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Items: 1 to 50 of 638

1.

The Arachidonic Acid Monooxygenase. From Biochemical Curiosity to Physiological/Pathophysiological Significance.

Capdevila JH, Falck JR.

J Lipid Res. 2018 Aug 28. pii: jlr.R087882. doi: 10.1194/jlr.R087882. [Epub ahead of print]

2.

HIGH FAT DIET-INDUCED OBESITY AND INSULIN RESISTANCE IN CYP4A14-/- MICE IS MEDIATED BY 20-HETE.

Gilani A, Pandey V, Garcia V, Agostinucci K, Singh SP, Schragenheim J, Bellner L, Falck JR, Paudyal MP, Capdevila JH, Abraham NG, Laniado Schwartzman M.

Am J Physiol Regul Integr Comp Physiol. 2018 Aug 8. doi: 10.1152/ajpregu.00125.2018. [Epub ahead of print]

PMID:
30088983
3.

Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia inducible factor-1α via down regulation of prolyl hydroxylase 3.

Neckar J, Hsu A, Hye Khan MA, Gross GJ, Nithipatikom K, Cyprova M, Benak D, Hlavackova M, Sotakova D, Falck JR, Sedmera D, Kolar F, Imig JD.

Am J Physiol Heart Circ Physiol. 2018 Aug 3. doi: 10.1152/ajpheart.00726.2017. [Epub ahead of print]

PMID:
30074840
4.

20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.

Sedláková L, Kikerlová S, Husková Z, Červenková L, Chábová VČ, Zicha J, Falck JR, Imig JD, Kompanowska-Jezierska E, Sadowski J, Krátký V, Červenka L, Kopkan L.

Biosci Rep. 2018 Sep 12;38(5). pii: BSR20171496. doi: 10.1042/BSR20171496. Print 2018 Oct 31.

5.

The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury.

Zhang X, El Demerdash N, Falck JR, Munnuri S, Koehler RC, Yang ZJ.

Prostaglandins Other Lipid Mediat. 2018 Jul;137:63-68. doi: 10.1016/j.prostaglandins.2018.07.001. Epub 2018 Jul 6. Review.

PMID:
30041768
6.

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.

Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A.

Cancer Res. 2018 Sep 1;78(17):4865-4877. doi: 10.1158/0008-5472.CAN-17-3977. Epub 2018 Jul 16.

PMID:
30012669
7.

GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells.

Park SK, Herrnreiter A, Pfister SL, Gauthier KM, Falck BA, Falck JR, Campbell WB.

J Biol Chem. 2018 Jul 6;293(27):10675-10691. doi: 10.1074/jbc.RA117.001297. Epub 2018 May 18.

PMID:
29777058
8.

CYP-450 Epoxygenase Derived Epoxyeicosatrienoic Acid Contribute To Reversal of Heart Failure in Obesity-Induced Diabetic Cardiomyopathy via PGC-1 α Activation.

Singh SP, McClung JA, Bellner L, Cao J, Waldman M, Schragenheim J, Arad M, Hochhauser E, Falck JR, Weingarten JA, Peterson SJ, Abraham NG.

Cardiovasc Pharm Open Access. 2018;7(1). pii: 233. doi: 10.4172/2329-6607.1000233. Epub 2018 Feb 8.

9.

Corrigendum to "Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation" [J. Mol. Cell. Cardiol. 117 (2018) 88-99].

Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P.

J Mol Cell Cardiol. 2018 Aug;121:308. doi: 10.1016/j.yjmcc.2018.03.015. Epub 2018 Apr 4. No abstract available.

PMID:
29625729
10.

Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.

Červenka L, Husková Z, Kopkan L, Kikerlová S, Sedláková L, Vaňourková Z, Alánová P, Kolář F, Hammock BD, Hwang SH, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckář J.

J Hypertens. 2018 Jun;36(6):1326-1341. doi: 10.1097/HJH.0000000000001708.

PMID:
29570510
11.

20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.

Han X, Zhao X, Lan X, Li Q, Gao Y, Liu X, Wan J, Yang Z, Chen X, Zang W, Guo AM, Falck JR, Koehler RC, Wang J.

J Cereb Blood Flow Metab. 2018 Feb 27:271678X18762645. doi: 10.1177/0271678X18762645. [Epub ahead of print]

PMID:
29485354
12.

Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages.

Kriska T, Thomas MJ, Falck JR, Campbell WB.

J Lipid Res. 2018 Apr;59(4):615-624. doi: 10.1194/jlr.M081448. Epub 2018 Feb 22.

PMID:
29472381
13.

Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.

Soler A, Hunter I, Joseph G, Hutcheson R, Hutcheson B, Yang J, Zhang FF, Joshi SR, Bradford C, Gotlinger KH, Maniyar R, Falck JR, Proctor S, Schwartzman ML, Gupte SA, Rocic P.

J Mol Cell Cardiol. 2018 Apr;117:88-99. doi: 10.1016/j.yjmcc.2018.02.005. Epub 2018 Feb 8. Erratum in: J Mol Cell Cardiol. 2018 Apr 4;:.

PMID:
29428638
14.

Stereospecific Stille Cross-Couplings Using Mn(II)Cl2.

Dakarapu R, Falck JR.

J Org Chem. 2018 Feb 2;83(3):1241-1251. doi: 10.1021/acs.joc.7b02780. Epub 2018 Jan 17.

PMID:
29320181
15.

Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization.

Munnuri S, Adebesin AM, Paudyal MP, Yousufuddin M, Dalipe A, Falck JR.

J Am Chem Soc. 2017 Dec 20;139(50):18288-18294. doi: 10.1021/jacs.7b09901. Epub 2017 Dec 5.

PMID:
29182870
16.

Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male Rat Adrenal Gland In Vivo.

Shah AJ, Kriska T, Gauthier KM, Falck JR, Campbell WB.

Endocrinology. 2018 Jan 1;159(1):217-226. doi: 10.1210/en.2016-1594.

PMID:
29140411
17.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1314. doi: 10.1016/j.chembiol.2017.09.012. No abstract available.

PMID:
29053951
18.

Orally Active Epoxyeicosatrienoic Acid Analogs.

Campbell WB, Imig JD, Schmitz JM, Falck JR.

J Cardiovasc Pharmacol. 2017 Oct;70(4):211-224. doi: 10.1097/FJC.0000000000000523. Review.

19.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6. doi: 10.1016/j.chembiol.2017.08.009. Epub 2017 Sep 14.

PMID:
28919040
20.

The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

Pandey V, Garcia V, Gilani A, Mishra P, Zhang FF, Paudyal MP, Falck JR, Nasjletti A, Wang WH, Schwartzman ML.

J Pharmacol Exp Ther. 2017 Dec;363(3):412-418. doi: 10.1124/jpet.117.243618. Epub 2017 Sep 14.

PMID:
28912346
21.

Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Ledent C, Tilley SL, Nayeem MA.

Prostaglandins Other Lipid Mediat. 2017 Jul;131:83-95. doi: 10.1016/j.prostaglandins.2017.09.001. Epub 2017 Sep 7.

22.

Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7545-E7553. doi: 10.1073/pnas.1620898114. Epub 2017 Aug 21.

23.

Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa.

Yonker LM, Mou H, Chu KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP.

Sci Rep. 2017 Aug 15;7(1):8182. doi: 10.1038/s41598-017-08567-w.

24.

Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition.

Skibba M, Hye Khan MA, Kolb LL, Yeboah MM, Falck JR, Amaradhi R, Imig JD.

Front Pharmacol. 2017 Jun 30;8:406. doi: 10.3389/fphar.2017.00406. eCollection 2017.

25.

EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice.

Cao J, Singh SP, McClung JA, Joseph G, Vanella L, Barbagallo I, Jiang H, Falck JR, Arad M, Shapiro JI, Abraham NG.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H368-H380. doi: 10.1152/ajpheart.00093.2017. Epub 2017 Jun 2.

26.

11,12 -Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus.

Mule NK, Orjuela Leon AC, Falck JR, Arand M, Marowsky A.

Neuropharmacology. 2017 Sep 1;123:310-321. doi: 10.1016/j.neuropharm.2017.05.013. Epub 2017 May 17.

27.

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Mar 22;12(3):e0174137. doi: 10.1371/journal.pone.0174137. eCollection 2017.

28.

20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.

Garcia V, Gilani A, Shkolnik B, Pandey V, Zhang FF, Dakarapu R, Gandham SK, Reddy NR, Graves JP, Gruzdev A, Zeldin DC, Capdevila JH, Falck JR, Schwartzman ML.

Circ Res. 2017 May 26;120(11):1776-1788. doi: 10.1161/CIRCRESAHA.116.310525. Epub 2017 Mar 21.

29.

Upregulation of 20-HETE Synthetic Cytochrome P450 Isoforms by Oxygen-Glucose Deprivation in Cortical Neurons.

Zhang H, Falck JR, Roman RJ, Harder DR, Koehler RC, Yang ZJ.

Cell Mol Neurobiol. 2017 Oct;37(7):1279-1286. doi: 10.1007/s10571-017-0462-8. Epub 2017 Jan 21.

30.

Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice.

Singh SP, Bellner L, Vanella L, Cao J, Falck JR, Kappas A, Abraham NG.

J Nutr Metab. 2016;2016:9039754. doi: 10.1155/2016/9039754. Epub 2016 Dec 20.

31.

Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Jan 5;12(1):e0169584. doi: 10.1371/journal.pone.0169584. eCollection 2017.

32.

Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction.

Joseph G, Soler A, Hutcheson R, Hunter I, Bradford C, Hutcheson B, Gotlinger KH, Jiang H, Falck JR, Proctor S, Schwartzman ML, Rocic P.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H528-H540. doi: 10.1152/ajpheart.00561.2016. Epub 2016 Dec 23.

33.

Role of vascular reactive oxygen species in regulating cytochrome P450-4A enzyme expression in Dahl salt-sensitive rats.

Lukaszewicz KM, Paudyal MP, Falck JR, Lombard JH.

Microcirculation. 2016 Oct;23(7):540-548. doi: 10.1111/micc.12304.

35.

Dirhodium-catalyzed C-H arene amination using hydroxylamines.

Paudyal MP, Adebesin AM, Burt SR, Ess DH, Ma Z, Kürti L, Falck JR.

Science. 2016 Sep 9;353(6304):1144-7. doi: 10.1126/science.aaf8713.

36.

Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.

El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM.

PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016.

37.

Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.

Jíchová Š, Kopkan L, Husková Z, Doleželová Š, Neckář J, Kujal P, Vernerová Z, Kramer HJ, Sadowski J, Kompanowska-Jezierska E, Reddy RN, Falck JR, Imig JD, Červenka L.

J Hypertens. 2016 Oct;34(10):2008-25. doi: 10.1097/HJH.0000000000001029.

38.

PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid.

Singh SP, Schragenheim J, Cao J, Falck JR, Abraham NG, Bellner L.

Prostaglandins Other Lipid Mediat. 2016 Sep;125:8-18. doi: 10.1016/j.prostaglandins.2016.07.004. Epub 2016 Jul 11.

39.

The epoxyeicosatrienoic acid analog PVPA ameliorates cyclosporine-induced hypertension and renal injury in rats.

Yeboah MM, Hye Khan MA, Chesnik MA, Sharma A, Paudyal MP, Falck JR, Imig JD.

Am J Physiol Renal Physiol. 2016 Sep 1;311(3):F576-85. doi: 10.1152/ajprenal.00288.2016. Epub 2016 Jun 29.

40.
41.

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.

Dordea AC, Vandenwijngaert S, Garcia V, Tainsh RE, Nathan DI, Allen K, Raher MJ, Tainsh LT, Zhang F, Lieb WS, Mikelman S, Kirby A, Stevens C, Thoonen R, Hindle AG, Sips PY, Falck JR, Daly MJ, Brouckaert P, Bloch KD, Bloch DB, Malhotra R, Schwartzman ML, Buys ES.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1790-800. doi: 10.1152/ajpheart.00877.2015. Epub 2016 May 3.

42.

Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids.

Sporková A, Reddy RN, Falck JR, Imig JD, Kopkan L, Sadowski J, Červenka L.

Am J Med Sci. 2016 May;351(5):513-9. doi: 10.1016/j.amjms.2016.02.030. Epub 2016 Feb 23.

43.

20-HETE contributes to ischemia-induced angiogenesis.

Chen L, Joseph G, Zhang FF, Nguyen H, Jiang H, Gotlinger KH, Falck JR, Yang J, Schwartzman ML, Guo AM.

Vascul Pharmacol. 2016 Aug;83:57-65. doi: 10.1016/j.vph.2016.04.002. Epub 2016 Apr 13.

44.

Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.

Kizub IV, Lakhkar A, Dhagia V, Joshi SR, Jiang H, Wolin MS, Falck JR, Koduru SR, Errabelli R, Jacobs ER, Schwartzman ML, Gupte SA.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L772-83. doi: 10.1152/ajplung.00377.2015. Epub 2016 Feb 19.

45.

Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.

Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B.

Inflamm Res. 2016 May;65(5):367-87. doi: 10.1007/s00011-016-0922-5. Epub 2016 Feb 13.

PMID:
26875149
46.

Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy.

Hye Khan MA, Fish B, Wahl G, Sharma A, Falck JR, Paudyal MP, Moulder JE, Imig JD, Cohen EP.

Clin Sci (Lond). 2016 Apr;130(8):587-99. doi: 10.1042/CS20150778. Epub 2016 Jan 15.

47.

20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding.

Garcia V, Shkolnik B, Milhau L, Falck JR, Schwartzman ML.

J Pharmacol Exp Ther. 2016 Mar;356(3):525-33. doi: 10.1124/jpet.115.229377. Epub 2015 Dec 23.

48.

Vascular hepoxilin and trioxilins mediate vasorelaxation through TP receptor inhibition in mouse arteries.

Siangjong L, Goldman DH, Kriska T, Gauthier KM, Smyth EM, Puli N, Kumar G, Falck JR, Campbell WB.

Acta Physiol (Oxf). 2017 Jan;219(1):188-201. doi: 10.1111/apha.12642. Epub 2016 Jan 4.

49.

Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans.

Zhou Y, Falck JR, Rothe M, Schunck WH, Menzel R.

J Lipid Res. 2015 Nov;56(11):2110-23. doi: 10.1194/jlr.M061887. Epub 2015 Sep 23.

50.

Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.

Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L.

Vascul Pharmacol. 2015 Oct;73:45-56. doi: 10.1016/j.vph.2015.08.013. Epub 2015 Aug 22.

PMID:
26304700

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