T, Levin MJ, Falsey AR.

J Infect Dis. 2017 Dec 12;216(11):1362-1370. doi: 10.1093/infdis/jix503.


Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.

Schuetz P, Wirz Y, Sager R, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, Nobre V, Wei L, Bucher HC, Bhatnagar N, Annane D, Reinhart K, Branche A, Damas P, Nijsten M, de Lange DW, Deliberato RO, Lima SS, Maravić-Stojković V, Verduri A, Cao B, Shehabi Y, Beishuizen A, Jensen JS, Corti C, Van Oers JA, Falsey AR, de Jong E, Oliveira CF, Beghe B, Briel M, Mueller B.

Cochrane Database Syst Rev. 2017 Oct 12;10:CD007498. doi: 10.1002/14651858.CD007498.pub3. Review.


Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants.

Mariani TJ, Qiu X, Chu C, Wang L, Thakar J, Holden-Wiltse J, Corbett A, Topham DJ, Falsey AR, Caserta MT, Walsh EE.

J Infect Dis. 2017 Nov 15;216(8):1027-1037. doi: 10.1093/infdis/jix400.


Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines.

Kim L, Rha B, Abramson JS, Anderson LJ, Byington CL, Chen GL, DeVincenzo J, Edwards KM, Englund JA, Falsey AR, Griffin MR, Karron RA, Martin KG, Meissner HC, Munoz FM, Pavia AT, Piedra PA, Schaffner W, Simões EAF, Singleton R, Talbot HK, Walsh EE, Zucker JR, Gerber SI.

Clin Infect Dis. 2017 Sep 15;65(6):1020-1025. doi: 10.1093/cid/cix432.


Can Analysis of Routine Viral Testing Provide Accurate Estimates of Respiratory Syncytial Virus Disease Burden in Adults?

Datta S, Walsh EE, Peterson DR, Falsey AR.

J Infect Dis. 2017 Jun 1;215(11):1706-1710. doi: 10.1093/infdis/jix196.


Pseudomonas Endocarditis with an unstable phenotype: the challenges of isolate characterization and Carbapenem stewardship with a partial review of the literature.

Lesho E, Snesrud E, Kwak Y, Ong A, Maybank R, Laguio-Vila M, Falsey AR, Hinkle M.

Antimicrob Resist Infect Control. 2017 Aug 29;6:87. doi: 10.1186/s13756-017-0245-5. eCollection 2017.


Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness.

Bhattacharya S, Rosenberg AF, Peterson DR, Grzesik K, Baran AM, Ashton JM, Gill SR, Corbett AM, Holden-Wiltse J, Topham DJ, Walsh EE, Mariani TJ, Falsey AR.

Sci Rep. 2017 Jul 26;7(1):6548. doi: 10.1038/s41598-017-06738-3.


Viral Diagnostics: Only Half the Battle.

Branche AR, Falsey AR.

J Infect Dis. 2017 Nov 15;216(8):923-925. doi: 10.1093/infdis/jix289. No abstract available.


Acute Disseminated Histoplasmosis with Atypical Lymphocytosis in an Immunocompetent Host.

Elbadawi A, Ahmed HM, Adly H, Elkhouly MA, Abohamed S, Falsey AR.

IDCases. 2016 Nov 25;7:23-24. doi: 10.1016/j.idcr.2016.11.006. eCollection 2017.


Compassionate use experience with high-titer respiratory syncytical virus (RSV) immunoglobulin in RSV-infected immunocompromised persons.

Falsey AR, Koval C, DeVincenzo JP, Walsh EE.

Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12657. Epub 2017 Mar 6.


Development of a Global Respiratory Severity Score for Respiratory Syncytial Virus Infection in Infants.

Caserta MT, Qiu X, Tesini B, Wang L, Murphy A, Corbett A, Topham DJ, Falsey AR, Holden-Wiltse J, Walsh EE.

J Infect Dis. 2017 Mar 1;215(5):750-756. doi: 10.1093/infdis/jiw624. Erratum in: J Infect Dis. 2017 Sep 15;216(6):786.


Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis.

Ruiz-Palacios GM, Leroux-Roels G, Beran J, Devaster JM, Esen M, Launay O, McElhaney JE, van Essen GA, Benoit A, Claeys C, Dewé W, Durand C, Duval X, Falsey AR, Feldman G, Galtier F, Gervais P, Hwang SJ, McNeil S, Richardus JH, Trofa A, Oostvogels L; Influence65 study group.

Hum Vaccin Immunother. 2016 Dec;12(12):3043-3055. doi: 10.1080/21645515.2016.1219809.


The Healthy Infant Nasal Transcriptome: A Benchmark Study.

Chu CY, Qiu X, Wang L, Bhattacharya S, Lofthus G, Corbett A, Holden-Wiltse J, Grier A, Tesini B, Gill SR, Falsey AR, Caserta MT, Walsh EE, Mariani TJ.

Sci Rep. 2016 Sep 23;6:33994. doi: 10.1038/srep33994.


Challenges and opportunities in RSV vaccine development: Meeting report from FDA/NIH workshop.

Roberts JN, Graham BS, Karron RA, Munoz FM, Falsey AR, Anderson LJ, Marshall V, Kim S, Beeler JA.

Vaccine. 2016 Sep 22;34(41):4843-4849. doi: 10.1016/j.vaccine.2016.07.057. Epub 2016 Aug 25.


Parainfluenza Virus Infection.

Branche AR, Falsey AR.

Semin Respir Crit Care Med. 2016 Aug;37(4):538-54. doi: 10.1055/s-0036-1584798. Epub 2016 Aug 3. Review.


Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus.

Maifeld SV, Ro B, Mok H, Chu M, Yu L, Yamagata R, Leonardson T, Chio V, Parhy B, Park S, Carlson M, Machhi S, Ulbrandt N, Falsey AR, Walsh EE, Wang CK, Esser MT, Zuo F.

PLoS One. 2016 Apr 12;11(4):e0153019. doi: 10.1371/journal.pone.0153019. eCollection 2016.


Provider Decisions to Treat Respiratory Illnesses with Antibiotics: Insights from a Randomized Controlled Trial.

Branche AR, Walsh EE, Jadhav N, Karmally R, Baran A, Peterson DR, Falsey AR.

PLoS One. 2016 Apr 4;11(4):e0152986. doi: 10.1371/journal.pone.0152986. eCollection 2016.


Improved immunogenicity of high-dose influenza vaccine compared to standard-dose influenza vaccine in adult oncology patients younger than 65 years receiving chemotherapy: A pilot randomized clinical trial.

Jamshed S, Walsh EE, Dimitroff LJ, Santelli JS, Falsey AR.

Vaccine. 2016 Jan 27;34(5):630-635. doi: 10.1016/j.vaccine.2015.12.037. Epub 2015 Dec 22.


Therapeutic Immunoglobulin Selected for High Antibody Titer to RSV also Contains High Antibody Titers to Other Respiratory Viruses.

Orange JS, Du W, Falsey AR.

Front Immunol. 2015 Aug 28;6:431. doi: 10.3389/fimmu.2015.00431. eCollection 2015.


Treatment with novel RSV Ig RI-002 controls viral replication and reduces pulmonary damage in immunocompromised Sigmodon hispidus.

Boukhvalova M, Blanco JC, Falsey AR, Mond J.

Bone Marrow Transplant. 2016 Jan;51(1):119-26. doi: 10.1038/bmt.2015.212. Epub 2015 Sep 14.


The Global Influenza Initiative recommendations for the vaccination of pregnant women against seasonal influenza.

Macias AE, Precioso AR, Falsey AR; Global Influenza Initiative.

Influenza Other Respir Viruses. 2015 Aug;9 Suppl 1:31-7. doi: 10.1111/irv.12320. Review.


Should clinical case definitions of influenza in hospitalized older adults include fever?

Falsey AR, Baran A, Walsh EE.

Influenza Other Respir Viruses. 2015 Aug;9 Suppl 1:23-9. doi: 10.1111/irv.12316.


Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.

Halliley JL, Tipton CM, Liesveld J, Rosenberg AF, Darce J, Gregoretti IV, Popova L, Kaminiski D, Fucile CF, Albizua I, Kyu S, Chiang KY, Bradley KT, Burack R, Slifka M, Hammarlund E, Wu H, Zhao L, Walsh EE, Falsey AR, Randall TD, Cheung WC, Sanz I, Lee FE.

Immunity. 2015 Jul 21;43(1):132-45. doi: 10.1016/j.immuni.2015.06.016. Epub 2015 Jul 14.


Addressing a challenge with a challenge. Investigating respiratory syncytial virus immunity with the human challenge model.

Falsey AR.

Am J Respir Crit Care Med. 2015 May 1;191(9):975-7. doi: 10.1164/rccm.201503-0471ED. No abstract available.


Serum Procalcitonin Measurement and Viral Testing to Guide Antibiotic Use for Respiratory Infections in Hospitalized Adults: A Randomized Controlled Trial.

Branche AR, Walsh EE, Vargas R, Hulbert B, Formica MA, Baran A, Peterson DR, Falsey AR.

J Infect Dis. 2015 Dec 1;212(11):1692-700. doi: 10.1093/infdis/jiv252. Epub 2015 Apr 24.


Respiratory syncytial virus infection in older adults: an under-recognized problem.

Branche AR, Falsey AR.

Drugs Aging. 2015 Apr;32(4):261-9. doi: 10.1007/s40266-015-0258-9.


Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans.

Lee AJ, Das SR, Wang W, Fitzgerald T, Pickett BE, Aevermann BD, Topham DJ, Falsey AR, Scheuermann RH.

J Virol. 2015 May;89(10):5427-40. doi: 10.1128/JVI.03636-14. Epub 2015 Mar 4.


Superiority of transcriptional profiling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults.

Suarez NM, Bunsow E, Falsey AR, Walsh EE, Mejias A, Ramilo O.

J Infect Dis. 2015 Jul 15;212(2):213-22. doi: 10.1093/infdis/jiv047. Epub 2015 Jan 29. Erratum in: J Infect Dis. 2015 Dec 15;212(12):2023.


Safety and immunogenicity of a quadrivalent intradermal influenza vaccine in adults.

Gorse GJ, Falsey AR, Ozol-Godfrey A, Landolfi V, Tsang PH.

Vaccine. 2015 Feb 25;33(9):1151-9. doi: 10.1016/j.vaccine.2015.01.025. Epub 2015 Jan 19.


Detection of respiratory viruses in sputum from adults by use of automated multiplex PCR.

Branche AR, Walsh EE, Formica MA, Falsey AR.

J Clin Microbiol. 2014 Oct;52(10):3590-6. doi: 10.1128/JCM.01523-14. Epub 2014 Jul 23.

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