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Items: 15


The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences.

Fakira AK, Peck EG, Liu Y, Lueptow LM, Trimbake NA, Han MH, Calipari ES, Devi LA.

Neuropharmacology. 2019 Oct;157:107666. doi: 10.1016/j.neuropharm.2019.107666. Epub 2019 Jun 12.


The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance.

Lueptow LM, Fakira AK, Bobeck EN.

Front Neurosci. 2018 Nov 27;12:886. doi: 10.3389/fnins.2018.00886. eCollection 2018.


Targeting the Recently Deorphanized Receptor GPR83 for the Treatment of Immunological, Neuroendocrine and Neuropsychiatric Disorders.

Lueptow LM, Devi LA, Fakira AK.

Prog Mol Biol Transl Sci. 2018;159:1-25. doi: 10.1016/bs.pmbts.2018.07.002. Epub 2018 Aug 25. Review.


Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.

Bavley CC, Rice RC, Fischer DK, Fakira AK, Byrne M, Kosovsky M, Rizzo BK, Del Prete D, Alaedini A, Morón JA, Higgins JJ, D'Adamio L, Rajadhyaksha AM.

J Neurosci. 2018 Mar 14;38(11):2780-2795. doi: 10.1523/JNEUROSCI.0599-17.2018. Epub 2018 Feb 19.


Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.

Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA.

Neuropsychopharmacology. 2016 Oct;41(11):2668-78. doi: 10.1038/npp.2016.69. Epub 2016 May 10.


Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6041-6. doi: 10.1073/pnas.1521825113. Epub 2016 May 9.


Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.

Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694.


Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J.

Sci Signal. 2016 Jan 12;9(410):ra5. doi: 10.1126/scisignal.aab0467.


Evidence of CNIH3 involvement in opioid dependence.

Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW.

Mol Psychiatry. 2016 May;21(5):608-14. doi: 10.1038/mp.2015.102. Epub 2015 Aug 4.


In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z.

Pain. 2015 May;156(5):849-58. doi: 10.1097/j.pain.0000000000000124.


Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.

Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA.

J Neurosci. 2014 Jan 8;34(2):527-38. doi: 10.1523/JNEUROSCI.2838-13.2014.


Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.

Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA.

Biol Psychiatry. 2014 Jan 15;75(2):105-14. doi: 10.1016/j.biopsych.2013.04.026. Epub 2013 Jun 2.


Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.

Fakira AK, Gaspers LD, Thomas AP, Li H, Jain MR, Elkabes S.

Mol Cell Neurosci. 2012 Aug;51(1-2):22-31. doi: 10.1016/j.mcn.2012.07.001. Epub 2012 Jul 10.


Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.

Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA.

J Neurosci. 2011 Nov 9;31(45):16279-91. doi: 10.1523/JNEUROSCI.3835-11.2011.


Role of plasma membrane calcium ATPase 2 in spinal cord pathology.

Fakira AK, Elkabes S.

World J Biol Chem. 2010 May 26;1(5):103-8. doi: 10.4331/wjbc.v1.i5.103.

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