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Items: 1 to 50 of 140

1.

Generation and Characterization of SULT4A1 Mutant Mouse Models.

Garcia PL, Hossain MI, Andrabi SA, Falany CN.

Drug Metab Dispos. 2018 Jan;46(1):41-45. doi: 10.1124/dmd.117.077560. Epub 2017 Nov 6.

PMID:
29109113
2.

Expression, purification and characterization of human cytosolic sulfotransferase (SULT) 1C4.

Guidry AL, Tibbs ZE, Runge-Morris M, Falany CN.

Horm Mol Biol Clin Investig. 2017 Jan 1;29(1):27-36. doi: 10.1515/hmbci-2016-0053.

3.

A high frequency missense SULT1B1 allelic variant (L145V) selectively expressed in African descendants exhibits altered kinetic properties.

Tibbs ZE, Guidry AL, Falany JL, Kadlubar SA, Falany CN.

Xenobiotica. 2018 Jan;48(1):79-88. doi: 10.1080/00498254.2017.1282646. Epub 2017 Feb 5.

PMID:
28084139
4.

An engineered heterodimeric model to investigate SULT1B1 dependence on intersubunit communication.

Tibbs ZE, Falany CN.

Biochem Pharmacol. 2016 Sep 1;115:123-33. doi: 10.1016/j.bcp.2016.06.011. Epub 2016 Jun 23.

5.

Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity.

Styles NA, Shonsey EM, Falany JL, Guidry AL, Barnes S, Falany CN.

J Lipid Res. 2016 Jul;57(7):1133-43. doi: 10.1194/jlr.M064428. Epub 2016 May 25.

6.

Dimeric human sulfotransferase 1B1 displays cofactor-dependent subunit communication.

Tibbs ZE, Falany CN.

Pharmacol Res Perspect. 2015 Jun;3(3):e00147. doi: 10.1002/prp2.147. Epub 2015 May 8.

7.

Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish.

Crittenden F, Thomas HR, Parant JM, Falany CN.

Drug Metab Dispos. 2015 Jul;43(7):1037-44. doi: 10.1124/dmd.115.064485. Epub 2015 May 1. Erratum in: Drug Metab Dispos. 2015 Aug;43(8):1284.

8.

Structural plasticity in the human cytosolic sulfotransferase dimer and its role in substrate selectivity and catalysis.

Tibbs ZE, Rohn-Glowacki KJ, Crittenden F, Guidry AL, Falany CN.

Drug Metab Pharmacokinet. 2015 Feb;30(1):3-20. doi: 10.1016/j.dmpk.2014.10.004. Epub 2014 Nov 5. Review.

PMID:
25760527
9.

The allosteric binding sites of sulfotransferase 1A1.

Cook I, Wang T, Falany CN, Leyh TS.

Drug Metab Dispos. 2015 Mar;43(3):418-23. doi: 10.1124/dmd.114.061887. Epub 2014 Dec 22.

10.

The potent inhibition of human cytosolic sulfotransferase 1A1 by 17α-ethinylestradiol is due to interactions with isoleucine 89 on loop 1.

Rohn-Glowacki KJ, Falany CN.

Horm Mol Biol Clin Investig. 2014 Dec;20(3):81-90. doi: 10.1515/hmbci-2014-0028.

PMID:
25418972
11.

Paradigms of sulfotransferase catalysis: the mechanism of SULT2A1.

Wang T, Cook I, Falany CN, Leyh TS.

J Biol Chem. 2014 Sep 19;289(38):26474-80. doi: 10.1074/jbc.M114.573501. Epub 2014 Jul 23.

12.

Inhibition of SULT4A1 expression induces up-regulation of phototransduction gene expression in 72-hour postfertilization zebrafish larvae.

Crittenden F, Thomas H, Ethen CM, Wu ZL, Chen D, Kraft TW, Parant JM, Falany CN.

Drug Metab Dispos. 2014 May;42(5):947-53. doi: 10.1124/dmd.114.057042. Epub 2014 Feb 19.

13.

Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function.

Duniec-Dmuchowski Z, Rondini EA, Tibbs ZE, Falany CN, Runge-Morris M, Kocarek TA.

Drug Metab Dispos. 2014 Mar;42(3):352-60. doi: 10.1124/dmd.113.055665. Epub 2013 Dec 11. Erratum in: Drug Metab Dispos. 2014 May;42(5):853.

14.

High accuracy in silico sulfotransferase models.

Cook I, Wang T, Falany CN, Leyh TS.

J Biol Chem. 2013 Nov 29;288(48):34494-501. doi: 10.1074/jbc.M113.510974. Epub 2013 Oct 15.

15.

SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family.

Falany CN, Rohn-Glowacki KJ.

Drug Metab Rev. 2013 Nov;45(4):388-400. doi: 10.3109/03602532.2013.835609. Epub 2013 Sep 10. Review.

PMID:
24020383
16.

Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium.

Meinl W, Tsoi C, Swedmark S, Tibbs ZE, Falany CN, Glatt H.

Mutagenesis. 2013 Sep;28(5):609-19. doi: 10.1093/mutage/get039. Epub 2013 Jul 26.

PMID:
23894158
17.

Testing the sulfotransferase molecular pore hypothesis.

Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS.

J Biol Chem. 2013 Mar 22;288(12):8619-26. doi: 10.1074/jbc.M112.445015. Epub 2013 Jan 28.

18.

Regulation of the cytosolic sulfotransferases by nuclear receptors.

Runge-Morris M, Kocarek TA, Falany CN.

Drug Metab Rev. 2013 Feb;45(1):15-33. doi: 10.3109/03602532.2012.748794. Review.

19.

The gate that governs sulfotransferase selectivity.

Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS.

Biochemistry. 2013 Jan 15;52(2):415-24. doi: 10.1021/bi301492j. Epub 2012 Dec 28.

20.

Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1.

Edavana VK, Yu X, Dhakal IB, Williams S, Ning B, Cook IT, Caldwell D, Falany CN, Kadlubar S.

Pharmgenomics Pers Med. 2011 Nov 16;4:137-145.

21.

A nucleotide-gated molecular pore selects sulfotransferase substrates.

Cook I, Wang T, Falany CN, Leyh TS.

Biochemistry. 2012 Jul 17;51(28):5674-83. Epub 2012 Jun 29.

22.

Potent inhibition of human sulfotransferase 1A1 by 17α-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity.

Rohn KJ, Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Drug Metab Dispos. 2012 Aug;40(8):1588-95. doi: 10.1124/dmd.112.045583. Epub 2012 May 16.

23.

Hydroxysteroid sulfotransferase 2B1b expression and localization in normal human brain.

Salman ED, Faye-Petersen O, Falany CN.

Horm Mol Biol Clin Investig. 2011 Oct;8(1):445-454.

24.

Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity.

Salman ED, He D, Runge-Morris M, Kocarek TA, Falany CN.

J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):315-23. doi: 10.1016/j.jsbmb.2011.07.010. Epub 2011 Aug 6.

25.

Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1.

Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Horm Mol Biol Clin Investig. 2010 Dec;3(1):357-366.

26.

Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1.

Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Horm Mol Biol Clin Investig. 2010 Dec 1;3(1):367-74. doi: 10.1515/HMBCI.2010.041.

PMID:
25961208
27.

Structural rearrangement of SULT2A1: effects on dehydroepiandrosterone and raloxifene sulfation.

Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Horm Mol Biol Clin Investig. 2010;1(2):81-87.

28.

Expression of sulfotransferases and sulfatases in human breast cancer: impact on resveratrol metabolism.

Miksits M, Wlcek K, Svoboda M, Thalhammer T, Ellinger I, Stefanzl G, Falany CN, Szekeres T, Jaeger W.

Cancer Lett. 2010 Mar 28;289(2):237-45. doi: 10.1016/j.canlet.2009.08.020. Epub 2009 Sep 10.

PMID:
19747768
29.

24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation.

Cook IT, Duniec-Dmuchowski Z, Kocarek TA, Runge-Morris M, Falany CN.

Drug Metab Dispos. 2009 Oct;37(10):2069-78. doi: 10.1124/dmd.108.025759. Epub 2009 Jul 9.

30.

Regulation of hepatic sulfotransferase (SULT) 1E1 expression and effects on estrogenic activity in cystic fibrosis (CF).

Falany CN, He D, Li L, Falany JL, Wilborn TW, Kocarek TA, Runge-Morris M.

J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):113-9. doi: 10.1016/j.jsbmb.2009.02.009. Epub 2009 Mar 3.

31.

Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.

Fu J, Weise AM, Falany JL, Falany CN, Thibodeau BJ, Miller FR, Kocarek TA, Runge-Morris M.

Breast Cancer Res Treat. 2010 Feb;120(1):35-45. doi: 10.1007/s10549-009-0363-8. Epub 2009 Mar 24.

32.

Expression and localization of cytosolic sulfotransferase (SULT) 1A1 and SULT1A3 in normal human brain.

Salman ED, Kadlubar SA, Falany CN.

Drug Metab Dispos. 2009 Apr;37(4):706-9. doi: 10.1124/dmd.108.025767. Epub 2009 Jan 26.

33.

Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation.

Li L, He D, Wilborn TW, Falany JL, Falany CN.

Steroids. 2009 Jan;74(1):20-9. doi: 10.1016/j.steroids.2008.09.002. Epub 2008 Sep 11.

34.

Repression of CFTR activity in human MMNK-1 cholangiocytes induces sulfotransferase 1E1 expression in co-cultured HepG2 hepatocytes.

He D, Wilborn TW, Falany JL, Li L, Falany CN.

Biochim Biophys Acta. 2008 Dec;1783(12):2391-7. doi: 10.1016/j.bbamcr.2008.08.012. Epub 2008 Sep 11.

35.

Sulfotransferase 2B1b in human breast: differences in subcellular localization in African American and Caucasian women.

Dumas NA, He D, Frost AR, Falany CN.

J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):171-7. doi: 10.1016/j.jsbmb.2008.05.006. Epub 2008 Jun 8.

36.

Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenal.

Shonsey EM, Eliuk SM, Johnson MS, Barnes S, Falany CN, Darley-Usmar VM, Renfrow MB.

J Lipid Res. 2008 Feb;49(2):282-94. Epub 2007 Oct 27.

37.

Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.

Fang HL, Strom SC, Ellis E, Duanmu Z, Fu J, Duniec-Dmuchowski Z, Falany CN, Falany JL, Kocarek TA, Runge-Morris M.

J Pharmacol Exp Ther. 2007 Nov;323(2):586-98. Epub 2007 Aug 8.

38.

Interactions of the human cytosolic sulfotransferases and steroid sulfatase in the metabolism of tibolone and raloxifene.

Falany JL, Falany CN.

J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):202-10. Epub 2007 Jun 26.

40.

Quantification and regulation of the subcellular distribution of bile acid coenzyme A:amino acid N-acyltransferase activity in rat liver.

Styles NA, Falany JL, Barnes S, Falany CN.

J Lipid Res. 2007 Jun;48(6):1305-15. Epub 2007 Mar 22.

41.

Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization.

Falany CN, He D, Dumas N, Frost AR, Falany JL.

J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):214-21. Epub 2006 Oct 19.

42.

Regulation of SULT1E1 expression in Ishikawa adenocarcinoma cells by tibolone.

Falany JL, Falany CN.

Steroids. 2006 Oct;71(10):880-5. Epub 2006 Jul 20.

PMID:
16857224
44.
45.

Association of SULT2A1 allelic variants with plasma adrenal androgens and prostate cancer in African American men.

Wilborn TW, Lang NP, Smith M, Meleth S, Falany CN.

J Steroid Biochem Mol Biol. 2006 Jun;99(4-5):209-14. Epub 2006 Apr 17.

PMID:
16617014
46.

Pharmacogenetics of human cytosolic sulfotransferases.

Nowell S, Falany CN.

Oncogene. 2006 Mar 13;25(11):1673-8. Review.

PMID:
16550167
47.

Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids.

Shonsey EM, Sfakianos M, Johnson M, He D, Falany CN, Falany J, Merkler DJ, Barnes S.

Methods Enzymol. 2005;400:374-94.

PMID:
16399361
48.

Synthesis of bile acid coenzyme a thioesters in the amino acid conjugation of bile acids.

Shonsey EM, Wheeler J, Johnson M, He D, Falany CN, Falany J, Barnes S.

Methods Enzymol. 2005;400:360-73.

PMID:
16399360
49.

Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases.

Falany JL, Pilloff DE, Leyh TS, Falany CN.

Drug Metab Dispos. 2006 Mar;34(3):361-8. Epub 2005 Dec 28.

50.

Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre- and postnatal human liver.

Duanmu Z, Weckle A, Koukouritaki SB, Hines RN, Falany JL, Falany CN, Kocarek TA, Runge-Morris M.

J Pharmacol Exp Ther. 2006 Mar;316(3):1310-7. Epub 2005 Dec 9.

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