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Items: 1 to 50 of 172

1.

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Halim TYF, Rana BMJ, Walker JA, Kerscher B, Knolle MD, Jolin HE, Serrao EM, Haim-Vilmovsky L, Teichmann SA, Rodewald HR, Botto M, Vyse TJ, Fallon PG, Li Z, Withers DR, McKenzie ANJ.

Immunity. 2018 Jun 19;48(6):1195-1207.e6. doi: 10.1016/j.immuni.2018.05.003. Epub 2018 Jun 12.

2.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

PMID:
29590092
3.

Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.

Vandeghinste N, Klattig J, Jagerschmidt C, Lavazais S, Marsais F, Haas JD, Auberval M, Lauffer F, Moran T, Ongenaert M, Van Balen M, Dupont S, Lepescheux L, Garcia T, Härtle S, Eyerich K, Fallon PG, Brys R, Steidl S.

J Invest Dermatol. 2018 Jul;138(7):1555-1563. doi: 10.1016/j.jid.2018.01.036. Epub 2018 Feb 21.

PMID:
29474945
4.

The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses.

Oleszycka E, McCluskey S, Sharp FA, Muñoz-Wolf N, Hams E, Gorman AL, Fallon PG, Lavelle EC.

Eur J Immunol. 2018 Apr;48(4):705-715. doi: 10.1002/eji.201747150. Epub 2018 Feb 15.

PMID:
29349774
5.

Helminth Modulation of Lung Inflammation.

Schwartz C, Hams E, Fallon PG.

Trends Parasitol. 2018 May;34(5):388-403. doi: 10.1016/j.pt.2017.12.007. Epub 2018 Jan 12. Review.

PMID:
29339033
6.

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance.

Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion A, O'Donnell JS.

Blood. 2018 Feb 22;131(8):911-916. doi: 10.1182/blood-2017-06-787853. Epub 2017 Dec 27.

PMID:
29282218
7.

Innate lymphoid cells and parasites: Ancient foes with shared history.

Neill DR, Fallon PG.

Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12513.

8.

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, Aid M, Tsui C, Maldonado P, Nair U, Ghneim K, Fallon PG, Sekaly RP, Barouch DH, Shalek AK, Bruckbauer A, Strid J, Batista FD.

Cell. 2018 Jan 25;172(3):517-533.e20. doi: 10.1016/j.cell.2017.11.036. Epub 2017 Dec 14.

9.

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC.

QJM. 2018 Apr 1;111(4):217-224. doi: 10.1093/qjmed/hcx243.

PMID:
29237089
10.

SIPPET: insights into factor VIII immunogenicity.

Fallon PG, Lavin M, O'Donnell JS.

J Thromb Haemost. 2018 Jan;16(1):36-38. doi: 10.1111/jth.13886. Epub 2017 Nov 18. No abstract available.

PMID:
29080389
11.

Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.

Floudas A, Cluxton CD, Fahel J, Khan AR, Saunders SP, Amu S, Alcami A, Fallon PG.

PLoS Negl Trop Dis. 2017 Oct 26;11(10):e0006012. doi: 10.1371/journal.pntd.0006012. eCollection 2017 Oct.

12.

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM.

Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013.

13.

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie ANJ, Fallon PG.

J Exp Med. 2017 Sep 4;214(9):2507-2521. doi: 10.1084/jem.20170051. Epub 2017 Jul 26.

14.

IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.

Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG.

J Immunol. 2017 Jul 15;199(2):707-717. doi: 10.4049/jimmunol.1602185. Epub 2017 Jun 14.

15.

Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis.

Fleury OM, McAleer MA, Feuillie C, Formosa-Dague C, Sansevere E, Bennett DE, Towell AM, McLean WHI, Kezic S, Robinson DA, Fallon PG, Foster TJ, Dufrêne YF, Irvine AD, Geoghegan JA.

Infect Immun. 2017 May 23;85(6). pii: e00994-16. doi: 10.1128/IAI.00994-16. Print 2017 Jun.

16.

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.

de Kleer IM, Kool M, de Bruijn MJ, Willart M, van Moorleghem J, Schuijs MJ, Plantinga M, Beyaert R, Hams E, Fallon PG, Hammad H, Hendriks RW, Lambrecht BN.

Immunity. 2016 Dec 20;45(6):1285-1298. doi: 10.1016/j.immuni.2016.10.031. Epub 2016 Dec 6.

17.

The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases.

Walsh PT, Fallon PG.

Ann N Y Acad Sci. 2018 Apr;1417(1):23-34. doi: 10.1111/nyas.13280. Epub 2016 Oct 26.

PMID:
27783881
18.

N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.

O'Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O'Donnell JS.

J Thromb Haemost. 2016 Dec;14(12):2446-2457. doi: 10.1111/jth.13537. Epub 2016 Dec 9.

PMID:
27732771
19.

Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year.

Kennedy EA, Connolly J, Hourihane JO, Fallon PG, McLean WHI, Murray D, Jo JH, Segre JA, Kong HH, Irvine AD.

J Allergy Clin Immunol. 2017 Jan;139(1):166-172. doi: 10.1016/j.jaci.2016.07.029. Epub 2016 Sep 5.

20.

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance.

Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS.

Blood. 2016 Oct 13;128(15):1959-1968. Epub 2016 Aug 23.

21.

Hypoxia-dependent regulation of inflammatory pathways in immune cells.

Taylor CT, Doherty G, Fallon PG, Cummins EP.

J Clin Invest. 2016 Oct 3;126(10):3716-3724. doi: 10.1172/JCI84433. Epub 2016 Jul 25. Review.

22.

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells.

Korniotis S, Gras C, Letscher H, Montandon R, Mégret J, Siegert S, Ezine S, Fallon PG, Luther SA, Fillatreau S, Zavala F.

Nat Commun. 2016 Jul 11;7:12134. doi: 10.1038/ncomms12134.

23.

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.

Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, Yang X, Nakamura M, Wang J, Zhuang R, Morikawa H, Xue Y, Braun H, Beyaert R, Samani N, Nakae S, Hams E, Dissing S, Fallon PG, Langer R, Cao Y.

Nat Commun. 2016 May 6;7:11385. doi: 10.1038/ncomms11385.

24.

New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression.

Floudas A, Amu S, Fallon PG.

J Clin Immunol. 2016 May;36 Suppl 1:25-33. doi: 10.1007/s10875-016-0263-8. Epub 2016 Mar 23. Review.

PMID:
27008462
25.

Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer.

Schwartz C, O'Grady K, Lavelle EC, Fallon PG.

Eur J Immunol. 2016 May;46(5):1091-100. doi: 10.1002/eji.201545780. Epub 2016 Apr 13. Review.

26.

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase.

Jarrett R, Salio M, Lloyd-Lavery A, Subramaniam S, Bourgeois E, Archer C, Cheung KL, Hardman C, Chandler D, Salimi M, Gutowska-Owsiak D, de la Serna JB, Fallon PG, Jolin H, Mckenzie A, Dziembowski A, Podobas EI, Bal W, Johnson D, Moody DB, Cerundolo V, Ogg G.

Sci Transl Med. 2016 Feb 10;8(325):325ra18. doi: 10.1126/scitranslmed.aad6833.

27.

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.

Russell SE, Horan RM, Stefanska AM, Carey A, Leon G, Aguilera M, Statovci D, Moran T, Fallon PG, Shanahan F, Brint EK, Melgar S, Hussey S, Walsh PT.

Mucosal Immunol. 2016 Sep;9(5):1193-204. doi: 10.1038/mi.2015.134. Epub 2016 Jan 27.

PMID:
26813344
28.

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN.

J Biol Chem. 2016 Jan 22;291(4):1604. doi: 10.1074/jbc.A112.371757. No abstract available.

29.

Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis.

Hams E, Bermingham R, Fallon PG.

Front Immunol. 2015 Nov 23;6:597. doi: 10.3389/fimmu.2015.00597. eCollection 2015. Review.

30.

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.

Halim TY, Hwang YY, Scanlon ST, Zaghouani H, Garbi N, Fallon PG, McKenzie AN.

Nat Immunol. 2016 Jan;17(1):57-64. doi: 10.1038/ni.3294. Epub 2015 Nov 2.

31.

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria.

O'Regan N, Gegenbauer K, O'Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O'Donnell JS.

Blood. 2016 Mar 3;127(9):1192-201. doi: 10.1182/blood-2015-07-654921. Epub 2015 Oct 28.

32.

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.

Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG.

FASEB J. 2016 Feb;30(2):824-35. doi: 10.1096/fj.15-277822. Epub 2015 Oct 21.

33.

Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation.

Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ.

Sci Transl Med. 2015 Sep 2;7(303):303ra140. doi: 10.1126/scitranslmed.aab3459.

PMID:
26333936
34.

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.

Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG.

J Allergy Clin Immunol. 2016 Feb;137(2):482-91. doi: 10.1016/j.jaci.2015.06.045. Epub 2015 Aug 20.

35.

Functional conservation of an ancestral Pellino protein in helminth species.

Cluxton CD, Caffrey BE, Kinsella GK, Moynagh PN, Fares MA, Fallon PG.

Sci Rep. 2015 Jun 29;5:11687. doi: 10.1038/srep11687.

36.

Bcl11b is essential for group 2 innate lymphoid cell development.

Walker JA, Oliphant CJ, Englezakis A, Yu Y, Clare S, Rodewald HR, Belz G, Liu P, Fallon PG, McKenzie AN.

J Exp Med. 2015 Jun 1;212(6):875-82. doi: 10.1084/jem.20142224. Epub 2015 May 11.

37.

Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer.

Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne KJ.

Mol Cancer. 2015 Feb 20;14:45. doi: 10.1186/s12943-015-0310-8.

38.

Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.

Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG.

Eur J Immunol. 2015 Jun;45(6):1842-54. doi: 10.1002/eji.201445211. Epub 2015 Apr 14.

39.

PD-L1hi B cells are critical regulators of humoral immunity.

Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG.

Nat Commun. 2015 Jan 22;6:5997. doi: 10.1038/ncomms6997.

PMID:
25609381
40.

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes.

MacLeod AK, Fallon PG, Sharp S, Henderson CJ, Wolf CR, Huang JT.

Mol Cell Proteomics. 2015 Mar;14(3):750-60. doi: 10.1074/mcp.M114.043661. Epub 2015 Jan 5.

41.

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.

Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN.

Immunity. 2014 Aug 21;41(2):283-95. doi: 10.1016/j.immuni.2014.06.016. Epub 2014 Jul 31.

42.

The alarmin IL-33 promotes regulatory T-cell function in the intestine.

Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BMJ, Löhning M, Belkaid Y, Fallon PG, Powrie F.

Nature. 2014 Sep 25;513(7519):564-568. doi: 10.1038/nature13577. Epub 2014 Jul 16.

43.

The generation of regulatory B cells by helminth parasites.

Khan AR, Amu S, Saunders SP, Fallon PG.

Methods Mol Biol. 2014;1190:143-62. doi: 10.1007/978-1-4939-1161-5_11.

PMID:
25015279
44.

Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.

Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC.

Aging Cell. 2014 Aug;13(4):699-708. doi: 10.1111/acel.12223. Epub 2014 May 12.

45.

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M.

Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616.

46.

MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.

Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG.

Am J Physiol Gastrointest Liver Physiol. 2014 May 1;306(9):G769-78. doi: 10.1152/ajpgi.00399.2013. Epub 2014 Mar 6.

47.

Btk regulates macrophage polarization in response to lipopolysaccharide.

Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA.

PLoS One. 2014 Jan 21;9(1):e85834. doi: 10.1371/journal.pone.0085834. eCollection 2014.

48.

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.

Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):367-72. doi: 10.1073/pnas.1315854111. Epub 2013 Dec 16.

49.

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.

Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, Huang LC, Johnson D, Scanlon ST, McKenzie AN, Fallon PG, Ogg GS.

J Exp Med. 2013 Dec 16;210(13):2939-50. doi: 10.1084/jem.20130351. Epub 2013 Dec 9.

50.

Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.

Hams E, Locksley RM, McKenzie AN, Fallon PG.

J Immunol. 2013 Dec 1;191(11):5349-53. doi: 10.4049/jimmunol.1301176. Epub 2013 Oct 28.

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