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Items: 22


Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002.

Wuerth K, Lee AHY, Falsafi R, Gill EE, Hancock REW.

Infect Immun. 2018 Dec 19;87(1). pii: e00661-18. doi: 10.1128/IAI.00661-18. Print 2019 Jan.


Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility.

Sun E, Gill EE, Falsafi R, Yeung A, Liu S, Hancock REW.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00848-18. doi: 10.1128/AAC.00848-18. Print 2018 Sep.


Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection.

Wuerth KC, Falsafi R, Hancock REW.

PLoS One. 2017 Nov 6;12(11):e0187565. doi: 10.1371/journal.pone.0187565. eCollection 2017.


Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.

Yang H, Kozicky L, Saferali A, Fung SY, Afacan N, Cai B, Falsafi R, Gill E, Liu M, Kollmann TR, Hancock RE, Sly LM, Turvey SE.

Biomaterials. 2016 Dec;111:90-102. doi: 10.1016/j.biomaterials.2016.09.032. Epub 2016 Oct 3.


A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.

Hancock DG, Shklovskaya E, Guy TV, Falsafi R, Fjell CD, Ritchie W, Hancock RE, Fazekas de St Groth B.

PLoS One. 2014 Jun 20;9(6):e100613. doi: 10.1371/journal.pone.0100613. eCollection 2014.


Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation.

Pena OM, Afacan N, Pistolic J, Chen C, Madera L, Falsafi R, Fjell CD, Hancock RE.

PLoS One. 2013;8(1):e52449. doi: 10.1371/journal.pone.0052449. Epub 2013 Jan 7.


Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.

Mayer ML, Blohmke CJ, Falsafi R, Fjell CD, Madera L, Turvey SE, Hancock RE.

J Immunol. 2013 Feb 1;190(3):1227-38. doi: 10.4049/jimmunol.1201404. Epub 2012 Dec 21.


Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

Blohmke CJ, Mayer ML, Tang AC, Hirschfeld AF, Fjell CD, Sze MA, Falsafi R, Wang S, Hsu K, Chilvers MA, Hogg JC, Hancock RE, Turvey SE.

J Immunol. 2012 Dec 1;189(11):5467-75. doi: 10.4049/jimmunol.1103661. Epub 2012 Oct 26.


Time dependency and topography of hepatic nuclear factor κB activation after hemorrhagic shock and resuscitation in mice.

Korff S, Falsafi R, Czerny C, Jobin C, Nau C, Jakob H, Marzi I, Lehnert M.

Shock. 2012 Nov;38(5):486-92. doi: 10.1097/SHK.0b013e3182699072.


The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

Nijnik A, Pistolic J, Cho P, Filewod NC, Falsafi R, Ramin A, Harder KW, Hancock RE.

J Leukoc Biol. 2012 Apr;91(4):599-607. doi: 10.1189/jlb.0411191. Epub 2012 Jan 13.


The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility.

Lewenza S, Falsafi R, Bains M, Rohs P, Stupak J, Sprott GD, Hancock RE.

FEMS Microbiol Lett. 2011 Jul;320(2):95-102. doi: 10.1111/j.1574-6968.2011.02295.x. Epub 2011 May 11.


Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses.

Brown KL, Poon GF, Birkenhead D, Pena OM, Falsafi R, Dahlgren C, Karlsson A, Bylund J, Hancock RE, Johnson P.

J Immunol. 2011 May 1;186(9):5497-505. doi: 10.4049/jimmunol.1002508. Epub 2011 Mar 25.


Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.

Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Turvey S, Finlay BB, Speert DP, Hancock RE.

J Transl Med. 2010 Jan 27;8:6. doi: 10.1186/1479-5876-8-6.


G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9.

Gong JH, Nicholls EF, Elliott MR, Brown KL, Hokamp K, Roche FM, Cheung CY, Falsafi R, Brinkman FS, Bowdish DM, Hancock RE.

Cell Immunol. 2010;261(2):105-13. doi: 10.1016/j.cellimm.2009.11.007. Epub 2009 Dec 3.


Intracellular receptor for human host defense peptide LL-37 in monocytes.

Mookherjee N, Lippert DN, Hamill P, Falsafi R, Nijnik A, Kindrachuk J, Pistolic J, Gardy J, Miri P, Naseer M, Foster LJ, Hancock RE.

J Immunol. 2009 Aug 15;183(4):2688-96. doi: 10.4049/jimmunol.0802586. Epub 2009 Jul 15.


Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.

Mookherjee N, Hamill P, Gardy J, Blimkie D, Falsafi R, Chikatamarla A, Arenillas DJ, Doria S, Kollmann TR, Hancock RE.

Mol Biosyst. 2009 May;5(5):483-96. doi: 10.1039/b813787k. Epub 2009 Mar 19.


ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease.

Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott MR, Falsafi R, Hancock RE, Speert DP.

Clin Immunol. 2008 Oct;129(1):90-102. doi: 10.1016/j.clim.2008.06.005. Epub 2008 Jul 26.


The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.

Cosseau C, Devine DA, Dullaghan E, Gardy JL, Chikatamarla A, Gellatly S, Yu LL, Pistolic J, Falsafi R, Tagg J, Hancock RE.

Infect Immun. 2008 Sep;76(9):4163-75. doi: 10.1128/IAI.00188-08. Epub 2008 Jul 14.


Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide.

Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu JJ, Li Y, Veatch S, Roche FM, Brown KL, Brinkman FS, Hokamp K, Potter A, Babiuk LA, Griebel PJ, Hancock RE.

J Leukoc Biol. 2006 Dec;80(6):1563-74. Epub 2006 Aug 30.


Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37.

Mookherjee N, Brown KL, Bowdish DM, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, Powers JP, Bryan J, Brinkman FS, Hancock RE.

J Immunol. 2006 Feb 15;176(4):2455-64.


Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.

Lewenza S, Falsafi RK, Winsor G, Gooderham WJ, McPhee JB, Brinkman FS, Hancock RE.

Genome Res. 2005 Apr;15(4):583-9.


Effects of inositol trisphosphate on calcium mobilization in bone cells.

Falsafi R, Tatakis DN, Hagel-Bradway S, Dziak R.

Calcif Tissue Int. 1991 Nov;49(5):333-9.


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