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Items: 1 to 50 of 110


Heme binding to human CLOCK affects interactions with the E-box.

Freeman SL, Kwon H, Portolano N, Parkin G, Venkatraman Girija U, Basran J, Fielding AJ, Fairall L, Svistunenko DA, Moody PCE, Schwabe JWR, Kyriacou CP, Raven EL.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19911-19916. doi: 10.1073/pnas.1905216116. Epub 2019 Sep 16.


Evaluation of a collaborative care model for integrated primary care of common mental disorders comorbid with chronic conditions in South Africa.

Petersen I, Bhana A, Fairall LR, Selohilwe O, Kathree T, Baron EC, Rathod SD, Lund C.

BMC Psychiatry. 2019 Apr 3;19(1):107. doi: 10.1186/s12888-019-2081-z.


e-PC101: an electronic clinical decision support tool developed in South Africa for primary care in low-income and middle-income countries.

Yau M, Timmerman V, Zwarenstein M, Mayers P, Cornick RV, Bateman E, Fairall L.

BMJ Glob Health. 2019 Feb 20;3(Suppl 5):e001093. doi: 10.1136/bmjgh-2018-001093. eCollection 2018.


Empowering frontline providers to deliver universal primary healthcare using the Practical and Approach to care kit.

Fairall L, Cornick R, Bateman E.

BMJ Glob Health. 2018 Nov 19;3(Suppl 5). pii: bmjgh-2018-k4451rep. doi: 10.1136/bmjgh-2018-k4451rep. eCollection 2018. No abstract available.


The Practical Approach to Care Kit (PACK) training programme: scaling up and sustaining support for health workers to improve primary care.

Simelane ML, Georgeu-Pepper D, Ras CJ, Anderson L, Pascoe M, Faris G, Fairall L, Cornick R.

BMJ Glob Health. 2018 Nov 14;3(Suppl 5):e001124. doi: 10.1136/bmjgh-2018-001124. eCollection 2018. Review.


Using a mentorship model to localise the Practical Approach to Care Kit (PACK): from South Africa to Ethiopia.

Mekonnen Y, Hanlon C, Emyu S, Cornick RV, Fairall L, Gebremichael D, Teka T, Shiferaw S, Walelgne W, Mamo Y, Ayehu T, Wale M, Eastman T, Awotiwon A, Wattrus C, Picken SC, Ras CJ, Anderson L, Doherty T, Prince MJ, Tegabu D.

BMJ Glob Health. 2018 Nov 16;3(Suppl 5):e001108. doi: 10.1136/bmjgh-2018-001108. eCollection 2018. Review.


Crossing borders: the PACK experience of spreading a complex health system intervention across low-income and middle-income countries.

Cornick R, Wattrus C, Eastman T, Ras CJ, Awotiwon A, Anderson L, Bateman E, Zepeda J, Zwarenstein M, Doherty T, Fairall L.

BMJ Glob Health. 2018 Oct 26;3(Suppl 5):e001088. doi: 10.1136/bmjgh-2018-001088. eCollection 2018.


Using a mentorship model to localise the Practical Approach to Care Kit (PACK): from South Africa to Brazil.

Wattrus C, Zepeda J, Cornick RV, Zonta R, Pacheco de Andrade M, Fairall L, Georgeu-Pepper D, Anderson L, Eastman T, Bateman ED, Cruz AA, Bachmann MO, Natal S, Doherty T, Stelmach R.

BMJ Glob Health. 2018 Oct 25;3(Suppl 5):e001016. doi: 10.1136/bmjgh-2018-001016. eCollection 2018.


Integrated care for people with long-term mental and physical health conditions in low-income and middle-income countries.

Thornicroft G, Ahuja S, Barber S, Chisholm D, Collins PY, Docrat S, Fairall L, Lempp H, Niaz U, Ngo V, Patel V, Petersen I, Prince M, Semrau M, Unützer J, Yueqin H, Zhang S.

Lancet Psychiatry. 2019 Feb;6(2):174-186. doi: 10.1016/S2215-0366(18)30298-0. Epub 2018 Nov 15. Review.


Using a mentorship model to localise the Practical Approach to Care Kit (PACK): from South Africa to Nigeria.

Awotiwon A, Sword C, Eastman T, Ras CJ, Ana P, Cornick RV, Fairall L, Bateman E, Dube A, Curran R, Udoekwere I, Essien UO, Assem O, Edu TS, Ismail HB, Olubajo OO, Ana J.

BMJ Glob Health. 2018 Oct 23;3(Suppl 5):e001079. doi: 10.1136/bmjgh-2018-001079. eCollection 2018.


PACK Child: the development of a practical guide to extend the scope of integrated primary care for children and young adolescents.

Picken S, Hannington J, Fairall L, Doherty T, Bateman E, Richards M, Wattrus C, Cornick R.

BMJ Glob Health. 2018 Oct 23;3(Suppl 5):e000957. doi: 10.1136/bmjgh-2018-000957. eCollection 2018.


Strengthening the quality of paediatric primary care: protocol for the process evaluation of a health systems intervention in South Africa.

Murdoch J, Curran R, Bachmann M, Bateman E, Cornick RV, Doherty T, Picken SC, Simelane ML, Fairall L.

BMJ Glob Health. 2018 Oct 23;3(Suppl 5):e000945. doi: 10.1136/bmjgh-2018-000945. eCollection 2018.


The Practical Approach to Care Kit (PACK) guide: developing a clinical decision support tool to simplify, standardise and strengthen primary healthcare delivery.

Cornick R, Picken S, Wattrus C, Awotiwon A, Carkeek E, Hannington J, Spiller P, Bateman E, Doherty T, Zwarenstein M, Fairall L.

BMJ Glob Health. 2018 Oct 17;3(Suppl 5):e000962. doi: 10.1136/bmjgh-2018-000962. eCollection 2018.


Empowering frontline providers to deliver universal primary healthcare using the Practical Approach to Care Kit.

Fairall L, Cornick R, Bateman E.

BMJ. 2018 Oct 24;363:k4451. doi: 10.1136/bmj.k4451. No abstract available.


Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.


Integrating primary care of chronic respiratory disease, cardiovascular disease and diabetes in Brazil: Practical Approach to Care Kit (PACK Brazil): study protocol for randomised controlled trials.

Bachmann MO, Bateman ED, Stelmach R, Cruz ÁA, Pacheco de Andrade M, Zonta R, Zepeda J, Natal S, Cornick R, Wattrus C, Anderson L, Lombard C, Fairall LR.

J Thorac Dis. 2018 Jul;10(7):4667-4677. doi: 10.21037/jtd.2018.07.34. Review.


A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations.

Agostini M, Schoenmakers E, Beig J, Fairall L, Szatmari I, Rajanayagam O, Muskett FW, Adams C, Marais AD, O'Rahilly S, Semple RK, Nagy L, Majithia AR, Schwabe JWR, Blom DJ, Murphy R, Chatterjee K, Savage DB.

Diabetes. 2018 Jun;67(6):1086-1092. doi: 10.2337/db17-1236. Epub 2018 Apr 5.


Collaborative care for the detection and management of depression among adults receiving antiretroviral therapy in South Africa: study protocol for the CobALT randomised controlled trial.

Fairall L, Petersen I, Zani B, Folb N, Georgeu-Pepper D, Selohilwe O, Petrus R, Mntambo N, Bhana A, Lombard C, Bachmann M, Lund C, Hanass-Hancock J, Chisholm D, McCrone P, Carmona S, Gaziano T, Levitt N, Kathree T, Thornicroft G; CobALT research team.

Trials. 2018 Mar 22;19(1):193. doi: 10.1186/s13063-018-2517-7.


Collaborative care for the detection and management of depression among adults with hypertension in South Africa: study protocol for the PRIME-SA randomised controlled trial.

Petersen I, Bhana A, Folb N, Thornicroft G, Zani B, Selohilwe O, Petrus R, Mntambo N, Georgeu-Pepper D, Kathree T, Lund C, Lombard C, Bachmann M, Gaziano T, Levitt N, Fairall L; PRIME-SA research team.

Trials. 2018 Mar 22;19(1):192. doi: 10.1186/s13063-018-2518-6.


Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.


Evaluating the effect of the Practical Approach to Care Kit on teaching medical students primary care: Quasi-experimental study.

Mash R, Pather M, Rhode H, Fairall L.

Afr J Prim Health Care Fam Med. 2017 Dec 8;9(1):e1-e8. doi: 10.4102/phcfm.v9i1.1602.


Expression and Purification of Protein Complexes Suitable for Structural Studies Using Mammalian HEK 293F Cells.

Nigi I, Fairall L, Schwabe JWR.

Curr Protoc Protein Sci. 2017 Nov 1;90:5.28.1-5.28.16. doi: 10.1002/cpps.44.


Backbone resonance assignment of the BCL6-BTB/POZ domain.

Lin LY, Evans SE, Fairall L, Schwabe JWR, Wagner SD, Muskett FW.

Biomol NMR Assign. 2018 Apr;12(1):47-50. doi: 10.1007/s12104-017-9778-z. Epub 2017 Sep 19.


Socioeconomic position and depression in South African adults with long-term health conditions: a longitudinal study of causal pathways.

Elwell-Sutton T, Folb N, Clark A, Fairall LR, Lund C, Bachmann MO.

Epidemiol Psychiatr Sci. 2019 Apr;28(2):199-209. doi: 10.1017/S2045796017000427. Epub 2017 Aug 14.


Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.

Moran C, Agostini M, McGowan A, Schoenmakers E, Fairall L, Lyons G, Rajanayagam O, Watson L, Offiah A, Barton J, Price S, Schwabe J, Chatterjee K.

Thyroid. 2017 Jul;27(7):973-982. doi: 10.1089/thy.2017.0157.


Evidence-based decision-making for primary care: The interpretation and role of pragmatic trials.

Fairall LR, Mahomed O, Bateman ED.

S Afr Med J. 2017 Mar 29;107(4):278-279. doi: 10.7196/SAMJ.2017.v107i4.12413. No abstract available.


Genetic disorders of nuclear receptors.

Achermann JC, Schwabe J, Fairall L, Chatterjee K.

J Clin Invest. 2017 Apr 3;127(4):1181-1192. doi: 10.1172/JCI88892. Epub 2017 Apr 3. Review.


Health workers are vital to sustainable development goals and universal health coverage.

Fairall L, Bateman E.

BMJ. 2017 Mar 23;356:j1357. doi: 10.1136/bmj.j1357. No abstract available.


Targeting Class I Histone Deacetylases in a "Complex" Environment.

Millard CJ, Watson PJ, Fairall L, Schwabe JWR.

Trends Pharmacol Sci. 2017 Apr;38(4):363-377. doi: 10.1016/ Epub 2017 Jan 28. Review.


Socioeconomic and modifiable predictors of blood pressure control for hypertension in primary care attenders in the Western Cape, South Africa.

Folb N, Bachmann MO, Bateman ED, Steyn K, Levitt NS, Timmerman V, Lombard C, Gaziano TA, Fairall LR.

S Afr Med J. 2016 Dec 1;106(12):1241-1246. doi: 10.7196/SAMJ.2016.v106.i12.12005.


Educational Outreach with an Integrated Clinical Tool for Nurse-Led Non-communicable Chronic Disease Management in Primary Care in South Africa: A Pragmatic Cluster Randomised Controlled Trial.

Fairall LR, Folb N, Timmerman V, Lombard C, Steyn K, Bachmann MO, Bateman ED, Lund C, Cornick R, Faris G, Gaziano T, Georgeu-Pepper D, Zwarenstein M, Levitt NS.

PLoS Med. 2016 Nov 22;13(11):e1002178. doi: 10.1371/journal.pmed.1002178. eCollection 2016 Nov.


Mutations in TBL1X Are Associated With Central Hypothyroidism.

Heinen CA, Losekoot M, Sun Y, Watson PJ, Fairall L, Joustra SD, Zwaveling-Soonawala N, Oostdijk W, van den Akker EL, Alders M, Santen GW, van Rijn RR, Dreschler WA, Surovtseva OV, Biermasz NR, Hennekam RC, Wit JM, Schwabe JW, Boelen A, Fliers E, van Trotsenburg AS.

J Clin Endocrinol Metab. 2016 Dec;101(12):4564-4573. Epub 2016 Sep 7.


The structure of the core NuRD repression complex provides insights into its interaction with chromatin.

Millard CJ, Varma N, Saleh A, Morris K, Watson PJ, Bottrill AR, Fairall L, Smith CJ, Schwabe JW.

Elife. 2016 Apr 21;5:e13941. doi: 10.7554/eLife.13941.


Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate.

Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JW, Leverkus M, Cain K, MacFarlane M.

Mol Cell. 2016 Mar 17;61(6):834-49. doi: 10.1016/j.molcel.2016.02.023.


Innovating to improve primary care in less developed countries: towards a global model.

Fairall L, Bateman E, Cornick R, Faris G, Timmerman V, Folb N, Bachmann M, Zwarenstein M, Smith R.

BMJ Innov. 2015 Oct;1(4):196-203. Epub 2015 Jul 23. Review.


Socioeconomic predictors and consequences of depression among primary care attenders with non-communicable diseases in the Western Cape, South Africa: cohort study within a randomised trial.

Folb N, Lund C, Fairall LR, Timmerman V, Levitt NS, Steyn K, Bachmann MO.

BMC Public Health. 2015 Nov 30;15:1194. doi: 10.1186/s12889-015-2509-4.


Effect of antiretroviral treatment on the risk of tuberculosis during South Africa's programme expansion.

Bachmann MO, Timmerman V, Fairall LR.

AIDS. 2015 Nov;29(17):2261-8. doi: 10.1097/QAD.0000000000000806.


Practical tools for improving global primary care.

Fairall L, Walsh K.

BMJ. 2015 Oct 13;351:h5361. doi: 10.1136/bmj.h5361. No abstract available.


Multimorbidity, control and treatment of noncommunicable diseases among primary healthcare attenders in the Western Cape, South Africa.

Folb N, Timmerman V, Levitt NS, Steyn K, Bachmann MO, Lund C, Bateman ED, Lombard C, Gaziano TA, Zwarenstein M, Fairall LR.

S Afr Med J. 2015 Sep 21;105(8):642-7.


Integrating mental health into chronic care in South Africa: the development of a district mental healthcare plan.

Petersen I, Fairall L, Bhana A, Kathree T, Selohilwe O, Brooke-Sumner C, Faris G, Breuer E, Sibanyoni N, Lund C, Patel V.

Br J Psychiatry. 2016 Jan;208 Suppl 56:s29-39. doi: 10.1192/bjp.bp.114.153726. Epub 2015 Oct 7.


Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex.

Hudson GM, Watson PJ, Fairall L, Jamieson AG, Schwabe JW.

J Biol Chem. 2015 Jul 17;290(29):18237-44. doi: 10.1074/jbc.M115.661058. Epub 2015 Jun 8.


Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.

Itoh T, Fairall L, Muskett FW, Milano CP, Watson PJ, Arnaudo N, Saleh A, Millard CJ, El-Mezgueldi M, Martino F, Schwabe JW.

Nucleic Acids Res. 2015 Feb 27;43(4):2033-44. doi: 10.1093/nar/gkv068. Epub 2015 Feb 4.


Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins.

Nettleship JE, Watson PJ, Rahman-Huq N, Fairall L, Posner MG, Upadhyay A, Reddivari Y, Chamberlain JM, Kolstoe SE, Bagby S, Schwabe JW, Owens RJ.

Methods Mol Biol. 2015;1258:209-22. doi: 10.1007/978-1-4939-2205-5_11. Review.


Towards an understanding of the structure and function of MTA1.

Millard CJ, Fairall L, Schwabe JW.

Cancer Metastasis Rev. 2014 Dec;33(4):857-67. doi: 10.1007/s10555-014-9513-5. Review.


Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.

Portolano N, Watson PJ, Fairall L, Millard CJ, Milano CP, Song Y, Cowley SM, Schwabe JW.

J Vis Exp. 2014 Oct 16;(92):e51897. doi: 10.3791/51897.


Supporting middle-cadre health care workers in Malawi: lessons learned during implementation of the PALM PLUS package.

Sodhi S, Banda H, Kathyola D, Joshua M, Richardson F, Mah E, MacGregor H, Kanike E, Thompson S, Fairall L, Bateman E, Zwarenstein M, Schull MJ.

BMC Health Serv Res. 2014;14 Suppl 1:S8. doi: 10.1186/1472-6963-14-S1-S8. Epub 2014 May 12.


Optimizing lay counsellor services for chronic care in South Africa: a qualitative systematic review.

Petersen I, Fairall L, Egbe CO, Bhana A.

Patient Educ Couns. 2014 May;95(2):201-10. doi: 10.1016/j.pec.2014.02.001. Epub 2014 Feb 12. Review.


The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.

Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD.

PLoS One. 2014 Mar 4;9(3):e90889. doi: 10.1371/journal.pone.0090889. eCollection 2014.


An evolving understanding of nuclear receptor coregulator proteins.

Millard CJ, Watson PJ, Fairall L, Schwabe JW.

J Mol Endocrinol. 2013 Nov 7;51(3):T23-36. doi: 10.1530/JME-13-0227. Print 2013 Dec. Review.


Class I HDACs share a common mechanism of regulation by inositol phosphates.

Millard CJ, Watson PJ, Celardo I, Gordiyenko Y, Cowley SM, Robinson CV, Fairall L, Schwabe JW.

Mol Cell. 2013 Jul 11;51(1):57-67. doi: 10.1016/j.molcel.2013.05.020. Epub 2013 Jun 20.

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