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Items: 1 to 50 of 314

1.

Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities.

Lohman RJ, Nielsen DS, Kok WM, Hoang HN, Hill TA, Fairlie DP.

Chem Commun (Camb). 2019 Nov 18;55(89):13362-13365. doi: 10.1039/c9cc06234c. Epub 2019 Oct 21.

PMID:
31631195
2.

A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water.

Hoang HN, Wu C, Hill TA, Dantas de Araujo A, Bernhardt PV, Liu L, Fairlie DP.

Angew Chem Int Ed Engl. 2019 Oct 17. doi: 10.1002/anie.201911277. [Epub ahead of print]

PMID:
31625253
3.

Computer Modelling and Synthesis of Deoxy and Monohydroxy Analogues of a Ribitylaminouracil Bacterial Metabolite that Potently Activates Human T Cells.

Ler GJM, Xu W, Mak JYW, Liu L, Bernhardt PV, Fairlie DP.

Chemistry. 2019 Sep 17. doi: 10.1002/chem.201903732. [Epub ahead of print]

PMID:
31529537
4.

Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.

Meade RM, Fairlie DP, Mason JM.

Mol Neurodegener. 2019 Jul 22;14(1):29. doi: 10.1186/s13024-019-0329-1. Review.

5.

Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney.

Ma FY, Han Y, Ozols E, Chew P, Vesey DA, Gobe GC, Morais C, Lohman RJ, Suen JY, Johnson DW, Fairlie DP, Nikolic-Paterson DJ.

Nephrology (Carlton). 2019 Sep;24(9):983-991. doi: 10.1111/nep.13635. Epub 2019 Jul 31.

PMID:
31314137
6.

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation.

Loh Z, Fitzsimmons RL, Reid RC, Ramnath D, Clouston A, Gupta PK, Irvine KM, Powell EE, Schroder K, Stow JL, Sweet MJ, Fairlie DP, Iyer A.

Br J Pharmacol. 2019 Oct;176(19):3775-3790. doi: 10.1111/bph.14768. Epub 2019 Aug 17.

PMID:
31236923
7.

Diverse MR1-restricted T cells in mice and humans.

Koay HF, Gherardin NA, Xu C, Seneviratna R, Zhao Z, Chen Z, Fairlie DP, McCluskey J, Pellicci DG, Uldrich AP, Godfrey DI.

Nat Commun. 2019 May 21;10(1):2243. doi: 10.1038/s41467-019-10198-w.

8.

Crystal Structures of Protein-Bound Cyclic Peptides.

Malde AK, Hill TA, Iyer A, Fairlie DP.

Chem Rev. 2019 Sep 11;119(17):9861-9914. doi: 10.1021/acs.chemrev.8b00807. Epub 2019 May 2.

PMID:
31046237
9.

Oxazole-Benzenesulfonamide Derivatives Inhibit HIV-1 Reverse Transcriptase Interaction with Cellular eEF1A and Reduce Viral Replication.

Rawle DJ, Li D, Wu Z, Wang L, Choong M, Lor M, Reid RC, Fairlie DP, Harris J, Tachedjian G, Poulsen SA, Harrich D.

J Virol. 2019 May 29;93(12). pii: e00239-19. doi: 10.1128/JVI.00239-19. Print 2019 Jun 15.

PMID:
30918071
10.

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Han Y, Tian L, Ma F, Tesch G, Vesey DA, Gobe GC, Lohman RJ, Morais C, Suen JY, Fairlie DP, Nikolic-Paterson DJ.

Clin Exp Pharmacol Physiol. 2019 May;46(5):456-464. doi: 10.1111/1440-1681.13077. Epub 2019 Mar 25.

PMID:
30811624
11.

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques.

Juno JA, Wragg KM, Amarasena T, Meehan BS, Mak JYW, Liu L, Fairlie DP, McCluskey J, Eckle SBG, Kent SJ.

J Immunol. 2019 Apr 1;202(7):2105-2120. doi: 10.4049/jimmunol.1801405. Epub 2019 Feb 18.

PMID:
30777923
12.

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis.

Khalil ZG, Hill TA, De Leon Rodriguez LM, Lohman RJ, Hoang HN, Reiling N, Hillemann D, Brimble MA, Fairlie DP, Blumenthal A, Capon RJ.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01773-18. doi: 10.1128/AAC.01773-18. Print 2019 Mar.

13.

Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.

Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, Atkinson C, Ogretmen B, Tomlinson S, Yu XZ.

JCI Insight. 2018 Dec 20;3(24). pii: 121697. doi: 10.1172/jci.insight.121697.

14.

MAIT cells protect against pulmonary Legionella longbeachae infection.

Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z.

Nat Commun. 2018 Aug 22;9(1):3350. doi: 10.1038/s41467-018-05202-8.

15.

Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes.

Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ.

JCI Insight. 2018 Jul 26;3(14). pii: 120274. doi: 10.1172/jci.insight.120274. eCollection 2018 Jul 26.

16.

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis.

Kim SH, Redvers RP, Chi LH, Ling X, Lucke AJ, Reid RC, Fairlie DP, Martin ACBM, Anderson RL, Denoyer D, Pouliot N.

Dis Model Mech. 2018 Jul 6;11(7). pii: DMM034850. doi: 10.1242/dmm.034850.

17.

An overview on the identification of MAIT cell antigens.

Kjer-Nielsen L, Corbett AJ, Chen Z, Liu L, Mak JY, Godfrey DI, Rossjohn J, Fairlie DP, McCluskey J, Eckle SB.

Immunol Cell Biol. 2018 Jul;96(6):573-587. doi: 10.1111/imcb.12057. Epub 2018 May 15. Review.

PMID:
29656544
18.

Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.

J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.

19.

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins.

D de Araujo A, Lim J, Wu KC, Xiang Y, Good AC, Skerlj R, Fairlie DP.

J Med Chem. 2018 Apr 12;61(7):2962-2972. doi: 10.1021/acs.jmedchem.8b00010. Epub 2018 Mar 27.

PMID:
29584430
20.

Lysine Deacetylases and Regulated Glycolysis in Macrophages.

Shakespear MR, Iyer A, Cheng CY, Das Gupta K, Singhal A, Fairlie DP, Sweet MJ.

Trends Immunol. 2018 Jun;39(6):473-488. doi: 10.1016/j.it.2018.02.009. Epub 2018 Mar 19. Review.

PMID:
29567326
21.

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma.

Gherardin NA, Loh L, Admojo L, Davenport AJ, Richardson K, Rogers A, Darcy PK, Jenkins MR, Prince HM, Harrison SJ, Quach H, Fairlie DP, Kedzierska K, McCluskey J, Uldrich AP, Neeson PJ, Ritchie DS, Godfrey DI.

Sci Rep. 2018 Mar 7;8(1):4159. doi: 10.1038/s41598-018-22130-1.

22.

Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking.

Dantas de Araujo A, Perry SR, Fairlie DP.

Org Lett. 2018 Mar 2;20(5):1453-1456. doi: 10.1021/acs.orglett.8b00233. Epub 2018 Feb 20.

PMID:
29461066
23.

Human blood MAIT cell subsets defined using MR1 tetramers.

Gherardin NA, Souter MN, Koay HF, Mangas KM, Seemann T, Stinear TP, Eckle SB, Berzins SP, d'Udekem Y, Konstantinov IE, Fairlie DP, Ritchie DS, Neeson PJ, Pellicci DG, Uldrich AP, McCluskey J, Godfrey DI.

Immunol Cell Biol. 2018 May;96(5):507-525. doi: 10.1111/imcb.12021. Epub 2018 Mar 25.

24.

Glucuronic acid as a helix-inducing linker in short peptides.

Wu C, Hoang HN, Liu L, Fairlie DP.

Chem Commun (Camb). 2018 Feb 22;54(17):2162-2165. doi: 10.1039/c7cc09785a.

PMID:
29431766
25.

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection.

D'Souza C, Pediongco T, Wang H, Scheerlinck JY, Kostenko L, Esterbauer R, Stent AW, Eckle SBG, Meehan BS, Strugnell RA, Cao H, Liu L, Mak JYW, Lovrecz G, Lu L, Fairlie DP, Rossjohn J, McCluskey J, Every AL, Chen Z, Corbett AJ.

J Immunol. 2018 Mar 1;200(5):1901-1916. doi: 10.4049/jimmunol.1701512. Epub 2018 Jan 29.

26.

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability.

Perry SR, Hill TA, de Araujo AD, Hoang HN, Fairlie DP.

Org Biomol Chem. 2018 Jan 17;16(3):367-371. doi: 10.1039/c7ob02952g.

PMID:
29264603
27.

A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells.

Jiang Y, Yau MK, Lim J, Wu KC, Xu W, Suen JY, Fairlie DP.

J Pharmacol Exp Ther. 2018 Feb;364(2):246-257. doi: 10.1124/jpet.117.245027. Epub 2017 Dec 20.

PMID:
29263243
28.

Chemical Approaches to Modulating Complement-Mediated Diseases.

Iyer A, Xu W, Reid RC, Fairlie DP.

J Med Chem. 2018 Apr 26;61(8):3253-3276. doi: 10.1021/acs.jmedchem.7b00882. Epub 2017 Oct 18. Review.

PMID:
28977749
29.

Protease activated receptor 2 controls myelin development, resiliency and repair.

Yoon H, Radulovic M, Walters G, Paulsen AR, Drucker K, Starski P, Wu J, Fairlie DP, Scarisbrick IA.

Glia. 2017 Dec;65(12):2070-2086. doi: 10.1002/glia.23215. Epub 2017 Sep 18.

30.

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a.

Lohman RJ, Hamidon JK, Reid RC, Rowley JA, Yau MK, Halili MA, Nielsen DS, Lim J, Wu KC, Loh Z, Do A, Suen JY, Iyer A, Fairlie DP.

Nat Commun. 2017 Aug 24;8(1):351. doi: 10.1038/s41467-017-00414-w.

31.

Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun.

Baxter D, Perry SR, Hill TA, Kok WM, Zaccai NR, Brady RL, Fairlie DP, Mason JM.

ACS Chem Biol. 2017 Aug 18;12(8):2051-2061. doi: 10.1021/acschembio.7b00303. Epub 2017 Jun 21.

PMID:
28636317
32.

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor.

Dantas de Araujo A, Wu C, Wu KC, Reid RC, Durek T, Lim J, Fairlie DP.

Bioconjug Chem. 2017 Jun 21;28(6):1669-1676. doi: 10.1021/acs.bioconjchem.7b00132. Epub 2017 May 31.

PMID:
28562031
33.

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

Ward A, Dong L, Harris JM, Khanna KK, Al-Ejeh F, Fairlie DP, Wiegmans AP, Liu L.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100. doi: 10.1016/j.bmcl.2017.05.039. Epub 2017 May 15.

PMID:
28545975
34.

Orally Absorbed Cyclic Peptides.

Nielsen DS, Shepherd NE, Xu W, Lucke AJ, Stoermer MJ, Fairlie DP.

Chem Rev. 2017 Jun 28;117(12):8094-8128. doi: 10.1021/acs.chemrev.6b00838. Epub 2017 May 25. Review.

PMID:
28541045
35.

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

Mak JY, Xu W, Reid RC, Corbett AJ, Meehan BS, Wang H, Chen Z, Rossjohn J, McCluskey J, Liu L, Fairlie DP.

Nat Commun. 2017 Mar 8;8:14599. doi: 10.1038/ncomms14599.

36.

Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance.

Prinsep MR, Appleton TG, Hanson GR, Lane I, Smith CD, Puddick J, Fairlie DP.

Inorg Chem. 2017 May 15;56(10):5577-5585. doi: 10.1021/acs.inorgchem.6b03000. Epub 2017 Feb 27.

PMID:
28240882
37.

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.

Markiewski MM, Vadrevu SK, Sharma SK, Chintala NK, Ghouse S, Cho JH, Fairlie DP, Paterson Y, Astrinidis A, Karbowniczek M.

J Immunol. 2017 Apr 1;198(7):2989-2999. doi: 10.4049/jimmunol.1602057. Epub 2017 Feb 22.

38.

Biased Signaling by Agonists of Protease Activated Receptor 2.

Jiang Y, Yau MK, Kok WM, Lim J, Wu KC, Liu L, Hill TA, Suen JY, Fairlie DP.

ACS Chem Biol. 2017 May 19;12(5):1217-1226. doi: 10.1021/acschembio.6b01088. Epub 2017 Mar 14.

PMID:
28169521
39.

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP, McCluskey J, Rossjohn J.

Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.

PMID:
28166217
40.

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina.

Bagnall NH, Hines BM, Lucke AJ, Gupta PK, Reid RC, Fairlie DP, Kotze AC.

Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):51-60. doi: 10.1016/j.ijpddr.2017.01.001. Epub 2017 Jan 10.

41.

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.

Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS, Andrews KT.

Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):42-50. doi: 10.1016/j.ijpddr.2016.12.005. Epub 2016 Dec 23.

42.

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site.

de Araujo AD, Lim J, Good AC, Skerlj RT, Fairlie DP.

ACS Med Chem Lett. 2016 Nov 15;8(1):22-26. doi: 10.1021/acsmedchemlett.6b00395. eCollection 2017 Jan 12.

43.

PAR2 Modulators Derived from GB88.

Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Jiang Y, Cotterell AJ, Barry GD, Mak JY, Vesey DA, Reid RC, Fairlie DP.

ACS Med Chem Lett. 2016 Oct 10;7(12):1179-1184. eCollection 2016 Dec 8.

44.

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

Suen JY, Adams MN, Lim J, Madala PK, Xu W, Cotterell AJ, He Y, Yau MK, Hooper JD, Fairlie DP.

Pharmacol Res. 2017 Mar;117:328-342. doi: 10.1016/j.phrs.2016.12.020. Epub 2016 Dec 16.

PMID:
27993717
45.

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ.

Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18.

46.

Histone deacetylases (HDAC) in physiological and pathological bone remodelling.

Cantley MD, Zannettino ACW, Bartold PM, Fairlie DP, Haynes DR.

Bone. 2017 Feb;95:162-174. doi: 10.1016/j.bone.2016.11.028. Epub 2016 Nov 30. Review.

PMID:
27913271
47.

Product release is rate-limiting for catalytic processing by the Dengue virus protease.

Shannon AE, Pedroso MM, Chappell KJ, Watterson D, Liebscher S, Kok WM, Fairlie DP, Schenk G, Young PR.

Sci Rep. 2016 Nov 29;6:37539. doi: 10.1038/srep37539.

48.

Correction: Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency.

Shepherd NE, Harrison RS, Ruiz-Gomez G, Abbenante G, Mason JM, Fairlie DP.

Org Biomol Chem. 2016 Dec 28;14(48):11525. Epub 2016 Nov 23.

PMID:
27879976
49.

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

Do A, Reid RC, Lohman RJ, Sweet MJ, Fairlie DP, Iyer A.

J Pharmacol Exp Ther. 2017 Jan;360(1):140-151. Epub 2016 Nov 8.

PMID:
27827303
50.

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

Plisson F, Hill TA, Mitchell JM, Hoang HN, de Araujo AD, Xu W, Cotterell A, Edmonds DJ, Stanton RV, Derksen DR, Loria PM, Griffith DA, Price DA, Liras S, Fairlie DP.

Eur J Med Chem. 2017 Feb 15;127:703-714. doi: 10.1016/j.ejmech.2016.10.044. Epub 2016 Oct 21.

PMID:
27823886

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