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Items: 48


CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells.

Warda W, Larosa F, Neto Da Rocha M, Trad R, Deconinck E, Fajloun Z, Faure C, Caillot D, Moldovan M, Valmary-Degano S, Biichle S, Daguindau E, Garnache-Ottou F, Tabruyn S, Adotevi O, Deschamps M, Ferrand C.

Cancer Res. 2019 Feb 1;79(3):663-675. doi: 10.1158/0008-5472.CAN-18-1078. Epub 2018 Dec 4.


Vipers of the Middle East: A Rich Source of Bioactive Molecules.

Rima M, Alavi Naini SM, Karam M, Sadek R, Sabatier JM, Fajloun Z.

Molecules. 2018 Oct 22;23(10). pii: E2721. doi: 10.3390/molecules23102721. Review.


Determination of 16 PAHs and 22 PCBs in honey samples originated from different region of Lebanon and used as environmental biomonitors sentinel.

Al-Alam J, Fajloun Z, Chbani A, Millet M.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018 Sep 10:1-7. doi: 10.1080/10934529.2018.1500782. [Epub ahead of print]


Autism throughout genetics: Perusal of the implication of ion channels.

Daghsni M, Rima M, Fajloun Z, Ronjat M, Brusés JL, M'rad R, De Waard M.

Brain Behav. 2018 Aug;8(8):e00978. doi: 10.1002/brb3.978. Epub 2018 Jun 22. Review.


Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor.

Chaker D, Mouawad C, Azar A, Quilliot D, Achkar I, Fajloun Z, Makdissy N.

Stem Cell Res Ther. 2018 Jun 19;9(1):167. doi: 10.1186/s13287-018-0910-5.


Montivipera bornmuelleri venom has immunomodulatory effects mainly up-regulating pro-inflammatory cytokines in the spleens of mice.

Yacoub T, Rima M, Sadek R, Hleihel W, Fajloun Z, Karam M.

Toxicol Rep. 2018 Mar 1;5:318-323. doi: 10.1016/j.toxrep.2018.02.011. eCollection 2018.


Essential role of ATP6AP2 enrichment in caveolae/lipid raft microdomains for the induction of neuronal differentiation of stem cells.

Makdissy N, Haddad K, AlBacha JD, Chaker D, Ismail B, Azar A, Oreibi G, Ayoub D, Achkar I, Quilliot D, Fajloun Z.

Stem Cell Res Ther. 2018 May 11;9(1):132. doi: 10.1186/s13287-018-0862-9.


In Utero Exposure to Maternal Diabetes Is Associated With Early Abnormal Vascular Structure in Offspring.

Dib A, Payen C, Bourreau J, Munier M, Grimaud L, Fajloun Z, Loufrani L, Henrion D, Fassot C.

Front Physiol. 2018 Apr 4;9:350. doi: 10.3389/fphys.2018.00350. eCollection 2018.


Evidence for in vitro antiophidian properties of aqueous buds extract of Eucalyptus against Montivipera bornmuelleri venom.

Khoury J, Dabbousy R, Sadek R, Antoun S, Hleihel W, Legros C, Fajloun Z.

J Venom Res. 2017 Oct 18;8:25-30. eCollection 2017.


Down-regulation of the Wnt/β-catenin signaling pathway by Cacnb4.

Rima M, Daghsni M, Lopez A, Fajloun Z, Lefrancois L, Dunach M, Mori Y, Merle P, Brusés JL, De Waard M, Ronjat M.

Mol Biol Cell. 2017 Dec 1;28(25):3699-3708. doi: 10.1091/mbc.E17-01-0076. Epub 2017 Oct 11.


A multiresidue method for the analysis of 90 pesticides, 16 PAHs, and 22 PCBs in honey using QuEChERS-SPME.

Al-Alam J, Fajloun Z, Chbani A, Millet M.

Anal Bioanal Chem. 2017 Aug;409(21):5157-5169. doi: 10.1007/s00216-017-0463-y. Epub 2017 Jul 5.


The β4 subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells.

Rima M, Daghsni M, De Waard S, Gaborit N, Fajloun Z, Ronjat M, Mori Y, Brusés JL, De Waard M.

Int J Biochem Cell Biol. 2017 Aug;89:57-70. doi: 10.1016/j.biocel.2017.05.032. Epub 2017 Jun 3.


Montivipera bornmuelleri venom selectively exhibits high cytotoxic effects on keratinocytes cancer cell lines.

Sawan S, Yaacoub T, Hraoui-Bloquet S, Sadek R, Hleihel W, Fajloun Z, Karam M.

Exp Toxicol Pathol. 2017 Apr 4;69(4):173-178. doi: 10.1016/j.etp.2017.01.001. Epub 2017 Jan 8.


Analysis of Dithiocarbamate Fungicides in Vegetable Matrices Using HPLC-UV Followed by Atomic Absorption Spectrometry.

Al-Alam J, Bom L, Chbani A, Fajloun Z, Millet M.

J Chromatogr Sci. 2017 Apr 1;55(4):429-435. doi: 10.1093/chromsci/bmw198.


The use of conifer needles as biomonitor candidates for the study of temporal air pollution variation in the Strasbourg region.

Al-Alam J, Fajloun Z, Chbani A, Millet M.

Chemosphere. 2017 Feb;168:1411-1421. doi: 10.1016/j.chemosphere.2016.11.103. Epub 2016 Dec 1.


The relaxant effect of the Montivipera bornmuelleri snake venom on vascular contractility.

Accary C, Hraoui-Bloquet S, Sadek R, Alameddine A, Fajloun Z, Desfontis JC, Mallem Y.

J Venom Res. 2016 Feb 23;7:10-15. eCollection 2016.


Protein partners of the calcium channel β subunit highlight new cellular functions.

Rima M, Daghsni M, Fajloun Z, M'rad R, Brusés JL, Ronjat M, De Waard M.

Biochem J. 2016 Jul 1;473(13):1831-44. doi: 10.1042/BCJ20160125. Review.


Contribution to the food products' analysis: A research and evaluation on the hemolytic effect of some pesticides used in Lebanon.

Al-Alam J, Millet M, Chbani A, Fajloun Z.

J Environ Sci Health B. 2015;50(11):788-96. doi: 10.1080/03601234.2015.1058095.


High Incidence of ACE/PAI-1 in Association to a Spectrum of Other Polymorphic Cardiovascular Genes Involving PBMCs Proinflammatory Cytokines in Hypertensive Hypercholesterolemic Patients: Reversibility with a Combination of ACE Inhibitor and Statin.

AlBacha Jd, Khoury M, Mouawad C, Haddad K, Hamoui S, Azar A, Fajloun Z, Makdissy N.

PLoS One. 2015 May 14;10(5):e0127266. doi: 10.1371/journal.pone.0127266. eCollection 2015.


The cardiovascular effects of salidroside in the Goto-Kakizaki diabetic rat model.

Alameddine A, Fajloun Z, Bourreau J, Gauquelin-Koch G, Yuan M, Gauguier D, Derbre S, Ayer A, Custaud MA, Navasiolava N.

J Physiol Pharmacol. 2015 Apr;66(2):249-57.


Protein content analysis and antimicrobial activity of the crude venom of Montivipera bornmuelleri; a viper from Lebanon.

Accary C, Hraoui-Bloquet S, Hamze M, Mallem Y, El Omar F, Sabatier JM, Desfontis JC, Fajloun Z.

Infect Disord Drug Targets. 2014;14(1):49-55.


Identification of L-amino acid oxidase (Mb-LAAO) with antibacterial activity in the venom of Montivipera bornmuelleri, a viper from Lebanon.

Rima M, Accary C, Haddad K, Sadek R, Hraoui-Bloquet S, Desfontis JC, Fajloun Z.

Infect Disord Drug Targets. 2013 Oct;13(5):337-43.


Lacticin LC14, a new bacteriocin produced by Lactococcus lactis BMG6.14: isolation, purification and partial characterization.

Lasta S, Ouzari H, Andreotti N, Fajloun Z, Mansuelle P, Boudabous A, Sampieri F, Sabatier JM.

Infect Disord Drug Targets. 2012 Aug;12(4):316-25.


Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K(+) channel.

Fajloun Z, Andreotti N, Fathallah M, Sabatier JM, De Waard M.

J Pept Sci. 2011 Mar;17(3):200-10. doi: 10.1002/psc.1313. Epub 2011 Jan 11.


Chemical synthesis and characterization of J46 peptide, an atypical class IIa bacteriocin from Lactococcus lactis subsp. cremoris J46 Strain.

Lasta S, Fajloun Z, Darbon H, Mansuelle P, Andreotti N, Sabatier JM, Boudabous A, Sampieri F.

J Antibiot (Tokyo). 2008 Feb;61(2):89-93. doi: 10.1038/ja.2008.116.


[Chemical synthesis of lactococcin B and functional evaluation of the N-terminal domain using a truncated synthetic analogue].

Lasta S, Fajloun Z, Mansuelle P, Sabatier JM, Boudabous A, Sampieri F.

Arch Inst Pasteur Tunis. 2008;85(1-4):9-19. French.


Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins.

Pimentel C, M'Barek S, Visan V, Grissmer S, Sampieri F, Sabatier JM, Darbon H, Fajloun Z.

Protein Sci. 2008 Jan;17(1):107-18. Epub 2007 Nov 27.


CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity.

Guieu R, Fenouillet E, Devaux C, Fajloun Z, Carrega L, Sabatier JM, Sauze N, Marguet D.

Behav Brain Res. 2006 Jan 30;166(2):230-5. Epub 2005 Sep 8.


Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.

M'Barek S, Chagot B, Andreotti N, Visan V, Mansuelle P, Grissmer S, Marrakchi M, El Ayeb M, Sampieri F, Darbon H, Fajloun Z, De Waard M, Sabatier JM.

Proteins. 2005 Aug 15;60(3):401-11.


First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector.

M'Barek S, Fajloun Z, Cestèle S, Devaux C, Mansuelle P, Mosbah A, Jouirou B, Mantegazza M, Van Rietschoten J, El Ayeb M, Rochat H, Sabatier JM, Sampieri F.

J Pept Sci. 2004 Nov;10(11):666-77.


Mapping of maurotoxin binding sites on hKv1.2, hKv1.3, and hIKCa1 channels.

Visan V, Fajloun Z, Sabatier JM, Grissmer S.

Mol Pharmacol. 2004 Nov;66(5):1103-12. Epub 2004 Jul 30.


Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.

Jouirou B, Mosbah A, Visan V, Grissmer S, M'Barek S, Fajloun Z, Van Rietschoten J, Devaux C, Rochat H, Lippens G, El Ayeb M, De Waard M, Mabrouk K, Sabatier JM.

Biochem J. 2004 Jan 1;377(Pt 1):37-49.


Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.

M'Barek S, Mosbah A, Sandoz G, Fajloun Z, Olamendi-Portugal T, Rochat H, Sampieri F, Guijarro JI, Mansuelle P, Delepierre M, De Waard M, Sabatier JM.

Eur J Biochem. 2003 Sep;270(17):3583-92.


A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.

M'Barek S, Lopez-Gonzalez I, Andreotti N, di Luccio E, Visan V, Grissmer S, Judge S, El Ayeb M, Darbon H, Rochat H, Sampieri F, Béraud E, Fajloun Z, De Waard M, Sabatier JM.

J Biol Chem. 2003 Aug 15;278(33):31095-104. Epub 2003 Jun 3.


Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels.

Castle NA, London DO, Creech C, Fajloun Z, Stocker JW, Sabatier JM.

Mol Pharmacol. 2003 Feb;63(2):409-18.


Synthesis, 3-D structure, and pharmacology of a reticulated chimeric peptide derived from maurotoxin and Tsk scorpion toxins.

Fajloun Z, Ferrat G, Carlier E, M'Barek S, Regaya I, Fathallah M, Rochat H, Darbon H, de Waard M, Sabatier JM.

Biochem Biophys Res Commun. 2002 Mar 1;291(3):640-8.


Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro.

di Luccio E, Matavel A, Opi S, Regaya I, Sandoz G, M'barek S, Carlier E, Estève E, Carrega L, Fajloun Z, Rochat H, Loret E, de Waard M, Sabatier JM.

Biochem J. 2002 Jan 15;361(Pt 2):409-16.


Parameters affecting in vitro oxidation/folding of maurotoxin, a four-disulphide-bridged scorpion toxin.

di Luccio E, Azulay DO, Regaya I, Fajloun Z, Sandoz G, Mansuelle P, Kharrat R, Fathallah M, Carrega L, Estève E, Rochat H, De Waard M, Sabatier JM.

Biochem J. 2001 Sep 15;358(Pt 3):681-92.


Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG.

J Biol Chem. 2001 Nov 16;276(46):43145-51. Epub 2001 Aug 29.


Disulfide bridge reorganization induced by proline mutations in maurotoxin.

Carlier E, Fajloun Z, Mansuelle P, Fathallah M, Mosbah A, Oughideni R, Sandoz G, Di Luccio E, Geib S, Regaya I, Brocard J, Rochat H, Darbon H, Devaux C, Sabatier JM, de Waard M.

FEBS Lett. 2001 Feb 2;489(2-3):202-7.


Ion channel activation by SPC3, a peptide derived from the HIV-1 gp120 V3 loop.

Carlier E, Mabrouk K, Moulard M, Fajloun Z, Rochat H, De Waard M, Sabatier JM.

J Pept Res. 2000 Dec;56(6):427-37.


Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns.

Fajloun Z, Mosbah A, Carlier E, Mansuelle P, Sandoz G, Fathallah M, di Luccio E, Devaux C, Rochat H, Darbon H, De Waard M, Sabatier JM.

J Biol Chem. 2000 Dec 15;275(50):39394-402.


Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels.

Fajloun Z, Carlier E, Lecomte C, Geib S, Di Luccio E, Bichet D, Mabrouk K, Rochat H, De Waard M, Sabatier JM.

Eur J Biochem. 2000 Aug;267(16):5149-55.


Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels.

Carlier E, Avdonin V, Geib S, Fajloun Z, Kharrat R, Rochat H, Sabatier JM, Hoshi T, De Waard M.

J Pept Res. 2000 Jun;55(6):419-27.


A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel.

Mosbah A, Kharrat R, Fajloun Z, Renisio JG, Blanc E, Sabatier JM, El Ayeb M, Darbon H.

Proteins. 2000 Aug 15;40(3):436-42.


Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins.

Fajloun Z, Ferrat G, Carlier E, Fathallah M, Lecomte C, Sandoz G, di Luccio E, Mabrouk K, Legros C, Darbon H, Rochat H, Sabatier JM, De Waard M.

J Biol Chem. 2000 May 5;275(18):13605-12.


Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors.

Fajloun Z, Kharrat R, Chen L, Lecomte C, Di Luccio E, Bichet D, El Ayeb M, Rochat H, Allen PD, Pessah IN, De Waard M, Sabatier JM.

FEBS Lett. 2000 Mar 10;469(2-3):179-85.


Chemical synthesis and structure-activity relationships of Ts kappa, a novel scorpion toxin acting on apamin-sensitive SK channel.

Lecomte C, Ferrat G, Fajloun Z, Van Rietschoten J, Rochat H, Martin-Eauclaire MF, Darbon H, Sabatier JM.

J Pept Res. 1999 Nov;54(5):369-76.


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