Fahrner M[au] - PubMed

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Items: 37

Select item 317449291.

Sequential activation of STIM1 links Ca²⁺ with luminal domain unfolding.

Schober R, Bonhenry D, Lunz V, Zhu J, Krizova A, Frischauf I, Fahrner M, Zhang M, Waldherr L, Schmidt T, Derler I, Stathopulos PB, Romanin C, Ettrich RH, Schindl R.

Sci Signal. 2019 Nov 19;12(608). pii: eaax3194. doi: 10.1126/scisignal.aax3194.

PMID:: 31744929

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Select item 302996452.

Studies of Structure-Function and Subunit Composition of Orai/STIM Channel.

Fahrner M, Schindl R, Romanin C.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 2.

PMID:: 30299645

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Select item 295271413.

Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization.

Föll MC, Fahrner M, Oria VO, Kühs M, Biniossek ML, Werner M, Bronsert P, Schilling O.

Clin Proteomics. 2018 Mar 6;15:11. doi: 10.1186/s12014-018-9188-y. eCollection 2018.

PMID:: 29527141

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Select item 294835064.

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state.

Fahrner M, Stadlbauer M, Muik M, Rathner P, Stathopulos P, Ikura M, Müller N, Romanin C.

Nat Commun. 2018 Feb 26;9(1):825. doi: 10.1038/s41467-018-03062-w.

PMID:: 29483506

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Select item 294140685.

Rapid NMR-scale purification of ¹⁵N,¹³C isotope-labeled recombinant human STIM1 coiled coil fragments.

Rathner P, Stadlbauer M, Romanin C, Fahrner M, Derler I, Müller N.

Protein Expr Purif. 2018 Jun;146:45-50. doi: 10.1016/j.pep.2018.01.013.

PMID:: 29414068

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Select item 292377346.

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus.

Derler I, Butorac C, Krizova A, Stadlbauer M, Muik M, Fahrner M, Frischauf I, Romanin C.

J Biol Chem. 2018 Jan 26;293(4):1259-1270. doi: 10.1074/jbc.M117.812206. Epub 2017 Dec 13.

PMID:: 29237734

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Select item 292377337.

Communication between N terminus and loop2 tunes Orai activation.

Fahrner M, Pandey SK, Muik M, Traxler L, Butorac C, Stadlbauer M, Zayats V, Krizova A, Plenk P, Frischauf I, Schindl R, Gruber HJ, Hinterdorfer P, Ettrich R, Romanin C, Derler I.

J Biol Chem. 2018 Jan 26;293(4):1271-1285. doi: 10.1074/jbc.M117.812693. Epub 2017 Dec 13.

PMID:: 29237733

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Select item 291581638.

Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.

Föll MC, Fahrner M, Gretzmeier C, Thoma K, Biniossek ML, Kiritsi D, Meiss F, Schilling O, Nyström A, Kern JS.

Matrix Biol. 2018 Mar;66:1-21. doi: 10.1016/j.matbio.2017.11.004. Epub 2017 Nov 20.

PMID:: 29158163

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Select item 290242989.

Detailed Evidence for an Unparalleled Interaction Mode between Calmodulin and Orai Proteins.

Traxler L, Rathner P, Fahrner M, Stadlbauer M, Faschinger F, Charnavets T, Müller N, Romanin C, Hinterdorfer P, Gruber HJ.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15755-15759. doi: 10.1002/anie.201708667. Epub 2017 Nov 6.

PMID:: 29024298

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Select item 2890090910.

The STIM-Orai Pathway: The Interactions Between STIM and Orai.

Fahrner M, Schindl R, Muik M, Derler I, Romanin C.

Adv Exp Med Biol. 2017;993:59-81. doi: 10.1007/978-3-319-57732-6_4. Review.

PMID:: 28900909

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Select item 2716122311.

The STIM1: Orai Interaction.

Frischauf I, Fahrner M, Jardín I, Romanin C.

Adv Exp Med Biol. 2016;898:25-46. doi: 10.1007/978-3-319-26974-0_2. Review.

PMID:: 27161223

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Select item 2681423112.

Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.

PMID:: 26814231

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Select item 2591839413.

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation.

Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6206-11. doi: 10.1073/pnas.1418852112. Epub 2015 Apr 27.

PMID:: 25918394

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Select item 2534274914.

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C.

J Biol Chem. 2014 Nov 28;289(48):33231-44. doi: 10.1074/jbc.M114.610022. Epub 2014 Oct 23.

PMID:: 25342749

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Select item 2435197215.

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.

Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M.

Nat Commun. 2013;4:2963. doi: 10.1038/ncomms3963.

PMID:: 24351972

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Select item 2410792116.

The STIM1/Orai signaling machinery.

Fahrner M, Derler I, Jardin I, Romanin C.

Channels (Austin). 2013 Sep-Oct;7(5):330-43. doi: 10.4161/chan.26742. Epub 2013 Oct 9. Review.

PMID:: 24107921

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Select item 2394361917.

The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.

Derler I, Plenk P, Fahrner M, Muik M, Jardin I, Schindl R, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2013 Oct 4;288(40):29025-34. doi: 10.1074/jbc.M113.501510. Epub 2013 Aug 13.

PMID:: 23943619

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Select item 2387839218.

Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.

Zhang X, González-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M.

Mol Cell Biol. 2013 Sep;33(18):3715-23. doi: 10.1128/MCB.00554-13. Epub 2013 Jul 22.

PMID:: 23878392

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Select item 2334924519.

Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.

González-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, Muik M, Spinelli AM, Bisaillon JM, Shinde AV, Fahrner M, Singer HA, Matrougui K, Barroso M, Romanin C, Trebak M.

Circ Res. 2013 Mar 29;112(7):1013-25. doi: 10.1161/CIRCRESAHA.111.300220. Epub 2013 Jan 24.

PMID:: 23349245

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Select item 2280212620.

Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.

Muik M, Schindl R, Fahrner M, Romanin C.

Cell Mol Life Sci. 2012 Dec;69(24):4163-76. doi: 10.1007/s00018-012-1072-8. Epub 2012 Jul 17. Review.

PMID:: 22802126

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Select item 2252213321.

Nanopatterned polymer substrates promote endothelial proliferation by initiation of β-catenin transcriptional signaling.

Schernthaner M, Reisinger B, Wolinski H, Kohlwein SD, Trantina-Yates A, Fahrner M, Romanin C, Itani H, Stifter D, Leitinger G, Groschner K, Heitz J.

Acta Biomater. 2012 Aug;8(8):2953-62. doi: 10.1016/j.actbio.2012.04.018. Epub 2012 Apr 20.

PMID:: 22522133

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Select item 2194855722.

Laser microstructuring of photomodified fluorinated ethylene propylene surface for confined growth of Chinese hamster ovary cells and single cell isolation.

Yakunin S, Fahrner M, Reisinger B, Itani H, Romanin C, Heitz J.

J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):170-6. doi: 10.1002/jbm.b.31935. Epub 2011 Sep 21.

PMID:: 21948557

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Select item 2172484523.

Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.

Bergsmann J, Derler I, Muik M, Frischauf I, Fahrner M, Pollheimer P, Schwarzinger C, Gruber HJ, Groschner K, Romanin C.

J Biol Chem. 2011 Sep 9;286(36):31565-75. doi: 10.1074/jbc.M111.227546. Epub 2011 Jul 1.

PMID:: 21724845

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Select item 2142770424.

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.

Muik M, Fahrner M, Schindl R, Stathopulos P, Frischauf I, Derler I, Plenk P, Lackner B, Groschner K, Ikura M, Romanin C.

EMBO J. 2011 May 4;30(9):1678-89. doi: 10.1038/emboj.2011.79. Epub 2011 Mar 22.

PMID:: 21427704

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Select item 2122042325.

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Frischauf I, Schindl R, Bergsmann J, Derler I, Fahrner M, Muik M, Fritsch R, Lackner B, Groschner K, Romanin C.

J Biol Chem. 2011 Mar 11;286(10):8577-84. doi: 10.1074/jbc.M110.187179. Epub 2011 Jan 10.

PMID:: 21220423

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Select item 2096185226.

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.

Madl J, Weghuber J, Fritsch R, Derler I, Fahrner M, Frischauf I, Lackner B, Romanin C, Schütz GJ.

J Biol Chem. 2010 Dec 24;285(52):41135-42. doi: 10.1074/jbc.M110.177881. Epub 2010 Oct 20.

PMID:: 20961852

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Select item 1975489227.

Mechanistic view on domains mediating STIM1-Orai coupling.

Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.

Immunol Rev. 2009 Sep;231(1):99-112. doi: 10.1111/j.1600-065X.2009.00815.x. Review.

PMID:: 19754892

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Select item 1973339328.

Recent progress on STIM1 domains controlling Orai activation.

Schindl R, Muik M, Fahrner M, Derler I, Fritsch R, Bergsmann J, Romanin C.

Cell Calcium. 2009 Oct;46(4):227-32. doi: 10.1016/j.ceca.2009.08.003. Epub 2009 Sep 4. Review.

PMID:: 19733393

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Select item 1962274729.

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.

Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Sep 11;284(37):24933-8. doi: 10.1074/jbc.C109.024083. Epub 2009 Jul 21.

PMID:: 19622747

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Select item 1950608130.

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.

Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Aug 7;284(32):21696-706. doi: 10.1074/jbc.M109.018408. Epub 2009 Jun 8.

PMID:: 19506081

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Select item 1936668931.

Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant.

Derler I, Fahrner M, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S, Romanin C.

J Biol Chem. 2009 Jun 5;284(23):15903-15. doi: 10.1074/jbc.M808312200. Epub 2009 Apr 14.

PMID:: 19366689

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Select item 1918996632.

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.

Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.

J Biol Chem. 2009 Mar 27;284(13):8421-6. doi: 10.1074/jbc.C800229200. Epub 2009 Feb 3.

PMID:: 19189966

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Select item 1876913633.

The STIM/Orai coupling machinery.

Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C.

Channels (Austin). 2008 Jul-Aug;2(4):261-8. Epub 2008 Jul 21. Review.

PMID:: 18769136

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Select item 1849965634.

2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.

J Biol Chem. 2008 Jul 18;283(29):20261-7. doi: 10.1074/jbc.M803101200. Epub 2008 May 21.

PMID:: 18499656

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Select item 1818742435.

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Muik M, Frischauf I, Derler I, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.

J Biol Chem. 2008 Mar 21;283(12):8014-22. doi: 10.1074/jbc.M708898200. Epub 2008 Jan 10.