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Items: 37


Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.

Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2019 Nov 19;12(608). pii: eaax3194. doi: 10.1126/scisignal.aax3194.


Studies of Structure-Function and Subunit Composition of Orai/STIM Channel.

Fahrner M, Schindl R, Romanin C.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 2.


Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization.

Föll MC, Fahrner M, Oria VO, Kühs M, Biniossek ML, Werner M, Bronsert P, Schilling O.

Clin Proteomics. 2018 Mar 6;15:11. doi: 10.1186/s12014-018-9188-y. eCollection 2018.


A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state.

Fahrner M, Stadlbauer M, Muik M, Rathner P, Stathopulos P, Ikura M, Müller N, Romanin C.

Nat Commun. 2018 Feb 26;9(1):825. doi: 10.1038/s41467-018-03062-w.


Rapid NMR-scale purification of 15N,13C isotope-labeled recombinant human STIM1 coiled coil fragments.

Rathner P, Stadlbauer M, Romanin C, Fahrner M, Derler I, Müller N.

Protein Expr Purif. 2018 Jun;146:45-50. doi: 10.1016/j.pep.2018.01.013.


Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus.

Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C.

J Biol Chem. 2018 Jan 26;293(4):1259-1270. doi: 10.1074/jbc.M117.812206. Epub 2017 Dec 13.


Communication between N terminus and loop2 tunes Orai activation.

Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I.

J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13.


Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.

Föll MC, Fahrner M, Gretzmeier C, Thoma K, Biniossek ML, Kiritsi D, Meiss F, Schilling O, Nyström A, Kern JS.

Matrix Biol. 2018 Mar;66:1-21. doi: 10.1016/j.matbio.2017.11.004. Epub 2017 Nov 20.


Detailed Evidence for an Unparalleled Interaction Mode between Calmodulin and Orai Proteins.

Traxler L, Rathner P, Fahrner M, Stadlbauer M, Faschinger F, Charnavets T, Müller N, Romanin C, Hinterdorfer P, Gruber HJ.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15755-15759. doi: 10.1002/anie.201708667. Epub 2017 Nov 6.


The STIM-Orai Pathway: The Interactions Between STIM and Orai.

Fahrner M, Schindl R, Muik M, Derler I, Romanin C.

Adv Exp Med Biol. 2017;993:59-81. doi: 10.1007/978-3-319-57732-6_4. Review.


The STIM1: Orai Interaction.

Frischauf I, Fahrner M, Jardín I, Romanin C.

Adv Exp Med Biol. 2016;898:25-46. doi: 10.1007/978-3-319-26974-0_2. Review.


Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.


Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation.

Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6206-11. doi: 10.1073/pnas.1418852112. Epub 2015 Apr 27.


A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C.

J Biol Chem. 2014 Nov 28;289(48):33231-44. doi: 10.1074/jbc.M114.610022. Epub 2014 Oct 23.


STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.

Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M.

Nat Commun. 2013;4:2963. doi: 10.1038/ncomms3963.


The STIM1/Orai signaling machinery.

Fahrner M, Derler I, Jardin I, Romanin C.

Channels (Austin). 2013 Sep-Oct;7(5):330-43. doi: 10.4161/chan.26742. Epub 2013 Oct 9. Review.


The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.

Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2013 Oct 4;288(40):29025-34. doi: 10.1074/jbc.M113.501510. Epub 2013 Aug 13.


Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Zhang X, González-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M.

Mol Cell Biol. 2013 Sep;33(18):3715-23. doi: 10.1128/MCB.00554-13. Epub 2013 Jul 22.


Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

González-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, Muik M, Spinelli AM, Bisaillon JM, Shinde AV, Fahrner M, Singer HA, Matrougui K, Barroso M, Romanin C, Trebak M.

Circ Res. 2013 Mar 29;112(7):1013-25. doi: 10.1161/CIRCRESAHA.111.300220. Epub 2013 Jan 24.


Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.

Muik M, Schindl R, Fahrner M, Romanin C.

Cell Mol Life Sci. 2012 Dec;69(24):4163-76. doi: 10.1007/s00018-012-1072-8. Epub 2012 Jul 17. Review.


Nanopatterned polymer substrates promote endothelial proliferation by initiation of β-catenin transcriptional signaling.

Schernthaner M, Reisinger B, Wolinski H, Kohlwein SD, Trantina-Yates A, Fahrner M, Romanin C, Itani H, Stifter D, Leitinger G, Groschner K, Heitz J.

Acta Biomater. 2012 Aug;8(8):2953-62. doi: 10.1016/j.actbio.2012.04.018. Epub 2012 Apr 20.


Laser microstructuring of photomodified fluorinated ethylene propylene surface for confined growth of Chinese hamster ovary cells and single cell isolation.

Yakunin S, Fahrner M, Reisinger B, Itani H, Romanin C, Heitz J.

J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):170-6. doi: 10.1002/jbm.b.31935. Epub 2011 Sep 21.


Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P, Schwarzinger C, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2011 Sep 9;286(36):31565-75. doi: 10.1074/jbc.M111.227546. Epub 2011 Jul 1.


STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.


Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.


Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.

Madl J, Weghuber J, Fritsch R, Derler I, Fahrner M, Frischauf I, Lackner B, Romanin C, Schütz GJ.

J Biol Chem. 2010 Dec 24;285(52):41135-42. doi: 10.1074/jbc.M110.177881. Epub 2010 Oct 20.


Mechanistic view on domains mediating STIM1-Orai coupling.

Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.

Immunol Rev. 2009 Sep;231(1):99-112. doi: 10.1111/j.1600-065X.2009.00815.x. Review.


Recent progress on STIM1 domains controlling Orai activation.

Schindl R, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C.

Cell Calcium. 2009 Oct;46(4):227-32. doi: 10.1016/j.ceca.2009.08.003. Epub 2009 Sep 4. Review.


A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.

Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Sep 11;284(37):24933-8. doi: 10.1074/jbc.C109.024083. Epub 2009 Jul 21.


Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Aug 7;284(32):21696-706. doi: 10.1074/jbc.M109.018408. Epub 2009 Jun 8.


Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant.

Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S, Romanin C.

J Biol Chem. 2009 Jun 5;284(23):15903-15. doi: 10.1074/jbc.M808312200. Epub 2009 Apr 14.


A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.

Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.

J Biol Chem. 2009 Mar 27;284(13):8421-6. doi: 10.1074/jbc.C800229200. Epub 2009 Feb 3.


The STIM/Orai coupling machinery.

Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C.

Channels (Austin). 2008 Jul-Aug;2(4):261-8. Epub 2008 Jul 21. Review.


2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.

J Biol Chem. 2008 Jul 18;283(29):20261-7. doi: 10.1074/jbc.M803101200. Epub 2008 May 21.


Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.

J Biol Chem. 2008 Mar 21;283(12):8014-22. doi: 10.1074/jbc.M708898200. Epub 2008 Jan 10.


Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue.

Wolbank S, Peterbauer A, Fahrner M, Hennerbichler S, van Griensven M, Stadler G, Redl H, Gabriel C.

Tissue Eng. 2007 Jun;13(6):1173-83.


Pathology and behavior of small breast carcinomas.

Meyer JS, Fahrner M, Daniel FC.

Semin Diagn Pathol. 1999 Aug;16(3):257-68.


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