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Items: 45


Connexin-43 K63-polyubiquitylation on lysines 264 and 303 regulates gap junction internalization.

Kells-Andrews RM, Margraf RA, Fisher CG, Falk MM.

J Cell Sci. 2018 Aug 9;131(15). pii: jcs204321. doi: 10.1242/jcs.204321.


New bioactive glass scaffolds with exceptional qualities for bone tissue regeneration: response of osteoblasts and osteoclasts.

Kowal TJ, Hahn NC, Eider S, Marzillier JY, Fodera DM, Thamma U, Jain H, Falk MM.

Biomed Mater. 2018 Jan 24;13(2):025005. doi: 10.1088/1748-605X/aa9385.


Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover.

Thévenin AF, Margraf RA, Fisher CG, Kells-Andrews RM, Falk MM.

Mol Biol Cell. 2017 Dec 1;28(25):3595-3608. doi: 10.1091/mbc.E16-07-0496. Epub 2017 Oct 11.


Role of phase separation on the biological performance of 45S5 Bioglass®.

Kowal TJ, Golovchak R, Chokshi T, Harms J, Thamma U, Jain H, Falk MM.

J Mater Sci Mater Med. 2017 Sep 13;28(10):161. doi: 10.1007/s10856-017-5976-6.


Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions.

Falk MM, Bell CL, Kells Andrews RM, Murray SA.

BMC Cell Biol. 2016 May 24;17 Suppl 1:22. doi: 10.1186/s12860-016-0087-7. Review.


Primary cilia found on HeLa and other cancer cells.

Kowal TJ, Falk MM.

Cell Biol Int. 2015 Nov;39(11):1341-7. doi: 10.1002/cbin.10500. Epub 2015 Aug 6.


Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization.

Nimlamool W, Andrews RM, Falk MM.

Mol Biol Cell. 2015 Aug 1;26(15):2755-68. doi: 10.1091/mbc.E14-06-1105. Epub 2015 Jun 10.


EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368.

Fong JT, Nimlamool W, Falk MM.

FEBS Lett. 2014 Mar 3;588(5):836-44. doi: 10.1016/j.febslet.2014.01.048. Epub 2014 Jan 31.


Degradation of connexins and gap junctions.

Falk MM, Kells RM, Berthoud VM.

FEBS Lett. 2014 Apr 17;588(8):1221-9. doi: 10.1016/j.febslet.2014.01.031. Epub 2014 Jan 30. Review.


Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis.

Fong JT, Kells RM, Falk MM.

Mol Biol Cell. 2013 Sep;24(18):2834-48. doi: 10.1091/mbc.E13-02-0111. Epub 2013 Jul 24.


Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation.

Thévenin AF, Kowal TJ, Fong JT, Kells RM, Fisher CG, Falk MM.

Physiology (Bethesda). 2013 Mar;28(2):93-116. doi: 10.1152/physiol.00038.2012. Review.


Nanoporosity significantly enhances the biological performance of engineered glass tissue scaffolds.

Wang S, Kowal TJ, Marei MK, Falk MM, Jain H.

Tissue Eng Part A. 2013 Jul;19(13-14):1632-40. doi: 10.1089/ten.TEA.2012.0585. Epub 2013 Mar 26.


Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspective.

Falk MM, Fong JT, Kells RM, O'Laughlin MC, Kowal TJ, Thévenin AF.

J Membr Biol. 2012 Aug;245(8):465-76. Epub 2012 Jul 24. Review.


Internalized gap junctions are degraded by autophagy.

Fong JT, Kells RM, Gumpert AM, Marzillier JY, Davidson MW, Falk MM.

Autophagy. 2012 May 1;8(5):794-811. doi: 10.4161/auto.19390. Epub 2012 May 1.


Evaluation of 3D nano-macro porous bioactive glass scaffold for hard tissue engineering.

Wang S, Falk MM, Rashad A, Saad MM, Marques AC, Almeida RM, Marei MK, Jain H.

J Mater Sci Mater Med. 2011 May;22(5):1195-203. doi: 10.1007/s10856-011-4297-4. Epub 2011 Mar 29.


Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells.

Govindarajan R, Chakraborty S, Johnson KE, Falk MM, Wheelock MJ, Johnson KR, Mehta PP.

Mol Biol Cell. 2010 Dec;21(23):4089-107. doi: 10.1091/mbc.E10-05-0403. Epub 2010 Sep 29.


Adherens junctions remain dynamic.

Falk MM.

BMC Biol. 2010 Apr 8;8:34. doi: 10.1186/1741-7007-8-34.


E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells.

Chakraborty S, Mitra S, Falk MM, Caplan SH, Wheelock MJ, Johnson KR, Mehta PP.

J Biol Chem. 2010 Apr 2;285(14):10761-76. doi: 10.1074/jbc.M109.053348. Epub 2010 Jan 10.


Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles.

Falk MM, Baker SM, Gumpert AM, Segretain D, Buckheit RW 3rd.

Mol Biol Cell. 2009 Jul;20(14):3342-52. doi: 10.1091/mbc.E09-04-0288. Epub 2009 May 20.


Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen.

Gilleron J, Fiorini C, Carette D, Avondet C, Falk MM, Segretain D, Pointis G.

J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78. doi: 10.1242/jcs.033373. Epub 2008 Nov 25.


Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation.

Baker SM, Kim N, Gumpert AM, Segretain D, Falk MM.

FEBS Lett. 2008 Dec 10;582(29):4039-46. doi: 10.1016/j.febslet.2008.10.043. Epub 2008 Nov 4.


Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery.

Gumpert AM, Varco JS, Baker SM, Piehl M, Falk MM.

FEBS Lett. 2008 Aug 20;582(19):2887-92. doi: 10.1016/j.febslet.2008.07.024. Epub 2008 Jul 24.


Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels.

Iovine MK, Gumpert AM, Falk MM, Mendelson TC.

FEBS Lett. 2008 Jan 23;582(2):165-70. Epub 2007 Dec 7.


Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process.

Piehl M, Lehmann C, Gumpert A, Denizot JP, Segretain D, Falk MM.

Mol Biol Cell. 2007 Feb;18(2):337-47. Epub 2006 Nov 15.


Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes.

Eastman SD, Chen TH, Falk MM, Mendelson TC, Iovine MK.

Genomics. 2006 Feb;87(2):265-74. Epub 2005 Dec 7.


Regulation of connexin biosynthesis, assembly, gap junction formation, and removal.

Segretain D, Falk MM.

Biochim Biophys Acta. 2004 Mar 23;1662(1-2):3-21. Review.


Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43.

Lagree V, Brunschwig K, Lopez P, Gilula NB, Richard G, Falk MM.

J Cell Sci. 2003 Aug 1;116(Pt 15):3189-201.


Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells.

Lauf U, Giepmans BN, Lopez P, Braconnot S, Chen SC, Falk MM.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10446-51. Epub 2002 Jul 29.


Distribution and dynamics of gap junction channels revealed in living cells.

Lopez P, Balicki D, Buehler LK, Falk MM, Chen SC.

Cell Commun Adhes. 2001;8(4-6):237-42.


Gap junction protein connexin-43 interacts directly with microtubules.

Giepmans BN, Verlaan I, Hengeveld T, Janssen H, Calafat J, Falk MM, Moolenaar WH.

Curr Biol. 2001 Sep 4;11(17):1364-8.


Connexins/connexons. Cell-free expression.

Falk MM.

Methods Mol Biol. 2001;154:91-116. No abstract available.


Biosynthesis and structural composition of gap junction intercellular membrane channels.

Falk MM.

Eur J Cell Biol. 2000 Aug;79(8):564-74. Review.


Synthesis, assembly and structure of gap junction intercellular channels.

Yeager M, Unger VM, Falk MM.

Curr Opin Struct Biol. 1998 Aug;8(4):517-24. Review. Erratum in: Curr Opin Struct Biol 1998 Dec;8(6):810-1.


Cell-free synthesis and assembly of connexins into functional gap junction membrane channels.

Falk MM, Buehler LK, Kumar NM, Gilula NB.

EMBO J. 1997 May 15;16(10):2703-16.


Cell-free expression of a GFP fusion protein allows quantitation in vitro and in vivo.

Kahn TW, Beachy RN, Falk MM.

Curr Biol. 1997 Apr 1;7(4):R207-8. No abstract available.


Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA.

Zibert A, Maass G, Strebel K, Falk MM, Beck E.

J Virol. 1990 Jun;64(6):2467-73.


Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3.

Falk MM, Grigera PR, Bergmann IE, Zibert A, Multhaup G, Beck E.

J Virol. 1990 Feb;64(2):748-56.

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