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Items: 25


AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke.

Kobayashi M, Benakis C, Anderson C, Moore MJ, Poon C, Uekawa K, Dyke JP, Fak JJ, Mele A, Park CY, Zhou P, Anrather J, Iadecola C, Darnell RB.

Cell Rep. 2019 Jul 23;28(4):979-991.e6. doi: 10.1016/j.celrep.2019.06.075.


Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk.

Zhou J, Park CY, Theesfeld CL, Wong AK, Yuan Y, Scheckel C, Fak JJ, Funk J, Yao K, Tajima Y, Packer A, Darnell RB, Troyanskaya OG.

Nat Genet. 2019 Jun;51(6):973-980. doi: 10.1038/s41588-019-0420-0. Epub 2019 May 27.


Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function.

Saito Y, Yuan Y, Zucker-Scharff I, Fak JJ, Jereb S, Tajima Y, Licatalosi DD, Darnell RB.

Neuron. 2019 Feb 20;101(4):707-720.e5. doi: 10.1016/j.neuron.2018.12.019. Epub 2019 Jan 9.


ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity.

Moore MJ, Blachere NE, Fak JJ, Park CY, Sawicka K, Parveen S, Zucker-Scharff I, Moltedo B, Rudensky AY, Darnell RB.

Elife. 2018 May 31;7. pii: e33057. doi: 10.7554/eLife.33057.


Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.

Jereb S, Hwang HW, Van Otterloo E, Govek EE, Fak JJ, Yuan Y, Hatten ME, Darnell RB.

Elife. 2018 Mar 26;7. pii: e34042. doi: 10.7554/eLife.34042.


cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.

Hwang HW, Saito Y, Park CY, Blachère NE, Tajima Y, Fak JJ, Zucker-Scharff I, Darnell RB.

Neuron. 2017 Sep 13;95(6):1334-1349.e5. doi: 10.1016/j.neuron.2017.08.024.


m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.

Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB.

Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117.


Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen.

Linderman JA, Kobayashi M, Rayannavar V, Fak JJ, Darnell RB, Chao MV, Wilson AC, Mohr I.

Cell Rep. 2017 Jan 31;18(5):1312-1323. doi: 10.1016/j.celrep.2017.01.017.


NOVA2-mediated RNA regulation is required for axonal pathfinding during development.

Saito Y, Miranda-Rottmann S, Ruggiu M, Park CY, Fak JJ, Zhong R, Duncan JS, Fabella BA, Junge HJ, Chen Z, Araya R, Fritzsch B, Hudspeth AJ, Darnell RB.

Elife. 2016 May 25;5. pii: e14371. doi: 10.7554/eLife.14371.


PAPERCLIP Identifies MicroRNA Targets and a Role of CstF64/64tau in Promoting Non-canonical poly(A) Site Usage.

Hwang HW, Park CY, Goodarzi H, Fak JJ, Mele A, Moore MJ, Saito Y, Darnell RB.

Cell Rep. 2016 Apr 12;15(2):423-35. doi: 10.1016/j.celrep.2016.03.023. Epub 2016 Mar 31.


miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity.

Moore MJ, Scheel TK, Luna JM, Park CY, Fak JJ, Nishiuchi E, Rice CM, Darnell RB.

Nat Commun. 2015 Nov 25;6:8864. doi: 10.1038/ncomms9864.


A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB.

Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.


Hepatitis C virus RNA functionally sequesters miR-122.

Luna JM, Scheel TK, Danino T, Shaw KS, Mele A, Fak JJ, Nishiuchi E, Takacs CN, Catanese MT, de Jong YP, Jacobson IM, Rice CM, Darnell RB.

Cell. 2015 Mar 12;160(6):1099-110. doi: 10.1016/j.cell.2015.02.025.


Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.

Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RB.

Neuron. 2012 Sep 20;75(6):1067-80. doi: 10.1016/j.neuron.2012.07.009.


Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB.

Genes Dev. 2012 Jul 15;26(14):1626-42. doi: 10.1101/gad.191338.112.


FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

Darnell JC, Van Driesche SJ, Zhang C, Hung KY, Mele A, Fraser CE, Stone EF, Chen C, Fak JJ, Chi SW, Licatalosi DD, Richter JD, Darnell RB.

Cell. 2011 Jul 22;146(2):247-61. doi: 10.1016/j.cell.2011.06.013.


Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.

Zhang C, Frias MA, Mele A, Ruggiu M, Eom T, Marney CB, Wang H, Licatalosi DD, Fak JJ, Darnell RB.

Science. 2010 Jul 23;329(5990):439-43. doi: 10.1126/science.1191150. Epub 2010 Jun 17.


The onconeural antigen cdr2 is a novel APC/C target that acts in mitosis to regulate c-myc target genes in mammalian tumor cells.

O'Donovan KJ, Diedler J, Couture GC, Fak JJ, Darnell RB.

PLoS One. 2010 Apr 7;5(4):e10045. doi: 10.1371/journal.pone.0010045.


Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.

Ruggiu M, Herbst R, Kim N, Jevsek M, Fak JJ, Mann MA, Fischbach G, Burden SJ, Darnell RB.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3513-8. doi: 10.1073/pnas.0813112106. Epub 2009 Feb 12.


HITS-CLIP yields genome-wide insights into brain alternative RNA processing.

Licatalosi DD, Mele A, Fak JJ, Ule J, Kayikci M, Chi SW, Clark TA, Schweitzer AC, Blume JE, Wang X, Darnell JC, Darnell RB.

Nature. 2008 Nov 27;456(7221):464-9. doi: 10.1038/nature07488. Epub 2008 Nov 2.


Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA.

Benach J, Chou YT, Fak JJ, Itkin A, Nicolae DD, Smith PC, Wittrock G, Floyd DL, Golsaz CM, Gierasch LM, Hunt JF.

J Biol Chem. 2003 Feb 7;278(6):3628-38. Epub 2002 Oct 27.


Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA.

Hunt JF, Weinkauf S, Henry L, Fak JJ, McNicholas P, Oliver DB, Deisenhofer J.

Science. 2002 Sep 20;297(5589):2018-26.


Regulation of rat pulmonary dendritic cell immunostimulatory activity by alveolar epithelial cell-derived granulocyte macrophage colony-stimulating factor.

Christensen PJ, Armstrong LR, Fak JJ, Chen GH, McDonald RA, Toews GB, Paine R 3rd.

Am J Respir Cell Mol Biol. 1995 Oct;13(4):426-33.


Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis.

Judge TA, Liu M, Christensen PJ, Fak JJ, Turka LA.

Int Immunol. 1995 Feb;7(2):171-8.


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