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Items: 1 to 50 of 114

1.

Genetic and functional diversity of the multiple lungfish myoglobins.

Lüdemann J, Fago A, Falke S, Wisniewsky M, Schneider I, Fabrizius A, Burmester T.

FEBS J. 2019 Oct 14. doi: 10.1111/febs.15094. [Epub ahead of print]

PMID:
31610084
2.

A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood.

Jensen B, Fago A.

Antioxid Redox Signal. 2019 Oct 14. doi: 10.1089/ars.2019.7877. [Epub ahead of print]

PMID:
31530173
3.

The Zebrafish Cytochrome b5/Cytochrome b5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b5/Cytochrome b5 Reductases during Vertebrate Evolution.

Amdahl MB, Petersen EE, Bocian K, Kaliszuk SJ, DeMartino AW, Tiwari S, Sparacino-Watkins CE, Corti P, Rose JJ, Gladwin MT, Fago A, Tejero J.

Biochemistry. 2019 Jul 23;58(29):3212-3223. doi: 10.1021/acs.biochem.9b00406. Epub 2019 Jul 10.

PMID:
31257865
4.

Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles.

Jensen B, Pardue S, Kevil CG, Fago A.

J Exp Biol. 2019 Jun 19;222(Pt 12). pii: jeb203976. doi: 10.1242/jeb.203976.

PMID:
31109970
5.

Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia.

Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A.

J Exp Biol. 2019 Jun 10;222(Pt 11). pii: jeb200410. doi: 10.1242/jeb.200410.

PMID:
31097599
6.

Hypoxia enhances blood O2 affinity and depresses skeletal muscle O2 consumption in zebrafish (Danio rerio).

Cadiz L, Bundgaard A, Malte H, Fago A.

Comp Biochem Physiol B Biochem Mol Biol. 2019 Aug;234:18-25. doi: 10.1016/j.cbpb.2019.05.003. Epub 2019 May 8.

PMID:
31075501
7.

Emergence of a Chimeric Globin Pseudogene and Increased Hemoglobin Oxygen Affinity Underlie the Evolution of Aquatic Specializations in Sirenia.

Signore AV, Paijmans JLA, Hofreiter M, Fago A, Weber RE, Springer MS, Campbell KL.

Mol Biol Evol. 2019 Jun 1;36(6):1134-1147. doi: 10.1093/molbev/msz044.

8.

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury.

Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A.

Sci Rep. 2019 Feb 26;9(1):2850. doi: 10.1038/s41598-019-39836-5.

9.

Globin E is a myoglobin-related, respiratory protein highly expressed in lungfish oocytes.

Lüdemann J, Verissimo KM, Dreger K, Fago A, Schneider I, Burmester T.

Sci Rep. 2019 Jan 22;9(1):280. doi: 10.1038/s41598-018-36592-w.

10.

Allosteric mechanisms underlying the adaptive increase in hemoglobin-oxygen affinity of the bar-headed goose.

Jendroszek A, Malte H, Overgaard CB, Beedholm K, Natarajan C, Weber RE, Storz JF, Fago A.

J Exp Biol. 2018 Sep 17;221(Pt 18). pii: jeb185470. doi: 10.1242/jeb.185470.

11.

Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose.

Natarajan C, Jendroszek A, Kumar A, Weber RE, Tame JRH, Fago A, Storz JF.

PLoS Genet. 2018 Apr 2;14(4):e1007331. doi: 10.1371/journal.pgen.1007331. eCollection 2018 Apr.

12.

Suppression of reactive oxygen species generation in heart mitochondria from anoxic turtles: the role of complex I S-nitrosation.

Bundgaard A, James AM, Joyce W, Murphy MP, Fago A.

J Exp Biol. 2018 Apr 25;221(Pt 8). pii: jeb174391. doi: 10.1242/jeb.174391.

13.

Reactions of ferric hemoglobin and myoglobin with hydrogen sulfide under physiological conditions.

Jensen B, Fago A.

J Inorg Biochem. 2018 May;182:133-140. doi: 10.1016/j.jinorgbio.2018.02.007. Epub 2018 Feb 10.

PMID:
29459272
14.

Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau.

Zhu X, Guan Y, Signore AV, Natarajan C, DuBay SG, Cheng Y, Han N, Song G, Qu Y, Moriyama H, Hoffmann FG, Fago A, Lei F, Storz JF.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1865-1870. doi: 10.1073/pnas.1720487115. Epub 2018 Feb 5.

15.

Functional diversification of sea lamprey globins in evolution and development.

Fago A, Rohlfing K, Petersen EE, Jendroszek A, Burmester T.

Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):283-291. doi: 10.1016/j.bbapap.2017.11.009. Epub 2017 Nov 23.

PMID:
29155105
16.

The Greenland shark Somniosus microcephalus-Hemoglobins and ligand-binding properties.

Russo R, Giordano D, Paredi G, Marchesani F, Milazzo L, Altomonte G, Del Canale P, Abbruzzetti S, Ascenzi P, di Prisco G, Viappiani C, Fago A, Bruno S, Smulevich G, Verde C.

PLoS One. 2017 Oct 12;12(10):e0186181. doi: 10.1371/journal.pone.0186181. eCollection 2017.

17.

Hemoglobin polymerization via disulfide bond formation in the hypoxia-tolerant turtle Trachemys scripta: implications for antioxidant defense and O2 transport.

Petersen AG, Petersen SV, Frische S, Drakulic S, Golas MM, Sander B, Fago A.

Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R84-R93. doi: 10.1152/ajpregu.00024.2017. Epub 2017 Sep 6.

18.

O2 binding and CO2 sensitivity in haemoglobins of subterranean African mole rats.

Weber RE, Jarvis JUM, Fago A, Bennett NC.

J Exp Biol. 2017 Nov 1;220(Pt 21):3939-3948. doi: 10.1242/jeb.160457. Epub 2017 Aug 29.

19.

Functional roles of globin proteins in hypoxia-tolerant ectothermic vertebrates.

Fago A.

J Appl Physiol (1985). 2017 Oct 1;123(4):926-934. doi: 10.1152/japplphysiol.00104.2017. Epub 2017 Apr 20. Review.

20.

Regulation of blood oxygen transport in hibernating mammals.

Revsbech IG, Fago A.

J Comp Physiol B. 2017 Jul;187(5-6):847-856. doi: 10.1007/s00360-017-1085-6. Epub 2017 Mar 21. Review.

PMID:
28324160
21.

Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.

Kumar A, Natarajan C, Moriyama H, Witt CC, Weber RE, Fago A, Storz JF.

Mol Biol Evol. 2017 May 1;34(5):1240-1251. doi: 10.1093/molbev/msx085.

22.

A comparison of blood nitric oxide metabolites and hemoglobin functional properties among diving mammals.

Fago A, Parraga DG, Petersen EE, Kristensen N, Giouri L, Jensen FB.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Mar;205:35-40. doi: 10.1016/j.cbpa.2016.12.013. Epub 2016 Dec 18.

PMID:
27993597
23.

Predictable convergence in hemoglobin function has unpredictable molecular underpinnings.

Natarajan C, Hoffmann FG, Weber RE, Fago A, Witt CC, Storz JF.

Science. 2016 Oct 21;354(6310):336-339.

24.

The roles of tissue nitrate reductase activity and myoglobin in securing nitric oxide availability in deeply hypoxic crucian carp.

Hansen MN, Lundberg JO, Filice M, Fago A, Christensen NM, Jensen FB.

J Exp Biol. 2016 Dec 15;219(Pt 24):3875-3883. Epub 2016 Oct 14.

25.

Repeated Prolonged Exercise Decreases Maximal Fat Oxidation in Older Men.

Morville T, Rosenkilde M, Munch-Andersen T, Andersen PR, Kjær Groenbæk K, Helbo S, Kristensen M, Vigelsø Hansen A, Mattsson N, Rasmusen HK, Guadalupe-Grau A, Fago A, Neigaard Hansen C, Twelkmeyer B, Løvind Andersen J, Dela F, Wulff Helge J.

Med Sci Sports Exerc. 2017 Feb;49(2):308-316. doi: 10.1249/MSS.0000000000001107.

PMID:
27685008
26.

The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen.

Sæderup KL, Stødkilde K, Graversen JH, Dickson CF, Etzerodt A, Hansen SW, Fago A, Gell D, Andersen CB, Moestrup SK.

J Biol Chem. 2016 Nov 11;291(46):23989-23998. Epub 2016 Sep 28.

27.

Students' motivation toward laboratory work in physiology teaching.

Dohn NB, Fago A, Overgaard J, Madsen PT, Malte H.

Adv Physiol Educ. 2016 Sep;40(3):313-8. doi: 10.1152/advan.00029.2016.

28.

Bohr effect and temperature sensitivity of hemoglobins from highland and lowland deer mice.

Jensen B, Storz JF, Fago A.

Comp Biochem Physiol A Mol Integr Physiol. 2016 May;195:10-4. doi: 10.1016/j.cbpa.2016.01.018. Epub 2016 Jan 22.

29.

Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level.

Natarajan C, Projecto-Garcia J, Moriyama H, Weber RE, Muñoz-Fuentes V, Green AJ, Kopuchian C, Tubaro PL, Alza L, Bulgarella M, Smith MM, Wilson RE, Fago A, McCracken KG, Storz JF.

PLoS Genet. 2015 Dec 4;11(12):e1005681. doi: 10.1371/journal.pgen.1005681. eCollection 2015 Dec.

30.

Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens.

Galen SC, Natarajan C, Moriyama H, Weber RE, Fago A, Benham PM, Chavez AN, Cheviron ZA, Storz JF, Witt CC.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13958-63. doi: 10.1073/pnas.1507300112. Epub 2015 Oct 12.

31.

Oxygenation properties and isoform diversity of snake hemoglobins.

Storz JF, Natarajan C, Moriyama H, Hoffmann FG, Wang T, Fago A, Malte H, Overgaard J, Weber RE.

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1178-91. doi: 10.1152/ajpregu.00327.2015. Epub 2015 Sep 9.

32.

Genetically based low oxygen affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard.

Janecka JE, Nielsen SS, Andersen SD, Hoffmann FG, Weber RE, Anderson T, Storz JF, Fago A.

J Exp Biol. 2015 Aug;218(Pt 15):2402-9. doi: 10.1242/jeb.125369.

33.

Kinetic properties and heme pocket structure of two domains of the polymeric hemoglobin of Artemia in comparison with the native molecule.

Borhani HA, Berghmans H, Trashin S, De Wael K, Fago A, Moens L, Habibi-Rezaei M, Dewilde S.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1307-16. doi: 10.1016/j.bbapap.2015.05.007. Epub 2015 May 22.

PMID:
26004089
34.

Inhibitory effects of nitrite on the reactions of bovine carbonic anhydrase II with CO2 and bicarbonate consistent with zinc-bound nitrite.

Nielsen PM, Fago A.

J Inorg Biochem. 2015 Aug;149:6-11. doi: 10.1016/j.jinorgbio.2015.04.013. Epub 2015 Apr 27.

PMID:
25951615
35.

Myoglobin oxygenation and autoxidation in three reptilian species.

Helbo S, Bundgaard AG, Fago A.

Comp Biochem Physiol A Mol Integr Physiol. 2015 Sep;187:8-12. doi: 10.1016/j.cbpa.2015.04.009. Epub 2015 Apr 18.

PMID:
25899737
36.

Hypoxia tolerance, nitric oxide, and nitrite: lessons from extreme animals.

Fago A, Jensen FB.

Physiology (Bethesda). 2015 Mar;30(2):116-26. doi: 10.1152/physiol.00051.2014. Review.

37.

A globin domain in a neuronal transmembrane receptor of Caenorhabditis elegans and Ascaris suum: molecular modeling and functional properties.

Tilleman L, Germani F, De Henau S, Helbo S, Desmet F, Berghmans H, Van Doorslaer S, Hoogewijs D, Schoofs L, Braeckman BP, Moens L, Fago A, Dewilde S.

J Biol Chem. 2015 Apr 17;290(16):10336-52. doi: 10.1074/jbc.M114.576520. Epub 2015 Feb 9.

38.

Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin.

Natarajan C, Hoffmann FG, Lanier HC, Wolf CJ, Cheviron ZA, Spangler ML, Weber RE, Fago A, Storz JF.

Mol Biol Evol. 2015 Apr;32(4):978-97. doi: 10.1093/molbev/msu403. Epub 2015 Jan 2.

39.

Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas.

Tufts DM, Natarajan C, Revsbech IG, Projecto-Garcia J, Hoffmann FG, Weber RE, Fago A, Moriyama H, Storz JF.

Mol Biol Evol. 2015 Feb;32(2):287-98. doi: 10.1093/molbev/msu311. Epub 2014 Nov 18.

40.

Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males.

Guadalupe-Grau A, Plenge U, Helbo S, Kristensen M, Andersen PR, Fago A, Belhage B, Dela F, Helge JW.

J Sports Sci. 2015;33(6):570-8. doi: 10.1080/02640414.2014.951872. Epub 2014 Sep 26.

PMID:
25259652
41.

High blood oxygen affinity in the air-breathing swamp eel Monopterus albus.

Damsgaard C, Findorf I, Helbo S, Kocagoz Y, Buchanan R, Huong do TT, Weber RE, Fago A, Bayley M, Wang T.

Comp Biochem Physiol A Mol Integr Physiol. 2014 Dec;178:102-8. doi: 10.1016/j.cbpa.2014.08.001. Epub 2014 Aug 17.

PMID:
25139401
42.

Integrating evolutionary and functional tests of adaptive hypotheses: a case study of altitudinal differentiation in hemoglobin function in an Andean Sparrow, Zonotrichia capensis.

Cheviron ZA, Natarajan C, Projecto-Garcia J, Eddy DK, Jones J, Carling MD, Witt CC, Moriyama H, Weber RE, Fago A, Storz JF.

Mol Biol Evol. 2014 Nov;31(11):2948-62. doi: 10.1093/molbev/msu234. Epub 2014 Aug 18.

43.

Enthalpic partitioning of the reduced temperature sensitivity of O2 binding in bovine hemoglobin.

Weber RE, Fago A, Campbell KL.

Comp Biochem Physiol A Mol Integr Physiol. 2014 Oct;176:20-5. doi: 10.1016/j.cbpa.2014.06.012. Epub 2014 Jun 28.

PMID:
24983927
44.

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation.

Revsbech IG, Shen X, Chakravarti R, Jensen FB, Thiel B, Evans AL, Kindberg J, Fröbert O, Stuehr DJ, Kevil CG, Fago A.

Free Radic Biol Med. 2014 Aug;73:349-57. doi: 10.1016/j.freeradbiomed.2014.05.025. Epub 2014 Jun 5.

45.

Oxygen-linked S-nitrosation in fish myoglobins: a cysteine-specific tertiary allosteric effect.

Helbo S, Gow AJ, Jamil A, Howes BD, Smulevich G, Fago A.

PLoS One. 2014 May 30;9(5):e97012. doi: 10.1371/journal.pone.0097012. eCollection 2014.

46.

Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds.

Projecto-Garcia J, Natarajan C, Moriyama H, Weber RE, Fago A, Cheviron ZA, Dudley R, McGuire JA, Witt CC, Storz JF.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20669-74. doi: 10.1073/pnas.1315456110. Epub 2013 Dec 2.

47.

Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges.

Revsbech IG, Tufts DM, Projecto-Garcia J, Moriyama H, Weber RE, Storz JF, Fago A.

J Exp Biol. 2013 Nov 15;216(Pt 22):4264-71. doi: 10.1242/jeb.091397.

48.

Hemoglobin isoform differentiation and allosteric regulation of oxygen binding in the turtle, Trachemys scripta.

Damsgaard C, Storz JF, Hoffmann FG, Fago A.

Am J Physiol Regul Integr Comp Physiol. 2013 Oct 15;305(8):R961-7. doi: 10.1152/ajpregu.00284.2013. Epub 2013 Aug 28.

49.

Epistasis among adaptive mutations in deer mouse hemoglobin.

Natarajan C, Inoguchi N, Weber RE, Fago A, Moriyama H, Storz JF.

Science. 2013 Jun 14;340(6138):1324-7. doi: 10.1126/science.1236862.

50.

Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin.

Weber RE, Fago A, Malte H, Storz JF, Gorr TA.

Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R300-12. doi: 10.1152/ajpregu.00014.2013. Epub 2013 May 29.

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