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ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).

Weskamp G, Tüshaus J, Li D, Feederle R, Maretzky T, Swendeman S, Falck-Pedersen E, McIlwain DR, Mak TW, Salmon JE, Lichtenthaler SF, Blobel CP.

J Biol Chem. 2020 Feb 14. pii: jbc.RA119.011136. doi: 10.1074/jbc.RA119.011136. [Epub ahead of print]


Parvovirus B19 integration into human CD36+ erythroid progenitor cells.

Janovitz T, Wong S, Young NS, Oliveira T, Falck-Pedersen E.

Virology. 2017 Nov;511:40-48. doi: 10.1016/j.virol.2017.08.011. Epub 2017 Aug 12.


The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores.

Huffman JB, Daniel GR, Falck-Pedersen E, Huet A, Smith GA, Conway JF, Homa FL.

J Virol. 2017 Jul 12;91(15). pii: e00641-17. doi: 10.1128/JVI.00641-17. Print 2017 Aug 1.


Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity.

Anghelina D, Lam E, Falck-Pedersen E.

J Virol. 2016 Jun 10;90(13):5915-27. doi: 10.1128/JVI.00500-16. Print 2016 Jul 1.


Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells.

Lam E, Falck-Pedersen E.

J Virol. 2014 Dec;88(24):14426-39. doi: 10.1128/JVI.02608-14. Epub 2014 Oct 8.


Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints.

Janovitz T, Sadelain M, Falck-Pedersen E.

Virol J. 2014 Jan 27;11:15. doi: 10.1186/1743-422X-11-15.


Highly divergent integration profile of adeno-associated virus serotype 5 revealed by high-throughput sequencing.

Janovitz T, Oliveira T, Sadelain M, Falck-Pedersen E.

J Virol. 2014 Mar;88(5):2481-8. doi: 10.1128/JVI.03419-13. Epub 2013 Dec 11.


Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.

Lam E, Stein S, Falck-Pedersen E.

J Virol. 2014 Jan;88(2):974-81. doi: 10.1128/JVI.02702-13. Epub 2013 Nov 6.


High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration.

Janovitz T, Klein IA, Oliveira T, Mukherjee P, Nussenzweig MC, Sadelain M, Falck-Pedersen E.

J Virol. 2013 Aug;87(15):8559-68. doi: 10.1128/JVI.01135-13. Epub 2013 May 29.


Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response.

Stein SC, Lam E, Falck-Pedersen E.

J Virol. 2012 Dec;86(24):13303-12. doi: 10.1128/JVI.02296-12. Epub 2012 Sep 26.


Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells.

Stein SC, Falck-Pedersen E.

J Virol. 2012 Apr;86(8):4527-37. doi: 10.1128/JVI.07071-11. Epub 2012 Feb 15.


Serotype 5 Adenovirus fiber (F7F41S) chimeric vectors incur packaging deficiencies when targeting peptides are inserted into Ad41 short fiber.

Schoggins JW, Falck-Pedersen E.

Virology. 2009 Dec 5;395(1):10-20. doi: 10.1016/j.virol.2009.08.041. Epub 2009 Sep 25.


Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells.

Diaz F, Gravotta D, Deora A, Schreiner R, Schoggins J, Falck-Pedersen E, Rodriguez-Boulan E.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11143-8. doi: 10.1073/pnas.0811227106. Epub 2009 Jun 19.


Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling.

Nociari M, Ocheretina O, Murphy M, Falck-Pedersen E.

J Virol. 2009 May;83(9):4081-91. doi: 10.1128/JVI.02591-08. Epub 2009 Feb 11.


Adenovirus capsid chimeras: fiber terminal exon insertions/gene replacements in the major late transcription unit.

Gall J, Schoggins J, Falck-Pedersen E.

Methods Mol Med. 2007;130:107-23.


Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation.

Schoggins JW, Nociari M, Philpott N, Falck-Pedersen E.

J Virol. 2005 Sep;79(18):11627-37.


Adeno-associated virus site-specific integration and AAVS1 disruption.

Hamilton H, Gomos J, Berns KI, Falck-Pedersen E.

J Virol. 2004 Aug;78(15):7874-82.


Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway.

Philpott NJ, Nociari M, Elkon KB, Falck-Pedersen E.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6200-5. Epub 2004 Apr 7.


Transgene expression after rep-mediated site-specific integration into chromosome 19.

Philpott NJ, Gomos J, Falck-Pedersen E.

Hum Gene Ther. 2004 Jan;15(1):47-61.


A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.

Philpott NJ, Gomos J, Berns KI, Falck-Pedersen E.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12381-5. Epub 2002 Sep 9.


Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation.

Hu X, Herrero C, Li WP, Antoniv TT, Falck-Pedersen E, Koch AE, Woods JM, Haines GK, Ivashkiv LB.

Nat Immunol. 2002 Sep;3(9):859-66. Epub 2002 Aug 12.


Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis.

Philpott NJ, Giraud-Wali C, Dupuis C, Gomos J, Hamilton H, Berns KI, Falck-Pedersen E.

J Virol. 2002 Jun;76(11):5411-21.


TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection.

Trevejo JM, Marino MW, Philpott N, Josien R, Richards EC, Elkon KB, Falck-Pedersen E.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12162-7. Epub 2001 Oct 2.


Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.

Miyazawa N, Leopold PL, Hackett NR, Ferris B, Worgall S, Falck-Pedersen E, Crystal RG.

J Virol. 1999 Jul;73(7):6056-65.


Inhibition of tumor necrosis factor alpha by an adenovirus-encoded soluble fusion protein extends transgene expression in the liver and lung.

Peng Y, Trevejo J, Zhou J, Marino MW, Crystal RG, Falck-Pedersen E, Elkon KB.

J Virol. 1999 Jun;73(6):5098-109.


Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.

Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG.

Am J Respir Cell Mol Biol. 1999 Mar;20(3):361-70.


Construction of an adenovirus type 7a E1A- vector.

Abrahamsen K, Kong HL, Mastrangeli A, Brough D, Lizonova A, Crystal RG, Falck-Pedersen E.

J Virol. 1997 Nov;71(11):8946-51.


Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors.

Elkon KB, Liu CC, Gall JG, Trevejo J, Marino MW, Abrahamsen KA, Song X, Zhou JL, Old LJ, Crystal RG, Falck-Pedersen E.

Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9814-9.


Sequence-mediated regulation of adenovirus gene expression by repression of mRNA accumulation.

Prescott JC, Liu L, Falck-Pedersen E.

Mol Cell Biol. 1997 Apr;17(4):2207-16.


Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype.

Mack CA, Song WR, Carpenter H, Wickham TJ, Kovesdi I, Harvey BG, Magovern CJ, Isom OW, Rosengart T, Falck-Pedersen E, Hackett NR, Crystal RG, Mastrangeli A.

Hum Gene Ther. 1997 Jan 1;8(1):99-109.


Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

Worgall S, Wolff G, Falck-Pedersen E, Crystal RG.

Hum Gene Ther. 1997 Jan 1;8(1):37-44.


Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain.

Yoon SO, Lois C, Alvirez M, Alvarez-Buylla A, Falck-Pedersen E, Chao MV.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11974-9.


Polarity of TRH receptors in transfected MDCK cells is independent of endocytosis signals and G protein coupling.

Yeaman C, Heinflink M, Falck-Pedersen E, Rodriguez-Boulan E, Gershengorn MC.

Am J Physiol. 1996 Mar;270(3 Pt 1):C753-62.


Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH.

Wolff G, Mastrangeli A, Heinflink M, Falck-Pedersen E, Gershengorn MC, Crystal RG.

Nat Genet. 1996 Mar;12(3):274-9.


Circumventing the immune response to adenovirus-mediated gene therapy.

Kass-Eisler A, Leinwand L, Gall J, Bloom B, Falck-Pedersen E.

Gene Ther. 1996 Feb;3(2):154-62.


The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer.

Kass-Eisler A, Falck-Pedersen E, Elfenbein DH, Alvira M, Buttrick PM, Leinwand LA.

Gene Ther. 1994 Nov;1(6):395-402.


Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin-releasing hormone desensitization is cell specific.

Falck-Pedersen E, Heinflink M, Alvira M, Nussenzveig DR, Gershengorn MC.

Mol Pharmacol. 1994 Apr;45(4):684-9.


Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

Kass-Eisler A, Falck-Pedersen E, Alvira M, Rivera J, Buttrick PM, Wittenberg BA, Cipriani L, Leinwand LA.

Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11498-502.

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