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Items: 1 to 50 of 103

1.

Folding unpredicted.

Schwenk J, Fakler B.

Science. 2019 Dec 6;366(6470):1194-1195. doi: 10.1126/science.aaz8642. No abstract available.

PMID:
31806799
2.

High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis.

Müller CS, Bildl W, Klugbauer N, Haupt A, Fakler B, Schulte U.

J Vis Exp. 2019 Oct 15;(152). doi: 10.3791/60096.

PMID:
31680678
3.

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.

Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B.

Neuron. 2019 Nov 20;104(4):680-692.e9. doi: 10.1016/j.neuron.2019.08.033. Epub 2019 Oct 8.

PMID:
31604597
4.

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing.

Dinamarca MC, Raveh A, Schneider A, Fritzius T, Früh S, Rem PD, Stawarski M, Lalanne T, Turecek R, Choo M, Besseyrias V, Bildl W, Bentrop D, Staufenbiel M, Gassmann M, Fakler B, Schwenk J, Bettler B.

Nat Commun. 2019 Mar 22;10(1):1331. doi: 10.1038/s41467-019-09164-3.

5.

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.

Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T.

Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569.

PMID:
30792303
6.

Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance.

Schmidt N, Kollewe A, Constantin CE, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte U.

Neuron. 2017 Nov 15;96(4):827-838.e9. doi: 10.1016/j.neuron.2017.09.038. Epub 2017 Oct 19.

7.

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.

EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8.

8.

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability.

Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna'a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler B.

Nat Commun. 2017 Jul 4;8:15910. doi: 10.1038/ncomms15910.

9.

Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling.

Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5707-5712. doi: 10.1073/pnas.1616394114. Epub 2017 May 15.

10.

Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomes.

Bettler B, Fakler B.

Curr Opin Neurobiol. 2017 Aug;45:16-23. doi: 10.1016/j.conb.2017.02.011. Epub 2017 Mar 7. Review.

PMID:
28282540
11.

Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand.

Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1253-E1262. doi: 10.1073/pnas.1621321114. Epub 2017 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 4;114(14 ):E2984.

12.

KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons.

Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik Á.

Cereb Cortex. 2017 Mar 1;27(3):2318-2334. doi: 10.1093/cercor/bhw090.

13.

Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function.

Kim G, Luján R, Schwenk J, Kelley MH, Aguado C, Watanabe M, Fakler B, Maylie J, Adelman JP.

Elife. 2016 Feb 12;5. pii: e12637. doi: 10.7554/eLife.12637.

14.

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics.

Schwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler B.

Nat Neurosci. 2016 Feb;19(2):233-42. doi: 10.1038/nn.4198. Epub 2015 Dec 21.

PMID:
26691831
15.

Cryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome Profiling.

Müller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte U.

Mol Cell Proteomics. 2016 Feb;15(2):669-81. doi: 10.1074/mcp.M115.054080. Epub 2015 Nov 23.

16.

Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca(2+) channels.

Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik Á.

Front Cell Neurosci. 2015 Aug 11;9:315. doi: 10.3389/fncel.2015.00315. eCollection 2015.

17.

More than a pore: ion channel signaling complexes.

Lee A, Fakler B, Kaczmarek LK, Isom LL.

J Neurosci. 2014 Nov 12;34(46):15159-69. doi: 10.1523/JNEUROSCI.3275-14.2014. Review.

18.

Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.

Subramaniam M, Althof D, Gispert S, Schwenk J, Auburger G, Kulik A, Fakler B, Roeper J.

J Neurosci. 2014 Oct 8;34(41):13586-99. doi: 10.1523/JNEUROSCI.5069-13.2014.

19.

Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain.

Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, Fakler B, Schulte U.

Neuron. 2014 Oct 1;84(1):41-54. doi: 10.1016/j.neuron.2014.08.044. Epub 2014 Sep 18.

20.

Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses.

Boudkkazi S, Brechet A, Schwenk J, Fakler B.

Neuron. 2014 May 21;82(4):848-58. doi: 10.1016/j.neuron.2014.03.031.

21.

Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization.

Turecek R, Schwenk J, Fritzius T, Ivankova K, Zolles G, Adelfinger L, Jacquier V, Besseyrias V, Gassmann M, Schulte U, Fakler B, Bettler B.

Neuron. 2014 Jun 4;82(5):1032-44. doi: 10.1016/j.neuron.2014.04.015. Epub 2014 May 15.

22.

Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).

Ivankova K, Turecek R, Fritzius T, Seddik R, Prezeau L, Comps-Agrar L, Pin JP, Fakler B, Besseyrias V, Gassmann M, Bettler B.

J Biol Chem. 2013 Aug 23;288(34):24848-56. doi: 10.1074/jbc.M113.476770. Epub 2013 Jul 10.

23.

Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells.

Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M.

J Neurosci. 2013 May 29;33(22):9508-19. doi: 10.1523/JNEUROSCI.5689-12.2013.

24.

Ligand-gating by Ca2+ is rate limiting for physiological operation of BK(Ca) channels.

Berkefeld H, Fakler B.

J Neurosci. 2013 Apr 24;33(17):7358-67. doi: 10.1523/JNEUROSCI.5443-12.2013.

25.

Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization.

Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B.

J Biol Chem. 2012 Nov 16;287(47):39869-77. doi: 10.1074/jbc.M112.412767. Epub 2012 Oct 3.

26.

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.

Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B.

Neuron. 2012 May 24;74(4):621-33. doi: 10.1016/j.neuron.2012.03.034.

27.

AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signaling.

Harmel N, Cokic B, Zolles G, Berkefeld H, Mauric V, Fakler B, Stein V, Klöcker N.

PLoS One. 2012;7(1):e30681. doi: 10.1371/journal.pone.0030681. Epub 2012 Jan 24.

28.

Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications.

Bildl W, Haupt A, Müller CS, Biniossek ML, Thumfart JO, Hüber B, Fakler B, Schulte U.

Mol Cell Proteomics. 2012 Feb;11(2):M111.007955. doi: 10.1074/mcp.M111.007955. Epub 2011 Nov 8.

29.

A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.

Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver D.

EMBO J. 2011 Jun 24;30(14):2793-804. doi: 10.1038/emboj.2011.202.

30.

Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

Metz M, Gassmann M, Fakler B, Schaeren-Wiemers N, Bettler B.

J Comp Neurol. 2011 Jun 1;519(8):1435-54. doi: 10.1002/cne.22610.

PMID:
21452234
31.

Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.

López-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martínez A, Estévez R, van der Knaap MS.

Am J Hum Genet. 2011 Apr 8;88(4):422-32. doi: 10.1016/j.ajhg.2011.02.009. Epub 2011 Mar 17.

32.

Ca2+-activated K+ channels: from protein complexes to function.

Berkefeld H, Fakler B, Schulte U.

Physiol Rev. 2010 Oct;90(4):1437-59. doi: 10.1152/physrev.00049.2009. Review.

33.

Ion channels and their molecular environments--glimpses and insights from functional proteomics.

Schulte U, Müller CS, Fakler B.

Semin Cell Dev Biol. 2011 Apr;22(2):132-44. doi: 10.1016/j.semcdb.2010.09.015. Epub 2010 Oct 8. Review.

PMID:
20934526
34.

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):14950-7. doi: 10.1073/pnas.1005940107. Epub 2010 Jul 28.

35.

Gene expression associated with the onset of hearing detected by differential display in rat organ of Corti.

Reisinger E, Meintrup D, Oliver D, Fakler B.

Eur J Hum Genet. 2010 Dec;18(12):1327-32. doi: 10.1038/ejhg.2010.111. Epub 2010 Jul 21.

36.

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits.

Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schulte U, Fakler B, Bettler B.

Nature. 2010 May 13;465(7295):231-5. doi: 10.1038/nature08964. Epub 2010 Apr 18.

PMID:
20400944
37.

Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation.

Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart JO, Vlachos A, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker N.

Neuron. 2009 Jun 25;62(6):814-25. doi: 10.1016/j.neuron.2009.05.008.

38.

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.

Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N.

Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.

39.

Control of K(Ca) channels by calcium nano/microdomains.

Fakler B, Adelman JP.

Neuron. 2008 Sep 25;59(6):873-81. doi: 10.1016/j.neuron.2008.09.001. Review.

40.

Repolarizing responses of BKCa-Cav complexes are distinctly shaped by their Cav subunits.

Berkefeld H, Fakler B.

J Neurosci. 2008 Aug 13;28(33):8238-45. doi: 10.1523/JNEUROSCI.2274-08.2008.

41.

Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity.

Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS.

Mol Cell Proteomics. 2008 Nov;7(11):2188-98. doi: 10.1074/mcp.M800063-MCP200. Epub 2008 Jun 23.

42.

NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes.

Schwenk J, Zolles G, Kandias NG, Neubauer I, Kalbacher H, Covarrubias M, Fakler B, Bentrop D.

J Biol Chem. 2008 Jul 4;283(27):18937-46. doi: 10.1074/jbc.M800976200. Epub 2008 May 5.

43.

Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.

Hardel N, Harmel N, Zolles G, Fakler B, Klöcker N.

Cardiovasc Res. 2008 Jul 1;79(1):52-60. doi: 10.1093/cvr/cvn062. Epub 2008 Mar 7.

PMID:
18326556
44.

Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexes.

Allen D, Fakler B, Maylie J, Adelman JP.

J Neurosci. 2007 Feb 28;27(9):2369-76.

45.

Pacemaking by HCN channels requires interaction with phosphoinositides.

Zolles G, Klöcker N, Wenzel D, Weisser-Thomas J, Fleischmann BK, Roeper J, Fakler B.

Neuron. 2006 Dec 21;52(6):1027-36.

46.

Interaction of prestin (SLC26A5) with monovalent intracellular anions.

Oliver D, Schächinger T, Fakler B.

Novartis Found Symp. 2006;273:244-53; discussion 253-60, 261-4.

PMID:
17120772
47.

BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.

Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B.

Science. 2006 Oct 27;314(5799):615-20.

48.

The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery.

Oliver D, Taberner AM, Thurm H, Sausbier M, Arntz C, Ruth P, Fakler B, Liberman MC.

J Neurosci. 2006 Jun 7;26(23):6181-9.

49.

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B.

Neuron. 2006 Mar 2;49(5):697-706.

50.

Ca2+-independent activation of BKCa channels at negative potentials in mammalian inner hair cells.

Thurm H, Fakler B, Oliver D.

J Physiol. 2005 Nov 15;569(Pt 1):137-51. Epub 2005 Sep 8.

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