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Items: 1 to 50 of 145

1.

Toll-like receptors as novel therapeutic targets for herpes simplex virus infection.

Jahanban-Esfahlan R, Seidi K, Majidinia M, Karimian A, Yousefi B, Nabavi SM, Astani A, Berindan-Neagoe I, Gulei D, Fallarino F, Gargaro M, Manni G, Pirro M, Xu S, Sadeghi M, Nabavi SF, Shirooie S.

Rev Med Virol. 2019 Jul;29(4):e2048. doi: 10.1002/rmv.2048. Epub 2019 Jul 2. Review.

PMID:
31265195
2.

IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.

Panfili E, Mondanelli G, Orabona C, Bianchi R, Gargaro M, Fallarino F, Puccetti P, Grohmann U, Volpi C, Belladonna ML.

J Cell Mol Med. 2019 May;23(5):3757-3761. doi: 10.1111/jcmm.14215. Epub 2019 Feb 22.

3.

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.

Platten M, Nollen EAA, Röhrig UF, Fallarino F, Opitz CA.

Nat Rev Drug Discov. 2019 May;18(5):379-401. doi: 10.1038/s41573-019-0016-5. Review.

PMID:
30760888
4.

Targeting indoleamine-2,3-dioxygenase in cancer: Scientific rationale and clinical evidence.

Ricciuti B, Leonardi GC, Puccetti P, Fallarino F, Bianconi V, Sahebkar A, Baglivo S, Chiari R, Pirro M.

Pharmacol Ther. 2019 Apr;196:105-116. doi: 10.1016/j.pharmthera.2018.12.004. Epub 2018 Dec 4. Review.

PMID:
30521884
5.

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration.

Meliani A, Boisgerault F, Hardet R, Marmier S, Collaud F, Ronzitti G, Leborgne C, Costa Verdera H, Simon Sola M, Charles S, Vignaud A, van Wittenberghe L, Manni G, Christophe O, Fallarino F, Roy C, Michaud A, Ilyinskii P, Kishimoto TK, Mingozzi F.

Nat Commun. 2018 Oct 5;9(1):4098. doi: 10.1038/s41467-018-06621-3.

6.

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

Romani L, Oikonomou V, Moretti S, Iannitti RG, D'Adamo MC, Villella VR, Pariano M, Sforna L, Borghi M, Bellet MM, Fallarino F, Pallotta MT, Servillo G, Ferrari E, Puccetti P, Kroemer G, Pessia M, Maiuri L, Goldstein AL, Garaci E.

Nat Med. 2018 Sep;24(9):1482. doi: 10.1038/s41591-018-0099-2.

PMID:
29934535
7.

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

Romani L, Oikonomou V, Moretti S, Iannitti RG, D'Adamo MC, Villella VR, Pariano M, Sforna L, Borghi M, Bellet MM, Fallarino F, Pallotta MT, Servillo G, Ferrari E, Puccetti P, Kroemer G, Pessia M, Maiuri L, Goldstein AL, Garaci E.

Nat Med. 2018 Sep;24(9):1481. doi: 10.1038/s41591-018-0100-0.

PMID:
29934534
8.

S1P promotes migration, differentiation and immune regulatory activity in amniotic-fluid-derived stem cells.

Romani R, Manni G, Donati C, Pirisinu I, Bernacchioni C, Gargaro M, Pirro M, Calvitti M, Bagaglia F, Sahebkar A, Clerici G, Matino D, Pomili G, Di Renzo GC, Talesa VN, Puccetti P, Fallarino F.

Eur J Pharmacol. 2018 Aug 15;833:173-182. doi: 10.1016/j.ejphar.2018.06.005. Epub 2018 Jun 7.

9.

IL-35, a hallmark of immune-regulation in cancer progression, chronic infections and inflammatory diseases.

Teymouri M, Pirro M, Fallarino F, Gargaro M, Sahebkar A.

Int J Cancer. 2018 Nov 1;143(9):2105-2115. doi: 10.1002/ijc.31382. Epub 2018 Mar 31. Review.

PMID:
29574719
10.

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U.

JCI Insight. 2018 Mar 22;3(6). pii: 96244. doi: 10.1172/jci.insight.96244.

11.

Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.

Volpi C, Fallarino F, Mondanelli G, Macchiarulo A, Grohmann U.

Expert Opin Drug Discov. 2018 May;13(5):411-423. doi: 10.1080/17460441.2018.1443076. Epub 2018 Feb 28. Review.

PMID:
29486616
12.

Targeting metabotropic glutamate receptors for the treatment of neuroinflammation.

Fazio F, Ulivieri M, Volpi C, Gargaro M, Fallarino F.

Curr Opin Pharmacol. 2018 Feb;38:16-23. doi: 10.1016/j.coph.2018.01.010. Epub 2018 Feb 19. Review.

PMID:
29471184
13.

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

Battino M, Giampieri F, Pistollato F, Sureda A, de Oliveira MR, Pittalà V, Fallarino F, Nabavi SF, Atanasov AG, Nabavi SM.

Biotechnol Adv. 2018 Mar - Apr;36(2):358-370. doi: 10.1016/j.biotechadv.2017.12.012. Epub 2017 Dec 22. Review.

PMID:
29277308
14.

Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist.

Dolciami D, Gargaro M, Cerra B, Scalisi G, Bagnoli L, Servillo G, Fazia MAD, Puccetti P, Quintana FJ, Fallarino F, Macchiarulo A.

ChemMedChem. 2018 Feb 6;13(3):270-279. doi: 10.1002/cmdc.201700669. Epub 2018 Jan 23.

PMID:
29266750
15.

Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells.

Bianconi V, Fallarino F, Mannarino MR, Bagaglia F, Kararoudi MN, Aragona CO, Romani R, Pirro M.

Curr Med Chem. 2018;25(35):4518-4534. doi: 10.2174/0929867324666171012111603. Review.

PMID:
29022506
16.

Interaction of 7-Alkoxycoumarins with the Aryl Hydrocarbon Receptor.

Gargaro M, Epifano F, Fiorito S, Taddeo VA, Genovese S, Pirro M, Turco A, Puccetti P, Schmidt-Weber CB, Fallarino F.

J Nat Prod. 2017 Jun 23;80(6):1939-1943. doi: 10.1021/acs.jnatprod.7b00173. Epub 2017 May 19.

PMID:
28525281
17.

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes.

Mondanelli G, Albini E, Pallotta MT, Volpi C, Chatenoud L, Kuhn C, Fallarino F, Matino D, Belladonna ML, Bianchi R, Vacca C, Bicciato S, Boon L, Ricci G, Grohmann U, Puccetti P, Orabona C.

Front Immunol. 2017 Apr 13;8:428. doi: 10.3389/fimmu.2017.00428. eCollection 2017.

18.

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

Romani L, Oikonomou V, Moretti S, Iannitti RG, D'Adamo MC, Villella VR, Pariano M, Sforna L, Borghi M, Bellet MM, Fallarino F, Pallotta MT, Servillo G, Ferrari E, Puccetti P, Kroemer G, Pessia M, Maiuri L, Goldstein AL, Garaci E.

Nat Med. 2017 May;23(5):590-600. doi: 10.1038/nm.4305. Epub 2017 Apr 10. Erratum in: Nat Med. 2018 Sep;24(9):1481. Nat Med. 2018 Sep;24(9):1482.

19.

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis.

Crooks J, Gargaro M, Vacca C, Volpi C, Pirro M, Scalisi G, Turco A, Romani R, Matino D, Rostami A, Puccetti P, Gran B, Fallarino F.

Mediators Inflamm. 2017;2017:1380615. doi: 10.1155/2017/1380615. Epub 2017 Mar 5.

20.

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U.

Immunity. 2017 Feb 21;46(2):233-244. doi: 10.1016/j.immuni.2017.01.005. Epub 2017 Feb 14.

21.

PCSK9 at the crossroad of cholesterol metabolism and immune function during infections.

Paciullo F, Fallarino F, Bianconi V, Mannarino MR, Sahebkar A, Pirro M.

J Cell Physiol. 2017 Sep;232(9):2330-2338. doi: 10.1002/jcp.25767. Epub 2017 Jan 31. Review.

PMID:
28063230
22.

Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.

Moretti S, Menicali E, Nucci N, Voce P, Colella R, Melillo RM, Liotti F, Morelli S, Fallarino F, Macchiarulo A, Santoro M, Avenia N, Puxeddu E.

J Biol Chem. 2017 Feb 3;292(5):1785-1797. doi: 10.1074/jbc.M116.745448. Epub 2016 Dec 19.

23.

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

Albini E, Rosini V, Gargaro M, Mondanelli G, Belladonna ML, Pallotta MT, Volpi C, Fallarino F, Macchiarulo A, Antognelli C, Bianchi R, Vacca C, Puccetti P, Grohmann U, Orabona C.

J Cell Mol Med. 2017 Jan;21(1):165-176. doi: 10.1111/jcmm.12954. Epub 2016 Sep 30.

24.

Xenograft of microencapsulated Sertoli cells restores glucose homeostasis in db/db mice with spontaneous diabetes mellitus.

Luca G, Arato I, Mancuso F, Calvitti M, Falabella G, Murdolo G, Basta G, Cameron DF, Hansen BC, Fallarino F, Baroni T, Aglietti MC, Tortoioli C, Bodo M, Calafiore R.

Xenotransplantation. 2016 Nov;23(6):429-439. doi: 10.1111/xen.12274. Epub 2016 Sep 27.

PMID:
27678013
25.

Effects of a nutraceutical combination on lipids, inflammation and endothelial integrity in patients with subclinical inflammation: a randomized clinical trial.

Pirro M, Mannarino MR, Ministrini S, Fallarino F, Lupattelli G, Bianconi V, Bagaglia F, Mannarino E.

Sci Rep. 2016 Mar 23;6:23587. doi: 10.1038/srep23587.

26.

IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.

Put K, Brisse E, Avau A, Imbrechts M, Mitera T, Janssens R, Proost P, Fallarino F, Wouters CH, Matthys P.

PLoS One. 2016 Feb 25;11(2):e0150075. doi: 10.1371/journal.pone.0150075. eCollection 2016.

27.

Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE.

Fallarino F, Gargaro M, Mondanell G, Downer EJ, Hossain MJ, Gran B.

Methods Mol Biol. 2016;1390:383-411. doi: 10.1007/978-1-4939-3335-8_23.

PMID:
26803641
28.

Effects of intraperitoneal injection of microencapsulated Sertoli cells on chronic and presymptomatic dystrophic mice.

Chiappalupi S, Luca G, Mancuso F, Madaro L, Fallarino F, Nicoletti C, Calvitti M, Arato I, Falabella G, Salvadori L, Di Meo A, Bufalari A, Giovagnoli S, Calafiore R, Donato R, Sorci G.

Data Brief. 2015 Nov 15;5:1015-21. doi: 10.1016/j.dib.2015.11.016. eCollection 2015 Dec.

29.

Aryl Hydrocarbon Receptor-Dependent Pathways in Immune Regulation.

Gargaro M, Pirro M, Romani R, Zelante T, Fallarino F.

Am J Transplant. 2016 Aug;16(8):2270-6. doi: 10.1111/ajt.13716. Epub 2016 Mar 10. Review.

30.

Intraperitoneal injection of microencapsulated Sertoli cells restores muscle morphology and performance in dystrophic mice.

Chiappalupi S, Luca G, Mancuso F, Madaro L, Fallarino F, Nicoletti C, Calvitti M, Arato I, Falabella G, Salvadori L, Di Meo A, Bufalari A, Giovagnoli S, Calafiore R, Donato R, Sorci G.

Biomaterials. 2016 Jan;75:313-326. doi: 10.1016/j.biomaterials.2015.10.029. Epub 2015 Oct 23.

PMID:
26523508
31.

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.

Volpi C, Mondanelli G, Pallotta MT, Vacca C, Iacono A, Gargaro M, Albini E, Bianchi R, Belladonna ML, Celanire S, Mordant C, Heroux M, Royer-Urios I, Schneider M, Vitte PA, Cacquevel M, Galibert L, Poli SM, Solari A, Bicciato S, Calvitti M, Antognelli C, Puccetti P, Orabona C, Fallarino F, Grohmann U.

Neuropharmacology. 2016 Mar;102:59-71. doi: 10.1016/j.neuropharm.2015.10.036. Epub 2015 Oct 30.

32.

Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype.

Amantea D, Certo M, Petrelli F, Tassorelli C, Micieli G, Corasaniti MT, Puccetti P, Fallarino F, Bagetta G.

Exp Neurol. 2016 Jan;275 Pt 1:116-25. doi: 10.1016/j.expneurol.2015.10.012. Epub 2015 Oct 27.

PMID:
26518285
33.

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

Matino D, Gargaro M, Santagostino E, Di Minno MN, Castaman G, Morfini M, Rocino A, Mancuso ME, Di Minno G, Coppola A, Talesa VN, Volpi C, Vacca C, Orabona C, Iannitti R, Mazzucconi MG, Santoro C, Tosti A, Chiappalupi S, Sorci G, Tagariello G, Belvini D, Radossi P, Landolfi R, Fuchs D, Boon L, Pirro M, Marchesini E, Grohmann U, Puccetti P, Iorio A, Fallarino F.

J Clin Invest. 2015 Oct 1;125(10):3766-81. doi: 10.1172/JCI81859. Epub 2015 Aug 31.

34.

Long-term stability, functional competence, and safety of microencapsulated specific pathogen-free neonatal porcine Sertoli cells: a potential product for cell transplant therapy.

Luca G, Mancuso F, Calvitti M, Arato I, Falabella G, Bufalari A, De Monte V, Tresoldi E, Nastruzzi C, Basta G, Fallarino F, Lilli C, Bellucci C, Baroni T, Aglietti MC, Giovagnoli S, Cameron DF, Bodo M, Calafiore R.

Xenotransplantation. 2015 Jul-Aug;22(4):273-83. doi: 10.1111/xen.12175. Epub 2015 Jul 2.

PMID:
26134468
35.

Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.

Puccetti P, Fallarino F, Italiano A, Soubeyran I, MacGrogan G, Debled M, Velasco V, Bodet D, Eimer S, Veldhoen M, Prendergast GC, Platten M, Bessede A, Guillemin GJ.

PLoS One. 2015 Apr 16;10(4):e0122046. doi: 10.1371/journal.pone.0122046. eCollection 2015.

36.

Comparative proteomic analysis of two distinct stem-cell populations from human amniotic fluid.

Romani R, Fallarino F, Pirisinu I, Calvitti M, Caselli A, Fiaschi T, Gamberi T, Matino D, Talesa VN, Donti E, Puccetti P, Modesti A, Magherini F.

Mol Biosyst. 2015 Jun;11(6):1622-32. doi: 10.1039/c5mb00018a. Epub 2015 Mar 26.

PMID:
25811139
37.

Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1.

Romani R, Pirisinu I, Calvitti M, Pallotta MT, Gargaro M, Bistoni G, Vacca C, Di Michele A, Orabona C, Rosati J, Pirro M, Giovagnoli S, Matino D, Prontera P, Rosi G, Grohmann U, Talesa VN, Donti E, Puccetti P, Fallarino F.

J Cell Mol Med. 2015 Jul;19(7):1593-605. doi: 10.1111/jcmm.12534. Epub 2015 Mar 17.

38.

Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ.

Put K, Avau A, Brisse E, Mitera T, Put S, Proost P, Bader-Meunier B, Westhovens R, Van den Eynde BJ, Orabona C, Fallarino F, De Somer L, Tousseyn T, Quartier P, Wouters C, Matthys P.

Rheumatology (Oxford). 2015 Aug;54(8):1507-17. doi: 10.1093/rheumatology/keu524. Epub 2015 Mar 12.

PMID:
25767156
39.

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

Sabatini S, Manfroni G, Barreca ML, Bauer SM, Gargaro M, Cannalire R, Astolfi A, Brea J, Vacca C, Pirro M, Massari S, Tabarrini O, Loza MI, Fallarino F, Laufer SA, Cecchetti V.

Chem Biol Drug Des. 2015 Oct;86(4):531-45. doi: 10.1111/cbdd.12516. Epub 2015 Feb 19.

PMID:
25589097
40.

Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis.

Zelante T, Iannitti RG, Fallarino F, Gargaro M, De Luca A, Moretti S, Bartoli A, Romani L.

Front Immunol. 2014 Dec 15;5:640. doi: 10.3389/fimmu.2014.00640. eCollection 2014. Review. No abstract available.

41.

In vitro cadmium effects on ECM gene expression in human bronchial epithelial cells.

Baroni T, Lilli C, Bellucci C, Luca G, Mancuso F, Fallarino F, Falabella G, Arato I, Calvitti M, Marinucci L, Muzi G, Dell'Omo M, Gambelunghe A, Bodo M.

Cytokine. 2015 Mar;72(1):9-16. doi: 10.1016/j.cyto.2014.12.002. Epub 2014 Dec 23.

PMID:
25541143
42.

AhR: far more than an environmental sensor.

Fallarino F, Romani L, Puccetti P.

Cell Cycle. 2014;13(17):2645-6. doi: 10.4161/15384101.2014.954219. No abstract available.

43.

Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR).

Nuti R, Gargaro M, Matino D, Dolciami D, Grohmann U, Puccetti P, Fallarino F, Macchiarulo A.

J Chem Inf Model. 2014 Dec 22;54(12):3373-83. doi: 10.1021/ci5005459. Epub 2014 Nov 21.

PMID:
25402742
44.

AhR-Mediated, Non-Genomic Modulation of IDO1 Function.

Pallotta MT, Fallarino F, Matino D, Macchiarulo A, Orabona C.

Front Immunol. 2014 Oct 15;5:497. doi: 10.3389/fimmu.2014.00497. eCollection 2014. Review.

45.

LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism.

Fallarino F, Pallotta MT, Matino D, Gargaro M, Orabona C, Vacca C, Mondanelli G, Allegrucci M, Boon L, Romani R, Talesa VN, Puccetti P, Grohmann U.

Immunobiology. 2015 Feb;220(2):315-21. doi: 10.1016/j.imbio.2014.09.017. Epub 2014 Sep 28.

PMID:
25278421
46.

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes.

Pallotta MT, Orabona C, Bianchi R, Vacca C, Fallarino F, Belladonna ML, Volpi C, Mondanelli G, Gargaro M, Allegrucci M, Talesa VN, Puccetti P, Grohmann U.

J Cell Mol Med. 2014 Oct;18(10):2082-91. doi: 10.1111/jcmm.12360. Epub 2014 Sep 12.

47.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P.

Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.

48.

Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice.

Bedke T, Iannitti RG, De Luca A, Giovannini G, Fallarino F, Berges C, Latgé JP, Einsele H, Romani L, Topp MS.

Immunol Cell Biol. 2014 Sep;92(8):659-70. doi: 10.1038/icb.2014.34. Epub 2014 May 13.

49.

NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells.

Bellet MM, Piobbico D, Bartoli D, Castelli M, Pieroni S, Brunacci C, Chiacchiaretta M, Del Sordo R, Fallarino F, Sidoni A, Puccetti P, Romani L, Servillo G, Della Fazia MA.

Cell Cycle. 2014;13(12):1902-11. doi: 10.4161/cc.28760. Epub 2014 Apr 17.

50.

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

Fazio F, Zappulla C, Notartomaso S, Busceti C, Bessede A, Scarselli P, Vacca C, Gargaro M, Volpi C, Allegrucci M, Lionetto L, Simmaco M, Belladonna ML, Nicoletti F, Fallarino F.

Neuropharmacology. 2014 Jun;81:237-43. doi: 10.1016/j.neuropharm.2014.02.011. Epub 2014 Feb 21.

PMID:
24565643

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