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Obesity-associated breast inflammation among Hispanic/Latina breast cancer patients.

Greenlee H, Shi Z, Hibshoosh H, Giri DD, Ahmed A, Williams S, Falcone DJ, Winston LA, Zhou XK, Hudis CA, Hershman DL, Dannenberg AJ, Iyengar NM.

Cancer Prev Res (Phila). 2018 Nov 7. pii: canprevres.0207.2018. doi: 10.1158/1940-6207.CAPR-18-0207. [Epub ahead of print]


FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation.

Wellberg EA, Kabos P, Gillen AE, Jacobsen BM, Brechbuhl HM, Johnson SJ, Rudolph MC, Edgerton SM, Thor AD, Anderson SM, Elias A, Zhou XK, Iyengar NM, Morrow M, Falcone DJ, El-Hely O, Dannenberg AJ, Sartorius CA, MacLean PS.

JCI Insight. 2018 Jul 25;3(14). pii: 120594. doi: 10.1172/jci.insight.120594. [Epub ahead of print]


Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice.

Miyazawa M, Subbaramaiah K, Bhardwaj P, Zhou XK, Wang H, Falcone DJ, Giri DD, Dannenberg AJ.

Cancer Prev Res (Phila). 2018 Apr;11(4):215-226. doi: 10.1158/1940-6207.CAPR-17-0296. Epub 2017 Dec 8.


Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women.

Iyengar NM, Chen IC, Zhou XK, Giri DD, Falcone DJ, Winston LA, Wang H, Williams S, Lu YS, Hsueh TH, Cheng AL, Hudis CA, Lin CH, Dannenberg AJ.

Cancer Prev Res (Phila). 2018 Apr;11(4):227-236. doi: 10.1158/1940-6207.CAPR-17-0283. Epub 2017 Dec 8.


Periprostatic adipose inflammation is associated with high-grade prostate cancer.

Gucalp A, Iyengar NM, Zhou XK, Giri DD, Falcone DJ, Wang H, Williams S, Krasne MD, Yaghnam I, Kunzel B, Morris PG, Jones LW, Pollak M, Laudone VP, Hudis CA, Scher HI, Scardino PT, Eastham JA, Dannenberg AJ.

Prostate Cancer Prostatic Dis. 2017 Dec;20(4):418-423. doi: 10.1038/pcan.2017.31. Epub 2017 Jun 27.


Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers.

Brown KA, Iyengar NM, Zhou XK, Gucalp A, Subbaramaiah K, Wang H, Giri DD, Morrow M, Falcone DJ, Wendel NK, Winston LA, Pollak M, Dierickx A, Hudis CA, Dannenberg AJ.

J Clin Endocrinol Metab. 2017 May 1;102(5):1692-1701. doi: 10.1210/jc.2016-3606.


Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index.

Iyengar NM, Brown KA, Zhou XK, Gucalp A, Subbaramaiah K, Giri DD, Zahid H, Bhardwaj P, Wendel NK, Falcone DJ, Wang H, Williams S, Pollak M, Morrow M, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2017 Apr;10(4):235-243. doi: 10.1158/1940-6207.CAPR-16-0314. Epub 2017 Mar 7.


Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE.

Diabetes. 2016 Jun;65(6):1577-89. doi: 10.2337/db15-1128. Epub 2016 Mar 25.


Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.

Haka AS, Barbosa-Lorenzi VC, Lee HJ, Falcone DJ, Hudis CA, Dannenberg AJ, Maxfield FR.

J Lipid Res. 2016 Jun;57(6):980-92. doi: 10.1194/jlr.M064089. Epub 2016 Apr 4.


Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice.

Bhardwaj P, Du B, Zhou XK, Sue E, Giri D, Harbus MD, Falcone DJ, Hudis CA, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2015 Aug;8(8):751-9. doi: 10.1158/1940-6207.CAPR-15-0082. Epub 2015 Jun 2.


Menopause is a determinant of breast adipose inflammation.

Iyengar NM, Morris PG, Zhou XK, Gucalp A, Giri D, Harbus MD, Falcone DJ, Krasne MD, Vahdat LT, Subbaramaiah K, Morrow M, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2015 May;8(5):349-58. doi: 10.1158/1940-6207.CAPR-14-0243. Epub 2015 Feb 26.


IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages.

Kothari P, Pestana R, Mesraoua R, Elchaki R, Khan KM, Dannenberg AJ, Falcone DJ.

J Immunol. 2014 Jan 1;192(1):349-57. doi: 10.4049/jimmunol.1301906. Epub 2013 Nov 27.


Caloric restriction reverses obesity-induced mammary gland inflammation in mice.

Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2013 Apr;6(4):282-9. doi: 10.1158/1940-6207.CAPR-12-0467. Epub 2013 Feb 19.


The annexin A2/S100A10 system in health and disease: emerging paradigms.

Hedhli N, Falcone DJ, Huang B, Cesarman-Maus G, Kraemer R, Zhai H, Tsirka SE, Santambrogio L, Hajjar KA.

J Biomed Biotechnol. 2012;2012:406273. doi: 10.1155/2012/406273. Epub 2012 Oct 14. Review.


ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.

Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, Hempstead BL.

J Exp Med. 2012 Nov 19;209(12):2291-305. doi: 10.1084/jem.20111749. Epub 2012 Oct 22.


Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-α and the EP4 prostanoid receptor.

Khan KM, Kothari P, Du B, Dannenberg AJ, Falcone DJ.

J Immunol. 2012 Feb 15;188(4):1970-80. doi: 10.4049/jimmunol.1102383. Epub 2012 Jan 6.


Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer.

Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila). 2011 Jul;4(7):1021-9. doi: 10.1158/1940-6207.CAPR-11-0110. Epub 2011 May 27.


Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.

Hou Z, Falcone DJ, Subbaramaiah K, Dannenberg AJ.

Carcinogenesis. 2011 May;32(5):695-702. doi: 10.1093/carcin/bgr027. Epub 2011 Feb 10.


Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2.

Steenport M, Khan KM, Du B, Barnhard SE, Dannenberg AJ, Falcone DJ.

J Immunol. 2009 Dec 15;183(12):8119-27. doi: 10.4049/jimmunol.0901925.


Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: evidence for an epidermal growth factor receptor dependent mechanism.

Du B, Leung H, Khan KM, Miller CG, Subbaramaiah K, Falcone DJ, Dannenberg AJ.

Cancer Res. 2007 Sep 15;67(18):8966-72.


Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages.

Pavlovic S, Du B, Sakamoto K, Khan KM, Natarajan C, Breyer RM, Dannenberg AJ, Falcone DJ.

J Biol Chem. 2006 Feb 10;281(6):3321-8. Epub 2005 Dec 7.


Extracellular matrix-induced cyclooxygenase-2 regulates macrophage proteinase expression.

Khan KM, Howe LR, Falcone DJ.

J Biol Chem. 2004 May 21;279(21):22039-46. Epub 2004 Mar 15.


Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages.

Brownstein C, Deora AB, Jacovina AT, Weintraub R, Gertler M, Khan KM, Falcone DJ, Hajjar KA.

Blood. 2004 Jan 1;103(1):317-24. Epub 2003 Sep 22.


Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload.

Borer JS, Truter S, Herrold EM, Falcone DJ, Pena M, Carter JN, Dumlao TF, Lee JA, Supino PG.

Circulation. 2002 Apr 16;105(15):1837-42.


Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression.

Faisal Khan KM, Laurie GW, McCaffrey TA, Falcone DJ.

J Biol Chem. 2002 Apr 19;277(16):13778-86. Epub 2002 Feb 4.


A mediator of cell surface-specific plasmin generation.

Brownstein C, Falcone DJ, Jacovina A, Hajjar KA.

Ann N Y Acad Sci. 2001 Dec;947:143-55; discussion 155-6.


Macrophage formation of angiostatin during inflammation. A byproduct of the activation of plasminogen.

Falcone DJ, Khan KM, Layne T, Fernandes L.

J Biol Chem. 1998 Nov 20;273(47):31480-5.


Health care reform? An American obsession with prescriptive incrementalism.

Broyles RW, Falcone DJ.

J Health Hum Serv Adm. 1996 Winter;18(3):328-52.


Roles of hospital administrators in South Carolina.

Brandt EN Jr, Broyles RW, Falcone DJ.

Hosp Health Serv Adm. 1996 Fall;41(3):373-84.


Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries.

McCaffrey TA, Pomerantz KB, Sanborn TA, Spokojny AM, Du B, Park MH, Folk JE, Lamberg A, Kivirikko KI, Falcone DJ, et al.

J Clin Invest. 1995 Feb;95(2):446-55.


Regulation of macrophage receptor-bound plasmin by autoproteolysis.

Falcone DJ, Borth W, McCaffrey TA, Mathew J, McAdam K.

J Biol Chem. 1994 Dec 23;269(51):32660-6.


Progress toward Healthy People 2000: a preliminary look at Oklahoma.

Brandt EN Jr, Broyles RW, Falcone DJ, Hann NE.

J Okla State Med Assoc. 1994 Dec;87(12):555-8.


Alpha 2-macroglobulin/transforming growth factor-beta 1 interactions. Modulation by heparin-like molecules and effects on vascular smooth muscle cells.

McCaffrey TA, Falcone DJ, Borth W, Weksler BB.

Ann N Y Acad Sci. 1994 Sep 10;737:368-82. No abstract available.


Local factors affecting the tendency to bypass local hospitals for inpatient mental health care: an exploratory analysis.

Goldsteen RL, Falcone DJ, Broyles RW, Goldsteen K, Reilly BJ.

J Rural Health. 1994 Spring;10(2):89-97.


Protection of transforming growth factor-beta 1 activity by heparin and fucoidan.

McCaffrey TA, Falcone DJ, Vicente D, Du B, Consigli S, Borth W.

J Cell Physiol. 1994 Apr;159(1):51-9.


Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation.

Falcone DJ, McCaffrey TA, Haimovitz-Friedman A, Vergilio JA, Nicholson AC.

J Biol Chem. 1993 Jun 5;268(16):11951-8.


Transforming growth factor-beta 1 stimulates macrophage urokinase expression and release of matrix-bound basic fibroblast growth factor.

Falcone DJ, McCaffrey TA, Haimovitz-Friedman A, Garcia M.

J Cell Physiol. 1993 Jun;155(3):595-605.


Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia.

McCaffrey TA, Falcone DJ, Borth W, Brayton CF, Weksler BB.

Biochem Biophys Res Commun. 1992 Apr 30;184(2):773-81.


Activation of platelet heparitinase by tumor cell-derived factors.

Haimovitz-Friedman A, Falcone DJ, Eldor A, Schirrmacher V, Vlodavsky I, Fuks Z.

Blood. 1991 Aug 1;78(3):789-96.

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