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Items: 12


High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.

Falanga YT, Frascoli M, Kaymaz Y, Forconi C, Ong'echa JM, Bailey JA, Berg LJ, Moormann AM.

JCI Insight. 2017 Aug 3;2(15). pii: 93814. doi: 10.1172/jci.insight.93814. eCollection 2017 Aug 3.


The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S.

J Allergy Clin Immunol. 2015 Apr;135(4):1008-18.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13.


Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Fernando J, Faber TW, Pullen NA, Falanga YT, Kolawole EM, Oskeritzian CA, Barnstein BO, Bandara G, Li G, Schwartz LB, Spiegel S, Straus DB, Conrad DH, Bunting KD, Ryan JJ.

J Immunol. 2013 Nov 1;191(9):4505-13. doi: 10.4049/jimmunol.1202723. Epub 2013 Sep 25.


Fyn kinase is required for optimal humoral responses.

Chaimowitz NS, Falanga YT, Ryan JJ, Conrad DH.

PLoS One. 2013 Apr 8;8(4):e60640. doi: 10.1371/journal.pone.0060640. Print 2013.


A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30.


The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling.

Pullen NA, Falanga YT, Morales JK, Ryan JJ.

Front Immunol. 2012 May 11;3:117. doi: 10.3389/fimmu.2012.00117. eCollection 2012.


Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.

Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ.

J Immunol. 2012 May 1;188(9):4360-8. doi: 10.4049/jimmunol.1003223. Epub 2012 Mar 26.


Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.

Pullen NA, Barnstein BO, Falanga YT, Wang Z, Suzuki R, Tamang TD, Khurana MC, Harry EA, Draber P, Bunting KD, Mizuno K, Wilson BS, Ryan JJ.

J Biol Chem. 2012 Jan 13;287(3):2045-54. doi: 10.1074/jbc.M111.311142. Epub 2011 Nov 30.


Mast cell homeostasis and the JAK-STAT pathway.

Morales JK, Falanga YT, Depcrynski A, Fernando J, Ryan JJ.

Genes Immun. 2010 Dec;11(8):599-608. doi: 10.1038/gene.2010.35. Epub 2010 Jun 10. Review.


IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.

Macey MR, Sturgill JL, Morales JK, Falanga YT, Morales J, Norton SK, Yerram N, Shim H, Fernando J, Gifillan AM, Gomez G, Schwartz L, Oskeritzian C, Spiegel S, Conrad D, Ryan JJ.

J Immunol. 2010 May 1;184(9):4688-95. doi: 10.4049/jimmunol.0903477. Epub 2010 Mar 19.


Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema.

Oskeritzian CA, Price MM, Hait NC, Kapitonov D, Falanga YT, Morales JK, Ryan JJ, Milstien S, Spiegel S.

J Exp Med. 2010 Mar 15;207(3):465-74. doi: 10.1084/jem.20091513. Epub 2010 Mar 1.


Mast cell regulation of the immune response.

Ryan JJ, Morales JK, Falanga YT, Fernando JF, Macey MR.

World Allergy Organ J. 2009 Oct;2(10):224-32. doi: 10.1097/WOX.0b013e3181c2a95e. Erratum in: World Allergy Organ J. 2010 Jan;3(1):14.

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