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Five Priority Areas for Improving Medications Development for Alcohol Use Disorder and Promoting Their Routine Use in Clinical Practice.

Litten RZ, Falk DE, Ryan ML, Fertig J, Leggio L.

Alcohol Clin Exp Res. 2019 Nov 5. doi: 10.1111/acer.14233. [Epub ahead of print] No abstract available.


How Australopithecus provided insight into human evolution.

Falk D.

Nature. 2019 Nov;575(7781):41-42. doi: 10.1038/d41586-019-02839-3. No abstract available.


AAV Gene Therapy Utilizing Glycosylation-Independent Lysosomal Targeting Tagged GAA in the Hypoglossal Motor System of Pompe Mice.

Doyle BM, Turner SMF, Sunshine MD, Doerfler PA, Poirier AE, Vaught LA, Jorgensen ML, Falk DJ, Byrne BJ, Fuller DD.

Mol Ther Methods Clin Dev. 2019 Aug 31;15:194-203. doi: 10.1016/j.omtm.2019.08.009. eCollection 2019 Dec 13.


Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies.

Leggio L, Falk DE, Ryan ML, Fertig J, Litten RZ.

Handb Exp Pharmacol. 2019 Oct 19. doi: 10.1007/164_2019_295. [Epub ahead of print]


Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy.

Byrne BJ, Fuller DD, Smith BK, Clement N, Coleman K, Cleaver B, Vaught L, Falk DJ, McCall A, Corti M.

Ann Transl Med. 2019 Jul;7(13):290. doi: 10.21037/atm.2019.05.56. Review.


Response to Dr. Mark Litt's Commentary.

Anton RF, Witkiewitz K, Falk D, Litten R, Hasin D, Mann K, O'Malley S; Alcohol Clinical Trials Initiative (ACTIVE) Group.

Alcohol Clin Exp Res. 2019 Oct;43(10):2255-2256. doi: 10.1111/acer.14160. Epub 2019 Aug 26. No abstract available.


Fire, climate and changing forests.

Keeley JE, van Mantgem P, Falk DA.

Nat Plants. 2019 Aug;5(8):774-775. doi: 10.1038/s41477-019-0485-x. No abstract available.


Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy.

McCall AL, Stankov SG, Cowen G, Cloutier D, Zhang Z, Yang L, Clement N, Falk DJ, Byrne BJ.

Curr Gene Ther. 2019;19(3):197-207. doi: 10.2174/1566523219666190621113807.


More on Asperger's Career: A Reply to Czech.

Falk D.

J Autism Dev Disord. 2019 Sep;49(9):3877-3882. doi: 10.1007/s10803-019-04099-6.


Reduction in non-abstinent World Health Organization (WHO) drinking risk levels and drug use disorders: 3-year follow-up results in the US general population.

Knox J, Wall M, Witkiewitz K, Kranzler HR, Falk DE, Litten R, Mann K, O'Malley SS, Scodes J, Anton R, Hasin DS; Alcohol Clinical Trials (ACTIVE) Workgroup.

Drug Alcohol Depend. 2019 Aug 1;201:16-22. doi: 10.1016/j.drugalcdep.2019.03.020. Epub 2019 May 29.


Surgical complications associated with congestive heart failure in elderly patients following primary hip hemiarthroplasty for femoral neck fractures.

Lee R, Lee D, Gowda NB, Probasco WV, Ibrahim G, Falk DP, Pandarinath R.

Eur J Orthop Surg Traumatol. 2019 Aug;29(6):1253-1261. doi: 10.1007/s00590-019-02438-y. Epub 2019 Apr 30.


HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice.

Chittoor-Vinod VG, Bazick H, Todd AG, Falk D, Morelli KH, Burgess RW, Foster TC, Notterpek L.

ACS Chem Neurosci. 2019 Jun 19;10(6):2890-2902. doi: 10.1021/acschemneuro.9b00105. Epub 2019 May 3.


Do Adaptors Shorten the Battery Life of Nonrechargeable Generators for Deep Brain Stimulation?

Helmers AK, Birkenfeld F, Deuschl G, Paschen S, Cohrs G, Mehdorn HM, Falk D.

World Neurosurg. 2019 Jul;127:e65-e68. doi: 10.1016/j.wneu.2019.02.064. Epub 2019 Apr 8.


Maintenance of World Health Organization Risk Drinking Level Reductions and Posttreatment Functioning Following a Large Alcohol Use Disorder Clinical Trial.

Witkiewitz K, Falk DE, Litten RZ, Hasin DS, Kranzler HR, Mann KF, O'Malley SS, Anton RF.

Alcohol Clin Exp Res. 2019 May;43(5):979-987. doi: 10.1111/acer.14018. Epub 2019 Apr 5.


Non-complicit: Revisiting Hans Asperger's Career in Nazi-era Vienna.

Falk D.

J Autism Dev Disord. 2019 Mar 18. doi: 10.1007/s10803-019-03981-7. [Epub ahead of print]


Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials: A Secondary Analysis of 3 Randomized Clinical Trials.

Falk DE, O'Malley SS, Witkiewitz K, Anton RF, Litten RZ, Slater M, Kranzler HR, Mann KF, Hasin DS, Johnson B, Meulien D, Ryan M, Fertig J; Alcohol Clinical Trials Initiative (ACTIVE) Workgroup.

JAMA Psychiatry. 2019 Apr 1;76(4):374-381. doi: 10.1001/jamapsychiatry.2018.3079.


Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population.

Knox J, Scodes J, Wall M, Witkiewitz K, Kranzler HR, Falk D, Litten R, Mann K, O'Malley SS, Anton R, Hasin DS; Alcohol Clinical Trials (ACTIVE) Workgroup.

Drug Alcohol Depend. 2019 Apr 1;197:228-235. doi: 10.1016/j.drugalcdep.2019.01.009. Epub 2019 Feb 14.


Seasonal and drought-related changes in leaf area profiles depend on height and light environment in an Amazon forest.

Smith MN, Stark SC, Taylor TC, Ferreira ML, de Oliveira E, Restrepo-Coupe N, Chen S, Woodcock T, Dos Santos DB, Alves LF, Figueira M, de Camargo PB, de Oliveira RC, Aragão LEOC, Falk DA, McMahon SM, Huxman TE, Saleska SR.

New Phytol. 2019 May;222(3):1284-1297. doi: 10.1111/nph.15726. Epub 2019 Mar 9.


Managing the cancer-work interface: the effect of cancer survivorship on unemployment.

Tracy JK, Falk D, Thompson RJ, Scheindlin L, Adetunji F, Swanberg JE.

Cancer Manag Res. 2018 Nov 28;10:6479-6487. doi: 10.2147/CMAR.S180649. eCollection 2018.


A comparison of narcotic usage and length of post-operative hospital stay in open versus minimally invasive lumbar interbody fusion with percutaneous pedicle screws.

Vora D, Kinnard M, Falk D, Hoy M, Gupta S, Piper C, Yu W, Siddiqui F, O'Brien J.

J Spine Surg. 2018 Sep;4(3):516-521. doi: 10.21037/jss.2018.08.04.


White Matter Changes Along the Electrode Lead in Patients Treated With Deep Brain Stimulation.

Erasmi R, Granert O, Zorenkov D, Falk D, Wodarg F, Deuschl G, Witt K.

Front Neurol. 2018 Nov 21;9:983. doi: 10.3389/fneur.2018.00983. eCollection 2018.


Gabapentin Enacarbil Extended-Release for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled, Multisite Trial Assessing Efficacy and Safety.

Falk DE, Ryan ML, Fertig JB, Devine EG, Cruz R, Brown ES, Burns H, Salloum IM, Newport DJ, Mendelson J, Galloway G, Kampman K, Brooks C, Green AI, Brunette MF, Rosenthal RN, Dunn KE, Strain EC, Ray L, Shoptaw S, Ait-Daoud Tiouririne N, Gunderson EW, Ransom J, Scott C, Leggio L, Caras S, Mason BJ, Litten RZ; National Institute on Alcohol Abuse and Alcoholism Clinical Investigations Group (NCIG) Study Group.

Alcohol Clin Exp Res. 2019 Jan;43(1):158-169. doi: 10.1111/acer.13917. Epub 2018 Dec 9.


Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.

Witkiewitz K, Kranzler HR, Hallgren KA, O'Malley SS, Falk DE, Litten RZ, Hasin DS, Mann KF, Anton RF.

Alcohol Clin Exp Res. 2018 Dec;42(12):2453-2465. doi: 10.1111/acer.13897. Epub 2018 Nov 5.


Neurostimulation in tardive dystonia/dyskinesia: A delayed start, sham stimulation-controlled randomized trial.

Gruber D, Südmeyer M, Deuschl G, Falk D, Krauss JK, Mueller J, Müller JU, Poewe W, Schneider GH, Schrader C, Vesper J, Volkmann J, Winter C, Kupsch A, Schnitzler A; DBS study group for dystonia.

Brain Stimul. 2018 Nov - Dec;11(6):1368-1377. doi: 10.1016/j.brs.2018.08.006. Epub 2018 Sep 11.


Reduction in Nonabstinent WHO Drinking Risk Levels and Change in Risk for Liver Disease and Positive AUDIT-C Scores: Prospective 3-Year Follow-Up Results in the U.S. General Population.

Knox J, Wall M, Witkiewitz K, Kranzler HR, Falk D, Litten R, Mann K, O'Malley SS, Scodes J, Anton R, Hasin DS; Alcohol Clinical Trials (ACTIVE) Workgroup.

Alcohol Clin Exp Res. 2018 Nov;42(11):2256-2265. doi: 10.1111/acer.13884. Epub 2018 Oct 3.


Pre-fire drought and competition mediate post-fire conifer mortality in western U.S. National Parks.

van Mantgem PJ, Falk DA, Williams EC, Das AJ, Stephenson NL.

Ecol Appl. 2018 Oct;28(7):1730-1739. doi: 10.1002/eap.1778. Epub 2018 Aug 27.


Life-threatening DBS withdrawal syndrome in Parkinson's disease can be treated with early reimplantation.

Reuter S, Deuschl G, Berg D, Helmers A, Falk D, Witt K.

Parkinsonism Relat Disord. 2018 Nov;56:88-92. doi: 10.1016/j.parkreldis.2018.06.035. Epub 2018 Jul 2.


Patterning Highly Conducting Conjugated Polymer Electrodes for Soft and Flexible Microelectrochemical Devices.

Khaldi A, Falk D, Bengtsson K, Maziz A, Filippini D, Robinson ND, Jager EWH.

ACS Appl Mater Interfaces. 2018 May 2;10(17):14978-14985. doi: 10.1021/acsami.8b01059. Epub 2018 Apr 18.


Identification of in vivo Sulci on the External Surface of Eight Adult Chimpanzee Brains: Implications for Interpreting Early Hominin Endocasts.

Falk D, Zollikofer CPE, Ponce de León M, Semendeferi K, Alatorre Warren JL, Hopkins WD.

Brain Behav Evol. 2018;91(1):45-58. doi: 10.1159/000487248. Epub 2018 Mar 13.


Complications of Impulse Generator Exchange Surgery for Deep Brain Stimulation: A Single-Center, Retrospective Study.

Helmers AK, Lübbing I, Birkenfeld F, Witt K, Synowitz M, Mehdorn HM, Falk D.

World Neurosurg. 2018 May;113:e108-e112. doi: 10.1016/j.wneu.2018.01.183. Epub 2018 Feb 14.


A Mixed Methods Review of Education and Patient Navigation Interventions to Increase Breast and Cervical Cancer Screening for Rural Women.

Falk D.

Soc Work Public Health. 2018;33(3):173-186. doi: 10.1080/19371918.2018.1434583. Epub 2018 Feb 7. Review.


Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities.

May PA, Chambers CD, Kalberg WO, Zellner J, Feldman H, Buckley D, Kopald D, Hasken JM, Xu R, Honerkamp-Smith G, Taras H, Manning MA, Robinson LK, Adam MP, Abdul-Rahman O, Vaux K, Jewett T, Elliott AJ, Kable JA, Akshoomoff N, Falk D, Arroyo JA, Hereld D, Riley EP, Charness ME, Coles CD, Warren KR, Jones KL, Hoyme HE.

JAMA. 2018 Feb 6;319(5):474-482. doi: 10.1001/jama.2017.21896.


Advances in Pharmacotherapy Development: Human Clinical Studies.

Litten RZ, Falk DE, Ryan ML, Fertig J, Leggio L.

Handb Exp Pharmacol. 2018;248:579-613. doi: 10.1007/164_2017_79. Review.


Pathologic Tuft Fracture in a Thumb: A Rare Presentation of Metastatic Endometrioid Ovarian Carcinoma: A Case Report and Review of the Literature.

Falk DP, Scully R, Moss D, Shaffer M.

JBJS Case Connect. 2017 Jul-Sep;7(3):e50. doi: 10.2106/JBJS.CC.16.00261. Review.


Direct and indirect climate controls predict heterogeneous early-mid 21st century wildfire burned area across western and boreal North America.

Kitzberger T, Falk DA, Westerling AL, Swetnam TW.

PLoS One. 2017 Dec 15;12(12):e0188486. doi: 10.1371/journal.pone.0188486. eCollection 2017.


Comparison of the Battery Life of Nonrechargeable Generators for Deep Brain Stimulation.

Helmers AK, Lübbing I, Deuschl G, Witt K, Synowitz M, Mehdorn HM, Falk D.

Neuromodulation. 2018 Aug;21(6):593-596. doi: 10.1111/ner.12720. Epub 2017 Nov 3.


Mechanical Ventilation for Duchenne Muscular Dystrophy: Sinner or Saint?

Smith BK, Falk DJ.

Muscle Nerve. 2018 Mar;57(3):353-355. doi: 10.1002/mus.25986. Epub 2017 Dec 27. No abstract available.


Locomotor and skeletal muscle abnormalities in trembler J neuropathic mice.

Falk DJ, Galatas T, Todd AG, Soto EP, Harris AB, Notterpek L.

Muscle Nerve. 2018 Apr;57(4):664-671. doi: 10.1002/mus.25987. Epub 2017 Oct 24.


13C/31P MRS Metabolic Biomarkers of Disease Progression and Response to AAV Delivery of hGAA in a Mouse Model of Pompe Disease.

Baligand C, Todd AG, Lee-McMullen B, Vohra RS, Byrne BJ, Falk DJ, Walter GA.

Mol Ther Methods Clin Dev. 2017 Sep 8;7:42-49. doi: 10.1016/j.omtm.2017.09.002. eCollection 2017 Dec 15.


Intra-ventricular migration of a subcutaneous reservoir after neuroendoscopy.

Falk D, Pinsker MO, Mehdorn HM, Nabavi A.

Childs Nerv Syst. 2017 Dec;33(12):2079-2080. doi: 10.1007/s00381-017-3606-8. Epub 2017 Oct 3. No abstract available.


Movement-Related Activity of Human Subthalamic Neurons during a Reach-to-Grasp Task.

Pötter-Nerger M, Reese R, Steigerwald F, Heiden JA, Herzog J, Moll CKE, Hamel W, Ramirez-Pasos U, Falk D, Mehdorn M, Gerloff C, Deuschl G, Volkmann J.

Front Hum Neurosci. 2017 Sep 7;11:436. doi: 10.3389/fnhum.2017.00436. eCollection 2017.


A Neuron-Specific Gene Therapy Relieves Motor Deficits in Pompe Disease Mice.

Lee NC, Hwu WL, Muramatsu SI, Falk DJ, Byrne BJ, Cheng CH, Shih NC, Chang KL, Tsai LK, Chien YH.

Mol Neurobiol. 2018 Jun;55(6):5299-5309. doi: 10.1007/s12035-017-0763-4. Epub 2017 Sep 11.


Postinjection delirium/sedation syndrome in patients with schizophrenia receiving olanzapine long-acting injection: results from a large observational study.

Meyers KJ, Upadhyaya HP, Landry JL, Chhabra-Khanna R, Falk DM, Seetharama Rao B, Jones ME.

BJPsych Open. 2017 Aug 10;3(4):186-192. doi: 10.1192/bjpo.bp.116.004382. eCollection 2017 Jul.


Letter to Editor in Response to Johnson's Commentary (2017) on the Witkiewitz and Colleagues (2017) Article.

Litten RZ, Falk DE, O'Malley SS, Witkiewitz KA, Mann KF, Anton RF.

Alcohol Clin Exp Res. 2017 Jul;41(7):1381-1382. doi: 10.1111/acer.13411. Epub 2017 May 23. No abstract available.


Change in non-abstinent WHO drinking risk levels and alcohol dependence: a 3 year follow-up study in the US general population.

Hasin DS, Wall M, Witkiewitz K, Kranzler HR, Falk D, Litten R, Mann K, O'Malley SS, Scodes J, Robinson RL, Anton R; Alcohol Clinical Trials Initiative (ACTIVE) Workgroup.

Lancet Psychiatry. 2017 Jun;4(6):469-476. doi: 10.1016/S2215-0366(17)30130-X. Epub 2017 Apr 26.


The Acute Effects of Aerobic Exercise on the Functional Connectivity of Human Brain Networks.

Weng TB, Pierce GL, Darling WG, Falk D, Magnotta VA, Voss MW.

Brain Plast. 2017 Mar 28;2(2):171-190. doi: 10.3233/BPL-160039.


Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study.

Witkiewitz K, Wilson AD, Pearson MR, Hallgren KA, Falk DE, Litten RZ, Kranzler HR, Mann KF, Hasin DS, O'Malley SS, Anton RF.

Alcohol Clin Exp Res. 2017 May;41(5):1054-1062. doi: 10.1111/acer.13371. Epub 2017 Apr 5.


Intraoperative Thresholds for Capsular Stimulation Are Reliable for Chronic Pallidal Deep Brain Stimulation in Dystonia.

Reese R, Reich MM, Falk D, Deuschl G, Mehdorn HM, Volkmann J.

Stereotact Funct Neurosurg. 2017;95(2):79-85. doi: 10.1159/000452674. Epub 2017 Feb 16.


Differences Between Treatment-Seeking and Nontreatment-Seeking Alcohol-Dependent Research Participants: An Exploratory Analysis.

Rohn MC, Lee MR, Kleuter SB, Schwandt ML, Falk DE, Leggio L.

Alcohol Clin Exp Res. 2017 Feb;41(2):414-420. doi: 10.1111/acer.13304.


Posttreatment Low-Risk Drinking as a Predictor of Future Drinking and Problem Outcomes Among Individuals with Alcohol Use Disorders: A 9-Year Follow-Up.

Kline-Simon AH, Litten RZ, Weisner CM, Falk DE.

Alcohol Clin Exp Res. 2017 Mar;41(3):653-658. doi: 10.1111/acer.13334. Epub 2017 Feb 7.

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