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Items: 1 to 50 of 101

1.

Glutathione analogs in prokaryotes.

Fahey RC.

Biochim Biophys Acta. 2013 May;1830(5):3182-98. doi: 10.1016/j.bbagen.2012.10.006. Epub 2012 Oct 14. Review.

PMID:
23075826
2.

Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis.

Upton H, Newton GL, Gushiken M, Lo K, Holden D, Fahey RC, Rawat M.

FEBS Lett. 2012 Apr 5;586(7):1004-8. doi: 10.1016/j.febslet.2012.02.028. Epub 2012 Mar 6.

3.

Detoxification of toxins by bacillithiol in Staphylococcus aureus.

Newton GL, Fahey RC, Rawat M.

Microbiology. 2012 Apr;158(Pt 4):1117-1126. doi: 10.1099/mic.0.055715-0. Epub 2012 Jan 19. Erratum in: Microbiology. 2012 Sep;158(Pt 9):2450.

4.

The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases.

Newton GL, Leung SS, Wakabayashi JI, Rawat M, Fahey RC.

Biochemistry. 2011 Dec 13;50(49):10751-60. doi: 10.1021/bi201460j. Epub 2011 Nov 17.

5.

The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth.

Hatzios SK, Schelle MW, Newton GL, Sogi KM, Holsclaw CM, Fahey RC, Bertozzi CR.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):4956-9. doi: 10.1016/j.bmcl.2011.06.057. Epub 2011 Jun 29.

6.

Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis.

Newton GL, Buchmeier N, La Clair JJ, Fahey RC.

Bioorg Med Chem. 2011 Jul 1;19(13):3956-64. doi: 10.1016/j.bmc.2011.05.028. Epub 2011 May 24.

7.

Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants.

Ta P, Buchmeier N, Newton GL, Rawat M, Fahey RC.

J Bacteriol. 2011 Apr;193(8):1981-90. doi: 10.1128/JB.01402-10. Epub 2011 Feb 18.

8.

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.

Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6482-6. doi: 10.1073/pnas.1000928107. Epub 2010 Mar 22.

9.

Bacillithiol is an antioxidant thiol produced in Bacilli.

Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC.

Nat Chem Biol. 2009 Sep;5(9):625-7. doi: 10.1038/nchembio.189. Epub 2009 Jul 5.

10.

Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Newton GL, Buchmeier N, Fahey RC.

Microbiol Mol Biol Rev. 2008 Sep;72(3):471-94. doi: 10.1128/MMBR.00008-08. Review.

11.

Unusual production of glutathione in Actinobacteria.

Johnson T, Newton GL, Fahey RC, Rawat M.

Arch Microbiol. 2009 Jan;191(1):89-93. doi: 10.1007/s00203-008-0423-1. Epub 2008 Aug 22.

12.

An N-acyl homolog of mycothiol is produced in marine actinomycetes.

Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC.

Arch Microbiol. 2008 Nov;190(5):547-57. doi: 10.1007/s00203-008-0405-3. Epub 2008 Jul 16.

13.

Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA.

Newton GL, Fahey RC.

Mol Microbiol. 2008 May;68(4):805-9. doi: 10.1111/j.1365-2958.2008.06222.x.

14.

Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production.

Bzymek KP, Newton GL, Ta P, Fahey RC.

J Bacteriol. 2007 Oct;189(19):6796-805. Epub 2007 Jul 20.

15.

Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology.

Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A.

Biochemistry. 2007 Mar 20;46(11):3234-45. Epub 2007 Feb 27.

16.
17.

Biochemistry of the initial steps of mycothiol biosynthesis.

Newton GL, Ta P, Bzymek KP, Fahey RC.

J Biol Chem. 2006 Nov 10;281(45):33910-20. Epub 2006 Aug 28.

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23.

Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation.

Seligman J, Newton GL, Fahey RC, Shalgi R, Kosower NS.

J Androl. 2005 Sep-Oct;26(5):629-37; discussion 638-40.

24.

Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein.

Rawat M, Uppal M, Newton G, Steffek M, Fahey RC, Av-Gay Y.

J Bacteriol. 2004 Sep;186(18):6050-8.

25.

Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman.

Sareen D, Newton GL, Fahey RC, Buchmeier NA.

J Bacteriol. 2003 Nov;185(22):6736-40.

26.

Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase.

Steffek M, Newton GL, Av-Gay Y, Fahey RC.

Biochemistry. 2003 Oct 21;42(41):12067-76.

PMID:
14556638
27.

The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.

Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN.

J Biol Chem. 2003 Nov 21;278(47):47166-70. Epub 2003 Sep 4.

28.

The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).

Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y.

J Bacteriol. 2003 Jun;185(11):3476-9.

29.

Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics.

Buchmeier NA, Newton GL, Koledin T, Fahey RC.

Mol Microbiol. 2003 Mar;47(6):1723-32.

30.

Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors.

Nicholas GM, Eckman LL, Newton GL, Fahey RC, Ray S, Bewley CA.

Bioorg Med Chem. 2003 Feb 20;11(4):601-8.

PMID:
12538025
31.

Mycothiol biochemistry.

Newton GL, Fahey RC.

Arch Microbiol. 2002 Dec;178(6):388-94. Epub 2002 Sep 3. Review.

PMID:
12420157
32.

Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics.

Rawat M, Newton GL, Ko M, Martinez GJ, Fahey RC, Av-Gay Y.

Antimicrob Agents Chemother. 2002 Nov;46(11):3348-55.

33.

Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.

Koledin T, Newton GL, Fahey RC.

Arch Microbiol. 2002 Nov;178(5):331-7. Epub 2002 Aug 15.

PMID:
12375100
35.

Blood thiols following amifostine and mesna infusions, a pediatric oncology group study.

Souid AK, Fahey RC, Aktas MK, Sayin OA, Karjoo S, Newton GL, Sadowitz PD, Dubowy RL, Bernstein ML.

Drug Metab Dispos. 2001 Nov;29(11):1460-6.

PMID:
11602522
36.

Novel thiols of prokaryotes.

Fahey RC.

Annu Rev Microbiol. 2001;55:333-56. Review.

PMID:
11544359
37.

Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase.

Nicholas GM, Newton GL, Fahey RC, Bewley CA.

Org Lett. 2001 May 17;3(10):1543-5.

PMID:
11388862
38.
39.

A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.

Newton GL, Av-Gay Y, Fahey RC.

Biochemistry. 2000 Sep 5;39(35):10739-46.

PMID:
10978158
41.

Improved methods for immunoassay of mycothiol.

Unson MD, Newton GL, Arnold KF, Davis CE, Fahey RC.

J Clin Microbiol. 1999 Jul;37(7):2153-7.

42.
43.

Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis.

Newton GL, Unson MD, Anderberg SJ, Aguilera JA, Oh NN, delCardayre SB, Av-Gay Y, Fahey RC.

Biochem Biophys Res Commun. 1999 Feb 16;255(2):239-44.

PMID:
10049692
46.

An immunoassay for the detection and quantitative determination of mycothiol.

Unson MD, Newton GL, Davis C, Fahey RC.

J Immunol Methods. 1998 May 1;214(1-2):29-39.

PMID:
9692856
47.

The limits to radioprotection of Chinese hamster V79 cells by WR-1065 under aerobic conditions.

Calabro-Jones PM, Aguilera JA, Ward JF, Fahey RC.

Radiat Res. 1998 Jun;149(6):550-9.

PMID:
9611093
48.
49.

Import and metabolism of glutathione by Streptococcus mutans.

Sherrill C, Fahey RC.

J Bacteriol. 1998 Mar;180(6):1454-9.

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