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Inter-organ communication: a gatekeeper for metabolic health.

Castillo-Armengol J, Fajas L, Lopez-Mejia IC.

EMBO Rep. 2019 Sep;20(9):e47903. doi: 10.15252/embr.201947903. Epub 2019 Aug 19. Review.


CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival.

Martínez-Carreres L, Puyal J, Leal-Esteban LC, Orpinell M, Castillo-Armengol J, Giralt A, Dergai O, Moret C, Barquissau V, Nasrallah A, Pabois A, Zhang L, Romero P, Lopez-Mejia IC, Fajas L.

Cancer Res. 2019 Oct 15;79(20):5245-5259. doi: 10.1158/0008-5472.CAN-19-0708. Epub 2019 Aug 8.


Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR.

Castellano-Castillo D, Denechaud PD, Fajas L, Moreno-Indias I, Oliva-Olivera W, Tinahones F, Queipo-Ortuño MI, Cardona F.

PLoS One. 2019 Apr 8;14(4):e0215083. doi: 10.1371/journal.pone.0215083. eCollection 2019.


CDK4, a new metabolic sensor that antagonizes AMPK.

Fajas L, Lopez-Mejia IC.

Mol Cell Oncol. 2018 May 16;5(5):e1409862. doi: 10.1080/23723556.2017.1409862. eCollection 2018.


β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice.

Somm E, Henry H, Bruce SJ, Bonnet N, Montandon SA, Niederländer NJ, Messina A, Aeby S, Rosikiewicz M, Fajas L, Sempoux C, Ferrari SL, Greub G, Pitteloud N.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E833-E847. doi: 10.1152/ajpendo.00182.2018. Epub 2018 Jun 26.


Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.

Trompette A, Gollwitzer ES, Pattaroni C, Lopez-Mejia IC, Riva E, Pernot J, Ubags N, Fajas L, Nicod LP, Marsland BJ.

Immunity. 2018 May 15;48(5):992-1005.e8. doi: 10.1016/j.immuni.2018.04.022.


E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.

Giralt A, Denechaud PD, Lopez-Mejia IC, Delacuisine B, Blanchet E, Bonner C, Pattou F, Annicotte JS, Fajas L.

Mol Metab. 2018 May;11:104-112. doi: 10.1016/j.molmet.2018.02.011. Epub 2018 Feb 26.


Chromatin immunoprecipitation improvements for the processing of small frozen pieces of adipose tissue.

Castellano-Castillo D, Denechaud PD, Moreno-Indias I, Tinahones F, Fajas L, Queipo-Ortuño MI, Cardona F.

PLoS One. 2018 Feb 14;13(2):e0192314. doi: 10.1371/journal.pone.0192314. eCollection 2018.


Editorial: Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions.

Giralt A, Fajas L.

Front Endocrinol (Lausanne). 2017 Dec 21;8:362. doi: 10.3389/fendo.2017.00362. eCollection 2017. No abstract available.


Cdkn2a deficiency promotes adipose tissue browning.

Rabhi N, Hannou SA, Gromada X, Salas E, Yao X, Oger F, Carney C, Lopez-Mejia IC, Durand E, Rabearivelo I, Bonnefond A, Caron E, Fajas L, Dani C, Froguel P, Annicotte JS.

Mol Metab. 2018 Feb;8:65-76. doi: 10.1016/j.molmet.2017.11.012. Epub 2017 Dec 1.


E2F1, a Novel Regulator of Metabolism.

Denechaud PD, Fajas L, Giralt A.

Front Endocrinol (Lausanne). 2017 Nov 10;8:311. doi: 10.3389/fendo.2017.00311. eCollection 2017. Review.


CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.

Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L.

Mol Cell. 2017 Oct 19;68(2):336-349.e6. doi: 10.1016/j.molcel.2017.09.034.


Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.

Lopez-Mejia IC, Castillo-Armengol J, Lagarrigue S, Fajas L.

Cell Mol Life Sci. 2018 Mar;75(6):975-987. doi: 10.1007/s00018-017-2668-9. Epub 2017 Oct 7. Review.


Cancer: Linking Powerhouses to Suicidal Bags.

Martinez-Carreres L, Nasrallah A, Fajas L.

Front Oncol. 2017 Sep 6;7:204. doi: 10.3389/fonc.2017.00204. eCollection 2017. Review.


The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway.

Khan AUH, Allende-Vega N, Gitenay D, Gerbal-Chaloin S, Gondeau C, Vo DN, Belkahla S, Orecchioni S, Talarico G, Bertolini F, Bozic M, Valdivielso JM, Bejjani F, Jariel I, Lopez-Mejia IC, Fajas L, Lecellier CH, Hernandez J, Daujat M, Villalba M.

Sci Rep. 2017 Sep 6;7(1):10654. doi: 10.1038/s41598-017-10339-5.


E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver.

Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L.

JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729. eCollection 2017 May 18.


β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.

Somm E, Henry H, Bruce SJ, Aeby S, Rosikiewicz M, Sykiotis GP, Asrih M, Jornayvaz FR, Denechaud PD, Albrecht U, Mohammadi M, Dwyer A, Acierno JS Jr, Schoonjans K, Fajas L, Greub G, Pitteloud N.

JCI Insight. 2017 Apr 20;2(8). pii: 91809. doi: 10.1172/jci.insight.91809. eCollection 2017 Apr 20.


Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma.

Morzyglod L, Caüzac M, Popineau L, Denechaud PD, Fajas L, Ragazzon B, Fauveau V, Planchais J, Vasseur-Cognet M, Fartoux L, Scatton O, Rosmorduc O, Guilmeau S, Postic C, Desdouets C, Desbois-Mouthon C, Burnol AF.

Hepatology. 2017 Apr;65(4):1352-1368. doi: 10.1002/hep.28972. Epub 2017 Feb 21.


[Cell cycle regulators CDK4 and E2F1 control glucose and lipid homeostasis].

Denechaud PD, Lopez-Mejia IC, Fajas L.

Med Sci (Paris). 2016 Oct;32(10):815-818. Epub 2016 Oct 19. French. No abstract available.


KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response.

Rabhi N, Denechaud PD, Gromada X, Hannou SA, Zhang H, Rashid T, Salas E, Durand E, Sand O, Bonnefond A, Yengo L, Chavey C, Bonner C, Kerr-Conte J, Abderrahmani A, Auwerx J, Fajas L, Froguel P, Annicotte JS.

Cell Rep. 2016 May 3;15(5):1051-1061. doi: 10.1016/j.celrep.2016.03.079. Epub 2016 Apr 21.


Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.

Scholz G, Jandus C, Zhang L, Grandclément C, Lopez-Mejia IC, Soneson C, Delorenzi M, Fajas L, Held W, Dormond O, Romero P.

EBioMedicine. 2016 Jan 16;4:50-61. doi: 10.1016/j.ebiom.2016.01.019. eCollection 2016 Feb.


Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.

Zhang L, Tschumi BO, Lopez-Mejia IC, Oberle SG, Meyer M, Samson G, Rüegg MA, Hall MN, Fajas L, Zehn D, Mach JP, Donda A, Romero P.

Cell Rep. 2016 Feb 9;14(5):1206-1217. doi: 10.1016/j.celrep.2015.12.095. Epub 2016 Jan 21.


CDK4 is an essential insulin effector in adipocytes.

Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escoté X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Huré S, Abella A, Tinahones FJ, Vendrell J, Dubus P, Bosch F, Kahn CR, Fajas L.

J Clin Invest. 2016 Jan;126(1):335-48. doi: 10.1172/JCI81480. Epub 2015 Dec 14.


E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.

Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, Annicotte JS, Fajas L.

J Clin Invest. 2016 Jan;126(1):137-50. doi: 10.1172/JCI81542. Epub 2015 Nov 30.


Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells.

Petrov PD, Ribot J, López-Mejía IC, Fajas L, Palou A, Bonet ML.

J Cell Physiol. 2016 Mar;231(3):708-18. doi: 10.1002/jcp.25121.


Cell cycle regulation of mitochondrial function.

Lopez-Mejia IC, Fajas L.

Curr Opin Cell Biol. 2015 Apr;33:19-25. doi: 10.1016/ Epub 2014 Nov 12. Review.


Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells.

Lopez-Royuela N, Rathore MG, Allende-Vega N, Annicotte JS, Fajas L, Ramachandran B, Gulick T, Villalba M.

Int J Biochem Cell Biol. 2014 Aug;53:253-61. doi: 10.1016/j.biocel.2014.05.026. Epub 2014 May 28.


Metabolic adaptation to cancer growth: from the cell to the organism.

Escoté X, Fajas L.

Cancer Lett. 2015 Jan 28;356(2 Pt A):171-5. doi: 10.1016/j.canlet.2014.03.034. Epub 2014 Apr 4. Review.


Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

Lopez-Mejia IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C, Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

EMBO Rep. 2014 May;15(5):529-39. doi: 10.1002/embr.201338126. Epub 2014 Mar 17.


Mice lacking the p43 mitochondrial T3 receptor become glucose intolerant and insulin resistant during aging.

Bertrand C, Blanchet E, Pessemesse L, Annicotte JS, Feillet-Coudray C, Chabi B, Levin J, Fajas L, Cabello G, Wrutniak-Cabello C, Casas F.

PLoS One. 2013 Sep 30;8(9):e75111. doi: 10.1371/journal.pone.0075111. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/844c2e7b-2f5f-4982-85d2-b82debdeffb1.


Metabolic control in cancer cells.

Fajas L.

Ann Endocrinol (Paris). 2013 May;74(2):71-3. doi: 10.1016/j.ando.2013.03.021. Epub 2013 Apr 12. Review.


Re-thinking cell cycle regulators: the cross-talk with metabolism.

Fajas L.

Front Oncol. 2013 Jan 24;3:4. doi: 10.3389/fonc.2013.00004. eCollection 2013.


Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth.

Fritz V, Benfodda Z, Henriquet C, Hure S, Cristol JP, Michel F, Carbonneau MA, Casas F, Fajas L.

Oncogene. 2013 Oct 17;32(42):5101-10. doi: 10.1038/onc.2012.523. Epub 2012 Dec 3.


E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism.

Blanchet E, Annicotte JS, Pradelli LA, Hugon G, Matecki S, Mornet D, Rivier F, Fajas L.

Hum Mol Genet. 2012 Sep 1;21(17):3910-7. doi: 10.1093/hmg/dds219. Epub 2012 Jun 7.


The RIP140 gene is a transcriptional target of E2F1.

Docquier A, Augereau P, Lapierre M, Harmand PO, Badia E, Annicotte JS, Fajas L, Cavaillès V.

PLoS One. 2012;7(5):e35839. doi: 10.1371/journal.pone.0035839. Epub 2012 May 18.


PPARγ contributes to PKM2 and HK2 expression in fatty liver.

Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Fajas L, Foretz M, Verdeguer F, Pontoglio M, Ferré P, Scoazec JY, Birnbaum MJ, Ricci JE, Pende M.

Nat Commun. 2012 Feb 14;3:672. doi: 10.1038/ncomms1667.


E2F1 at the crossroad of proliferation and oxidative metabolism.

Fajas L, Annicotte JS.

Cell Cycle. 2011 Dec 15;10(24):4193-4. doi: 10.4161/cc.10.24.18362. Epub 2011 Dec 15. No abstract available.


Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis.

Blanchet E, Bertrand C, Annicotte JS, Schlernitzauer A, Pessemesse L, Levin J, Fouret G, Feillet-Coudray C, Bonafos B, Fajas L, Cabello G, Wrutniak-Cabello C, Casas F.

FASEB J. 2012 Jan;26(1):40-50. doi: 10.1096/fj.11-186841. Epub 2011 Sep 13.


E2F transcription factor-1 regulates oxidative metabolism.

Blanchet E, Annicotte JS, Lagarrigue S, Aguilar V, Clapé C, Chavey C, Fritz V, Casas F, Apparailly F, Auwerx J, Fajas L.

Nat Cell Biol. 2011 Aug 14;13(9):1146-52. doi: 10.1038/ncb2309.


[Emerging key role of cell cycle regulators in cell metabolism].

Lagarrigue S, Blanchet É, Annicotte JS, Fajas L.

Med Sci (Paris). 2011 May;27(5):508-13. doi: 10.1051/medsci/2011275016. Epub 2011 May 25. Review. French.


The CDK4-pRB-E2F1 pathway : A new modulator of insulin secretion.

Fajas L, Blanchet E, Annicotte JS.

Islets. 2010 Jan-Feb;2(1):51-3. doi: 10.4161/isl.2.1.10338. Review.


Cyclin G2 regulates adipogenesis through PPAR gamma coactivation.

Aguilar V, Annicotte JS, Escote X, Vendrell J, Langin D, Fajas L.

Endocrinology. 2010 Nov;151(11):5247-54. doi: 10.1210/en.2010-0461. Epub 2010 Sep 15.


Cycling through metabolism.

Aguilar V, Fajas L.

EMBO Mol Med. 2010 Sep;2(9):338-48. doi: 10.1002/emmm.201000089. Review.


Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth.

Botton T, Puissant A, Cheli Y, Tomic T, Giuliano S, Fajas L, Deckert M, Ortonne JP, Bertolotto C, Tartare-Deckert S, Ballotti R, Rocchi S.

Cell Death Differ. 2011 Jan;18(1):109-21. doi: 10.1038/cdd.2010.75. Epub 2010 Jul 2.


Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice.

Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avancès C, Allory Y, de la Taille A, Culine S, Blancou H, Cristol JP, Michel F, Sardet C, Fajas L.

Mol Cancer Ther. 2010 Jun;9(6):1740-54. doi: 10.1158/1535-7163.MCT-09-1064. Epub 2010 Jun 8.


Metabolism and proliferation share common regulatory pathways in cancer cells.

Fritz V, Fajas L.

Oncogene. 2010 Aug 5;29(31):4369-77. doi: 10.1038/onc.2010.182. Epub 2010 May 31. Review.


CDK4, pRB and E2F1: connected to insulin.

Fajas L, Blanchet E, Annicotte JS.

Cell Div. 2010 Feb 5;5(1):6. doi: 10.1186/1747-1028-5-6.


CXCL5 drives obesity to diabetes, and further.

Chavey C, Fajas L.

Aging (Albany NY). 2009 Jul 2;1(7):674-7.


Persistent organic pollutant exposure leads to insulin resistance syndrome.

Ruzzin J, Petersen R, Meugnier E, Madsen L, Lock EJ, Lillefosse H, Ma T, Pesenti S, Sonne SB, Marstrand TT, Malde MK, Du ZY, Chavey C, Fajas L, Lundebye AK, Brand CL, Vidal H, Kristiansen K, Frøyland L.

Environ Health Perspect. 2010 Apr;118(4):465-71. doi: 10.1289/ehp.0901321. Epub 2009 Nov 19.


Cell cycle regulators in the control of metabolism.

Blanchet E, Annicotte JS, Fajas L.

Cell Cycle. 2009 Dec 15;8(24):4029-31. Epub 2009 Dec 17.

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