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Items: 48


Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.

Eaton N, Drew C, Wieser J, Munday AD, Falet H.

Haematologica. 2019 Jul 11. pii: haematol.2019.218644. doi: 10.3324/haematol.2019.218644. [Epub ahead of print]


Singling out FLI1 in Paris-Trousseau syndrome.

Falet H.

Blood. 2017 Jun 29;129(26):3399-3401. doi: 10.1182/blood-2017-05-781252. No abstract available.


Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.

Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK.

Cardiovasc Res. 2017 Sep 1;113(11):1307-1317. doi: 10.1093/cvr/cvx071.


Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

Hoffmeister KM, Falet H.

Thromb Res. 2016 May;141 Suppl 2:S68-72. doi: 10.1016/S0049-3848(16)30370-X. Review.


Glycans and the platelet life cycle.

Li R, Hoffmeister KM, Falet H.

Platelets. 2016 Sep;27(6):505-11. doi: 10.3109/09537104.2016.1171304. Epub 2016 May 2. Review.


Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1164-73. doi: 10.1161/ATVBAHA.116.307461. Epub 2016 Apr 14.


Regulating billions of blood platelets: glycans and beyond.

Grozovsky R, Giannini S, Falet H, Hoffmeister KM.

Blood. 2015 Oct 15;126(16):1877-84. doi: 10.1182/blood-2015-01-569129. Epub 2015 Sep 1. Review.


Novel mechanisms of platelet clearance and thrombopoietin regulation.

Grozovsky R, Giannini S, Falet H, Hoffmeister KM.

Curr Opin Hematol. 2015 Sep;22(5):445-51. doi: 10.1097/MOH.0000000000000170. Review.


FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H.

Blood. 2015 Jul 2;126(1):80-8. doi: 10.1182/blood-2014-07-587600. Epub 2015 Apr 2.


Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2015 Mar 6;6:6507. doi: 10.1038/ncomms7507. No abstract available.


The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.

Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM.

Nat Med. 2015 Jan;21(1):47-54. doi: 10.1038/nm.3770. Epub 2014 Dec 8.


Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.

Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WH, Hoffmeister KM, Falet H.

Blood. 2015 Feb 5;125(6):1014-24. doi: 10.1182/blood-2014-07-587857. Epub 2014 Dec 2.


Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.

Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746. Erratum in: Nat Commun. 2015;6:6507. Heinze, Katrin [corrected to Heinze, Katrin G].


Post-translational arginylation as a novel regulator of platelet function.

Bender M, Falet H.

Haematologica. 2014 Mar;99(3):402-4. doi: 10.3324/haematol.2013.103119. No abstract available.


Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1.

Kim H, Falet H, Hoffmeister KM, Hartwig JH.

J Biol Chem. 2013 Nov 29;288(48):34352-63. doi: 10.1074/jbc.M113.459750. Epub 2013 Oct 16.


Sitosterolemia: platelets on high-sterol diet.

Falet H.

Blood. 2013 Oct 10;122(15):2534-5. doi: 10.1182/blood-2013-08-521153. No abstract available.


Platelet size: finding the right balance.

Falet H.

Blood. 2012 Mar 22;119(12):2702-3. doi: 10.1182/blood-2012-01-400754. No abstract available.


New insights into the versatile roles of platelet FlnA.

Falet H.

Platelets. 2013;24(1):1-5. doi: 10.3109/09537104.2011.654004. Epub 2012 Feb 28. Review.


B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.

Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD.

Blood. 2012 Mar 22;119(12):2819-28. doi: 10.1182/blood-2011-09-379412. Epub 2012 Feb 1.


Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.

Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM.

Blood. 2012 Feb 2;119(5):1263-73. doi: 10.1182/blood-2011-05-355628. Epub 2011 Nov 18.


Gelsolin-independent podosome formation in dendritic cells.

Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP.

PLoS One. 2011;6(7):e21615. doi: 10.1371/journal.pone.0021615. Epub 2011 Jul 11.


FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.

Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H.

Blood. 2011 Aug 25;118(8):2285-95. doi: 10.1182/blood-2011-04-348482. Epub 2011 Jun 7.


Novel clearance mechanisms of platelets.

Grozovsky R, Hoffmeister KM, Falet H.

Curr Opin Hematol. 2010 Nov;17(6):585-9. doi: 10.1097/MOH.0b013e32833e7561. Review.


A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.

Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH.

J Exp Med. 2010 Aug 30;207(9):1967-79. doi: 10.1084/jem.20100222. Epub 2010 Aug 16.


Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.

Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH.

Blood. 2009 Nov 19;114(21):4729-37. doi: 10.1182/blood-2009-02-202721. Epub 2009 Aug 19.


Differential stimulation of monocytic cells results in distinct populations of microparticles.

Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD.

J Thromb Haemost. 2009 Jun;7(6):1019-28. doi: 10.1111/j.1538-7836.2009.03434.x.


Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function.

Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16263-8. Epub 2005 Oct 27.


Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics.

Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH.

Am J Physiol Cell Physiol. 2005 Oct;289(4):C819-25. Epub 2005 May 18.


WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.

Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS.

J Exp Med. 2004 Feb 2;199(3):357-68.


Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.

Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS.

Int Immunol. 2003 Dec;15(12):1431-40.


Platelet moesin interacts with PECAM-1 (CD31).

Gamulescu MA, Seifert K, Tingart M, Falet H, Hoffmeister KM.

Platelets. 2003 Jun;14(4):211-7.


Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change.

Barkalow KL, Falet H, Italiano JE Jr, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH.

Am J Physiol Cell Physiol. 2003 Oct;285(4):C797-805. Epub 2003 Jun 4.


Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells.

Kettner A, Pivniouk V, Kumar L, Falet H, Lee JS, Mulligan R, Geha RS.

Mol Cell Biol. 2003 Apr;23(7):2395-406.


Mechanisms and implications of platelet discoid shape.

Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA.

Blood. 2003 Jun 15;101(12):4789-96. Epub 2003 Feb 13.


The clearance mechanism of chilled blood platelets.

Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH.

Cell. 2003 Jan 10;112(1):87-97.


Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants.

Michaud SE, Wang LZ, Korde N, Bucki R, Randhawa PK, Pastore JJ, Falet H, Hoffmeister K, Kuuse R, Uibo R, Herod J, Sawyer E, Janmey PA.

Thromb Res. 2002 Sep 1;107(5):245-54.


Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.

Falet H, Hoffmeister KM, Neujahr R, Italiano JE Jr, Stossel TP, Southwick FS, Hartwig JH.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16782-7. Epub 2002 Dec 3.


Normal Arp2/3 complex activation in platelets lacking WASp.

Falet H, Hoffmeister KM, Neujahr R, Hartwig JH.

Blood. 2002 Sep 15;100(6):2113-22.


Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells.

Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP.

J Cell Biol. 2001 Nov 12;155(4):511-7. Epub 2001 Nov 12.


Mechanisms of cold-induced platelet actin assembly.

Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH.

J Biol Chem. 2001 Jul 6;276(27):24751-9. Epub 2001 Apr 27.


Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway.

Pain S, Falet H, Saci A, Bachelot-Loza C, Rendu F.

Cell Signal. 2000 Mar;12(3):165-71.


Calpain controls the balance between protein tyrosine kinase and tyrosine phosphatase activities during platelet activation.

Pain S, Monstero-Lastres A, Falet H, Brohard-Bohn B, Fraiz N, Bachelot-Loza C, Cano E, Rendu F.

FEBS Lett. 1999 Jun 18;453(1-2):119-23.


Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain.

Falet H, Pain S, Rendu F.

Biochem Biophys Res Commun. 1998 Nov 9;252(1):51-5.


Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets.

Falet H, Ramos-Morales F, Bachelot C, Fischer S, Rendu F.

FEBS Lett. 1996 Apr 1;383(3):165-9.


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