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Induction of spontaneous curvature and endocytosis: Unwanted consequences of cholesterol extraction using methyl-β-Cyclodextrin.

Hirama T, Fairn GD.

Commun Integr Biol. 2018 Mar 13;11(2):1-4. doi: 10.1080/19420889.2018.1444306. eCollection 2018.


Salmonella exploits host Rho GTPase signalling pathways through the phosphatase activity of SopB.

Truong D, Boddy KC, Canadien V, Brabant D, Fairn GD, D'Costa VM, Coyaud E, Raught B, Pérez-Sala D, Park WS, Heo WD, Grinstein S, Brumell JH.

Cell Microbiol. 2018 Oct;20(10):e12938. doi: 10.1111/cmi.12938. Epub 2018 Aug 3.


7-Ketocholesterol impairs phagocytosis and efferocytosis via dysregulation of phosphatidylinositol 4,5-bisphosphate.

Lu SM, Fairn GD.

Traffic. 2018 Aug;19(8):591-604. doi: 10.1111/tra.12576. Epub 2018 Jun 10.


Phospholipid subcellular localization and dynamics.

Yang Y, Lee M, Fairn GD.

J Biol Chem. 2018 Apr 27;293(17):6230-6240. doi: 10.1074/jbc.R117.000582. Epub 2018 Mar 27. Review.


PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.

Sohn M, Korzeniowski M, Zewe JP, Wills RC, Hammond GRV, Humpolickova J, Vrzal L, Chalupska D, Veverka V, Fairn GD, Boura E, Balla T.

J Cell Biol. 2018 May 7;217(5):1797-1813. doi: 10.1083/jcb.201710095. Epub 2018 Feb 22.


Mesoscale organization of domains in the plasma membrane - beyond the lipid raft.

Lu SM, Fairn GD.

Crit Rev Biochem Mol Biol. 2018 Apr;53(2):192-207. doi: 10.1080/10409238.2018.1436515. Epub 2018 Feb 18.


Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites.

Lee M, Fairn GD.

Biochem Biophys Res Commun. 2018 Feb 19;496(4):1088-1094. doi: 10.1016/j.bbrc.2018.01.138. Epub 2018 Feb 2.


Should basic science matter to clinicians?

Filewod NC, Batt J, Kapus A, Szaszi K, Fairn GD, Slutsky AS, Lee WL.

Lancet. 2018 Feb 3;391(10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. No abstract available.


SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1.

Fung KY, Wang C, Nyegaard S, Heit B, Fairn GD, Lee WL.

Front Physiol. 2017 Oct 30;8:841. doi: 10.3389/fphys.2017.00841. eCollection 2017.


Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis.

Hirama T, Lu SM, Kay JG, Maekawa M, Kozlov MM, Grinstein S, Fairn GD.

Nat Commun. 2017 Nov 9;8(1):1393. doi: 10.1038/s41467-017-01554-9.


Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis.

Zhao L, Thorsheim CL, Suzuki A, Stalker TJ, Min SH, Lian L, Fairn GD, Cockcroft S, Durham A, Krishnaswamy S, Abrams CS.

Nat Commun. 2017 Oct 31;8(1):1216. doi: 10.1038/s41467-017-01181-4.


Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities.

Fung KYY, Fairn GD, Lee WL.

Traffic. 2018 Jan;19(1):5-18. doi: 10.1111/tra.12533. Epub 2017 Nov 21. Review.


Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane.

Hirama T, Das R, Yang Y, Ferguson C, Won A, Yip CM, Kay JG, Grinstein S, Parton RG, Fairn GD.

J Biol Chem. 2017 Aug 25;292(34):14292-14307. doi: 10.1074/jbc.M117.791400. Epub 2017 Jul 11.


PPAR-delta modulates membrane cholesterol and cytokine signaling in malignant B cells.

Sun L, Shi Y, Wang G, Wang X, Zeng S, Dunn SE, Fairn GD, Li YJ, Spaner DE.

Leukemia. 2018 Jan;32(1):184-193. doi: 10.1038/leu.2017.162. Epub 2017 May 30.


VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.

Hua R, Cheng D, Coyaud É, Freeman S, Di Pietro E, Wang Y, Vissa A, Yip CM, Fairn GD, Braverman N, Brumell JH, Trimble WS, Raught B, Kim PK.

J Cell Biol. 2017 Feb;216(2):367-377. doi: 10.1083/jcb.201608128. Epub 2017 Jan 20.


The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic.

Bone LN, Dayam RM, Lee M, Kono N, Fairn GD, Arai H, Botelho RJ, Antonescu CN.

Mol Biol Cell. 2017 Jan 1;28(1):161-172. doi: 10.1091/mbc.E16-09-0668. Epub 2016 Nov 9.


Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis.

Levin R, Hammond GR, Balla T, De Camilli P, Fairn GD, Grinstein S.

Mol Biol Cell. 2017 Jan 1;28(1):128-140. doi: 10.1091/mbc.E16-06-0451. Epub 2016 Nov 9.


Quantitative Live-Cell Fluorescence Microscopy During Phagocytosis.

Lu SM, Grinstein S, Fairn GD.

Methods Mol Biol. 2017;1519:79-91.


Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.

Maekawa M, Lee M, Wei K, Ridgway ND, Fairn GD.

Sci Rep. 2016 Nov 2;6:35762. doi: 10.1038/srep35762.


Cresyl violet: a superior fluorescent lysosomal marker.

Ostrowski PP, Fairn GD, Grinstein S, Johnson DE.

Traffic. 2016 Dec;17(12):1313-1321. doi: 10.1111/tra.12447. Epub 2016 Oct 17.


Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis.

Schlam D, Canton J, Carreño M, Kopinski H, Freeman SA, Grinstein S, Fairn GD.

MBio. 2016 Apr 5;7(2):e02242. doi: 10.1128/mBio.02242-15.


Perfringolysin O Theta Toxin as a Tool to Monitor the Distribution and Inhomogeneity of Cholesterol in Cellular Membranes.

Maekawa M, Yang Y, Fairn GD.

Toxins (Basel). 2016 Mar 8;8(3). pii: E67. doi: 10.3390/toxins8030067. Review.


CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor- and Complement Receptor 3-Dependent Mechanisms.

Amash A, Wang L, Wang Y, Bhakta V, Fairn GD, Hou M, Peng J, Sheffield WP, Lazarus AH.

J Immunol. 2016 Apr 15;196(8):3331-40. doi: 10.4049/jimmunol.1502198. Epub 2016 Mar 4.


Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.

Cho KJ, van der Hoeven D, Zhou Y, Maekawa M, Ma X, Chen W, Fairn GD, Hancock JF.

Mol Cell Biol. 2015 Nov 16;36(2):363-74. doi: 10.1128/MCB.00719-15. Print 2016 Jan 15.


Is basic science disappearing from medicine? The decline of biomedical research in the medical literature.

Steinberg BE, Goldenberg NM, Fairn GD, Kuebler WM, Slutsky AS, Lee WL.

FASEB J. 2016 Feb;30(2):515-8. doi: 10.1096/fj.15-281758. Epub 2015 Oct 14.


Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.

Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S.

Nat Commun. 2015 Oct 14;6:8623. doi: 10.1038/ncomms9623.


Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol.

Maekawa M, Fairn GD.

J Cell Sci. 2015 Apr 1;128(7):1422-33. doi: 10.1242/jcs.164715. Epub 2015 Feb 6.


Molecular probes to visualize the location, organization and dynamics of lipids.

Maekawa M, Fairn GD.

J Cell Sci. 2014 Nov 15;127(Pt 22):4801-12. doi: 10.1242/jcs.150524. Epub 2014 Sep 1.


Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes.

Mukherjee D, Sen A, Boettner DR, Fairn GD, Schlam D, Bonilla Valentin FJ, Michael McCaffery J, Hazbun T, Staiger CJ, Grinstein S, Lemmon SK, Claudio Aguilar R.

J Cell Sci. 2013 Oct 15;126(Pt 20):4560-71. doi: 10.1242/jcs.117663. Epub 2013 Aug 13.


Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.

Strijbis K, Tafesse FG, Fairn GD, Witte MD, Dougan SK, Watson N, Spooner E, Esteban A, Vyas VK, Fink GR, Grinstein S, Ploegh HL.

PLoS Pathog. 2013;9(6):e1003446. doi: 10.1371/journal.ppat.1003446. Epub 2013 Jun 27.


Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.

Schlam D, Bohdanowicz M, Chatgilialoglu A, Steinberg BE, Ueyama T, Du G, Grinstein S, Fairn GD.

J Biol Chem. 2013 Aug 9;288(32):23090-104. doi: 10.1074/jbc.M113.457606. Epub 2013 Jun 27. Erratum in: J Biol Chem. 2014 Feb 21;289(8):4813. Chatilialoglu, Alexandros [corrected to Chatgilialoglu, Alexandros].


The yeast oxysterol binding protein Kes1 maintains sphingolipid levels.

LeBlanc MA, Fairn GD, Russo SB, Czyz O, Zaremberg V, Cowart LA, McMaster CR.

PLoS One. 2013 Apr 4;8(4):e60485. doi: 10.1371/journal.pone.0060485. Print 2013.


Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes.

Bohdanowicz M, Schlam D, Hermansson M, Rizzuti D, Fairn GD, Ueyama T, Somerharju P, Du G, Grinstein S.

Mol Biol Cell. 2013 Jun;24(11):1700-12, S1-7. doi: 10.1091/mbc.E12-11-0789. Epub 2013 Apr 10.


Localization of lipid raft proteins to the plasma membrane is a major function of the phospholipid transfer protein Sec14.

Curwin AJ, Leblanc MA, Fairn GD, McMaster CR.

PLoS One. 2013;8(1):e55388. doi: 10.1371/journal.pone.0055388. Epub 2013 Jan 30.


Cell biology. Precursor or charge supplier?

Fairn GD, Grinstein S.

Science. 2012 Aug 10;337(6095):653-4. doi: 10.1126/science.1227096. No abstract available.


How nascent phagosomes mature to become phagolysosomes.

Fairn GD, Grinstein S.

Trends Immunol. 2012 Aug;33(8):397-405. doi: 10.1016/ Epub 2012 May 3. Review.


Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin.

Liu J, Fairn GD, Ceccarelli DF, Sicheri F, Wilde A.

Curr Biol. 2012 Jan 10;22(1):64-9. doi: 10.1016/j.cub.2011.11.040. Epub 2011 Dec 22.


Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity.

Fairn GD, Hermansson M, Somerharju P, Grinstein S.

Nat Cell Biol. 2011 Oct 2;13(12):1424-30. doi: 10.1038/ncb2351.


A weak base-generating system suitable for selective manipulation of lysosomal pH.

Carraro-Lacroix LR, Jaumouillé V, Fairn GD, Grinstein S.

Traffic. 2011 Nov;12(11):1490-500. doi: 10.1111/j.1600-0854.2011.01266.x. Epub 2011 Sep 6.


High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine.

Fairn GD, Schieber NL, Ariotti N, Murphy S, Kuerschner L, Webb RI, Grinstein S, Parton RG.

J Cell Biol. 2011 Jul 25;194(2):257-75. doi: 10.1083/jcb.201012028.


Rapamycin-based inducible translocation systems for studying phagocytosis.

Bohdanowicz M, Fairn GD.

Methods Mol Biol. 2011;748:183-93. doi: 10.1007/978-1-61779-139-0_13.


An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis.

Fairn GD, Ogata K, Botelho RJ, Stahl PD, Anderson RA, De Camilli P, Meyer T, Wodak S, Grinstein S.

J Cell Biol. 2009 Nov 30;187(5):701-14. doi: 10.1083/jcb.200909025.


Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation.

Yeung T, Heit B, Dubuisson JF, Fairn GD, Chiu B, Inman R, Kapus A, Swanson M, Grinstein S.

J Cell Biol. 2009 Jun 1;185(5):917-28. doi: 10.1083/jcb.200903020.


Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.

Curwin AJ, Fairn GD, McMaster CR.

J Biol Chem. 2009 Mar 13;284(11):7364-75. doi: 10.1074/jbc.M808732200. Epub 2009 Jan 6.


Cell biology. A one-sided signal.

Fairn GD, Grinstein S.

Science. 2008 Apr 25;320(5875):458-60. doi: 10.1126/science.1158173. No abstract available.


Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling.

Fairn GD, McMaster CR.

Cell Mol Life Sci. 2008 Jan;65(2):228-36. Review.


The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function.

Fairn GD, Curwin AJ, Stefan CJ, McMaster CR.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15352-7. Epub 2007 Sep 19.


The roles of the human lipid-binding proteins ORP9S and ORP10S in vesicular transport.

Fairn GD, McMaster CR.

Biochem Cell Biol. 2005 Oct;83(5):631-6.


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