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CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.

Maeda K, Otomo K, Yoshida N, Abu-Asab MS, Ichinose K, Nishino T, Kono M, Ferretti A, Bhargava R, Maruyama S, Bickerton S, Fahmy TM, Tsokos MG, Tsokos GC.

J Clin Invest. 2018 Jul 9. pii: 99507. doi: 10.1172/JCI99507. [Epub ahead of print]


Magnetically Coated Bioabsorbable Stents for Renormalization of Arterial Vessel Walls after Stent Implantation.

Lee JS, Han P, Song E, Kim D, Lee H, Labowsky M, Taavitsainen J, Ylä-Herttuala S, Hytönen J, Gülcher M, Perampaladas K, Sinusas AJ, Martin J, Mathur A, Fahmy TM.

Nano Lett. 2018 Jan 10;18(1):272-281. doi: 10.1021/acs.nanolett.7b04096. Epub 2017 Dec 28.


Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty.

Bai H, Lee JS, Hu H, Wang T, Isaji T, Liu S, Guo J, Liu H, Wolf K, Ono S, Guo X, Yatsula B, Xing Y, Fahmy TM, Dardik A.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):195-205. doi: 10.1161/ATVBAHA.117.310372. Epub 2017 Nov 16.


Artificial Antigen-Presenting Cells for Immunotherapies.

Siefert AL, Fahmy TM, Kim D.

Methods Mol Biol. 2017;1530:343-353. doi: 10.1007/978-1-4939-6646-2_21.


Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia.

Bai H, Lee JS, Chen E, Wang M, Xing Y, Fahmy TM, Dardik A.

Sci Rep. 2017 Jan 10;7:40142. doi: 10.1038/srep40142.


Precise manipulation of biophysical particle parameters enables control of proinflammatory cytokine production in presence of TLR 3 and 4 ligands.

Kakizawa Y, Lee JS, Bell B, Fahmy TM.

Acta Biomater. 2017 Jul 15;57:136-145. doi: 10.1016/j.actbio.2017.01.025. Epub 2017 Jan 6.


Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model.

Siefert AL, Ehrlich A, Corral MJ, Goldsmith-Pestana K, McMahon-Pratt D, Fahmy TM.

Biomaterials. 2016 Nov;108:168-76. doi: 10.1016/j.biomaterials.2016.09.004. Epub 2016 Sep 6.


Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy.

Siefert AL, Caplan MJ, Fahmy TM.

Biomaterials. 2016 Aug;97:85-96. doi: 10.1016/j.biomaterials.2016.03.039. Epub 2016 Apr 1.


Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy.

Srivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA.

J Allergy Clin Immunol. 2016 Aug;138(2):536-543.e4. doi: 10.1016/j.jaci.2016.01.047. Epub 2016 Apr 26.


Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity.

Hong E, Usiskin IM, Bergamaschi C, Hanlon DJ, Edelson RL, Justesen S, Pavlakis GN, Flavell RA, Fahmy TM.

J Biol Chem. 2016 Apr 22;291(17):8931-50. doi: 10.1074/jbc.M115.695304. Epub 2015 Dec 30.


Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.

Otomo K, Koga T, Mizui M, Yoshida N, Kriegel C, Bickerton S, Fahmy TM, Tsokos GC.

J Immunol. 2015 Dec 15;195(12):5533-7. doi: 10.4049/jimmunol.1501603. Epub 2015 Nov 11.


Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells.

McHugh MD, Park J, Uhrich R, Gao W, Horwitz DA, Fahmy TM.

Biomaterials. 2015 Aug;59:172-81. doi: 10.1016/j.biomaterials.2015.04.003. Epub 2015 May 15.


Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF).

Rittchen S, Boyd A, Burns A, Park J, Fahmy TM, Metcalfe S, Williams A.

Biomaterials. 2015 Jul;56:78-85. doi: 10.1016/j.biomaterials.2015.03.044. Epub 2015 Apr 15.


A dynamic model of chemoattractant-induced cell migration.

Yang H, Gou X, Wang Y, Fahmy TM, Leung AY, Lu J, Sun D.

Biophys J. 2015 Apr 7;108(7):1645-1651. doi: 10.1016/j.bpj.2014.12.060.


The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.

Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.


TGFβR1 inhibition blocks the formation of stenosis in tissue-engineered vascular grafts.

Duncan DR, Chen PY, Patterson JT, Lee YU, Hibino N, Cleary M, Naito Y, Yi T, Gilliland T, Kurobe H, Church SN, Shinoka T, Fahmy TM, Simons M, Breuer CK.

J Am Coll Cardiol. 2015 Feb 10;65(5):512-4. doi: 10.1016/j.jacc.2014.08.057. No abstract available.


An in silico analysis of nanoparticle/cell diffusive transfer: application to nano-artificial antigen-presenting cell:T-cell interaction.

Labowsky M, Lowenthal J, Fahmy TM.

Nanomedicine. 2015 May;11(4):1019-28. doi: 10.1016/j.nano.2014.12.019. Epub 2015 Jan 31.


Multiple Sclerosis and the LIF/IL-6 Axis: Use of Nanotechnology to Harness the Tolerogenic and Reparative Properties of LIF.

Metcalfe SM, Strom TB, Williams A, Fahmy TM.

Nanobiomedicine (Rij). 2015 Jan 1;2:5. doi: 10.5772/60622. eCollection 2015 Jan-Dec. Review.


Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA.

Zeller S, Choi CS, Uchil PD, Ban HS, Siefert A, Fahmy TM, Mothes W, Lee SK, Kumar P.

Chem Biol. 2015 Jan 22;22(1):50-62. doi: 10.1016/j.chembiol.2014.11.009. Epub 2014 Dec 24.


Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen.

Saluja SS, Hanlon DJ, Sharp FA, Hong E, Khalil D, Robinson E, Tigelaar R, Fahmy TM, Edelson RL.

Int J Nanomedicine. 2014 Nov 12;9:5231-46. doi: 10.2147/IJN.S66639. eCollection 2014.


Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance.

Strohbehn G, Coman D, Han L, Ragheb RR, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM, Zhou J.

J Neurooncol. 2015 Feb;121(3):441-9. doi: 10.1007/s11060-014-1658-0. Epub 2014 Nov 18.


A self-assembled polymeric micellar immunomodulator for cancer treatment based on cationic amphiphilic polymers.

Yim H, Park W, Kim D, Fahmy TM, Na K.

Biomaterials. 2014 Dec;35(37):9912-9919. doi: 10.1016/j.biomaterials.2014.08.029. Epub 2014 Sep 17.


A carbon nanotube-polymer composite for T-cell therapy.

Fadel TR, Sharp FA, Vudattu N, Ragheb R, Garyu J, Kim D, Hong E, Li N, Haller GL, Pfefferle LD, Justesen S, Herold KC, Fahmy TM.

Nat Nanotechnol. 2014 Aug;9(8):639-47. doi: 10.1038/nnano.2014.154. Epub 2014 Aug 3. Erratum in: Nat Nanotechnol. 2014 Sep;9(9):723. Harold, Kevin C [corrected to Herold, Kevan C].


Modelling of a targeted nanotherapeutic 'stroma' to deliver the cytokine LIF, or XAV939, a potent inhibitor of Wnt-β-catenin signalling, for use in human fetal dopaminergic grafts in Parkinson's disease.

Zhao JW, Dyson SC, Kriegel C, Tyers P, He X, Fahmy TM, Metcalfe SM, Barker RA.

Dis Model Mech. 2014 Oct;7(10):1193-203. doi: 10.1242/dmm.015859. Epub 2014 Aug 1.


Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.

Sehgal K, Ragheb R, Fahmy TM, Dhodapkar MV, Dhodapkar KM.

J Immunol. 2014 Sep 1;193(5):2297-305. doi: 10.4049/jimmunol.1400489. Epub 2014 Jul 30.


Immunotherapy applications of carbon nanotubes: from design to safe applications.

Fadel TR, Fahmy TM.

Trends Biotechnol. 2014 Apr;32(4):198-209. doi: 10.1016/j.tibtech.2014.02.005. Epub 2014 Mar 12. Review.


The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus.

Look M, Saltzman WM, Craft J, Fahmy TM.

Biomaterials. 2014 Jan;35(3):1089-95. doi: 10.1016/j.biomaterials.2013.10.046. Epub 2013 Nov 1.


Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice.

Look M, Stern E, Wang QA, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM.

J Clin Invest. 2013 Apr;123(4):1741-9.


Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics.

Ragheb RR, Kim D, Bandyopadhyay A, Chahboune H, Bulutoglu B, Ezaldein H, Criscione JM, Fahmy TM.

Magn Reson Med. 2013 Dec;70(6):1748-60. doi: 10.1002/mrm.24622. Epub 2013 Feb 7.


Immuno-isolation of pancreatic islet allografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice.

Dong H, Fahmy TM, Metcalfe SM, Morton SL, Dong X, Inverardi L, Adams DB, Gao W, Wang H.

PLoS One. 2012;7(12):e50265. doi: 10.1371/journal.pone.0050265. Epub 2012 Dec 5.


Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation.

Fadel TR, Li N, Shah S, Look M, Pfefferle LD, Haller GL, Justesen S, Wilson CJ, Fahmy TM.

Small. 2013 Mar 11;9(5):666-72. doi: 10.1002/smll.201201684. Epub 2012 Oct 23.


Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy.

Park J, Wrzesinski SH, Stern E, Look M, Criscione J, Ragheb R, Jay SM, Demento SL, Agawu A, Licona Limon P, Ferrandino AF, Gonzalez D, Habermann A, Flavell RA, Fahmy TM.

Nat Mater. 2012 Oct;11(10):895-905. doi: 10.1038/nmat3355. Epub 2012 Jul 15.


Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles.

Corradetti B, Freile P, Pells S, Bagnaninchi P, Park J, Fahmy TM, de Sousa PA.

Biomaterials. 2012 Oct;33(28):6634-43. doi: 10.1016/j.biomaterials.2012.06.011. Epub 2012 Jun 30.


Diffusive transfer between two intensely interacting cells with limited surface kinetics.

Labowsky M, Fahmy TM.

Chem Eng Sci. 2012 May 28;74:114-123. Epub 2012 Feb 6.


Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype.

Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM.

Biomaterials. 2012 Jun;33(19):4957-64. doi: 10.1016/j.biomaterials.2012.03.041. Epub 2012 Apr 6.


Cell-specific siRNA delivery by peptides and antibodies.

Lee SK, Siefert A, Beloor J, Fahmy TM, Kumar P.

Methods Enzymol. 2012;502:91-122. doi: 10.1016/B978-0-12-416039-2.00005-7. Review.


Targeted nanotherapy for induction of therapeutic immune responses.

Metcalfe SM, Fahmy TM.

Trends Mol Med. 2012 Feb;18(2):72-80. doi: 10.1016/j.molmed.2011.11.002. Epub 2011 Dec 14.


Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival.

Shirali AC, Look M, Du W, Kassis E, Stout-Delgado HW, Fahmy TM, Goldstein DR.

Am J Transplant. 2011 Dec;11(12):2582-92. doi: 10.1111/j.1600-6143.2011.03725.x. Epub 2011 Aug 30.


Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ, Fahmy TM.

Bioconjug Chem. 2011 Sep 21;22(9):1784-92. doi: 10.1021/bc200162r. Epub 2011 Sep 6.


An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response.

Steenblock ER, Fadel T, Labowsky M, Pober JS, Fahmy TM.

J Biol Chem. 2011 Oct 7;286(40):34883-92. doi: 10.1074/jbc.M111.276329. Epub 2011 Aug 17.


Determining the fate of seeded cells in venous tissue-engineered vascular grafts using serial MRI.

Harrington JK, Chahboune H, Criscione JM, Li AY, Hibino N, Yi T, Villalona GA, Kobsa S, Meijas D, Duncan DR, Devine L, Papademetri X, Shin'oka T, Fahmy TM, Breuer CK.

FASEB J. 2011 Dec;25(12):4150-61. doi: 10.1096/fj.11-185140. Epub 2011 Aug 16.


Determination of molecular configuration by debye length modulation.

Vacic A, Criscione JM, Rajan NK, Stern E, Fahmy TM, Reed MA.

J Am Chem Soc. 2011 Sep 7;133(35):13886-9. doi: 10.1021/ja205684a. Epub 2011 Aug 16.


Enhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates.

Park J, Mattessich T, Jay SM, Agawu A, Saltzman WM, Fahmy TM.

J Control Release. 2011 Nov 30;156(1):109-15. doi: 10.1016/j.jconrel.2011.06.025. Epub 2011 Jun 24.


A multiplexed electrospray process for single-step synthesis of stabilized polymer particles for drug delivery.

Almería B, Fahmy TM, Gomez A.

J Control Release. 2011 Sep 5;154(2):203-10. doi: 10.1016/j.jconrel.2011.05.018. Epub 2011 May 26.


Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.

Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM.

Self Nonself. 2010 Oct;1(4):335-340.


Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines.

Demento SL, Siefert AL, Bandyopadhyay A, Sharp FA, Fahmy TM.

Trends Biotechnol. 2011 Jun;29(6):294-306. doi: 10.1016/j.tibtech.2011.02.004. Epub 2011 Apr 2. Review.


The impact of nanoparticle ligand density on dendritic-cell targeted vaccines.

Bandyopadhyay A, Fine RL, Demento S, Bockenstedt LK, Fahmy TM.

Biomaterials. 2011 Apr;32(11):3094-105. doi: 10.1016/j.biomaterials.2010.12.054. Epub 2011 Jan 22.


Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.

Park J, Gao W, Whiston R, Strom TB, Metcalfe S, Fahmy TM.

Mol Pharm. 2011 Feb 7;8(1):143-52. doi: 10.1021/mp100203a. Epub 2010 Dec 8.


TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis.

Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM.

J Immunol. 2010 Sep 1;185(5):2989-97. doi: 10.4049/jimmunol.1000768. Epub 2010 Jul 26.

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